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Estimating the impact of drug use on US mortality, 1999-2016


Autoři: Dana A. Glei aff001;  Samuel H. Preston aff002
Působiště autorů: Center for Population and Health, Georgetown University, Washington, DC, United States of America aff001;  Sociology, University of Pennsylvania, Philadelphia, PA, United States of America aff002
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226732

Souhrn

The impact of rising drug use on US mortality may extend beyond deaths coded as drug-related to include excess mortality from other causes affected by drug use. Here, we estimate the full extent of drug-associated mortality. We use annual death rates for 1999–2016 by state, sex, five-year age group, and cause of death to model the relationship between drug-coded mortality—which serves as an indicator of the population-level prevalence of drug use—and mortality from other causes. Among residents aged 15–64 living in the 50 US states, the estimated number of drug-associated deaths in 2016 (141,695) was 2.2 times the number of drug-coded deaths (63,000). Adverse trends since 2010 in midlife mortality are largely attributable to drug-associated mortality. In the absence of drug use, we estimate that the probability of dying between ages 15 and 65 would have continued to decline after 2010 among men (to 15% in 2016) and would have remained at a low level (10%) among women. Our results suggest that an additional 3.9% of men and 1.8% of women died between ages 15 and 65 in 2016 because of drug use. In terms of life expectancy beyond age 15, we estimate that drug use cost men 1.4 years and women 0.7 years, on average. In the hardest-hit state (West Virginia), drug use cost men 3.6 and women 1.9 life years. Recent declines in US life expectancy have been blamed largely on the drug epidemic. Consistent with that inference, our results imply that, in the absence of drug use, life expectancy at age 15 would have increased slightly between 2014 and 2016. Drug-associated mortality in the US is roughly double that implied by drug-coded deaths alone. The drug epidemic is exacting a heavy cost to American lives, not only from overdoses but from a variety of causes.

Klíčová slova:

Age groups – Death rates – Drug users – Life expectancy – Lung and intrathoracic tumors – Poisoning – United States – West Virginia


Zdroje

1. Shiels MS, Berrington de Gonzalez A, Best AF, Chen Y, Chernyavskiy P, Hartge P, et al. Premature mortality from all causes and drug poisonings in the USA according to socioeconomic status and rurality: an analysis of death certificate data by county from 2000–15. Lancet Public Health. 2019 Feb;4(2): e97–e106. doi: 10.1016/S2468-2667(18)30208-1 30655229

2. National Center for Health Statistics. Overdose death rates. Tabulations of data from CDC Wonder. Available: https://www.drugabuse.gov/related-topics/trends-statistics/overdose-death-rates.

3. Degenhardt L, Bucello C, Mathers B, Briegleb C, Ali H, Hickman M, et al. Mortality among regular or dependent users of heroin and other opioids: a systematic review and meta-analysis of cohort studies. Addiction. 2011 Jan;106(1): 32–51. doi: 10.1111/j.1360-0443.2010.03140.x 21054613

4. Walker ER, Pratt LA, Schoenborn CA, Druss BG. Excess mortality among people who report lifetime use of illegal drugs in the United States: A 20-year follow-up of a nationally representative survey. Drug Alcohol Depend. 2017 Feb 1;171: 31–8. doi: 10.1016/j.drugalcdep.2016.11.026 28012429

5. Ahman A, Jerkeman A, Blome MA, Bjorkman P, Hakansson A. Mortality and causes of death among people who inject amphetamine: A long-term follow-up cohort study from a needle exchange program in Sweden. Drug Alcohol Depend. 2018 Jul 1;188: 274–80. doi: 10.1016/j.drugalcdep.2018.03.053 29803034

6. Olfson M, Crystal S, Wall M, Wang S, Liu SM, Blanco C. Causes of Death After Nonfatal Opioid Overdose. JAMA Psychiatry. 2018 Aug 1;75(8): 820–7. doi: 10.1001/jamapsychiatry.2018.1471 29926090

7. Mathers BM, Degenhardt L, Bucello C, Lemon J, Wiessing L, Hickman M. Mortality among people who inject drugs: a systematic review and meta-analysis. Bull World Health Organ. 2013 Feb 1;91(2): 102–23. doi: 10.2471/BLT.12.108282 23554523

8. Ronka S, Karjalainen K, Martikainen P, Makela P. Social determinants of drug-related mortality in a general population. Drug Alcohol Depend. 2017 Dec 1;181: 37–43. doi: 10.1016/j.drugalcdep.2017.09.005 29032023

9. National Institute on Drug Abuse. Health Consequences of Drug Misuse: Cardiovascular Effects. Available: https://www.drugabuse.gov/publications/health-consequences-drug-misuse/cardiovascular-effects;.

10. American Heart Association. Illegal drugs and heart disease. Available: https://www.heart.org/HEARTORG/Conditions/More/MyHeartandStrokeNews/Cocaine-Marijuana-and-Other-Drugs-and-Heart-Disease_UCM_428537_Article.jsp.

11. American Addiction Centers. The potential repercussion of substance abuse on the respiratory system. Available: https://americanaddictioncenters.org/health-complications-addiction/respiratory-system.

12. National Institute on Drug Abuse. Health Consequences of Drug Misuse: Respiratory Effects. Available: https://www.drugabuse.gov/publications/health-consequences-drug-misuse/respiratory-effects.

13. National Institute on Drug Abuse. Health Consequences of Drug Misuse: Liver Damage. Available: https://www.drugabuse.gov/publications/health-consequences-drug-misuse/liver-damage.

14. U.S. Department of Health and Human Services (HHS), Office of the Surgeon General. Facing addiction in American: the Surgeon General's report on alcohol, drugs, and health. Washington, DC: HHS; 2016

15. National Institute on Drug Abuse. Health Consequences of Drug Misuse. Available: https://www.drugabuse.gov/related-topics/health-consequences-drug-misuse.

16. National Institute on Drug Abuse. Viral Hepatitis—A Very Real Consequence of Substance Use. Available: www.drugabuse.gov/related-topics/viral-hepatatis-very-real-consequences/substance-use.

17. Compton WM, Thomas YF, Stinson FS, Grant BF. Prevalence, correlates, disability, and comorbidity of DSM-IV drug abuse and dependence in the United States: results from the national epidemiologic survey on alcohol and related conditions. Arch Gen Psychiatry. 2007 May;64(5): 566–76. doi: 10.1001/archpsyc.64.5.566 17485608

18. Grant BF, Stinson FS, Dawson DA, Chou SP, Dufour MC, Compton W, et al. Prevalence and co-occurrence of substance use disorders and independent mood and anxiety disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry. 2004 Aug;61(8): 807–16. doi: 10.1001/archpsyc.61.8.807 15289279

19. Harrell PT, Trenz RC, Scherer M, Pacek LR, Latimer WW. Cigarette smoking, illicit drug use, and routes of administration among heroin and cocaine users. Addict Behav. 2012 May;37(5): 678–81. doi: 10.1016/j.addbeh.2012.01.011 22305644

20. Benjamin-Johnson R, Moore A, Gilmore J, Watkins K. Access to medical care, use of preventive services, and chronic conditions among adults in substance abuse treatment. Psychiatr Serv. 2009 Dec;60(12): 1676–9. doi: 10.1176/ps.2009.60.12.1676 19952160

21. Lopez-Quintero C, Neumark Y. Prevalence and determinants of resistance to use drugs among adolescents who had an opportunity to use drugs. Drug Alcohol Depend. 2015 Apr 1;149: 55–62. doi: 10.1016/j.drugalcdep.2015.01.015 25659896

22. European Monitoring Centre for Drugs and Addiction. An overview of the drug-related deaths and mortality among drug users (DRD) key indicator. Available: http://www.emcdda.europa.eu/attachements.cfm/att_67050_EN_EMCDDA-DRD-overview.pdf.

23. Preston SH, Glei DA, Wilmoth JR. A new method for estimating smoking-attributable mortality in high-income countries. Int J Epidemiol. 2009 Dec 23

24. Preston SH, Glei DA, Wilmoth JR. Contribution of Smoking to International Differences in Life Expectancy. In: Crimmins EM, Preston SH, Cohen B, editors. International differences in mortality at older ages: dimensions and sources. Panel on Understanding Divergent Trends in Longevity in High-Income Countries. Committee on Population, Division of Behavioral and Social Sciences and Education. Washington, D.C.: The National Academies Press; 2010. pp.105–31.

25. Fenelon A, Preston SH. Estimating smoking-attributable mortality in the United States. Demography. 2012 Aug;49(3): 797–818. doi: 10.1007/s13524-012-0108-x 22610474

26. National Center for Health Statistics. Mortality multiple cause-of-death data files. Available: https://www.cdc.gov/nchs/nvss/mortality_public_use_data.htm.

27. United States Department of Health and Human Services (US DHHS), Centers for Disease Control and Prevention (CDC), National Center for Health Statistics (NCHS). Bridged-Race Population Estimates, United States July 1st resident population by state, county, age, sex, bridged-race, and Hispanic origin. Compiled from 1990–1999 bridged-race intercensal population estimates (released by NCHS on 7/26/2004); revised bridged-race 2000–2009 intercensal population estimates (released by NCHS on 10/26/2012); and bridged-race Vintage 2016 (2010–2016) postcensal population estimates (released by NCHS on 6/26/2017). Available on CDC WONDER Online Database. Available: http://wonder.cdc.gov/bridged-race-v2016.html.

28. Bjorkenstam C, Johansson LA, Nordstrom P, Thiblin I, Fugelstad A, Hallqvist J, et al. Suicide or undetermined intent? A register-based study of signs of misclassification. Popul Health Metr. 2014 Apr 17;12: 11,7954–12-11. eCollection 2014.

29. Rockett IRH, Caine ED, Stack S, Connery HS, Nolte KB, Lilly CL, et al. Method overtness, forensic autopsy, and the evidentiary suicide note: A multilevel National Violent Death Reporting System analysis. PLoS One. 2018 May 22;13(5): e0197805. doi: 10.1371/journal.pone.0197805 29787584

30. StataCorp. Stata: Release 14. Statistical Software. College Station, TX: StataCorp LP; 2015.

31. Toblin RL, Paulozzi LJ, Logan JE, Hall AJ, Kaplan JA. Mental illness and psychotropic drug use among prescription drug overdose deaths: a medical examiner chart review. J Clin Psychiatry. 2010 Apr;71(4): 491–6. doi: 10.4088/JCP.09m05567blu 20409446

32. Preston SH, Heuveline P, Guillot M. Demography: Measuring and Modeling Population Processes. Malden, MA: Blackwell Publishers; 2001.

33. Dowell D, Arias E, Kochanek K, Anderson R, Guy GP Jr, Losby JL, et al. Contribution of Opioid-Involved Poisoning to the Change in Life Expectancy in the United States, 2000–2015. JAMA. 2017 Sep 19;318(11): 1065–7. doi: 10.1001/jama.2017.9308 28975295

34. Ho JY, Hendi AS. Recent trends in life expectancy across high income countries: retrospective observational study. BMJ. 2018 Aug 15;362: k2562. doi: 10.1136/bmj.k2562 30111634

35. Ruhm CJ. Drug Mortality and Lost Life Years Among U.S. Midlife Adults, 1999–2015. Am J Prev Med. 2018 Jul;55(1): 11–8. doi: 10.1016/j.amepre.2018.03.014 29801685

36. Ho JY. The Contribution of Drug Overdose to Educational Gradients in Life Expectancy in the United States, 1992–2011. Demography. 2017 Jun;54(3): 1175–202. doi: 10.1007/s13524-017-0565-3 28324483

37. Geronimus AT, Bound J, Waidmann TA, Rodriguez JM, Timpe B. Weathering, Drugs, and Whack-a-Mole: Fundamental and Proximate Causes of Widening Educational Inequity in U.S. Life Expectancy by Sex and Race, 1990–2015. J Health Soc Behav. 2019 Jun;60(2): 222–39. doi: 10.1177/0022146519849932 31190569

38. Masters RK. Explaining recent mortality trends among younger and middle-aged white Americans. Int J Epidemiol. 2018;47(1): 81–8. doi: 10.1093/ije/dyx127 29040539

39. Masters RK. Overview of Trends and Differentials: Trends by age/period/cohort, sex, and race/ethnicity. Presentation at the Planning Meeting on Socioeconomic Status and Increasing Mid-life Mortality National Academy of Sciences, Committee on Population, June 16. 2017

40. Ruhm CJ. Deaths of despair or drug problems? Cambridge, MA: National Bureau of Economic Research; 2018

41. Mars SG, Fessel JN, Bourgois P, Montero F, Karandinos G, Ciccarone D. Heroin-related overdose: The unexplored influences of markets, marketing and source-types in the United States. Soc Sci Med. 2015 Sep;140: 44–53. doi: 10.1016/j.socscimed.2015.06.032 26202771

42. Unick G, Rosenblum D, Mars S, Ciccarone D. The relationship between US heroin market dynamics and heroin-related overdose, 1992–2008. Addiction. 2014 Nov;109(11): 1889–98. doi: 10.1111/add.12664 24938727

43. Case A, Deaton A. Rising morbidity and mortality in midlife among white non-Hispanic Americans in the 21st century. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49): 15078–83. doi: 10.1073/pnas.1518393112 26575631

44. Case A, Deaton A. Mortality and morbidity in the 21st century. Brookings Papers on Economic Activity. 2017(Spring): 397–476.

45. Cherlin AJ. Labor’s love lost: the rise and fall of the working class family in America. New York: Russell Sage; 2014.

46. Cherlin AJ. Why are white death rates rising? New York Times 2016 February 22, 2016;The Opinion Pages(February 25):A19

47. Stein EM, Gennuso KP, Ugboaja DC, Remington PL. The epidemic of despair among white Americans: trends in the leading causes of premature death, 1999–2015. Am J Public Health. 2017 Oct;107(10): 1541–7. doi: 10.2105/AJPH.2017.303941 28817333

48. Jalal H, Buchanich JM, Roberts MS, Balmert LC, Zhang K, Burke DS. Changing dynamics of the drug overdose epidemic in the United States from 1979 through 2016. Science. 2018 Sep 21;361(6408): eaau1184. doi: 10.1126/science.aau1184 30237320

49. Stein R, National Public Radio. Life expectancy drops again as opioid deaths surge in U.S. Available: https://www.npr.org/sections/health-shots/2017/12/21/572080314/life-expectancy-drops-again-as-opioid-deaths-surge-in-u-s.

50. Muennig PA, Reynolds M, Fink DS, Zafari Z, Geronimus AT. America's declining well-being, health, and life expectancy: not just a white problem. Am J Public Health. 2018 Sep 25;108(12): 1626–31. doi: 10.2105/AJPH.2018.304585 30252522

51. Bernstein L. U.S. life expectancy declines again, a dismal trend not seen since World War I. Washington Post 2018 November 29, 2018;Health and Science

52. Murphy SL, Xu JQ, Kochanek KD, Arias E. Mortality in the United States, 2017. Hyattsville, MD: National Center for Health Statistics; 2018


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