Platelet indices significantly correlate with liver fibrosis in HCV-infected patients


Autoři: Lin-Nan Shao aff001;  Shu-Ting Zhang aff001;  Ni Wang aff001;  Wei-Jian Yu aff001;  Mei Chen aff001;  Nan Xiao aff001;  Ying Duan aff001;  Ling-Zi Pan aff001;  Wen-Qian Song aff001;  Yue-Xin Xia aff001;  Li Zhang aff001;  Ning Qi aff001;  Ming Liu aff002;  Shi-Hang Zhou aff001
Působiště autorů: Dalian Blood Center, Zhongshan District, Dalian, Liaoning, China aff001;  Department of Cell Biology, Dalian Medical University, Dalian, Liaoning, China aff002
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0227544

Souhrn

Aim

A total of 241 patients with chronic HCV infection were recruited to investigate the association between liver fibrosis and PLT counts, as well as with MPV, PDW and P-LCR indices.

Methods

The determination of PLT indices was carried out using a Sysmex XT-1800i automated hematology analyzer. Serological tests for HA, LN, C-IV and PIIINP were performed in 210 patients. The liver stiffness was measured in 69 patients by transient elastography (FibroScan).

Results

The analysis showed that the four serum fibrosis markers were negatively correlated with PLT counts, but positively correlated with the MPV, PDW and P-LCR values. Moreover, a similar pattern was found after analyzing the FibroScan measurements, which were negatively correlated with PLT counts, but positively correlated with MPV, PDW and P-LCR values. We subdivided the HCV-infected patients into mild and advanced fibrosis groups. The PLT counts were significantly decreased and the MPV, PDW and P-LCR values were significantly increased in the advanced fibrosis group when compared with the mild fibrosis group.

Conclusions

Our results demonstrate that not only the PLT counts but also the MPV, PDW and P-LCR indices significantly correlate with liver fibrosis in HCV-infected patients. Therefore, these indices may be useful laboratory measures for evaluating liver fibrosis progression.

Klíčová slova:

Blood counts – Collagens – Fibrosis – Hematology – Hepatitis C virus – Chronic liver disease – Liver fibrosis – Platelets


Zdroje

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2020 Číslo 1