Relation of fibroblast growth factor receptor 2 expression to hepatocellular carcinoma recurrence after liver resection

Autoři: Baek Gyu Jun aff001;  Woong Cheul Lee aff002;  Jae Young Jang aff002;  Soung Won Jeong aff002;  Young Chang aff002;  Sae Hwan Lee aff003;  Young don Kim aff001;  Sang Gyune Kim aff004;  Gab Jin Cheon aff001;  Young Seok Kim aff004;  Hong Soo Kim aff003;  So Young Jin aff005
Působiště autorů: Department of Internal Medicine, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung, South Korea aff001;  Institute for Digestive Research, Digestive Disease Center, Department of Internal Medicine, College of Medicine, Soonchunhyang University, Seoul, Korea aff002;  Department of Internal Medicine, College of Medicine, Soonchunhyang University, Cheonan, Korea aff003;  Department of Internal Medicine, College of Medicine, Soonchunhyang University, Bucheon, Korea aff004;  Department of Pathology, College of Medicine, Soonchunhyang University, Seoul, Korea aff005
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0227440



Hepatocellular carcinoma (HCC) recurrence after liver resection depends upon the stage and histological grade of the tumor and the expression of certain biomarkers. However, it remains unclear which of these factors has the highest predictive value regarding HCC recurrence after surgical resection.


This study investigated the associations among clinicopathological characteristics, expression of biomarkers, and HCC recurrence after liver resection. Fifty-four patients having undergone liver resection for HCC were enrolled prospectively, and their data were analyzed retrospectively. Evaluated variables were clinical data, laboratory findings, modified Union for International Cancer Control (UICC) stage, vascular invasion, histological differentiation, and immunohistochemical staining for fibroblast growth factor receptor 2 (FGFR2), vascular endothelial growth factor, and tumor-necrosis-factor-related apoptosis-inducing ligand receptors 1 and 2.


Mean patient age was 58.6 years (range, 30–71), and the mean and SD for follow-up duration were 51.2 ± 34.8 months. Cumulative 1-, 3-, and 5-year recurrence rates were 32.9%, 53.6%, and 68.1%, respectively. In univariate analysis, FGFR2 (p = 0.026) and Edmonson-Steiner grade (E-S grade) (p = 0.030) were associated with recurrence after resection in HCC patients. In multivariate analyses, increased FGFR2 expression (p = 0.017) was the only significant predictor of HCC recurrence.


High FGFR2 expression had marginal association with poor E-S grade (p = 0.056). More intensive surveillance of HCC recurrence is warranted in HCC patients with increased FGFR2 expression.

Klíčová slova:

Biomarkers – Cirrhosis – Fibroblast growth factor – Hepatic resection – Hepatocellular carcinoma – Histology – Immune receptors – Surgical resection


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