Morphometric study of the diaphragmatic surface of the liver in the human fetus

Autoři: Monika Paruszewska-Achtel aff001;  Małgorzata Dombek aff001;  Mateusz Badura aff001;  Gabriela Elminowska-Wenda aff001;  Maria Dąbrowska aff001;  Magdalena Grzonkowska aff001;  Mariusz Baumgart aff001;  Anna Szpinda-Barczyńska aff002;  Michał Szpinda aff001
Působiště autorů: Department of Normal Anatomy, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, The Nicolaus Copernicus University in Toruń, Bydgoszcz, Poland aff001;  Department of Orthodontics, Medical University of Warsaw, Warszawa, Poland aff002
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0227872


This study aimed to examine age-specific reference intervals and growth dynamics of the best fit for liver dimensions on the diaphragmatic surface of the fetal liver. The research material consisted of 69 human fetuses of both sexes (32♂, 37♀) aged 18–30 weeks. Using methods of anatomical dissection, digital image analysis and statistics, a total of 10 measurements and 2 calculations were performed. No statistical significant differences between sexes were found (p>0.05). The parameters studied displayed growth models that followed natural logarithmic functions. The mean value of the transverse–to–vertical diameter ratio of the liver throughout the analyzed period was 0.71±0.11. The isthmic ratio decreased significantly from 0.81±0.12 in the 18–19th week to 0.62±0.06 in the 26–27th week, and then increased to 0.68±0.11 in the 28–30th week of fetal life (p<0.01). The morphometric parameters of the diaphragmatic surface of the liver present age-specific reference data. No sex differences are found. The transverse–to–vertical diameter ratio supports a proportionate growth of the fetal liver. Quantitative anatomy of the growing liver may be of relevance in both the ultrasound monitoring of the fetal development and the early detection of liver anomalies.

Klíčová slova:

Anemia – Diabetes mellitus – Fetuses – Hematopoiesis – Image analysis – Morphometry – Ultrasound imaging – Fetal development


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