Whole blood transcriptomic analysis of beef cattle at arrival identifies potential predictive molecules and mechanisms that indicate animals that naturally resist bovine respiratory disease


Autoři: Matthew A. Scott aff001;  Amelia R. Woolums aff001;  Cyprianna E. Swiderski aff002;  Andy D. Perkins aff003;  Bindu Nanduri aff004;  David R. Smith aff001;  Brandi B. Karisch aff005;  William B. Epperson aff001;  John R. Blanton, Jr. aff005
Působiště autorů: Department of Pathobiology and Population Medicine, Mississippi State University, Mississippi State, MS, United States of America aff001;  Department of Clinical Sciences, Mississippi State University, Mississippi State, MS, United States of America aff002;  Department of Computer Science and Engineering, Mississippi State University, Mississippi State, MS, United States of America aff003;  Department of Basic Sciences, Mississippi State University College of Veterinary Medicine, Mississippi State University, Mississippi State, MS, United States of America aff004;  Department of Animal and Dairy Sciences, Mississippi State University, Mississippi State, MS, United States of America aff005
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0227507

Souhrn

Bovine respiratory disease (BRD) is a multifactorial disease complex and the leading infectious disease in post-weaned beef cattle. Clinical manifestations of BRD are recognized in beef calves within a high-risk setting, commonly associated with weaning, shipping, and novel feeding and housing environments. However, the understanding of complex host immune interactions and genomic mechanisms involved in BRD susceptibility remain elusive. Utilizing high-throughput RNA-sequencing, we contrasted the at-arrival blood transcriptomes of 6 beef cattle that ultimately developed BRD against 5 beef cattle that remained healthy within the same herd, differentiating BRD diagnosis from production metadata and treatment records. We identified 135 differentially expressed genes (DEGs) using the differential gene expression tools edgeR and DESeq2. Thirty-six of the DEGs shared between these two analysis platforms were prioritized for investigation of their relevance to infectious disease resistance using WebGestalt, STRING, and Reactome. Biological processes related to inflammatory response, immunological defense, lipoxin metabolism, and macrophage function were identified. Production of specialized pro-resolvin mediators (SPMs) and endogenous metabolism of angiotensinogen were increased in animals that resisted BRD. Protein-protein interaction modeling of gene products with significantly higher expression in cattle that naturally acquire BRD identified molecular processes involving microbial killing. Accordingly, identification of DEGs in whole blood at arrival revealed a clear distinction between calves that went on to develop BRD and those that resisted BRD. These results provide novel insight into host immune factors that are present at the time of arrival that confer protection from BRD.

Klíčová slova:

Beef – Blood – Cattle – Gene expression – Inflammation – Livestock care – Macrophages – Veterinary diseases


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2020 Číslo 1