Serum visfatin and vaspin levels in hepatocellular carcinoma (HCC)

Autoři: Monika Pazgan-Simon aff001;  Michał Kukla aff001;  Jolanta Zuwała-Jagiełło aff003;  Aleksandra Derra aff004;  Martyna Bator aff004;  Tomasz Menżyk aff004;  Andrzej Lekstan aff005;  Ewa Grzebyk aff003;  Krzysztof Simon aff001
Působiště autorů: Department of Infectious Diseases and Hepatology, Wrocław Medical University, Wroclaw, Poland aff001;  Department of Gastroenterology and Hepatology, Medical University of Silesia in Katowice, Katowice, Poland aff002;  Department of Pharmaceutical Biochemistry, Wroclaw Medical University, Wroclaw, Poland aff003;  Medical University of Silesia in Katowice, Katowice, Poland aff004;  Department of Digestive Tract Surgery, Medical University of Silesia in Katowice, Katowice, Poland aff005
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0227459


Hepatocellular carcinoma (HCC) is the most common liver cancer, accountable for 90% cases. Visfatin and vaspin are adipocytokines with various suggested functions and proven significant correlations between BMI and percentage of body fat. The aim was to assess visfatin and vaspin serum levels in HCC patients and controls, compare their levels in patients with different cancer etiology and grade assessed according to the Barcelona-Clinic Liver Cancer (BCLC) staging system. The additional aim was to analyze relationship between analyzed adipokines and metabolic abnormalities and liver disfunction severity. The study was performed on 69 cirrhotic patients (54 males/15 females) with HCC, aged 59.0 ± 12.1 years, and with BMI 29.0 ± 4.5 kg/m2 compared to 20 healthy volunteers. Serum visfatin and vaspin concentrations were significantly increased in HCC patients compared to controls (p = 0.01 and p = 0.02, respectively). Serum vaspin was significantly higher in HCC patients with viral compared to those with non-viral etiology (p = 0.02), with more evident increase in chronic hepatitis C patients (CHC). Serum visfatin levels were significantly higher in patients with higher insulin resistance (p = 0.04) and with platelets count > 100 000/mm3 (p<0.001). Patients with BMI >30 kg/m2 had markedly up-regulated vaspin levels (p = 0.04). There was no difference in vaspin and visfatin serum levels with respect to liver dysfunction and BCLC classification. In conclusion, our study revealed serum vaspin and visfatin to be significantly increased in HCC patients independently of cancer etiology compared to controls. Additionally, serum vaspin was elevated in viral disease, especially in CHC. Vaspin up-regulation can be a compensatory mechanism against IR in HCC patients. Serum visfatin and vaspin, although up-regulated, seem not to be associated with cancer grade and cirrhosis severity.

Klíčová slova:

Adipokines – Adipose tissue – Body mass index – Etiology – Hepatocellular carcinoma – Insulin – Obesity – Platelets


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2020 Číslo 1