Type 1 diabetes is associated with an increased risk of venous thromboembolism: A retrospective population-based cohort study

Autoři: Yi-Hao Peng aff001;  Yu-Sheng Lin aff004;  Chia-Hung Chen aff005;  Kun-Yuan Tsai aff006;  Yi-Chih Hung aff007;  Hsuan-Ju Chen aff009;  Wei-Chih Liao aff005;  Wen-Chao Ho aff001
Působiště autorů: Department of Public Health, China Medical University, Taichung, Taiwan aff001;  Department of Respiratory Therapy, Asia University Hospital, Asia University, Taichung, Taiwan aff002;  Department of Respiratory Therapy, China Medical University, Taichung, Taiwan aff003;  Department of Chest Medicine, Division of Internal Medicine, Asia University Hospital, Asia University, Taichung, Taiwan aff004;  Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan aff005;  Division of Endocrinology and Metabolism, Chung-Hsin Clinic, New Taipei, Taiwan aff006;  Division of Endocrinology and Metabolism, Department of Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan aff007;  Graduate Institute of Clinical Medical Science, China Medical University, Taichung, Taiwan aff008;  Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan aff009;  Department of Nursing, Asia University, Taichung, Taiwan aff010
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0226997



It has been unclear whether diabetes mellitus (DM) is positively associated with a risk of venous thromboembolism (VTE). In addition, whether the risk of VTE is altered in patients with type 1 diabetes (T1DM) has rarely been explored.


We investigated whether patients with T1DM are at a relatively high risk of VTE development.


We retrieved data from the National Health Insurance Research Database of Taiwan to conduct this retrospective cohort study. The T1DM group consisted of 4967 patients diagnosed as having T1DM before 2003. The non-T1DM group comprised 19 868 age- and sex-matched enrollees without T1DM. Cox proportional hazard regression analysis was used to investigate the hazard ratio of VTE in patients with T1DM relative to those without T1DM.


During a mean follow-up period of 8.61 years, the risk of VTE in the T1DM group was 5.33-fold higher than in the non-T1DM group after adjusting for dyslipidemia, hypertension, stroke, lower leg fracture or surgery, and obesity. Further stratified analysis revealed that the risk of VTE was significantly high in both sexes and in all age groups below the age of 60.


T1DM appears to be an independent risk factor for VTE development.

Klíčová slova:

Age groups – diabetes mellitus – Heart failure – Hypertension – Obesity – Surgical and invasive medical procedures – Venous thromboembolism


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