Repeated noninvasive stimulation of the ventromedial prefrontal cortex reveals cumulative amplification of pleasant compared to unpleasant scene processing: A single subject pilot study


Autoři: Constantin Winker aff001;  Maimu A. Rehbein aff001;  Dean Sabatinelli aff003;  Markus Junghofer aff001
Působiště autorů: Institute for Biomagnetism and Biosignalanalysis, University of Muenster, Muenster, Germany aff001;  Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Muenster, Muenster, Germany aff002;  Department of Psychology and BioImaging Research Center, University of Georgia, Athens, Georgia, United States of America aff003
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222057

Souhrn

The ventromedial prefrontal cortex (vmPFC) is a major hub of the reward system and has been shown to activate specifically in response to pleasant / rewarding stimuli. Previous studies demonstrate enhanced pleasant cue reactivity after single applications of transcranial direct current stimulation (tDCS) to the vmPFC. Here we present a pilot case study in which we assess the cumulative impact of multiple consecutive vmPFC-tDCS sessions on the processing of visual emotional stimuli in an event-related MEG recording design. The results point to stable modulation of increased positivity biases (pleasant > unpleasant stimulus signal strength) after excitatory vmPFC stimulation and a reversed pattern (pleasant < unpleasant) after inhibitory stimulation across five consecutive tDCS sessions. Moreover, cumulative effects of these emotional bias modulations were observable for several source-localized spatio-temporal clusters, suggesting an increase in modulatory efficiency by repeated tDCS sessions. This pilot study provides evidence for improvements in the effectiveness and utility of a novel tDCS paradigm in the context of emotional processing.

Klíčová slova:

Butterworth filters – Emotions – Magnetoencephalography – Pilot studies – Prefrontal cortex – Reference electrodes – Transcranial direct-current stimulation – Transcranial magnetic stimulation


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2020 Číslo 1