Fecal transplant prevents gut dysbiosis and anxiety-like behaviour after spinal cord injury in rats


Autoři: Emma K. A. Schmidt aff001;  Abel Torres-Espin aff002;  Pamela J. F. Raposo aff002;  Karen L. Madsen aff004;  Kristina A. Kigerl aff005;  Phillip G. Popovich aff005;  Keith K. Fenrich aff001;  Karim Fouad aff001
Působiště autorů: Neuroscience and Mental Health Institute, University of Alberta; Edmonton, Canada aff001;  Faculty of Rehabilitation Medicine, University of Alberta; Edmonton, Canada aff002;  Department of Physical Therapy, University of Alberta; Edmonton, Canada aff003;  Division of Gastroenterology, Faculty of Medicine and Dentistry, University of Alberta; Edmonton, Canada aff004;  Department of Neuroscience, Center for Brain and Spinal Cord Repair, The Belford Center for Spinal Cord Injury, The Ohio State University, Wexner Medical Center; Columbus, United States of America aff005
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0226128

Souhrn

Secondary manifestations of spinal cord injury beyond motor and sensory dysfunction can negatively affect a person’s quality of life. Spinal cord injury is associated with an increased incidence of depression and anxiety; however, the mechanisms of this relationship are currently not well understood. Human and animal studies suggest that changes in the composition of the intestinal microbiota (dysbiosis) are associated with mood disorders. The objective of the current study is to establish a model of anxiety following a cervical contusion spinal cord injury in rats and to determine whether the microbiota play a role in the observed behavioural changes. We found that spinal cord injury caused dysbiosis and increased symptoms of anxiety-like behaviour. Treatment with a fecal transplant prevented both spinal cord injury-induced dysbiosis as well as the development of anxiety-like behaviour. These results indicate that an incomplete unilateral cervical spinal cord injury can cause affective disorders and intestinal dysbiosis, and that both can be prevented by treatment with fecal transplant therapy.

Klíčová slova:

Depression – Gastrointestinal tract – Inflammatory diseases – Microbiome – Principal component analysis – Rats – Spinal cord injury – Surgical and invasive medical procedures


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