Patch testing in Lao medical students


Autoři: Catriona I. Wootton aff001;  Mick Soukavong aff003;  Sonexai Kidoikhammouan aff003;  Bounthome Samountry aff003;  John S. C. English aff004;  Mayxay Mayfong aff001
Působiště autorů: Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU), Vientiane, Laos aff001;  Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, United Kingodm aff002;  Faculty of Basic Sciences, University of Health Sciences, Vientiane, Laos aff003;  Nottingham NHS Treatment Centre, Nottingham, United Kingodm aff004;  Institute of Research and Education Development (IRED), University of Health Sciences, Ministry of Health, Vientiane, Laos aff005;  Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, Churchill Hospital, Oxford, United Kingodm aff006
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0217192

Souhrn

Background

Dermatological services in Laos, South East Asia are limited to the capital and patch testing is currently not available, so no data exists regarding the common cutaneous allergens in this population.

Objectives

The aim of this study was to document positive patch tests in medical students without evidence of contact dermatitis in Laos.

Patients/Materials/Methods

One hundred and fifty medical students were patch tested using TRUE Test® panels 1 to 3 (35 allergens). Readings were taken at Days 2 and 4.

Results

Thirty-eight students (25.3%) had a positive reaction to at least one allergen, accounting for 52 reactions in total. The proportion of the students with positive patch test reading was significantly higher in the female [33/96 (34%)] than in the male [5/54 (9%)], p<0.001. The most common allergens were: nickel (10%), gold (6.6%), thiomersal (6.6%), cobalt dichloride (2%) and p-tert-Butylphenol formaldehyde resin (2%). Balsam of Peru (0.66%), black rubber mix (0.66%), Cl+Me-Isothiazolinone (0.66%), fragrance mix 1 (0.66%), quinolone mix (0.66%), methyldibromo glutaronitrile (0.66%), mercapto mix (0.66%), epoxy resin (0.66%), paraben mix (0.66%), thiuram (0.66%) and wool alcohols (0.66%) accounted for all of the other positive reactions.

Conclusion

This study represents the first documented patch test results in Lao medical students and in the adult Lao population. The results of this study will inform any future research into contact allergy in Laos and give an insight into the background level of contact sensitivity in this population.

Klíčová slova:

Allergens – Allergies – Food allergies – Formaldehyde – Lao people – Nickel – Contact dermatitis – Cobalt


Zdroje

1. Lao Population and Housing Census 2015. Vientiane: Lao Statistics Bureau. www.lsb.gov.la

2. Johnston GA, Exton LS, Mohd Mustapa MF, Slack JA, Coulson IH, English JS, et al. British Association of Dermatologists’ guidelines for the management of contact dermatitis 2017. Br J Dermatol 2017; 176:317–29. doi: 10.1111/bjd.15239 28244094

3. Boonchai W, Iamtharachai P. Risk factors for common contact allergens and patch test results using a modified European baseline series in patients tested during between 2000 and 2009 at Siriraj Hospital. Asian Pac J Allergy Immunol. 2014;32(1):60–5. doi: 10.12932/AP0326.32.1.2014 24641292

4. How KN, Tang MM, Kaur R, Johar A. Contact sensitisation in adults: a 5-year retrospective review in hospital Kuala Lumpur. Med J Malaysia 2017;72(2):113–118. 28473674

5. Hamann CR, Hamann DJ, Hamann QJ, Hamann CP, Boonchai W, Li LF, et al. Assessment of nickel release from earrings randomly purchased in China and Thailand using the dimethylglyoxime test. Contact Dermatitis 2010; 62:232–40. doi: 10.1111/j.1600-0536.2010.01694.x 20236158

6. Dararattanaroj W, Pootongkam S, Rojanawatsirive Nj, Wongpiyabovorn J. Patterns and risk factors of causative contact allergens in Thai adult patients with contact dermatitis. Asian Pac J Allergy Immunol 2017; 35:27–32. doi: 10.12932/AP0757 27362404

7. Moller H. All these positive tests to thimerosal. Contact Dermatitis 1994; 31:209–13. doi: 10.1111/j.1600-0536.1994.tb01989.x 7842673

8. https://www.smartpractice.com/dermatologyallergy/pdfs/allergens/Thimerosal-Patient-Info.pdf

9. Breithaupt A, Jacob SE. Thimerosal and the relevance of patch-test reactions in children. Dermatitis 2008; 19(5):275–7. 18845117

10. Yin R, Huang XY, Zhou XF, Hao F. A retrospective study of patch tests in Chongqing, China from 2004 to 2009. Contact Dermatitis 2011; 65:28–33. doi: 10.1111/j.1600-0536.2010.01854.x 21309787

11. Diepgen TL, Ofenloch RF, Bruze M, Bertuccio P, Cazzaniga S, Coenraads PJ, et al. Prevalence of contact allergy in the general population in different European regions. Br J Dermatol. 2016; 174(2):319–29. doi: 10.1111/bjd.14167 26370659


Článek vyšel v časopise

PLOS One


2020 Číslo 1