Heart rate variability helps to distinguish the intensity of menopausal symptoms: A prospective, observational and transversal study

Autoři: Patrícia Merly Martinelli aff001;  Isabel Cristina Esposito Sorpreso aff001;  Rodrigo Daminello Raimundo aff001;  Osvaldo de Souza Leal Junior aff002;  Juliana Zangirolami-Raimundo aff001;  Marcos Venicius Malveira de Lima aff001;  Andrés Pérez-Riera aff001;  Valdelias Xavier Pereira aff001;  Khalifa Elmusharaf aff004;  Vitor E. Valenti aff001;  Luiz Carlos de Abreu aff001
Působiště autorů: Laboratório de Delineamento de Estudos e Escrita Científica, Centro Universitário Saúde ABC, Santo André, São Paulo, Brazil aff001;  Laboratório de Delineamento de Estudos e Escrita Científica do Laboratório de Práticas Cientíticas, Centro Universitário Uninorte, Acre, Brazil aff002;  Disciplina de Ginecologia, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, São Paulo, Brazil aff003;  Graduate Entry Medical School, University of Limerick, Limerick, Ireland aff004;  Centro de Estudos do Sistema Nervoso Autônomo (CESNA), UNESP, Marilia, SP, Brazil aff005
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0225866


Heart Rate Variability (HRV) represents cardiac autonomic behavior and have been related to menopausal symptoms, mainly vasomotor symptoms and their imbalance to cardiovascular risk. It is not clear in the literature which index represents this imbalance and what is their involvement with the menopausal state. The aim of this study was to evaluate HRV in menopausal transition and post-menopausal symptoms with different intensities. This cross-sectional study was conducted in Rio Branco, State of Acre, Brazil from October 2016 to July 2017. We used Kupperman-Blatt Menopausal Index (KMI) to measure menopausal symptoms intensity. HRV analysis was performed based on the guidelines of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. HRV is lower in the group with moderate/intense menopausal symptoms compared to mild symptoms. (RMSSD: p = 0.005, Cohen’s d = 0.53, pNN50: p = 0.0004, Cohen’s d = 0.68; HF: p = 0.024, Cohen’s d = 0.44). There was association between HRV and KMI (RMSSD: r = -1.248, p = 0.004; and pNN50: r = -0.615, p: 0.029) in inverse relation to the intensity of vasomotor symptoms in women in TM. In conclusion, HRV was able to distinguish menopausal symptoms, indicating reduced vagal control in women with more intense symptoms.

Klíčová slova:

Blood pressure – Brazil – Cardiology – Cross-sectional studies – Heart rate – Linear regression analysis – Menopause – Reproductive physiology


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