Using machine learning methods to determine a typology of patients with HIV-HCV infection to be treated with antivirals

Autoři: Antonio Rivero-Juárez aff001;  David Guijo-Rubio aff002;  Francisco Tellez aff003;  Rosario Palacios aff004;  Dolores Merino aff005;  Juan Macías aff006;  Juan Carlos Fernández aff002;  Pedro Antonio Gutiérrez aff002;  Antonio Rivero aff001;  César Hervás-Martínez aff002
Působiště autorů: Unidad de Enfermedades Infecciosas, Hospital Universitario Reina Sofía de Córdoba, Instituto Maimónides de Investigación Biomédica de Córdoba, Universidad de Córdoba, Córdoba, España aff001;  Departamento de Informática y Análisis Numérico, Universidad de Córdoba, Córdoba, España aff002;  Unidad de Enfermedades Infecciosas, Hospital Universitario de Puerto Real, Cádiz, España aff003;  Unidad de Enfermedades Infecciosas, Hospital Juan Ramón Jiménez e Infanta Elena de Huelva, Huelva, España aff004;  Unidad de Enfermedades Infecciosas, Hospital Universitario Virgen de la Victoria, Complejo Hospitalario Provincial de Málaga, Málaga, España aff005;  Unidad de Enfermedades Infecciosas, Hospital Universitario de Valme, Instituto de Biomedicina de Sevilla, Sevilla, España aff006
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article


Several European countries have established criteria for prioritising initiation of treatment in patients infected with the hepatitis C virus (HCV) by grouping patients according to clinical characteristics. Based on neural network techniques, our objective was to identify those factors for HIV/HCV co-infected patients (to which clinicians have given careful consideration before treatment uptake) that have not being included among the prioritisation criteria. This study was based on the Spanish HERACLES cohort (NCT02511496) (April-September 2015, 2940 patients) and involved application of different neural network models with different basis functions (product-unit, sigmoid unit and radial basis function neural networks) for automatic classification of patients for treatment. An evolutionary algorithm was used to determine the architecture and estimate the coefficients of the model. This machine learning methodology found that radial basis neural networks provided a very simple model in terms of the number of patient characteristics to be considered by the classifier (in this case, six), returning a good overall classification accuracy of 0.767 and a minimum sensitivity (for the classification of the minority class, untreated patients) of 0.550. Finally, the area under the ROC curve was 0.802, which proved to be exceptional. The parsimony of the model makes it especially attractive, using just eight connections. The independent variable “recent PWID” is compulsory due to its importance. The simplicity of the model means that it is possible to analyse the relationship between patient characteristics and the probability of belonging to the treated group.

Klíčová slova:

Artificial neural networks – Drug abuse – Evolutionary algorithms – Hepatitis C virus – HIV – Liver fibrosis – Mental health therapies – Neural networks


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