Impact of lower limb osteoarthritis on health-related quality of life: A cross-sectional study to estimate the expressed loss of utility in the Spanish population

Autoři: Jesús Martín-Fernández aff001;  Roberto García -Maroto aff004;  Amaia Bilbao aff003;  Lidia García-Pérez aff003;  Blanca Gutiérrez-Teira aff009;  Antonio Molina-Siguero aff010;  Juan Carlos Arenaza aff003;  Vanesa Ramos-García aff008;  Gemma Rodríguez-Martínez aff012;  Fco Javier Sánchez-Jiménez aff013;  Gloria Ariza-Cardiel aff001
Působiště autorů: Unidad Docente Multiprofesional de Atención Familiar y Comunitaria Oeste, Gerencia Asistencial de Atención Primaria, Servicio Madrileño de Salud, Madrid, Spain aff001;  Facultad de Ciencias de la Salud, Universidad Rey Juan Carlos, Madrid, Spain aff002;  Red de Investigación en Servicios Sanitarios y Enfermedades Crónicas (REDISSEC), Spain aff003;  Servicio de Cirugía Ortopédica y Traumatología, Hospital Universitario Clínico San Carlos, Servicio Madrileño de Salud, Madrid, Spain aff004;  Doctorando en el Programa de Investigación en Ciencias Médico Quirúrgicas, Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain aff005;  Osakidetza, Hospital Universitario Basurto, Unidad de Investigación, Bilbao, Spain aff006;  Instituto de Investigación en Servicios de Salud Kronikgune, Barakaldo, Spain aff007;  Fundación Canaria Instituto de Investigación Sanitaria de Canarias (FIISC), Las Palmas de Gran Canaria, Spain aff008;  Centro de Salud El Soto, Gerencia Asistencial de Atención Primaria, Servicio Madrileño de Salud, Madrid, Spain aff009;  Centro de Salud Presentación Sabio, Gerencia Asistencial de Atención Primaria, Servicio Madrileño de Salud, Madrid, Spain aff010;  Osakidetza, Hospital Universitario Basurto, Servicio de Traumatología y Cirugía Ortopédica, Bilbao, Spain aff011;  Centro de Salud Infante Don Luis, Gerencia Asistencial de Atención Primaria, Servicio Madrileño de Salud, Madrid, Spain aff012;  Centro de Salud Gregorio Marañón, Gerencia Asistencial de Atención Primaria, Servicio Madrileño de Salud, Madrid, Spain aff013
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article



Osteoarthritis of the lower limb (OALL) worsens health-related quality of life (HRQL), but this impact has not been quantified with standardized measures. We intend to evaluate the impact of OALL on HRQL through measures based on individual preferences in comparison to the general population.


A cross-sectional study was designed. A total of 6234 subjects aged 50 years or older without OALL were selected from the Spanish general population (National Health Survey 2011–12). An opportunistic sample of patients aged 50 years or older diagnosed with hip (n = 331) or knee osteoarthritis (n = 393), using the American Rheumatism Association criteria, was recruited from six hospitals and 21 primary care centers in Vizcaya, Madrid and Tenerife between January and December 2015. HRQL was measured with the EQ-5D-5L, and the results were transformed into utility scores. Sociodemographic variables (age, sex, social group, cohabitation), number of chronic diseases, and body mass index were considered. The clinical stage of OALL was collected using the Western Ontario and McMaster Universities Osteoarthritis Index and the Oxford hip score and Oxford knee score. Generalized linear models were constructed using the utility index as the dependent variable.


HRQL expressed by OALL patients was significantly worse than this of the general population. After adjustment for sociodemographic and clinical characteristics, the mean utility loss was -0.347 (95% CI: -0.390, -0.303) for osteoarthritis of the hip and -0.295 (95% CI: -0.336, -0.255) for osteoarthritis of the knee. OALL patients who were treated at a hospital had an additional utility loss of -0.112 (95% CI: -0.158, -0.065).


OALL has a great impact on HRQL. People with OALL perceive a utility loss of approximately 0.3 points compared to the general population without osteoarthritis, which is very high in relation to the utility loss reported for other chronic diseases and for arthritis in general.

Klíčová slova:

Body limbs – Body Mass Index – Hip – Knee joints – Knees – Obesity – Osteoarthritis – Spain


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