Relationship between diabetic macular edema and choroidal layer thickness

Autoři: Hiroaki Endo aff001;  Satoru Kase aff002;  Mitsuo Takahashi aff001;  Michiyuki Saito aff001;  Masahiko Yokoi aff003;  Chisato Sugawara aff001;  Satoshi Katsuta aff001;  Susumu Ishida aff002;  Manabu Kase aff001
Působiště autorů: Department of Ophthalmology, Teine Keijinkai Hospital, Sapporo, Japan aff001;  Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan aff002;  Teine Yokoi Eye Clinic, Sapporo, Japan aff003
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0226630



To investigate the relationship between diabetic macular edema (DME) and the choroidal layer thickness in diabetic patients.


This is a retrospective observation study. Three hundred eighteen eyes of 159 diabetes mellitus (DM) patients and age-matched 100 eyes of 79 healthy controls were enrolled. DME was defined as over 300 μm in the central retinal subfield of the Early Treatment Diabetic Retinopathy Study (ETDRS) grid sector. The central choroidal thickness (CCT), as well as inner and outer layers were determined based on enhanced depth imaging (EDI)–OCT. Diabetic patients with/without systemic diabetic treatments (DT) at the start of this study was defined as DT+ and DT–, respectively. The number of eyes examined was 62 and 256 eyes in DME+and DME–groups, respectively. DM patients were further subdivided into 4 groups with/without DME and DT; DME+DT+(35 eyes), DME–DT+(159 eyes), DME+DT–(27 eyes), and DME–DT–group (97 eyes). Multiple comparisons on CCT layers including control and each DM group were statistically examined.


The total CCT layer was 254±83, 283±88, and 251±70 μm in the control, DME+, and DME–group, respectively. A total CCT layer in DME+was significantly thicker than the DME–group (P < 0.05). The outer CCT layer was 195±75, 222±83, and 193±63 μm in the control, DME+, and DME–group, respectively. The outer CCT layer in DME+ was significantly thicker than the DME–group (P < 0.05). In the subdivided groups, the total CCT layers in the control, DME+DT+, DME–DT+, DME+DT–and DME–DT–groups were 254±83, 274±88, 247±66, 290±84 and 258±75 μm, respectively. The outer CCT layers in each group were 195±75, 214±83, 189±58, 228±77, and 201±70 μm, respectively. Total CCT and the outer layer in DME+DT–was significantly thicker than the DME–DT+group (each P < 0.05). In contrast, there was no significant difference in inner layer between the groups.


The total and outer CCT layers of diabetic eyes were significantly thickened in the DME+DT–as compared with the DME–DT+group, suggesting that CCT may be related to the pathology of DME.

Klíčová slova:

Blood pressure – Diabetes mellitus – Edema – Eyes – HbA1c – Cholesterol – Choroid – Visual acuity


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