Lean back and wait for the alarm? Testing an automated alarm system for nosocomial outbreaks to provide support for infection control professionals


Autoři: Christin Schröder aff001;  Luis Alberto Peña Diaz aff001;  Anna Maria Rohde aff001;  Brar Piening aff001;  Seven Johannes Sam Aghdassi aff001;  Georg Pilarski aff001;  Norbert Thoma aff001;  Petra Gastmeier aff001;  Rasmus Leistner aff001;  Michael Behnke aff001
Působiště autorů: Charité – Universitätsmedizin Berlin, Institute of Hygiene and Environmental Medicine, Berlin, Germany aff001
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0227955

Souhrn

Introduction

Outbreaks of communicable diseases in hospitals need to be quickly detected in order to enable immediate control. The increasing digitalization of hospital data processing offers potential solutions for automated outbreak detection systems (AODS). Our goal was to assess a newly developed AODS.

Methods

Our AODS was based on the diagnostic results of routine clinical microbiological examinations. The system prospectively counted detections per bacterial pathogen over time for the years 2016 and 2017. The baseline data covers data from 2013–2015. The comparative analysis was based on six different mathematical algorithms (normal/Poisson and score prediction intervals, the early aberration reporting system, negative binomial CUSUMs, and the Farrington algorithm). The clusters automatically detected were then compared with the results of our manual outbreak detection system.

Results

During the analysis period, 14 different hospital outbreaks were detected as a result of conventional manual outbreak detection. Based on the pathogens’ overall incidence, outbreaks were divided into two categories: outbreaks with rarely detected pathogens (sporadic) and outbreaks with often detected pathogens (endemic). For outbreaks with sporadic pathogens, the detection rate of our AODS ranged from 83% to 100%. Every algorithm detected 6 of 7 outbreaks with a sporadic pathogen. The AODS identified outbreaks with an endemic pathogen were at a detection rate of 33% to 100%. For endemic pathogens, the results varied based on the epidemiological characteristics of each outbreak and pathogen.

Conclusion

AODS for hospitals based on routine microbiological data is feasible and can provide relevant benefits for infection control teams. It offers in-time automated notification of suspected pathogen clusters especially for sporadically occurring pathogens. However, outbreaks of endemically detected pathogens need further individual pathogen-specific and setting-specific adjustments.

Klíčová slova:

Algorithms – Bacterial pathogens – Binomials – Clostridium difficile – Epidemiology – Infectious disease control – Pathogens – Toxins


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Článek vyšel v časopise

PLOS One


2020 Číslo 1