Therapeutic hypothermia after out of hospital cardiac arrest improve 1-year survival rate for selective patients

Autoři: Ofir Koren aff001;  Ehud Rozner aff001;  Sawsan Yosefia aff003;  Yoav Turgeman aff001
Působiště autorů: Heart Institute, Emek Medical Center, Afula, Israel aff001;  Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel aff002;  Internal Medicine C, Emek Medical Center, Afula, Israel aff003
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0226956



Therapeutic Hypothermia (TH) is a standard of care after out-of-hospital cardiac arrest (OHCA). Previous reports failed to prove a significant benefit for survival or neurological outcomes. We examined whether the proper selection of patients would enhance treatment efficacy.


We conducted a retrospective cohort study. Data was collected from January 2000 and August 2018. Patients were enrolled after OHCA and classified into two groups, patients treated with TH and patients who were not treated with TH.


A total of 92 patients were included in the study. 57 (63%) patients were in the TH Group and 34 (37%) in the Non-TH group. There was no statistical difference in favorable neurological outcomes between the groups. Patients presenting with ventricular fibrillation had a higher 1-year survival rate from TH, while patients with asystole were found to benefit only if they were younger than 65 years (p < .007, p < .02, respectively).


Therapeutic Hypothermia patients failed to demonstrate a significant benefit in terms of improved neurological outcomes. Patients treated with TH following ventricular fibrillation experienced the most benefit in terms of 1-year survival, while patients who had suffered from asystole experienced a modest benefit only if they were younger than 65 years of age. Guidelines should address age and primary arrhythmia for proper treatment selection.

Klíčová slova:

Arrhythmia – Cardiac arrest – Cardiology – Critical care and emergency medicine – Death rates – Hypothermia – Myocardial infarction – Sepsis


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2020 Číslo 1