The impact of diabetes mellitus medication on the incidence of endogenous endophthalmitis

Autoři: Ke-Hung Chien aff001;  Ke-Hao Huang aff001;  Chi-Hsiang Chung aff004;  Yun-Hsiu Hsieh aff001;  Chang-Min Liang aff001;  Yu-Hua Chang aff006;  Tzu-Heng Weng aff001;  Wu-Chien Chien aff004
Působiště autorů: Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan aff001;  Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan aff002;  Department of Ophthalmology, Songshan Branch of Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan aff003;  School of Public Health, National Defense Medical Center, Taipei, Taiwan aff004;  Taiwanese Injury Prevention and Safety Promotion Association (TIPSPA), Taipei, Taiwan aff005;  Division of Colorectal Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan aff006;  Department of Medical Research, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan aff007;  Graduate Institute of Life Science, National Defense Medical Center, Taipei, Taiwan aff008
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0227442



This study aimed to evaluate the relationship between diabetic mellitus (DM) treatment and the incidence rate of endogenous endophthalmitis (EE).


This study used a matched cohort design. We utilized the Longitudinal Health Insurance Database to identify outpatients and inpatients who were diagnosed with DM and treated with medication from 2000 to 2010.


Several factors and different DM medications were also investigated. The influence of DM medication on the incidence of EE was examined by using Cox proportional hazards regression models, and the hazard ratios and 95% confidence intervals were determined.


The cumulative incidence of EE was lower in DM patients treated with medication than in subjects in the control group (P = 0.002). The adjusted hazard ratio (AHR) was 0.47-fold lower in the treatment group than in the control group (P = 0.004). With respect to DM medication, single-agent therapy with insulin, metformin, gliclazide, glimepiride, or repaglinide and combination therapy with glimepiride/metformin or repaglinide/metformin were associated with decreased AHRs (0.257–0.544, all P<0.05).


Diabetic patients treated with medication had lower AHRs than those in the control group. Further stratification indicated that liver abscess, liver disease DM patients who were treated with medication had a lower risk of developing EE. Several specific DM medications may decrease the incidence of EE.

Klíčová slova:

Abscesses – Cancer treatment – Diabetes mellitus – Drug therapy – Gastroenterology and hepatology – Liver diseases – Oncology – Pneumonia


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