The epidemiological characteristics and spatio-temporal analysis of childhood hand, foot and mouth disease in Korea, 2011-2017
Soojin Baek aff001; Seongwoo Park aff002; Hye Kyung Park aff002; Byung Chul Chun aff001
Působiště autorů: Department of Public Health, Korea University Graduate School, Seoul, Korea aff001; Division of Strategic Planning for Emerging Diseases, Korea Centers for Disease Control and Prevention, Chungcheongbuk-do, Korea aff002; Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Korea aff003
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
Hand-foot-mouth disease (HFMD) is a common viral infection in children, with a significant disease burden due to its high contagion rate. This report studied the epidemiological characteristics as well as the chronological and geographical distribution of HFMD in children younger than 6 years of age in Korea.
This report established a database by integrating population and geographical data from health insurance claims for HFMD between 2011 and 2017, with an age restriction of ≤6 years, and explored the epidemiological characteristics of both HFMD patients and hospitalized cases in Korea. The relative risk ratio and spatio-temporal scan statistics were calculated by administrative district, using SaTScan.
Over a 7-year period, 1,879,342 children under the age of 6 were diagnosed with HFMD (8.4 of 100 persons younger than 6 years of age). Seasonal incidence tended to increase from week 17 (May) peak between weeks 29 (July) and 39 (September), and increase rapidly in 1- to 2-year cycles. HFMD primarily occurred in children younger than 4 years of age. Furthermore, the greatest proportion of cases occurred at ages 1 (39.2%) and 2 (25.7%). Overall, 92.6% of all cases occurred before the age of 6. The proportion of cases before the age of 6was slightly higher in males. The timing of HFMD epidemics differed over the years. In 2015, the HFMD cumulative incidence was the lowest (5.5/1,000), and the spatio-temporal cluster (RR 2.32) was predominantly located south-central Korea, covering 65 counties for twenty-two weeks. In 2016, however, its cumulative incidence was high (RR 6.34) over a short period (11 weeks) in specific areas such as Ulsan, Daegu, Busan, and Gyeongnam. Also, the southern parts of Korea were found to have a higher rate of hospitalization.
HFMD in Korea is common in children younger than 6 years of age, and it tends to peak in the summer.
Diagnostic medicine – Geographic distribution – Hand, foot and mouth disease – Health insurance – Infectious disease surveillance – Korea – Respiratory infections – Spatial epidemiology
1. Gopalkrishna V, Patil PR, Patil GP, Chitambar SD. Circulation of multiple enterovirus serotypes causing hand, foot and mouth disease in India. J Med Microbiol. 2012; 61: 420–425. doi: 10.1099/jmm.0.036400-0 22052995
2. Xing W, Liao Q, Viboud C, Zhang J, Sun J, Wu JT, et al. Hand, foot, and mouth disease in China, 2008–12: an epidemiological study. Lancet Infect Dis. 2014; 14: 308–318. doi: 10.1016/S1473-3099(13)70342-6 24485991
3. Guideline for the prevention and control of enterovirus infection and hand, foot and mouth disease. Korea Centers for Disease Control and Prevention. 2017. Available from: http://www.cdc.go.kr/CDC/together/CdcKrTogether0302.jsp?menuIds=HOME006-MNU2804-MNU3027-MNU2979&fid=10713&q_type=title&q_value=%EC%88%98%EC%A1%B1%EA%B5%AC&cid=138078&pageNum=
4. Abzug MJ. Nonpolio Enteroviruses. In: Kliegman RM, ed. Nelson Textbook of Pediatrics, 18th ed. Philadelphia: Saunders, 2007. pp. 1350–1356.
5. A Guide to Clinical Management and Public Health Response for Hand, Foot and Mouth Disease (HFMD). World Health Organization, 2011. Available from: https://iris.wpro.who.int/bitstream/handle/10665.1/5521/9789290615255_eng.pdf
6. Kulldorff M. A spatial scan statistic. Commun Stat Theory Methods. 1997; 26: 1481–1496. doi: 10.1080/03610929708831995
7. Han Junhee, Lee Minjung. Cancer cluster detection using scan statistic. Bull Inf Cybern. 2016; 27: 193–120 doi: 10.7465/jkdi.2016.27.5.1193
8. Koh WM, Bogich T, Siegel K, Jin J, Chong EY, Tan CY, et al. The Epidemiology of Hand, Foot and Mouth Disease in Asia: A Systematic Review and Analysis. Pediatr Infect Dis J. 2016; 35: e285–300. doi: 10.1097/INF.0000000000001242 27273688
9. Western Pacific Region Hand, Foot and Mouth Disease (HFMD) Surveillance Summary. World Health Organization, 2018. Available from: http://www.wpro.who.int/entity/emergencies/wp_hfmd_biweekly/en/.
10. Report on the hand, foot, and mouth disease in Fuyang City, Anhui Province and the prevention and control in China. Beijing, Chinese Center for Disease Control and Prevention and the office of the World Health Organization in China 2008. Available from: http://www.wpro.who.int/china/topics/hand_foot_mouth_disease/en/
11. Hand, foot and mouth disease, 2000–2003, Japan. IASR. 2004; 25: 224–225. Available from: http://idsc.nih.go.jp/iasr/25/295/tpc295.html
12. Wu X, Hu S, Kwaku AB, Li Q, Luo K, Zhou Y, Tan H. Spatio-temporal clustering analysis and its determinants of hand, foot and mouth disease in Hunan, China, 2009–2015. BMC Infect Dis. 2017; 17: 645. doi: 10.1186/s12879-017-2742-9 28946852
13. Urashima M, Shindo N, Okabe N. Seasonal models of herpangina and hand-foot-mouth disease to simulate annual fluctuations in urban warming in Tokyo. Japanese Journal of Infectious Diseases 2003; 56: 48–53. 12824684
14. Public Health Weekly Report Disease Surveillance Statistics, 2018 PHWR. Korea Centers for Disease Control and Prevention. Available from: http://www.cdc.go.kr/board.es?mid=a30502000000&bid=0032.
15. Li L, Qiu W, Xu C, Wang J. A spatiotemporal mixed model to assess the influence of environmental and socioeconomic factors on the incidence of hand, foot and mouth disease. BMC Public Health. 2018 Feb 20; 18: 274. doi: 10.1186/s12889-018-5169-3 29463224
16. Ooi EE, Phoon MC, Ishak B, Chan SH. Seroepidemiology of human enterovirus 71, Singapore. Emerg Infect Dis. 2002 Sep; 8: 995–997. doi: 10.3201/eid0809.10.3201/eid0809.010397 12194783
17. Bélanger M, Gray-Donald K, O'Loughlin J, Paradis G, Hanley J. Influence of weather conditions and season on physical activity in adolescents. Ann Epidemiolo. 2009 Mar; 19: 180–186. doi: 10.1016/j.annepidem.2008.12.008 19217000
18. Kim JA, Yoon S, Kim LY, Kim DS. Towards Actualizing the Value Potential of Korea Health Insurance Review and Assessment (HIRA) Data as a Resource for Health Research: Strengths, Limitations, Applications, and Strategies for Optimal Use of HIRA Data. J Korean Med Sci. 2017;32(5):718–28. doi: 10.3346/jkms.2017.32.5.718 28378543
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