Incidence, risk factors and healthcare costs of central line-associated nosocomial bloodstream infections in hematologic and oncologic patients

Autoři: Claas Baier aff001;  Lena Linke aff001;  Matthias Eder aff002;  Frank Schwab aff003;  Iris Freya Chaberny aff004;  Ralf-Peter Vonberg aff001;  Ella Ebadi aff001
Působiště autorů: Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School, Hannover, Germany aff001;  Department of Hematology, Hemostasis, Oncology, and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany aff002;  Institute of Hygiene and Environmental Medicine, Charité - University Medicine, Berlin, Germany aff003;  Institute of Hygiene, Hospital Epidemiology and Environmental Medicine, Leipzig University Hospital, Leipzig, Germany aff004
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article


Non-implanted central vascular catheters (CVC) are frequently required for therapy in hospitalized patients with hematological malignancies or solid tumors. However, CVCs may represent a source for bloodstream infections (central line-associated bloodstream infections, CLABSI) and, thus, may increase morbidity and mortality of these patients. A retrospective cohort study over 3 years was performed. Risk factors were determined and evaluated by a multivariable logistic regression analysis. Healthcare costs of CLABSI were analyzed in a matched case-control study. In total 610 patients got included with a CLABSI incidence of 10.6 cases per 1,000 CVC days. The use of more than one CVC per case, CVC insertion for conditioning for stem cell transplantation, acute myeloid leukemia, leukocytopenia (≤ 1000/μL), carbapenem therapy and pulmonary diseases were independent risk factors for CLABSI. Hospital costs directly attributed to the onset of CLABSI were 8,810 € per case. CLABSI had a significant impact on the overall healthcare costs. Knowledge about risk factors and infection control measures for CLABSI prevention is crucial for best clinical practice.

Klíčová slova:

Acute myeloid leukemia – Bloodstream infections – Cancer risk factors – Catheters – Hematology – Jugular vein – Medical risk factors – Nosocomial infections


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