Systematic scoping review of the concept of ‘genetic identity’ and its relevance for germline modification

Autoři: Floor M. Goekoop aff001;  Carla G. van El aff002;  Guy A. M. Widdershoven aff001;  Nadza Dzinalija aff001;  Martina C. Cornel aff002;  Natalie Evans aff001
Působiště autorů: Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Medical Humanities, De Boelelaan, Amsterdam, Netherlands aff001;  Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Clinical Genetics, Section Community Genetics, Amsterdam Public Health research institute, Amsterdam, the Netherlands aff002
Vyšlo v časopise: PLoS ONE 15(1)
Kategorie: Research Article
doi: 10.1371/journal.pone.0228263


EU legislation prohibits clinical trials that modify germ line ‘genetic identity’. ‘Genetic identity’ however, is left undefined. This study aims to identify the use of the term ‘genetic identity’ in academic literature, and investigate its relevance for debates on genetic modification. A total of 616 articles that contained the term were identified. Content analysis revealed that the term was used in various and contradicting ways and a clear understanding of the term is lacking. This review demonstrates that the EU legislation is open to interpretation, because of the diversity of meaning with which ‘genetic identity’ is currently used. Because of the diversity of meaning with which ‘genetic identity’ is used and understood, further reflection is needed. This requires further medical, legal, ethical and social debate and a coordinated response at both a European and a global level.

Klíčová slova:

DNA – Gene regulation – Genetic determinism – Genetic engineering – Genetics of disease – Genomic medicine – Human genetics – Religion


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