Neonatal sepsis in Iran: A systematic review and meta-analysis on national prevalence and causative pathogens

Autoři: Zahra Akbarian-Rad aff001;  Seyed Mohammad Riahi aff002;  Ali Abdollahi aff003;  Parisa Sabbagh aff004;  Soheil Ebrahimpour aff004;  Mostafa Javanian aff004;  VeneelaKrishnaRekha Vasigala aff005;  Ali Rostami aff004
Působiště autorů: Department of Pediatrics, Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran aff001;  Cardiovascular Diseases Research Center, Department of Epidemiology and Biostatistics, Faculty of Health, Birjand University of Medical Sciences, Birjand, Iran aff002;  Department of Surgery, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran aff003;  Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran aff004;  Department of General medicine, Rangaraya Medical College, Kakinada, India aff005;  Immunoregulation Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran aff006
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article



Neonatal sepsis is accounted for 30–50% of annual neonatal deaths in developing countries. We performed a systematic review and meta-analysis study to evaluate the national prevalence and identification of the etiological pathogens of neonatal sepsis in Iran.


A comprehensive literature search was done on the national and international databases for studies published between 2000 and 2019. The DerSimonian and Laird random-effects model was used to calculate pooled prevalence estimates, with 95% confidence intervals (CIs). Subgroup analyses and meta-regressions regarding the gender, type of sepsis and time during were also performed. Data were extracted, analyzed, and presented according to PRISMA guideline.


Of 944 publications identified, 22 studies containing 14,683 neonates met the eligibility criteria. The pooled national prevalence of sepsis in Iran was 15.98% (95%CI, 11.96–20.46%; 1,367/14,683). Prevalence rate in boys (20.42%; 95%CI, 9.03–34.8%) was slightly higher than girls (18.5%; 95%CI, 7.4–32.8). A decreasing trend in prevalence of neonatal sepsis was found in recent years, although not statistically significant (c = -0.005; P value = 0.4). The most prevalent causative bacterial pathogens were Enterobacter spp. (23.04%), followed by Klebsiella pneumoniae (17.54%), coagulase-negative Staphylococci (14.06%), Escherichia coli (13.92%), Pseudomonas aeruginosa (12.67%), and Staphylococcus aureus (11.48%).


Our findings showed a high prevalence of neonatal sepsis in suspected neonates, suggesting the need to implement preventive measures, routine assessment, and close monitoring of neonates. Also, Enterobacter spp. and Klebsiella pneumoniae were identified as the principal bacterial pathogens responsible for neonatal septicemia in Iran.

Klíčová slova:

Bacterial pathogens – Database searching – Iran – Klebsiella pneumoniae – Metaanalysis – Neonatal sepsis – Neonates – Sepsis


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