Plasma Trimethylamine-N-oxide and impaired glucose regulation: Results from The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS)

Autoři: Sumith Roy aff001;  Melana Yuzefpolskaya aff002;  Renu Nandakumar aff003;  Paolo C. Colombo aff002;  Ryan T. Demmer aff001
Působiště autorů: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY, United States of America aff001;  Division of Cardiology, Department of Medicine, New York Presbyterian Hospital, Columbia University, New York, NY, United States of America aff002;  Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, NY, United States of America aff003;  Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, United States of America aff004
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article


Trimethylamine-N-oxide (TMAO)–a gut-microbiota metabolite–is a biomarker of cardiometabolic risk. No studies have investigated TMAO as an early biomarker of longitudinal glucose increase or prevalent impaired glucose regulation. In a longitudinal cohort study, 300 diabetes-free men and women (77%) aged 20–55 years (mean = 34±10) were enrolled at baseline and re-examined at 2-years to investigate the association between TMAO and biomarkers of diabetes risk. Plasma TMAO was measured using Ultra Performance Liquid Chromatography-Mass Spectrometry. After an overnight fast, FPG was measured longitudinally, HbA1C and insulin were measured only at baseline. Insulin resistance was defined using HOMA-IR. Multivariable generalized linear models regressed; i) FPG change (year 2 minus baseline) on baseline TMAO tertiles; and ii) HOMA-IR and HbA1c on TMAO tertiles. Multivariable relative risk regressions modeled prevalent prediabetes across TMAO tertiles. Mean values of 2-year longitudinal FPG±SE across tertiles of TMAO were 86.6±0.9, 86.7±0.9, 86.4±0.9 (p = 0.98). Trends were null for FPG, HbA1c, HOMA-IR, cross-sectionally. The prevalence ratio of prediabetes among participants in 2nd and 3rd TMAO tertiles (vs. the 1st) were 1.94 [95%CI 1.09–3.48] and 1.41 [95%CI: 0.76–2.61]. TMAO levels are associated with increased prevalence of prediabetes in a nonlinear fashion but not with insulin resistance or longitudinal FPG change.

Klíčová slova:

Biomarkers – Blood plasma – diabetes mellitus – Glucose – HbA1c – Insulin resistance – Renal system – Type 2 diabetes


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