Trends of the prevalence and incidence of hypertrophic cardiomyopathy in Korea: A nationwide population-based cohort study

Autoři: Inki Moon aff001;  Seo-Young Lee aff001;  Hyung-Kwan Kim aff001;  Kyung-Do Han aff002;  Soongu Kwak aff001;  Minkwan Kim aff001;  Hyun-Jung Lee aff001;  In-Chang Hwang aff003;  Heesun Lee aff004;  Jun-Bean Park aff001;  Yeonyee E. Yoon aff003;  Yong-Jin Kim aff001;  Goo-Yeong Cho aff003
Působiště autorů: Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea aff001;  Department of Medical Statistics, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea aff002;  Department of Cardiology, Cardiovascular Center, Seoul National University Bundang Hospital, Seongnam, Gyeonggi, South Korea aff003;  Division of Cardiology, Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea aff004
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article


Temporal trends of the prevalence and incidence of hypertrophic cardiomyopathy (HCM) have not been well established in Asian populations. Using the Korean National Health Insurance Services database, we identified patients with a confirmed diagnosis of HCM between 2010 and 2016. The annual prevalence and incidence of HCM, and their clinical characteristics were investigated. The prevalence of HCM has increased from 0.016% (n = 6313) in 2010 to 0.031% (n = 13,035) in 2016. During a 7-year period, 13,229 patients were newly diagnosed with HCM. The incidence rate increased from 4.15 (per 100,000 person-years) in 2010 to 5.6 in 2016. The prevalence and incidence of HCM increased with age and peaked during the 70s, with male predominance in all age groups. Chest pain is the most frequent clinical presentation followed by shortness of breath and syncope. Hypertension and dyslipidemia were the two most common comorbidities. Heart failure and atrial fibrillation was diagnosed in about 1/3 and 1/4 of patients with HCM, respectively. The prevalence and incidence of HCM gradually increased from 2010 to 2016, possibly due to heightened recognition of the disease. Given the progressively high incidence of HCM with age and high prevalence of coexisting modifiable risk factors, continued efforts are required to increase awareness regarding HCM-related symptoms and potential complications.

Klíčová slova:

Atrial fibrillation – Cohort studies – Diagnostic medicine – Health insurance – Hypertension – Medical risk factors – Cardiomyopathies


1. Authors/Task Force m, Elliott PM, Anastasakis A, Borger MA, Borggrefe M, Cecchi F, et al. 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy: the Task Force for the Diagnosis and Management of Hypertrophic Cardiomyopathy of the European Society of Cardiology (ESC). Eur Heart J. 2014;35(39):2733–79. doi: 10.1093/eurheartj/ehu284 25173338

2. Gersh BJ, Maron BJ, Bonow RO, Dearani JA, Fifer MA, Link MS, et al. 2011 ACCF/AHA guideline for the diagnosis and treatment of hypertrophic cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 2011;124(24):e783–831. doi: 10.1161/CIR.0b013e318223e2bd 22068434

3. Maron BJ, Ommen SR, Semsarian C, Spirito P, Olivotto I, Maron MS. Hypertrophic cardiomyopathy: present and future, with translation into contemporary cardiovascular medicine. J Am Coll Cardiol. 2014;64(1):83–99. doi: 10.1016/j.jacc.2014.05.003 24998133

4. Maron BJ, Gardin JM, Flack JM, Gidding SS, Kurosaki TT, Bild DE. Prevalence of hypertrophic cardiomyopathy in a general population of young adults. Echocardiographic analysis of 4111 subjects in the CARDIA Study. Coronary Artery Risk Development in (Young) Adults. Circulation. 1995;92(4):785–9. doi: 10.1161/01.cir.92.4.785 7641357

5. Adabag AS, Kuskowski MA, Maron BJ. Determinants for clinical diagnosis of hypertrophic cardiomyopathy. Am J Cardiol. 2006;98(11):1507–11. doi: 10.1016/j.amjcard.2006.07.029 17126660

6. Maron MS, Hellawell JL, Lucove JC, Farzaneh-Far R, Olivotto I. Occurrence of Clinically Diagnosed Hypertrophic Cardiomyopathy in the United States. Am J Cardiol. 2016;117(10):1651–4. doi: 10.1016/j.amjcard.2016.02.044 27006153

7. Maron BJ, Casey SA, Hauser RG, Aeppli DM. Clinical course of hypertrophiccardiomyopathy with survival to advanced age. J Am Coll Cardiol. 2003;42(5):882–8. doi: 10.1016/s0735-1097(03)00855-6 12957437

8. Choi YJ, Choi EK, Han KD, Jung JH, Park J, Lee E, et al. Temporal trends of the prevalence and incidence of atrial fibrillation and stroke among Asian patients with hypertrophic cardiomyopathy: A nationwide population-based study. Int J Cardiol. 2018;273:130–5. doi: 10.1016/j.ijcard.2018.08.038 30150122

9. Wu CS, Tsai YT, Tsai HJ. Antipsychotic drugs and the risk of ventricular arrhythmia and/or sudden cardiac death: a nation-wide case-crossover study. J Am Heart Assoc. 2015;4(2).

10. Choi YJ, Kim SH, Kang SH, Yoon CH, Lee HY, Youn TJ, et al. Reconsidering the cut-off diastolic blood pressure for predicting cardiovascular events: a nationwide population-based study from Korea. Eur Heart J. 2019;40(9):724–31. doi: 10.1093/eurheartj/ehy801 30535368

11. Maron BJ, Mathenge R, Casey SA, Poliac LC, Longe TF. Clinical profile of hypertrophic cardiomyopathy identified de novo in rural communities. J Am Coll Cardiol. 1999;33(6):1590–5. doi: 10.1016/s0735-1097(99)00039-x 10334429

12. Maron BJ, Spirito P, Roman MJ, Paranicas M, Okin PM, Best LG, et al. Prevalence of hypertrophic cardiomyopathy in a population-based sample of American Indians aged 51 to 77 years (the Strong Heart Study). Am J Cardiol. 2004;93(12):1510–4. doi: 10.1016/j.amjcard.2004.03.007 15194022

13. Husser D, Ueberham L, Jacob J, Heuer D, Riedel-Heller S, Walker J, et al. Prevalence of clinically apparent hypertrophic cardiomyopathy in Germany-An analysis of over 5 million patients. PLoS One. 2018;13(5):e0196612. doi: 10.1371/journal.pone.0196612 29723226

14. Olivotto I, Maron MS, Adabag AS, Casey SA, Vargiu D, Link MS, et al. Gender-related differences in the clinical presentation and outcome of hypertrophic cardiomyopathy. J Am Coll Cardiol. 2005;46(3):480–7. doi: 10.1016/j.jacc.2005.04.043 16053962

15. Kubo T, Kitaoka H, Okawa M, Hirota T, Hayato K, Yamasaki N, et al. Gender-specific differences in the clinical features of hypertrophic cardiomyopathy in a community-based Japanese population: results from Kochi RYOMA study. J Cardiol. 2010;56(3):314–9. doi: 10.1016/j.jjcc.2010.07.004 20719473

16. Cardim N, Brito D, Rocha Lopes L, Freitas A, Araujo C, Belo A, et al. The Portuguese Registry of Hypertrophic Cardiomyopathy: Overall results. Rev Port Cardiol. 2018;37(1):1–10. doi: 10.1016/j.repc.2017.08.005 29358015

17. Geske JB, Ong KC, Siontis KC, Hebl VB, Ackerman MJ, Hodge DO, et al. Women with hypertrophic cardiomyopathy have worse survival. Eur Heart J. 2017;38(46):3434–40. doi: 10.1093/eurheartj/ehx527 29020402

18. Ingles J, Burns C, Bagnall RD, Lam L, Yeates L, Sarina T, et al. Nonfamilial Hypertrophic Cardiomyopathy: Prevalence, Natural History, and Clinical Implications. Circ Cardiovasc Genet. 2017;10(2).

19. Perez-Sanchez I, Romero-Puche AJ, Garcia-Molina Saez E, Sabater-Molina M, Lopez-Ayala JM, Munoz-Esparza C, et al. Factors Influencing the Phenotypic Expression of Hypertrophic Cardiomyopathy in Genetic Carriers. Rev Esp Cardiol (Engl Ed). 2018;71(3):146–54.

20. Maron BJ, Casey SA, Haas TS, Kitner CL, Garberich RF, Lesser JR. Hypertrophic cardiomyopathy with longevity to 90 years or older. Am J Cardiol. 2012;109(9):1341–7. doi: 10.1016/j.amjcard.2011.12.027 22381158

21. Maron BJ, Rowin EJ, Casey SA, Garberich RF, Maron MS. What Do Patients With Hypertrophic Cardiomyopathy Die from? Am J Cardiol. 2016;117(3):434–5. doi: 10.1016/j.amjcard.2015.11.013 26718233

22. Maron BJ, Rowin EJ, Casey SA, Link MS, Lesser JR, Chan RH et al. Hypertrophic Cardiomyopathy in Adulthood Associated With Low Cardiovascular Mortality With Contemporary Management Strategies. J Am Coll Cardiol 2015;65(18):1915–28. doi: 10.1016/j.jacc.2015.02.061 25953744

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2020 Číslo 1
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