Hypertension testing and treatment in Uganda and Kenya through the SEARCH study: An implementation fidelity and outcome evaluation

Autoři: David J. Heller aff001;  Laura B. Balzer aff002;  Dhruv Kazi aff003;  Edwin D. Charlebois aff004;  Dalsone Kwarisiima aff005;  Florence Mwangwa aff005;  Vivek Jain aff004;  Prashant Kotwani aff004;  Gabriel Chamie aff004;  Craig R. Cohen aff004;  Tamara D. Clark aff004;  James Ayieko aff006;  Dathan M. Byonanabye aff007;  Maya Petersen aff008;  Moses R. Kamya aff005;  Diane Havlir aff004;  James G. Kahn aff004
Působiště autorů: Arnhold Institute for Global Health, New York, New York, United States of America aff001;  University of Massachusetts, Amherst, Massachusetts, United States of America aff002;  Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America aff003;  University of California, San Francisco, San Francisco, California, United States of America aff004;  Infectious Diseases Research Collaboration, Kampala, Uganda aff005;  Kenya Medical Research Institute (KEMRI), Nairobi, Kenya aff006;  School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda aff007;  University of California Berkeley School of Public Health, Berkeley, California, United States of America aff008;  School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda aff009
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0222801



Hypertension (HTN) is the single leading risk factor for human mortality worldwide, and more prevalent in sub-Saharan Africa than any other region [1]–although resources for HTN screening, treatment, and control are few. Most regional pilot studies to leverage HIV programs for HTN control have achieved blood pressure control in half of participants or fewer [2,3,4]. But this control gap may be due to inconsistent delivery of services, rather than ineffective underlying interventions.


We sought to evaluate the consistency of HTN program delivery within the SEARCH study (NCT01864603) among 95,000 adults in 32 rural communities in Uganda and Kenya from 2013–2016. To achieve this objective, we designed and performed a fidelity evaluation of the step-by-step process (cascade) of HTN care within SEARCH, calculating rates of HTN screening, linkage to care, and follow-up care. We evaluated SEARCH’s assessment of each participant’s HTN status against measured blood pressure and HTN history.


SEARCH completed blood pressure screens on 91% of participants. SEARCH HTN screening was 91% sensitive and over 99% specific for HTN relative to measured blood pressure and patient history. 92% of participants screened HTN+ received clinic appointments, and 42% of persons with HTN linked to subsequent care. At follow-up, 82% of SEARCH clinic participants received blood pressure checks; 75% received medication appropriate for their blood pressure; 66% remained in care; and 46% had normal blood pressure at their most recent visit.


The SEARCH study’s consistency in delivering screening and treatment services for HTN was generally high, but SEARCH could improve effectiveness in linking patients to care and achieving HTN control. Its model for implementing population-scale HTN testing and care through an existing HIV test-and-treat program–and protocol for evaluating the intervention’s stepwise fidelity and care outcomes–may be adapted, strengthened, and scaled up for use across multiple resource-limited settings.

Klíčová slova:

Blood pressure – Body Mass Index – diabetes mellitus – Health screening – HIV – Hypertension – Kenya – Uganda


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