Use of serum KL-6 level for detecting patients with restrictive allograft syndrome after lung transplantation

Autoři: Cristina Berastegui aff001;  Susana Gómez-Ollés aff001;  Alberto Mendoza-Valderrey aff001;  Thais Pereira-Veiga aff001;  Mario Culebras aff001;  Victor Monforte aff001;  Berta Saez aff001;  Manuel López-Meseguer aff001;  Helena Sintes-Permanyer aff001;  Victoria Ruiz de Miguel aff001;  Carlos Bravo aff001;  Judit Sacanell aff003;  María-Antonia Ramon aff001;  Laura Romero aff004;  María Deu aff004;  Antonio Román aff001
Působiště autorů: Servei de Pneumologia, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain aff001;  Ciber Enfermedades Respiratorias (Ciberes) aff002;  Servei de Medicina Intensiva, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain aff003;  Servei de Cirurgia Toràcica, Hospital Universitari Vall d’Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain aff004
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article


KL-6 is an antigen produced mainly by damaged type II pneumocytes that is involved in interstitial lung disease. Chronic lung allograft dysfunction (CLAD) after lung transplantation (LT) is a major concern for LT clinicians, especially in patients with restrictive allograft syndrome (RAS). We investigated KL-6 levels in serum and bronchoalveolar lavage fluid (BALF) as a potential biomarker of the RAS phenotype. Levels of KL-6 in serum and BALF were measured in 73 bilateral LT recipients, and patients were categorized into 4 groups: stable (ST), infection (LTI), bronchiolitis obliterans syndrome (BOS), and RAS. We also studied a healthy cohort to determine reference values for serum KL-6. The highest levels of KL-6 were found in the serum of patients with RAS (918 [487.8–1638] U/mL). No differences were found for levels of KL-6 in BALF. Using a cut-off value of 465 U/mL serum KL-6 levels was able to differentiate RAS patients from BOS patients with a sensitivity of 100% and a specificity of 75%. Furthermore, higher serum KL-6 levels were associated with a decline in Forced Vital Capacity (FVC) at 6 months after sample collection. Therefore, KL-6 in serum may well be a potential biomarker for differentiating between the BOS and RAS phenotypes of CLAD in LT recipients.

Klíčová slova:

Biomarkers – Bronchiolitis – Cystic fibrosis – Chronic obstructive pulmonary disease – Interstitial lung diseases – Lung transplantation – Opacity – Spirometry


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