Survival analysis of 230 patients with unresectable hepatocellular carcinoma treated with bland transarterial embolization


Autoři: Ezio Lanza aff001;  Riccardo Muglia aff002;  Isabella Bolengo aff002;  Dario Poretti aff001;  Felice D’Antuono aff001;  Roberto Ceriani aff003;  Guido Torzilli aff004;  Vittorio Pedicini aff001
Působiště autorů: Department of Diagnostic and Interventional Radiology, Humanitas Clinical and Research Hospital IRCCS, Rozzano, Milan, Italy aff001;  Training School in Radiology, Humanitas University, Pieve Emanuele, Milan, Italy aff002;  Department of Internal Medicine - Hepatology, Humanitas Clinical and Research Hospital IRCCS, Rozzano, Milan, Italy aff003;  Department of Surgery - Hepatobiliary and General Surgery, Humanitas Clinical and Research Hospital IRCCS, Rozzano, Milan, Italy aff004
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0227711

Souhrn

Locoregional therapies for hepatocellular carcinoma (HCC) include endovascular treatments such as chemoembolization (TACE) and bland embolization (TAE). TACE is the most adopted technique, despite a lack of definitive evidence of superiority over TAE, which is less costly and better tolerated due to the absence of chemotherapy. However, few studies have reported data on TAE monotherapy for unresectable HCC. We report our results in a cohort of 230 patients with unresectable HCC treated with TAE (TAE with 40-100micron microparticles, TAE with microparticles plus n-butyl-2-cyanoacrylate, TAE with Lipiodol) over the course of seven years. Thirty-seven patients (14%) were down-staged during observation and also received a percutaneous ablation. We observed 1-, 2-, 3-, 4- and 5-year rates of 84,8%, 58,7%, 38,3%, 28,3%, and 18,7%. Patients who also received percutaneous treatment performed best. Our results broaden the body of evidence for the use of TAE in advanced HCC.

Klíčová slova:

Alcoholism – Angiography – Cancer chemotherapy – Cancer treatment – Hepatocellular carcinoma – Oncology – Surgical and invasive medical procedures – Survival analysis


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2020 Číslo 1