Estimating associations between antidepressant use and incident mild cognitive impairment in older adults with depression


Autoři: Fang Han aff001;  Tyler Bonnett aff004;  Willa D. Brenowitz aff005;  Merilee A. Teylan aff002;  Lilah M. Besser aff002;  Yen-Chi Chen aff002;  Gary Chan aff002;  Ke-Gang Cao aff003;  Ying Gao aff003;  Xiao-Hua Zhou aff006
Působiště autorů: Department of Acupuncture and Moxibustion, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China aff001;  National Alzheimer’s Coordinating Center, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America aff002;  Department of Neurology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China aff003;  Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, Maryland, United States of America aff004;  Department of Psychiatry, University of California, San Francisco, California, United States of America aff005;  Department of Biostatistics, Beijing International Center for Mathematical Research, Peking University, Beijing, China aff006
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0227924

Souhrn

Introduction

Previous studies have provided equivocal evidence of antidepressant use on subsequent cognitive impairment; this could be due to inconsistent modeling approaches. Our goals are methodological and clinical. We evaluate the impact of statistical modeling approaches on the associations between antidepressant use and risk of Mild Cognitive Impairment (MCI) in older adults with depression.

Methods

716 participants were enrolled. Our primary analysis employed a time-dependent Cox proportional hazards model. We also implemented two fixed-covariate proportional hazards models—one based on having ever used antidepressants during follow-up, and the other restricted to baseline use only.

Results

Treating antidepressant use as a time-varying covariate, we found no significant association with incident MCI (HR = 0.92, 95% CI: 0.70, 1.20). In contrast, when antidepressant use was treated as a fixed covariate, we observed a significant association between having ever used antidepressants and lower risk of MCI (HR = 0.40, 95% CI: 0.28, 0.56). However, in the baseline-use only model, the association was non-significant (HR = 0.84, 95% CI: 0.60, 1.17).

Discussion

Our results were dependent upon statistical models and suggest that antidepressant use should be modeled as a time-varying covariate. Using a robust time-dependent analysis, antidepressant use was not significantly associated with incident MCI among cognitively normal persons with depression.

Klíčová slova:

Alzheimer's disease – Antidepressants – Cognitive impairment – Dementia – Depression – Diabetes mellitus – Geriatric depression – Hypercholesterolemia


Zdroje

1. Liu Q, He H, Yang J, Feng X, Zhao F, Lyu J. Changes in the global burden of depression from 1990 to 2017: Findings from the Global Burdenof Disease study. J Psychiatr Res. 2019.

2. Lepine JP, Briley M. The increasing burden of depression. Neuropsychiatr Dis Treat. 2011;7(Suppl 1):3–7. doi: 10.2147/NDT.S19617 21750622

3. 2019 Alzheimer’s disease facts and figures. Alzheimers & Dement. 2019; 15(3):321–387.

4. Jia J, Wei C, Chen S. The cost of Alzheimer’s disease in China and re-estimation of costs worldwide. Alzheimers & Dement. 2018;14(4):483–491.

5. Patterson, C. World Alzheimer Report 2018. The State of the Art of Dementia Research: New Frontiers. An Analysis of Prevalence, Incidence, Cost and Trends. Alzheimer’s Disease International.

6. Richard E, Reitz C, Honig LH, Schupf N, Tang MX, Manly JJ, et al. Late-life depression, mild cognitive impairment, and dementia. JAMA Neurol. 2013;70(3):374–382.

7. Mirza SS, Wolters FJ, Swanson SA, Koudstaal PJ, Hofman A, Tiemeier H, et al. 10-year trajectories of depressive symptoms and risk of dementia: a population-based study. Lancet Psychiatry. 2016;3(7):628–635. doi: 10.1016/S2215-0366(16)00097-3 27138970

8. da Silva J, Goncalves-Pereira M, Xavier M, Mukaetova-Ladinska EB. Affective disorders and risk of developing dementia: systematic review. Br J Psychiatry. 2013;202(3):177–186. doi: 10.1192/bjp.bp.111.101931 23457181

9. Moraros J, Nwankwo C, Patten SB, Mousseau DD. The association of antidepressant drug usage with cognitive impairment or dementia, including Alzheimer disease: A systematic review and meta-analysis. Depress Anxiety. 2017; 34(3):217–226. doi: 10.1002/da.22584 28029715

10. Then CK, Chi NF, Chung KH, Kuo L, Liu KH, Hu CJ, et al. Risk analysis of use of different classes of antidepressants on subsequent dementia: A nationwide cohort study in Taiwan. PLoS One. 2017; 12(4): e0175187. doi: 10.1371/journal.pone.0175187 28384235

11. Wang C, Gao S, Hendrie HC, Kesterson J, Campbell NL, Shekhar A, et al. Antidepressant Use in the Elderly Is Associated With an Increased Risk of Dementia. Alzheimer Dis Assoc Disord. 2016;30(2):99–104. doi: 10.1097/WAD.0000000000000103 26295747

12. Goveas JS, Hogan PE, Kotchen JM, Smoller JW, Denburg NL, Manson JE, et al. Depressive symptoms, antidepressant use, and future cognitive health in postmenopausal women: the Women’s Health Initiative Memory Study. Int Psychogeriatr. 2012; 24(8): 1252–1264. doi: 10.1017/S1041610211002778 22301077

13. Leng Y, Diem SJ, Stone KL, Yaffe K. Antidepressant Use and Cognitive Outcomes in Very Old Women. J Gerontol A Biol Sci Med Sci. 2018; 73(10): 1390–1395. doi: 10.1093/gerona/glx226 29244058

14. Kodesh A, Sandin S, Reichenberg A, Rotstein A, Pedersen NL, Ericsson M, et al. Exposure to antidepressant medication and the risk of incident dementia. Am J Geriatr Psychiatry. 2019.

15. Kessing LV, Sondergard L, Forman JL, Andersen PK. Antidepressants and dementia. J Affect Disord. 2009; 117(1–2): 24–29. doi: 10.1016/j.jad.2008.11.020 19138799

16. Burke SL, Maramaldi P, Cadet T, Kukull W. Decreasing hazards of Alzheimer’s disease with the use of antidepressants: mitigating the risk of depression and apolipoprotein E. Int J Geriatr Psychiatry. 2018; 33(1): 200–211. doi: 10.1002/gps.4709 28560728

17. Lee CW, Lin CL, Sung FC, Liang JA, Kao CH. Antidepressant treatment and risk of dementia: a population-based, retrospective case-control study. J Clin Psychiatry. 2016; 77(1):117–122. doi: 10.4088/JCP.14m09580 26845268

18. Kessing LV, Forman JL, Andersen PK. Do continued antidepressants protect against dementia in patients with severe depressive disorder? Int Clin Psychopharmacol. 2011; 26(6): 316–322. doi: 10.1097/YIC.0b013e32834ace0f 21876440

19. Carriere I, Norton J, Farre A, Wyart M, Tzourio C, Noize P, et al. Antidepressant use and cognitive decline in community-dwelling elderly people-The Three-City Cohort. BMC Med. 2017;15(1):81. doi: 10.1186/s12916-017-0847-z 28424070

20. Saczynski JS, Rosen AB, McCammon RJ, Zivin K, Andrade SE, Langa KM, et al. Antidepressant Use and Cognitive Decline: The Health and Retirement Study. Am J Med. 2015;128(7):739–746. doi: 10.1016/j.amjmed.2015.01.007 25644319

21. Bali V, Chatterjee S, Johnson ML, Chen H, Carnahan RM, Aparasu RR. Risk of Cognitive Decline Associated With Paroxetine Use in Elderly Nursing Home Patients With Depression. American Journal of Alzheimer’s Disease and Other Dementias. 2016; 31(8):678–686. doi: 10.1177/1533317516673463 27765867

22. Han L, McCusker J, Cole M, Capek R, Abrahamowicz M. Antidepressant use and cognitive functioning in older medical patients with major or minor depression: a prospective cohort study with database linkage. J Clin Psychopharmacol. 2011; 31(4): 429–435. doi: 10.1097/JCP.0b013e318221b2f8 21694621

23. Kostev K, Bohlken J, Jacob L. Analysis of the Effects of Selective Serotonin (and Noradrenaline) Reuptake Inhibitors on the Risk of Dementia in Patients with Depression. J Alzheimers Dis. 2019; 69(2):577–583. doi: 10.3233/JAD-190239 31104029

24. Tian Y, Du J, Spagna A, Mackie MA, Gu X, Dong Y, et al. Venlafaxine treatment reduces the deficit of executive control of attention in patients with major depressive disorder. Sci Rep. 2016; 6: 28028. doi: 10.1038/srep28028 27306061

25. Walraven CV, Davis D, Forster AJ, Wells GA. Time-dependent bias was common in survival analyses published in leading clinical journals[J]. Journal of Clinical Epidemiology, 2004, 57(7): 672–682. doi: 10.1016/j.jclinepi.2003.12.008 15358395

26. Beekly DL, Ramos EM, Lee WW, Deitrich WD, Jacka ME, Wu J, et al. The National Alzheimer’s Coordinating Center (NACC) database: the Uniform Data Set. Alzheimer Dis Assoc Disord. 2007; 21(3): 249–258. doi: 10.1097/WAD.0b013e318142774e 17804958

27. Besser L, Kukull W, Knopman DS, Chui H, Galasko D, Weintraub S, et al. Version 3 of the National Alzheimer’s Coordinating Center’s Uniform Data Set. Alzheimer Dis Assoc Disord.2018;32(4):351–358 30376508

28. Kaufer DI, Cummings JL, Ketchel P, Smith V, MacMillan A, Shelley T, et al. Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory. J Neuropsychiatry Clin Neurosci. 2000;12(2):233–239. doi: 10.1176/jnp.12.2.233 11001602

29. Schreiner AS, Hayakawa H, Morimoto T, Kakuma T. Screening for late life depression: cut-off scores for the Geriatric Depression Scale and the Cornell Scale for Depression in Dementia among Japanese subjects. Int J Geriatr Psychiatry. 2003;18(6):498–505. doi: 10.1002/gps.880 12789670

30. Fountoulakis KN, Tsolaki M, Iacovides A, Yesavage J, O’Hara R, Kazis A, et al. The validation of the short form of the Geriatric Depression Scale (GDS) in Greece. Aging (Milano). 1999;11(6):367–372.

31. Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med. 2004;256(3):183–194. doi: 10.1111/j.1365-2796.2004.01388.x 15324362

32. Petersen RC, Morris JC. Mild cognitive impairment as a clinical entity and treatment target. Arch Neurol. 2005;62(7):1160–1163. doi: 10.1001/archneur.62.7.1160 16009779

33. Boyle PA, Buchman AS, Wilson RS, Kelly JF, Bennett DA. The APOE epsilon4 allele is associated with incident mild cognitive impairment among community-dwelling older persons. Neuroepidemiology. 2010; 34(1):43–49. doi: 10.1159/000256662 19907191

34. Brainerd CJ, Reyna VF, Petersen RC, Smith GE, Kenney AE, Gross CJ, et al. The apolipoprotein E genotype predicts longitudinal transitions to mild cognitive impairment but not to Alzheimer’s dementia: findings from a nationally representative study. Neuropsychology. 2013;27(1):86–94. doi: 10.1037/a0030855 23356599

35. Evans DA, Beckett LA, Field TS, Feng L, Albert MS, Bennett DA, et al. Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons. JAMA. 1997;277(10):822–824. 9052713

36. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science. 1993; 261(5123):921–923. doi: 10.1126/science.8346443 8346443

37. Schoenfeld D. Partial Residuals for The Proportional Hazards Regression Model. Biometrika. 1982; 69(1): 239–241.

38. Jones M, Fowler R. Immortal time bias in observational studies of time-to-event outcomes. J Crit Care. 2016; 36:195–199. doi: 10.1016/j.jcrc.2016.07.017 27546771


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2020 Číslo 1