Implicit task switching in Parkinson’s disease is preserved when on medication

Autoři: Jacob A. Yaffe aff001;  Yair Zlotnik aff002;  Gal Ifergane aff002;  Shelly Levy-Tzedek aff003
Působiště autorů: Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel aff001;  Neurology Department, Soroka University Medical Center, Beer-Sheva, Israel aff002;  Recanati School for Community Health Professions, Department of Physical Therapy, Ben-Gurion University of the Negev, Beer-Sheva, Israel aff003;  Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel aff004;  Freiburg Institute for Advanced Studies (FRIAS), University of Freiburg, Freiburg, Germany aff005
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0227555


People with Parkinson’s disease have been shown to have difficulty switching between movement plans. In the great majority of studies, the need to switch between tasks was made explicitly. Here, we tested whether people with Parkinson’s disease, taking their normal medication, have difficulty switching between implicitly specified tasks. We further examined whether this switch is performed predictively or reactively. Twenty five people with Parkinson’s disease continuously increased or decreased the frequency of their arm movements, inducing an abrupt–but unaware–switch between rhythmic movements (at high frequencies) and discrete movements (at low frequencies). We tested whether that precipitous change was performed reactively or predictively. We found that 56% of participants predictively switched between the two movement types. The ability of people with Parkinson’s disease, taking their regular medication, to predictively control their movements on implicit tasks is thus preserved.

Klíčová slova:

Cognitive impairment – Dopamine – Dopaminergics – Ellipses – Forearms – Musculoskeletal system – Parkinson disease – Walking


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