Comparisons of recurrence-free survival and overall survival between microwave versus radiofrequency ablation treatment for hepatocellular carcinoma: A multiple centers retrospective cohort study with propensity score matching

Autoři: Shibin Du aff001;  Jian-Zhi Yang aff002;  Jing Chen aff003;  Wei-gang Zhou aff002;  Yan-Yan Sun aff001
Působiště autorů: Department of Anesthesiology, Shenzhen University Clinical Medical Academy, Shenzhen University, Shenzhen University General Hospital, Shenzhen, China aff001;  Department of Anesthesiology, Hanzhong Central Hospital, Hanzhong, Shanxi, China aff002;  Department of Endocrinology, The Second Affiliated Hospital, Kunming Medical University, Kunming, Yunnan, China aff003
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article


Both microwave (MW) ablation and radiofrequency (RF) ablation are widely used for hepatocellular carcinoma (HCC) treatments in clinic. However, it is still unclear if ablative methods could influence the recurrence-free survival (RFS) and overall survival (OS) of HCC patients. Therefore, we carried out this multi-center retrospective cohort study to investigate the differences of recurrence-free survival (RFS) and overall survival (OS) between MW ablation and RF ablation by survival analysis. From January 2014 to December 2016, patients who received thermal ablation surgery for HCC treatment were screened. Finally, 452 patients met the eligibility criteria and finished the follow-up. Univariable and multivariable regression analyses were used to identify independent predictive factors of the RFS and OS. Also, propensity score matching (PSM) was used to balance the bias between two groups. Finally, we found that before the PSM, the univariable and multivariable regression analyses revealed that there were no significant differences on the RFS between two groups. Same results were obtained for the OS. After PSM, 115 pairs of patients were created, and both the univariable and multivariable regression analyses suggested that there were still no significant differences on the RFS between two groups. Same results were obtained for the OS. In conclusion, our present study showed that there were no significant differences between MW ablation and RF ablation for HCC patients on the RFS or OS.

Klíčová slova:

Death rates – Hepatocellular carcinoma – Hypertension – Chemoradiotherapy – Regression analysis – Surgical and invasive medical procedures – Surgical oncology – Surgical resection


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