A network analysis revealed the essential and common downstream proteins related to inguinal hernia

Autoři: Yimin Mao aff001;  Le Chen aff001;  Jianghua Li aff001;  Anna Junjie Shangguan aff003;  Stacy Kujawa aff004;  Hong Zhao aff004
Působiště autorů: School of Information and Technology, Jiangxi University of Science and Technology, Jiangxi, China aff001;  Applied Science Institute, Jiangxi University of Science and Technology, Jiangxi, China aff002;  Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America aff003;  Division of Reproductive Science in Medicine, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America aff004
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226885


Although more than 1 in 4 men develop symptomatic inguinal hernia during their lifetime, the molecular mechanism behind inguinal hernia remains unknown. Here, we explored the protein-protein interaction network built on known inguinal hernia-causative genes to identify essential and common downstream proteins for inguinal hernia formation. We discovered that PIK3R1, PTPN11, TGFBR1, CDC42, SOS1, and KRAS were the most essential inguinal hernia-causative proteins and UBC, GRB2, CTNNB1, HSP90AA1, CBL, PLCG1, and CRK were listed as the most commonly-involved downstream proteins. In addition, the transmembrane receptor protein tyrosine kinase signaling pathway was the most frequently found inguinal hernia-related pathway. Our in silico approach was able to uncover a novel molecular mechanism underlying inguinal hernia formation by identifying inguinal hernia-related essential proteins and potential common downstream proteins of inguinal hernia-causative proteins.

Klíčová slova:

Centrality – Hernia – MAPK signaling cascades – Membrane receptor signaling – Protein interaction networks – Protein kinase signaling cascade – TGF-beta signaling cascade – VEGF signaling


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