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ReklamaImprovements in the learnability of smartphone haptic interfaces for visually impaired users
Authors: F. J. González-Cañete aff001; J. L. López Rodríguez aff001; P. M. Galdón aff001; A. Díaz-Estrella aff001
Authors place of work: Department of Electronic Technology, University of Malaga, Campus de Teatinos, Malaga, Spain aff001
Published in the journal: PLoS ONE 14(11)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0225053Summary
We report the results of a study on the learnability of haptic icons used as alerts or notifications in smartphones. The aim was to explore the feasibility of using haptic icons to create assistive technologies for people with visual impairments. We compared the performance and satisfaction of users with different visual capacities (visually impaired vs. sighted) and using different learning processes (with or without a reinforcement learning stage). The reinforcement learning stage improves the recognition rate in both types of users, although the improvement obtained by the visually impaired users is even better as their recognition rates become very similar to those obtained by the sighted users. Finally, it was observed that the better recognized haptic icons are those assigned to the most employed applications by the user.
Keywords:
Learning – Human learning – Visual impairments – Vision – Vibration – Cell phones – Tactile sensation – Vibration engineering
Introduction
Research on haptics for smartphones has demonstrated that the use of vibrotactile stimuli is an excellent way to transmit complex information [1]. Recently, high-resolution haptic feedback systems for mobile phones have become prevalent, allowing the transmission of rich information through the haptic channel. For example, the TouchSense technology created by Immersion has been recently deployed in LG smartphones [2]. Similarly, Apple devices such as the iPhone 6 s and newer iPhone models as well as the Apple Watch and MacBooks from 2015 implement the Taptic Engine as part of their Force Touch technology [3].
Initially, most vibrotactile stimuli used in typical mobile phones transmitted very simple information, such as alerts. However, modern operating systems such as iOS allow the assignment of vibration sequences (predefined or user defined) to contacts in the agenda or to native services. A similar functionality can be achieved in Android-based smartphones using applications such as Good Vibrations [4]. This application allows the configuring of vibration patterns not only for different applications but also for specific contacts.
Adding complex vibrotactile stimuli to smartphones is a key advantage for users with some type of sensory deficiency, such as users that are deaf or visually impaired (VI). This technology allows improved communication using the sense of touch to compensate or even substitute for deficiencies in other senses [5][6]. In addition, the vibrotactile stimuli also increase privacy, as the vibrations are only perceived by the user. These stimuli also improve the user’s experience as they employ an additional channel for communication apart from the standard ones (audio and visual channels), and in some cases, such as in loud environments (e.g., a concert), they could substitute for the audio channel [7].
To communicate complex information, the vibrotactile stimuli need to be associated with specific meanings. These meaningful tactile stimuli are called tactons (tactile icons) or haptic icons. Tactons are defined as structured abstract messages that can be used to communicate messages non-visually [8]. Haptic icons use a metaphorical approach to establish an association between the vibrations and the concept [9].
In a previous study [10], an application (ConTactos) was presented that associated the haptic icons and the vibration pattern using a metaphor. For instance, the vibration associated with the contact called ‘partner’ was a heartbeat, and the vibration of the contact called ‘neighbours’ was a knocking door. This kind of metaphor is not used here because the current work allows associating the haptic icons with the alerts freely and not in a predetermined way.
Vibration signals are mainly employed as a way to transmit alert information as they have the capability to attract the user’s attention even in loud environments. Consequently, they are ideal for notifications such as for incoming calls or meetings. These notifications are usually composed of a simple vibration to attract the user’s attention but without any other type of related information.
The human cognitive system imposes potential limitations for the use of haptic icons [11,12], and hence, their design should allow the information-processing limitations to be clearly perceived and their meaning easily learned [13][14][15].
Design of haptic icons for mobile phones
Currently, some tools and development kits allow for the easy development of haptic icons. Android Haptics [16] is a section of the Material Design Guidelines, Components and Tools that support the best practices of user interface design for the Android operating system. Texas Instruments has developed the TI Haptics technology [17]. It is composed of a set of hardware actuators and drivers that are controlled and configured by the Haptic Control Console software.
Learnability of haptic icons
Learnability is one of the key aspects when designing and implementing haptic icons. Consequently, understanding the process of learning the meaning of a set of haptic icons has been an important issue in haptic icon research [18]. From the beginning of the use of computer graphical interfaces, there has been a set of designed icons that are now easily recognized and identified by users. However, icons are not inherently meaningful, and users must learn the link between the stimulus and its meaning. For instance, the save icon is usually represented with a floppy disk, although young people have probably never used one. However, they learn that this icon is employed to save even though there is not a clear correspondence for them about the meaning of the image. The link between the stimulus and its meaning can range from representational to abstract. Some icons are purely representational, linking objects and their meanings. For instance, a tweet sound could indicate the reception of a message from the Twitter application. Other icons are abstract without intrinsic meanings but are associated with arbitrary relationships that have to be learned, such as Windows error sounds [19].
To learn the association between a haptic icon and its meaning, in the work of Enriquez et al [20], a three-stage approximation was proposed. The first stage is a self-guided learning process in which users learn the association between the haptic stimuli and its meaning. In this stage, the haptic stimuli are presented along with a representation of their meaning. This representation can be a textual, audio, and/or a graphical description. The second stage is based on reinforcement; in other words, the user must recognize the associated meaning of a haptic stimulus and receive feedback on whether the answer is correct. The last stage is the same as the second stage but without feedback.
In the study of Adam Swerdfeger [21], a unimodal learning process was employed in which a textual description was displayed on the screen next to a button. This button triggers the associated haptic stimulus when pressed. However, multimodal learning processes are advantageous, as stated in several learning theories such as the dual coding theory [22] or the multimedia learning theory [23].
In recent years, game dynamics have been employed to obtain better results in the learning process [24]. This technique is named gamification and can also be applied to help visually impaired people learn to use a smartphone. The usage of games to improve learning capacity is a line of research currently in development [25]. In the work of [26], a gamified mobile application, oriented toward elderly or mildly visually impaired people, was implemented. In [27], a videogame named Audio Haptic Maze was designed, implemented and evaluated. It was oriented toward blind people and used sounds as well as haptic interfaces to guide the user to the exit of a maze. An application that assists visually impaired children in learning to type words was presented in [28], while the work of [29] developed an application for reinforcing the binary calculation skills of engineering students.
Haptic abilities of visually impaired people
For non-visually impaired people, haptic icons can support (or substitute if desired) the visual sensation; meanwhile, for visually impaired people, haptic icons can provide them with an alternative form of sensory information. Indeed, as the number of VI people who use mobile technologies increases [30] several applications that use haptic icons to communicate information have been developed, including an assistive technology that uses the haptic channel to give feedback to the user being guided [31].
It has been noticed that visually impaired people outperform sighted people in terms of recognition when using the haptic information due to cognitive-processing differences [32]. Some authors have provided empirical evidence, from a neurophysiological perspective, stating that people without the ability to see can compensate for this by enhancing their other senses, that is, sensory compensation [33]. For instance, significant sensory differences have been identified between visually impaired and sighted people in terms of their tactile sensory threshold [34]. In addition, some studies [12] [35] [36] have demonstrated that visually impaired people have better memorization skills and show better recognition performance at haptic tasks than sighted people.
Objectives of the study
In this study, a mobile application has been designed to assist users in learning the association between a set of vibrotactile stimuli and the alarms and notifications of a set of commonly used mobile applications. This application uses gamification and a reinforcement stage to improve the learning process.
Based on the literature reviewed, our hypotheses were as follows:
A reinforcement stage could improve the recognition rate as well as the subjective perception and distinction of the haptic icons.
The use of haptic icons can benefit visually impaired users.
The use of haptic icons associated with smartphone application alerts improves the user experience.
Both improvements also apply to visually impaired users.
Materials and methods
Participants
Forty-six participants of ages between eighteen and sixty performed the experiments. Eighteen of the participants were visually impaired so that they could not use graphical user interfaces, and twenty-eight of them were fully sighted non-visually impaired users. All of them were smartphone users, those with vision problems used applications such as the Android Accessibility Suite as a way to interact with their smartphones. This suite is usually preinstalled in Android-based smartphones.
The data obtained were analysed anonymously and the study was reviewed and approved by the Experimentation Ethic Committee of the University of Málaga. They are all available from S1 File.
Experimental design
This study followed a 2x2 design, taking the user’s visual capacity (VI vs. non-VI) and the learning process (with and without reinforcement) as independent variables. The dependent variables were the time taken to answer the test, the proportion of recognized haptic icons and the results obtained by a usability questionnaire.
In the reinforcement learning scenario, some participants performed a previous learning stage in which they had to pair haptic icons with the application alerts. They received feedback informing them if their answer was right or wrong. This stage was named learning reinforcement.
Half of the VI subjects performed the reinforcement stage as well as half of the non-VI subjects. Consequently, nine VI and fourteen non-VI subjects executed the reinforcement stage and nine VI and fourteen non-VI subjects did not use reinforcement.
Stimuli and devices
An Android application named HAPP (Haptic APPlication) has been developed to perform this study. Its source code can be accessed online (https://github.com/Equinoxe-fgc/HAPP). HAPP implements a set of sixteen haptic icons each of which is associated with an application alert for the smartphone. The haptic icons have been designed using the Haptic Studio tool [37], and they follow rhythmic patterns with a short duration (2–4 seconds) to easily memorize and distinguish them. Hence, they do not follow any predefined meaning or relationship with the application they represent.
The main parameters to take into consideration for the design of haptic icons are the frequency, amplitude, waveform and duration of the vibrotactile stimulus [38] [39]. However, haptic icons must be designed to be easily recognized, and hence, a more complex combination of those parameters can be employed. Musical techniques are useful for obtaining sets of identifiable haptic icons that are distinguishable from one another. For instance, rhythm, defined as a group of pulses of different durations and amplitude, have been proven to be easily remembered [40]. In addition to rhythm, other musical techniques have been applied to create sets of haptic icons, such as the use of crescendo, defined as a steady increase in force or intensity [41] and melody, defined as a variation in rhythm, frequency and amplitude [21].
Fig 1 shows the vibration pattern for the haptic icons used by the HAPP application.
Fig. 1. Vibrating patterns associated with the haptic icons used by the HAPP application. X-axis represents the time in milliseconds and the Y-axis represents the relative intensity of the vibration. A zero value denotes no vibration meanwhile a one value is the maximum vibration intensity. The Y axis represents the intensity of the signal from 0 to 1, with a value of 0 representing the absence of a vibration and a value of 1 representing the maximum vibration intensity. The X axis represents the time, in milliseconds, that the vibration lasts. Most of the patterns use combinations of full vibration intensity and no vibration. However, the E-Mail, Facebook and SMS applications also employ lower vibration values (between 0,2 and 0,3). The Battery and Camera applications use sforzandos, defined as a high intensity vibration followed by a silence and a crescendo or decrescendo in the intensity of the vibration. The use of sforzandos in the design of haptic icons was studied in [41] where it was concluded that they should not be used because they caused confusion and were not clearly differentiated. Nevertheless, this work did not consider the effect of training, and it is proposed as future work. Finally, Twitter uses the ASDR (Attack-Sustain-Decay-Release) technique, where the vibration magnitude increases from 0 to the highest level (Attack), and it is maintained for a certain amount of time (Sustain). Afterwards, the vibration intensity decreases (Decay) and is maintained again to finally decrease to 0 (Release).
To evaluate the distinctiveness of the designed haptic icons, we performed a multidimensional scaling study. The selected vibration attributes are as follows:
Number of pulses: defined as the number of vibrations between the absences of vibration.
Number of repetitions: The number of times a pattern is repeated.
Duration: The time that a vibration lasts in seconds.
Softness: This parameter indicates whether the vibration has any crescendo or decrescendo (value 3) or not (value 1).
Sharpness: Similar to softness, this parameter indicates whether the vibration has any abrupt change from no vibration to high vibration (value 3) or not (value 1).
Crescendo: The Battery and Camera have the same vibration characteristics except for the use of a crescendo or decrescendo for the intensity of the vibration. Hence, this parameter indicates whether the vibration has a crescendo (value of 3) or not (value of 1). In addition, the Twitter haptic icon has both a crescendo and decrescendo, although the crescendo time is longer than the decrescendo time.
Two-level intensity: A value of 3 indicates that the vibration has two different levels of intensity; otherwise, the intensity is the highest.
Frequency dispersion: This parameter defines the variation in the frequency of the vibration. It is calculated as the quotient between the maximum and minimum periods of the vibration.
We consider the selected parameters to be sufficient to characterize the difference between the vibration patterns. The values obtained to develop the study are shown in Fig 2.
Fig. 2. Multidimensional scaling attributes. The figure shows the selected values of the eight attributes used to perform the multidimensional scaling study of the vibration patterns. We used the Euclidean distance to perform a multidimensional scaling study and obtained a stress value of 0,01, which indicates a good fit as it is very close to zero. The representation of the multidimensional scaling is shown in Fig 3.
Fig. 3. Multidimensional scaling representation of the vibration characteristics of the designed haptic icons. Short distances between icons denotes similarity; on the contrary long distances between icons represent dissimilarity. It can be observed that the distance between the haptic icon vibrations is enough to be differentiated. The Update, Calendar, Google+ and Twitter haptic icons as well as those for the pair composed of Battery and Camera are very distinguishable as they are very far from each other. On the one hand, the Update, Calendar and Google+ haptic icons employ a rhythmic pattern that is not used in the rest of the haptic icons. On the other hand, the Battery haptic icon employs a decrescendo, the Camera haptic icon employs a crescendo and the Twitter haptic icon employs both a crescendo and decrescendo.
Apart from the mathematical study of vibration distinguishability, we have also performed a perceptual similarity map study with five subjects to confirm the distinguishability assumption. Each subject had to use the haptic icons in pairs and fill out a perceptual table in which each position represents the distinguishability of a pair of icons. The selected values range from 1 to 5. A value of 1 indicates that the two vibration patterns are almost undistinguishable. In contrast, a value of 5 indicates that the vibration patterns compared are clearly distinguishable.
Fig 4 depicts the obtained perceptual similarity map where each value is the mean of the values selected by the five users. All the obtained perceptual similarity maps are available in S1 File.
Fig. 4. Perceptual similarity map of the haptic icon vibration patterns. Values greater than 4 represent low similarity; values ranging from 3 to 4 denote medium similarity and values lower than 3 represent high similarity. Values greater than 4 are shown with a green background, indicating that the vibration pair is easily distinguishable. Values ranging from 3 to 4 are depicted using a yellow background. Values lower than 3 are shown in red, indicating that they could be difficult to distinguish.
The pairs Battery-Camera and Camera-Twitter obtained the lowest values; these are the haptic icons that use a crescendo and/or decrescendo. The Battery haptic icon uses a short vibration pulse and a decrescendo, while the Camera haptic icon uses a short vibration and a crescendo both with the same duration. It seems that people have difficulty in differentiating these vibrations, as was studied in [41], although the multidimensional scaling representation showed that the vibrations are distinguishable. Nevertheless, these icons will not be discarded as we are going to study the influence of the reinforcement learning process as suggested by [42]. Surprisingly, the Camera-Twitter haptic icon pair is shown to be very far apart in the multidimensional scaling representation, and apart from the Twitter haptic icon, it is the only one that has an ADSR vibration pattern; these icons present the lowest perception value. Despite the apparent recognition problems obtained, we decided to maintain the initial haptic icon design as the mathematical distinguishability test obtained very different results.
The HAPP application implements visual icons, haptic icons, and audio described help to be usable by visually impaired people. The usage of screen read tools such as TalkBack was rejected as they interfere with the application usability. Hence, an interface that emulates the help provided by TalkBack has been developed for visually impaired people.
The application also implements an event log to register the time of all the touches performed by the user while the application is in use. The event log records the instant when an event is triggered (touch an icon) as well as the icon touched. This allows for the deduction of the usage speed and the success ratio when the icons are paired.
Experimental procedure
Prior to the sessions, the participants were instructed to memorize the association between a set of sixteen vibrotactile stimuli and their associated application. The experiment should determine if the usage of complex vibrations obtains a good success ratio relative to the capacity to learn the association between the haptic icons and the application alerts and if the usage of a reinforcement stage improves this success ratio. In addition, the experiment should also determine whether both improvements apply to visually impaired people, and if so, whether they could be employed to improve the smartphone accessibility for people with visual disabilities.
Following the learning process proposed by [20], the application usage was divided into three stages: two learning stages and one stage where the subjects filled in a form designed to determine how easily they remembered the associations between the haptic icons and the application alerts.
The usage stages are as follows:
In the first learning stage, sixteen haptic icons are shown to the subject for their memorization. In this stage, the subject explores the smartphone screen, and a recorded description associated with each application is played when the subject touches the haptic icons. When a haptic icon is pressed, the smartphone plays the vibration associated with the haptic icon of this application. Fig 5 shows the screen for this learning stage of the application.
In the reinforcement learning stage, the subject plays a game with the aim of improving the recognition of the haptic icons. The objective of the game is to pair the applications with their corresponding haptic icon as in the pair card game. In this stage, two screens with a grid of the sixteen icons were shown to the user. The eight icons located at the top of the screen vibrate when they are pressed according to their related haptic icon. The eight icons located at the bottom of the screen are the application icons, and they are initially hidden by a question mark (?) symbol. When a pair of icons are pressed (one of the top group and one of the bottom group), a voice says the name of the application and whether the pairing is correct. If the pairing is correct, the application icon will be shown face up as in the card game, and a voice saying the name of the application will be played when it is pressed again. If the pairing is wrong, the icons are hidden again. To be usable by people with a visual disability, different feedback sounds (beeps) are played depending on the zone (top or bottom zone), where the screen is pressed (Fig 6).
The test stage has the objective of checking whether the subjects are able to remember the association between the haptic icons and the applications. This stage shows two screens with a grid of sixteen icons, and the subject has to pair the haptic icons with their applications as fast as possible. As in the reinforcement stage, the screen is divided into two sections. The section located at the top of the screen contains eight haptic icons that play the vibrations associated with the application it represents as they are pressed. Similarly, the icons located at the bottom section provide the sound information about the associated application when they are pressed. When two icons are pressed (one from the top section and the other from the bottom section), the icon associated with the application is shown at the top section, and the name of the application is played as a voice message as well as whether the pairing is correct. If the pairing is correct, the haptic icon at the top section will remain visible, and the icon located at the bottom section will be hidden. On the other hand, if the pairing is wrong, the haptic icon will be replaced by a cross icon, and the icon located at the bottom section will be shown again. As in the reinforcement learning stage, different feedback sounds are played (beeps) depending on the zone of the screen that is pressed (top or bottom zone) (Fig 7).
Fig. 5. Screen capture of the learning stage of the HAPP application. In the learning mode users feel the vibration of each selected haptic icon and listen to the icon description. Fig. 6. Screen capture of the reinforcement learning stage of the HAPP application. Users must pair the applications with their corresponding haptic icons. Feedback is given to inform whether the pair is correct. Fig. 7. Screen capture of the test stage of the HAPP application. This stage tests if users are able to remember the pairs of vibrations and applications. The HAPP application has two modes of operation that enable an evaluation of the capacity of the subjects to memorize the association between the haptic icons and the applications as a function of the learning process (with and without a reinforcement learning stage).
After the test was completed, all the subjects were required to fill out a usability form composed of six questions. Three of the questions were an adaptation of the System Usability Scale (SUS) and Computer System Usability Questionnaire (CSUQ) [43] usability forms. The other three questions were focused on learning-related aspects: perception, differentiation and recognition [40]. A Likert scale from 1 to 7 (from totally disagree to totally agree) was employed for answering the questions on the evaluation form. Table 1 shows the evaluation questions.
Tab. 1. Usability form. Results
In this section, we present the main results of the experiment focusing on the statistically significant results (p < 0.05).
Test time
The mean time taken to complete the test stage was 4 : 14 minutes (with a minimum time of 1 : 48 and a maximum time of 10 : 43). The analysis of variance (ANOVA) results confirmed the differences in execution time between the VI and non-VI subjects (F(1,42) = 8.01, p<0.01). These differences are due to the time needed to explore the screen to locate the icons to press.
Recognition rate
The two-way ANOVA study of the percentage of recognized haptic icons during the test stage showed significant differences between subjects with different visual capacities (F(1,42) = 13.33, p<0.05) and learning processes (F(1,42) = 25.00, p<0,001). As shown in Fig 8, the recognition rate improves when the reinforcement stage is applied, especially for the VI subjects. The non-VI subjects present a better recognition rate when the reinforcement stage is not applied compared to the VI subjects, although this difference practically disappears when the reinforcement learning is used (F(1,21) = 1.23, p>0.05).
Fig. 8. Global haptic icon recognition ratio. For all the subjects, this figure the recognition ratio as a function of the use or not of the reinforcement stage and differentiating VI and non-VI subjects. There are significant differences between the recognition rate of the Camera and LinkedIn haptic icons (t45 = 4.29, p<0.001) as well as between the recognition rate of the Twitter and Email haptic icons (t45 = 3.31, p<0.001). Fig 9 represents the recognition rate of VI and Non-VI subjects without taking into consideration if they used reinforcement or not. Meanwhile, Fig 10 depicts the recognition rate as a function of the reinforcement without taking into consideration if users were VI or not.
Fig. 9. Per haptic icon recognition rate. VI vs Non-VI users for all the population. Fig. 10. Per haptic icon recognition rate. Reinforcement vs No reinforcement for all the population. Although the obtained similarity map showed that the Twitter, Camera and Calendar haptic icons could be difficult to distinguish, the results show very different behaviour. These three haptic icons obtained recognition rates close to or greater than 0,8, and were the most recognizable icons in some cases, especially when the reinforcement learning is applied. Consequently, the supposition made by [41] that training users could avoid the misrecognition of sforzandos in haptic icons is confirmed.
Fig 11 shows the recognition rate for each application for the non-VI subjects and compares the results with and without reinforcement learning. Most of the haptic icons have improved recognition rates with reinforcement learning that is maintained, except for the Facebook and WhatsApp applications.
Fig. 11. Per haptic icon recognition rate. Non-VI people with and without reinforcement. Fig 12 represents the recognition rate for each application for the VI subjects with and without reinforcement learning. The improvement obtained by the VI subjects when using the reinforcement stage is very high for almost every application except for Facebook and LinkedIn where the recognition rate decreases.
Fig. 12. Per haptic icon recognition rate. VI people with and without reinforcement. If we compare the recognition rate of the VI and non-VI subjects when no reinforcement is applied, Fig 13 is obtained.
Fig. 13. Per haptic icon recognition rate. VI and Non-VI people without reinforcement. The non-VI subjects obtain a better recognition rate than VI for all applications except for LinkedIn. In some cases, such as Camera, WiFi or Update, the difference is very high. However, once the reinforcement learning is applied, this difference is lower or sometimes the VI subjects obtain a better recognition rate, as shown in Fig 14. The VI subjects who did not use the reinforcement stage obtained the lowest recognition rates (between 11% and 56%). In contrast, the non-VI subjects who did use the reinforcement stage obtained the highest rates (between 40% and 100%).
Fig. 14. Per haptic icon recognition rate. VI and Non-VI people with reinforcement. Both the VI and non-VI subjects improve their recognition rates. Even the applications, such as Twitter, Phone, Line, Update or Camera, obtain rates close to 1.
Usability form
We performed non-parametric Mann-Whitney U tests to compare the replies to the usability form in terms of the use or not of the reinforcement learning stage for the VI and non-VI subjects.
Considering the reinforcement learning condition, the VI users stated that they were able to better recognize the meanings of the vibrations when the reinforcement learning stage was used (Mann-Whitney U = 17, p<0.05). In contrast, the non-VI subjects did not notice a difference in terms of the reinforcement learning stage (all the answers have p>0.05). However, there were no clear differences in the application usability between the VI and non-VI groups when they used the reinforcement learning stage (p>0.05). However, the visually impaired subjects better distinguished (Mann-Whitney U = 22, p<0.05) and recognized (Mann-Witney U = 28.5, p>0.05) the haptic icons when using the reinforcement stage, although it did not affect the application usability (Mann-Whitney U = 30, p>0.1). Table 2 shows the usability answers from the HAPP application.
Tab. 2. Median of the HAPP application usability form. Discussion
In this study, we performed a group of experiments on the learning of a set of haptic icons to identify the alerts for a set of smartphone applications. The results show that learning the set of icons can be performed in less than ten minutes, although this time changes according to the visual capacity of the participant. In the next sections, we discuss the obtained results.
Design of the haptic icons
We designed sixteen haptic icons and performed a study to evaluate their distinguishability using a multidimensional scaling study. The obtained results showed that they could be easily recognized because the two-dimensional representation of the distances between them was high enough. However, the differentiation test performed by the subjects showed different results, where pairs of applications, such as Twitter and Camera, were difficult to distinguish. This behaviour could be caused by the absence of a learning process, as the test was performed by the subjects who had not previously used the HAPP application. In fact, the recognition rates of those haptic icons (Twitter and Camera) were greater than 0.7 and, in some cases, close to 1.
Effect on the learning process
Our hypothesis was that a reinforcement learning stage could improve the recognition rate as well as the subjective perception and distinction of the haptic icons. According to the obtained results, we can affirm that the use of a reinforcement stage is positive for the learning process. This claim is derived from the improvement in the recognition rate as well as the answers of the usability form.
Effect of the subjects’ visual condition
First, it should be noted that the VI and non-VI subjects scored the application usability as high whether or not it was used with the reinforcement learning stage. However, the inclusion of the reinforcement learning stage greatly improved the recognition rate of the blind subjects, making their results as good as the results obtained by the non-VI subjects. Moreover, the inclusion of the reinforcement learning stage also improved the subjective perception of the VI subjects on some particular aspects of application usability. This conclusion is derived from the answers given in the usability form, such as the recognition of the vibration meaning and the distinctiveness of the haptic icons.
There is an interesting effect in this test considering the best and worst recognized icons. The subjects were asked why they had recognized some icons very well but others very badly. Many of them answered that they could easily recognize the icons associated with applications that they used frequently, nevertheless, for the applications that they rarely use or are unknown to them, it was very difficult to identify the associated haptic icon.
Conclusions
In this paper, haptic icons were employed to identify the alerts generated by applications on a smartphone. Users with a visual impairment greatly improved their recognition rate and their subjective perception of haptic icon recognition when a reinforcement learning stage was added to the learning process.
All the subjects that performed the tests agreed that it was useful to associate different vibrations with the application alerts on the smartphone, although some of the subjects stated that they would only associate the vibrations with those applications that they used frequently. This suggestion is very interesting as it indicates that the utility of the haptic icons could be better if they were applied only to the most commonly used applications or if the user was given a choice to establish a relationship between a haptic icon and an alert.
It should be noted that the subjects did not need much time to learn the associations between the alerts and haptic icons. In addition, the reinforcement learning stage improved the recognition rate of all kinds of users, although this improvement was even better for the VI subjects.
As a future work we propose to test the HAPP application using different smartphones models and test if the recognition rate change due to different perceptions of the vibrations as they may change their intensity and accuracy depending on the smartphone model. Another future development would be to allow the subjects to assign the predefined vibration patterns to the applications and measure if the recognition rate improves.
Supporting information
S1 File [zip]
Data files for the perceptual map and recognition per user.
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- Discovery of actionable genetic alterations with targeted panel sequencing in children with relapsed or refractory solid tumors
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- Psychology of personal data donation
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- MARGO (Massively Automated Real-time GUI for Object-tracking), a platform for high-throughput ethology
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- Results from a World Health Organization pilot of the Basic Emergency Care Course in Sub Saharan Africa
- Scientists’ opinions and attitudes towards citizens’ understanding of science and their role in public engagement activities
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- Integrated pan-cancer gene expression and drug sensitivity analysis reveals SLFN11 mRNA as a solid tumor biomarker predictive of sensitivity to DNA-damaging chemotherapy
- Does membrane feeding compromise the quality of Aedes aegypti mosquitoes?
- Morphology, phylogeny, and taxonomy of two species of colonial volvocine green algae from Lake Victoria, Tanzania
- Metabolomics profiles associated with HbA1c levels in patients with type 2 diabetes
- Exploring local realities: Perceptions and experiences of healthcare workers on the management and control of drug-resistant tuberculosis in Addis Ababa, Ethiopia
- Sex differences in the treatment and outcome of emergency general surgery
- Comorbidities and costs in HIV patients: A retrospective claims database analysis in Germany
- Barriers to integration of bioinformatics into undergraduate life sciences education: A national study of US life sciences faculty uncover significant barriers to integrating bioinformatics into undergraduate instruction
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- A comparison of body composition assessment methods in climbers: Which is better?
- Comparison of an in-house ‘home-brew’ and commercial ViroSeq integrase genotyping assays on HIV-1 subtype C samples
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- Inducible microRNA-200c decreases motility of breast cancer cells and reduces filamin A
- Pharmacological signatures of the reduced incidence and the progression of cognitive decline in ageing populations suggest the protective role of beneficial polypharmacy
- Continuous influenza virus production in a tubular bioreactor system provides stable titers and avoids the “von Magnus effect”
- Complex interaction networks of cytokines after transarterial chemotherapy in patients with hepatocellular carcinoma
- Gender essentialism in transgender and cisgender children
- Insertional mutagenesis in the zoonotic pathogen Chlamydia caviae
- Being there: A scoping review of grief support training in medical education
- Does the psychological profile influence the position of promising young futsal players?
- Effect of self-rated health status on functioning difficulties among older adults in Ghana: Coarsened exact matching method of analysis of the World Health Organization’s study on global AGEing and adult health, Wave 2
- Olfactory screening of Parkinson’s Disease patients and healthy subjects in China and Germany: A study of cross-cultural adaptation of the Sniffin’ Sticks 12-identification test
- Molecular evolution of cytochrome C oxidase-I protein of insects living in Saudi Arabia
- Correlates of leisure-time sedentary behavior among 181,793 adolescents aged 12-15 years from 66 low- and middle-income countries
- Cost-effectiveness analysis of Mucosal Leishmaniasis diagnosis with PCR-based vs parasitological tests in Colombia
- Spatiotemporal analysis of historical records (2001–2012) on dengue fever in Vietnam and development of a statistical model for forecasting risk
- Resilience assessment of Puerto Rico’s coral reefs to inform reef management
- Effect of community based health education on knowledge and attitude towards iron and folic acid supplementation among pregnant women in Kiambu County, Kenya: A quasi experimental study
- Implementation and effectiveness of non-specialist mediated interventions for children with Autism Spectrum Disorder: A systematic review and meta-analysis
- A tailored cognitive behavioral program for juvenile justice-referred females at risk of substance use and delinquency: A pilot quasi-experimental trial
- Impact of adjusted kidney volume measured in the bench surgery on one-year renal function in kidney transplantation
- Machine learning algorithm validation with a limited sample size
- The magnitude of suicidal ideation, attempts and associated factors of HIV positive youth attending ART follow ups at St. Paul’s hospital Millennium Medical College and St. Peter’s specialized hospital, Addis Ababa, Ethiopia, 2018
- The nonlinear effect of financial and fiscal policies on poverty alleviation in China—An empirical analysis of Chinese 382 impoverished counties with PSTR models
- Impacts of risk and competition on the profitability of banks: Empirical evidence from Pakistan
- Molecular characterization of lung adenocarcinoma from Korean patients using next generation sequencing
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- Joint image compression and encryption based on sparse Bayesian learning and bit-level 3D Arnold cat maps
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- Live observation of the oviposition process in Daphnia magna
- On the accuracy of displacement-based wave intensity analysis: Effect of vessel wall viscoelasticity and nonlinearity
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- Tributyltin chloride (TBT) induces RXRA down-regulation and lipid accumulation in human liver cells
- Amazon climatic factors driving terpene composition of Iryanthera polyneura Ducke in terra-firme forest: A statistical approach
- Differences in clinical features of cluster headache between drinkers and nondrinkers in Japan
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- Automated content analysis across six languages
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- The prognostic significance of tumor-infiltrating lymphocytes assessment with hematoxylin and eosin sections in resected primary lung adenocarcinoma
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- Serial block-face scanning electron microscopy reveals neuronal-epithelial cell fusion in the mouse cornea
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- Pragmatic language dysfunction in systemic lupus erythematosus patients: Results from a single center Italian study
- Association between cerebral atrophy and osteoporotic vertebral compression fractures
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- Gene expression based survival prediction for cancer patients—A topic modeling approach
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- The association between psychological distress and angina pectoris: A population-based study
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- Psychological and physiological effects of applying self-control to the mobile phone
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- Modulating transcription through development of semi-synthetic yeast core promoters
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- Cost-effectiveness analysis of PSA-based mass screening: Evidence from a randomised controlled trial combined with register data
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- Validation of the group tasks uncertainty model (MITAG) in a German sample
- Parent psychological wellbeing in a single-family room versus an open bay neonatal intensive care unit
- Optimizing the procedure of grain nutrient predictions in barley via hyperspectral imaging
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- Race disparity in blood sphingolipidomics associated with lupus cardiovascular comorbidity
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- Predictors of never having a mammogram among Chinese, Vietnamese, and Korean immigrant women in the U.S.
- The impact of hepatic steatosis on portal hypertension
- How do and could clinical guidelines support patient-centred care for women: Content analysis of guidelines
- Study of the epidemiological behavior of malaria in the Darien Region, Panama. 2015–2017
- School-based obesity prevention for busy low-income families—Organisational and personal barriers and facilitators to implementation
- Neighborhood crime, disorder and substance use in the Caribbean context: Jamaica National Drug Use Prevalence Survey 2016
- Genomic comparison of diverse Salmonella serovars isolated from swine
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- Modeling of inter-organizational coordination dynamics in resilience planning of infrastructure systems: A multilayer network simulation framework
- Manipulating the odds: The effects of Machiavellianism and construal level on cheating behavior
- Early recognition of anorexia through patient-generated assessment predicts survival in patients with oesophagogastric cancer
- Identifying publications in questionable journals in the context of performance-based research funding
- ITGAM is a risk factor to systemic lupus erythematosus and possibly a protection factor to rheumatoid arthritis in patients from Mexico
- Nurses’ and patients’ experiences and preferences of the ankle-brachial pressure index and multi-site photoplethysmography for the diagnosis of peripheral arterial disease: A qualitative study
- Cluster tendency assessment in neuronal spike data
- Voluntary medical male circumcision for HIV prevention among adolescents in Kenya: Unintended consequences of pursuing service-delivery targets
- Primary care in five European countries: A citizens’ perspective on the quality of care for children
- High Order Profile Expansion to tackle the new user problem on recommender systems
- Psychometric properties of the Korean version of the Health Literacy on Social Determinants of Health Questionnaire (K-HL-SDHQ)
- Flood hazard mapping and assessment in data-scarce Nyaungdon area, Myanmar
- Methods for the identification of farm escapees in feral mink (Neovison vison) populations
- Transcriptional analysis of amino acid, metal ion, vitamin and carbohydrate uptake in butanol-producing Clostridium beijerinckii NRRL B-598
- Long-term vancomycin use had low risk of ototoxicity
- Overcoming platinum resistance in ovarian cancer by targeting pregnancy-associated plasma protein-A
- Exploration of muscle loss and metabolic state during prolonged critical illness: Implications for intervention?
- Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model
- Efficacy of interleukin 10 gene hydrofection in pig liver vascular isolated ‘in vivo’ by surgical procedure with interest in liver transplantation
- Molecular characteristics of segment 5, a unique fragment encoding two partially overlapping ORFs in the genome of rice black-streaked dwarf virus
- Early economic evaluation of MRI-guided laser interstitial thermal therapy (MRgLITT) and epilepsy surgery for mesial temporal lobe epilepsy
- GLADS: A gel-less approach for detection of STMS markers in wheat and rice
- Anterior tooth-use behaviors among early modern humans and Neandertals
- Incidence patterns of orofacial clefts in purebred dogs
- Capacity of the medullary cavity of tibia and femur for intra-bone marrow transplantation in mice
- Association of thoracic spine deformity and cardiovascular disease in a mouse model for Marfan syndrome
- Predicting atrial fibrillation in primary care using machine learning
- M3VR—A multi-stage, multi-resolution, and multi-volumes-of-interest volume registration method applied to 3D endovaginal ultrasound
- A developmental trajectory supporting the evaluation and achievement of competencies: Articulating the Mastery Rubric for the nurse practitioner (MR-NP) program curriculum
- Mobile medication manager application to improve adherence with immunosuppressive therapy in renal transplant recipients: A randomized controlled trial
- Default Mode Network structural alterations in Kocher-Monro trajectory white matter transection: A 3 and 7 tesla simulation modeling approach
- Phylogenetic revision of Gymnotidae (Teleostei: Gymnotiformes), with descriptions of six subgenera
- Population genetic analysis of 36 Y-chromosomal STRs yields comprehensive insights into the forensic features and phylogenetic relationship of Chinese Tai-Kadai-speaking Bouyei
- Prevention of suicidal behaviour: Results of a controlled community-based intervention study in four European countries
- An assessment of khat consumption habit and its linkage to household economies and work culture: The case of Harar city
- Fixation of genetic variation and optimization of gene expression: The speed of evolution in isolated lizard populations undergoing Reverse Island Syndrome
- One simple claudication question as first step in Peripheral Arterial Disease (PAD) screening: A meta-analysis of the association with reduced Ankle Brachial Index (ABI) in 27,945 subjects
- Direct cost of health care for individuals with community associated Clostridium difficile infections: A population-based cohort study
- Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients
- A qualitative research synthesis of contextual factors contributing to female overweight and obesity over the life course in sub-Saharan Africa
- Insight into the relationship between aryl-hydrocarbon receptor and β-catenin in human colon cancer cells
- Hidden noise in immunologic parameters might explain rapid progression in early-onset periodontitis
- The role of stigma in the acceptance and disclosure of HIV among recently diagnosed men who have sex with men in Australia: A qualitative study
- Detection of Schistosoma japonicum and Oncomelania hupensis quadrasi environmental DNA and its potential utility to schistosomiasis japonica surveillance in the Philippines
- Does age influence the quality of life in children with atopic dermatitis?
- Questioning the lasting effect of galvanic vestibular stimulation on postural control
- Identification of a novel monocytic phenotype in Classic Hodgkin Lymphoma tumor microenvironment
- Characterization of 20 complete plastomes from the tribe Laureae (Lauraceae) and distribution of small inversions
- Binding and dynamics of melatonin at the interface of phosphatidylcholine-cholesterol membranes
- Recent climate-driven ecological change across a continent as perceived through local ecological knowledge
- Nonalcoholic fatty liver disease is an early predictor of metabolic diseases in a metabolically healthy population
- Occurrence and multilocus genotyping of Giardia duodenalis from post-weaned dairy calves in Sichuan province, China
- Retinoic acid-stimulated ERK1/2 pathway regulates meiotic initiation in cultured fetal germ cells
- Gender disparities in scientific production: A nationwide assessment among physicians in Peru
- Effect of F1 and F2 generations on genetic variability and working steps of doubled haploid production in maize
- Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data
- A caspase-6-cleaved fragment of Glial Fibrillary Acidic Protein as a potential serological biomarker of CNS injury after cardiac arrest
- A handy method to remove bacterial contamination from fungal cultures
- The self-care profiles and its determinants among adults with hypertension in primary health care clinics in Selangor, Malaysia
- The mutational landscape of quinolone resistance in Escherichia coli
- Exploring the influence of self-perceptions on the relationship between motor competence and identity in adolescents
- Study on the damage characteristics of gas-bearing shale under different unloading stress paths
- EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
- 16S rDNA droplet digital PCR for monitoring bacterial DNAemia in bloodstream infections
- Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening
- Diversity of endocervical microbiota associated with genital Chlamydia trachomatis infection and infertility among women visiting obstetrics and gynecology clinics in Malaysia
- Health impact of hepatic-venous-occlusive disease in a small town in Ethiopia—Case study from Tahtay koraro district in Tigray region, 2017
- Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
- Development of a quantitative PCR assay for the detection and enumeration of a potentially ciguatoxin-producing dinoflagellate, Gambierdiscus lapillus (Gonyaulacales, Dinophyceae)
- Association of clinical factors with survival outcomes in laryngeal squamous cell carcinoma (LSCC)
- Seasonal oyster harvesting recorded in a Late Archaic period shell ring
- Population preferences for breast cancer screening policies: Discrete choice experiment in Belarus
- Respiratory health and inflammatory markers - Exposure to respirable dust and quartz and chemical binders in Swedish iron foundries
- Trends and predictors of mother-to-child transmission of HIV in an era of protocol changes: Findings from two large health facilities in North East Nigeria
- Elevated Ki-67 (MIB-1) expression as an independent predictor for unfavorable pathologic outcomes and biochemical recurrence after radical prostatectomy in patients with localized prostate cancer: A propensity score matched study
- Genome-wide identification and gene expression analysis of SOS family genes in tuber mustard (Brassica juncea var. tumida)
- Carvedilol improves glucose tolerance and insulin sensitivity in treatment of adrenergic overdrive in high fat diet-induced obesity in mice
- Institutional differences in USMLE Step 1 and 2 CK performance: Cross-sectional study of 89 US allopathic medical schools
- Molecular epidemiological characteristics of dengue virus carried by 34 patients in Guangzhou in 2018
- Heteroplasmy in the complete chicken mitochondrial genome
- Candida blood stream infections observed between 2011 and 2016 in a large Italian University Hospital: A time-based retrospective analysis on epidemiology, biofilm production, antifungal agents consumption and drug-susceptibility
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- Appropriate management of acute gastroenteritis in Australian children: A population-based study
- The plasma metabolome of women in early pregnancy differs from that of non-pregnant women
- Effectiveness of four types of neuraminidase inhibitors approved in Japan for the treatment of influenza
- More than just availability: Who has access and who administers take-home naloxone in Baltimore, MD
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- Serum uromodulin is associated with the severity of clinicopathological findings in ANCA-associated glomerulonephritis
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- ADAPTS: Automated deconvolution augmentation of profiles for tissue specific cells
- Comparison of shape quantification methods for genomic prediction, and genome-wide association study of sorghum seed morphology
- An attempt to identify the issues underlying the lack of consistent conceptualisations in the field of student mathematics-related beliefs
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- Bioinformatic analysis of a novel Echinococcus granulosus nuclear receptor with two DNA binding domains
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- Involvement of extracellular vesicles in the macrophage-tumor cell communication in head and neck squamous cell carcinoma
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- Concurrent validity and discriminative ability of Dutch performance-based motor tests in 5 to 6 years old children
- Cumulative viral load as a predictor of CD4+ T-cell response to antiretroviral therapy using Bayesian statistical models
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- Mutation and immune profiling of metaplastic breast cancer: Correlation with survival
- The clinicopathological significance of Thrombospondin-4 expression in the tumor microenvironment of gastric cancer
- Propofol-based total intravenous anesthesia did not improve survival compared to desflurane anesthesia in breast cancer surgery
- Association between ossification of the posterior longitudinal ligament and ossification of the nuchal ligament in the cervical spine
- Effects of Debaryomyces hansenii treatment on intestinal mucosa microecology in mice with antibiotic-associated diarrhea
- Molecular validation of clinical Pantoea isolates identified by MALDI-TOF
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- Evolution of high tooth replacement rates in theropod dinosaurs
- Outpatient facility-based order variation in combined imaging
- Ethnic-racial identity affirmation: Validation in Aboriginal Australian children
- Non-intubated anesthesia in patients undergoing video-assisted thoracoscopic surgery: A systematic review and meta-analysis
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- Changes of serum pentraxin-3 and hypersensitive CRP levels during pregnancy and their relationship with gestational diabetes mellitus
- Synergistic immuno-modulatory activity in human macrophages of a medicinal mushroom formulation consisting of Reishi, Shiitake and Maitake
- Investigating reindeer pastoralism and exploitation of high mountain zones in northern Mongolia through ice patch archaeology
- Diversity pattern of Plasmodium knowlesi merozoite surface protein 4 (MSP4) in natural population of Malaysia
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- “What gets measured better gets done better”: The landscape of validation of global maternal and newborn health indicators through key informant interviews
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- The impact of “male clinics” on health-seeking behaviors of adult men in rural Kenya
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- Reproducibility, stability, and accuracy of microbial profiles by fecal sample collection method in three distinct populations
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- High salinity tolerance of invasive blue catfish suggests potential for further range expansion in the Chesapeake Bay region
- From waste to food: Optimising the breakdown of oil palm waste to provide substrate for insects farmed as animal feed
- Quantitative assessment of interstitial lung disease in Sjögren’s syndrome
- Comparative efficacy of tenofovir and entecavir in nucleos(t)ide analogue-naive chronic hepatitis B: A systematic review and meta-analysis
- Reference ranges for ultrasonographic renal dimensions as functions of age and body indices: A retrospective observational study in Taiwan
- Finding phrases: On the role of co-verbal facial information in learning word order in infancy
- Mathematical modeling reveals the factors involved in the phenomena of cancer stem cells stabilization
- Effects of forest management and roe deer impact on a mountain forest development in the Italian Apennines: A modelling approach using LANDIS-II
- Evaluation of comprehensive improvement for mild and moderate soil salinization in arid zone
- Efficacy, acceptability and feasibility of daily text-messaging in promoting glycaemic control and other clinical outcomes in a low-resource setting of South Africa: A randomised controlled trial
- Magnitude and associated factors of postpartum depression among women in Nekemte town, East Wollega zone, west Ethiopia, 2019: A community-based study
- Comparison of continuous wave and cold lateral condensation filling techniques in 3D printed simulated C-shape canals instrumented with Reciproc Blue or Hyflex EDM
- Effect of caffeine on neuromuscular function following eccentric-based exercise
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- The gut microbiome of freshwater Unionidae mussels is determined by host species and is selectively retained from filtered seston
- Alcohol consumption and survival after breast cancer diagnosis in Japanese women: A prospective patient cohort study
- Selection of reference genes for normalization of cranberry (Vaccinium macrocarpon Ait.) gene expression under different experimental conditions
- The household economic costs associated with depression symptoms: A cross-sectional household study conducted in the North West province of South Africa
- Increased cell size, structural complexity and migration of cancer cells acquiring fibroblast organelles by cell-projection pumping
- Acute low- compared to high-load resistance training to failure results in greater energy expenditure during exercise in healthy young men
- Impact of body mass index and metabolically unhealthy status on mortality in the Japanese general population: The JMS cohort study
- Characterization of two thermophilic cellulases from Talaromyces leycettanus JCM12802 and their synergistic action on cellulose hydrolysis
- Ecohydrology of urban trees under passive and active irrigation in a semiarid city
- Cyclosporine A eyedrops with self-nanoemulsifying drug delivery systems have improved physicochemical properties and efficacy against dry eye disease in a murine dry eye model
- LFastqC: A lossless non-reference-based FASTQ compressor
- Highly accurate prediction of flammability limits of chemical compounds using novel integrated hybrid models
- Nonsteroidal anti-inflammatory drugs and acetaminophen ameliorate muscular mechanical hyperalgesia developed after lengthening contractions via cyclooxygenase-2 independent mechanisms in rats
- A popular Indian clove-based mosquito repellent is less effective against Culex quinquefasciatus and Aedes aegypti than DEET
- Yeasts affect tolerance of Drosophila melanogaster to food substrate with high NaCl concentration
- The effect of climate change on cholera disease: The road ahead using artificial neural network
- Grit (effortful persistence) can be measured with a short scale, shows little variation across socio-demographic subgroups, and is associated with career success and career engagement
- Micro-dislodgement during transcatheter aortic valve implantation with a contemporary self-expandable prosthesis
- Improving the antimicrobial efficacy against resistant Staphylococcus aureus by a combined use of conjugated oligoelectrolytes
- Kin discrimination and outer membrane exchange in Myxococcus xanthus: Experimental analysis of a natural population
- Inflammatory cell infiltrates, hypoxia, vascularization, pentraxin 3 and osteoprotegerin in abdominal aortic aneurysms – A quantitative histological study
- Effects of virtual reality rehabilitation training on gait and balance in patients with Parkinson's disease: A systematic review
- Serum miR-33a is associated with steatosis and inflammation in patients with non-alcoholic fatty liver disease after liver transplantation
- Association between housing tenure and self-rated health in Japan: Findings from a nationwide cross-sectional survey
- Investigation of biochemical and physiological parameters of the newborn Saiga antelope (Saiga tatarica) in Gansu Province, China
- One-year follow-up of changes in refraction and aberrations induced by corneal incision
- Evaluation of upper limb superficial venous percussion as a sign of anatomical location and venous permeability. A comparative study of superficial venous percussion to ultrasound findings on non-renal patients and on chronic kidney disease patients
- An assessment of the Dutch experience with health insurers acting as healthcare advisors
- Perception of potential harm and benefits of HIV vaccine trial participation: A qualitative study from urban Tanzania
- Veterans with Gulf War Illness exhibit distinct respiratory patterns during maximal cardiopulmonary exercise
- Deep brain stimulation restores the glutamatergic and GABAergic synaptic transmission and plasticity to normal levels in kindled rats
- Metformin strongly affects transcriptome of peripheral blood cells in healthy individuals
- Cranberry extracts promote growth of Bacteroidaceae and decrease abundance of Enterobacteriaceae in a human gut simulator model
- Long-term retention on antiretroviral therapy among infants, children, adolescents and adults in Malawi: A cohort study
- Histochemical quantification of collagen content in articular cartilage
- Optogenetically transduced human ES cell-derived neural progenitors and their neuronal progenies: Phenotypic characterization and responses to optical stimulation
- Ion torrent high throughput mitochondrial genome sequencing (HTMGS)
- Outpatient antibiotic prescription rate and pattern in the private sector in India: Evidence from medical audit data
- Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination
- Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon
- Home-cage monitoring ascertains signatures of ictal and interictal behavior in mouse models of generalized seizures
- CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say
- Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches
- Proton pump inhibitor use increases the risk of peritonitis in peritoneal dialysis patients
- Comparative distribution of extended-spectrum beta-lactamase–producing Escherichia coli from urine infections and environmental waters
- Sex differences in thigh muscle volumes, sprint performance and mechanical properties in national-level sprinters
- Maternal serum and cord blood leptin concentrations at delivery
- Winter nitrification in ice-covered lakes
- Intolerance of uncertainty fuels depressive symptoms through rumination: Cross-sectional and longitudinal studies
- Monitoring exercise-induced muscle damage indicators and myoelectric activity during two weeks of knee extensor exercise training in young and old men
- Can adoption of pollution prevention techniques reduce pollution substitution?
- The association between self-efficacy and self-management behaviors among Chinese patients with type 2 diabetes
- Poly-arginine-18 peptides do not exacerbate bleeding, or improve functional outcomes following collagenase-induced intracerebral hemorrhage in the rat
- Affective disorders in the elderly in different European countries: Results from the MentDis_ICF65+ study
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- Proton pencil minibeam irradiation of an in-vivo mouse ear model spares healthy tissue dependent on beam size
- Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring
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- Microbial metabolisms in an abyssal ferromanganese crust from the Takuyo-Daigo Seamount as revealed by metagenomics
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- The impact of short-term machine perfusion on the risk of cancer recurrence after rat liver transplantation with donors after circulatory death
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- Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012
- The effects of prolonged single night session of videogaming on sleep and declarative memory
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- Positive selection and precipitation effects on the mitochondrial NADH dehydrogenase subunit 6 gene in brown hares (Lepus europaeus) under a phylogeographic perspective
- Evaluation of Minimum Inhibitory Concentrations for 154 Mycoplasma synoviae isolates from Italy collected during 2012-2017
- Enhancement of antibiotics antimicrobial activity due to the silver nanoparticles impact on the cell membrane
- Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
- Correction: Effect of corruption on perceived difficulties in healthcare access in sub-Saharan Africa
- Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters
- Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects
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- Verification of hub genes in the expression profile of aortic dissection
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- Qualification programmes for immigrant health professionals: A systematic review
- An analytical model to minimize the latency in healthcare internet-of-things in fog computing environment
- Grain filling of early-season rice cultivars grown under mechanical transplanting
- Intercalation of small molecules into DNA in chromatin is primarily controlled by superhelical constraint
- Correlative evidence for co-regulation of phosphorus and carbon exchanges with symbiotic fungus in the arbuscular mycorrhizal Medicago truncatula
- How to design a dose-finding study on combined agents: Choice of design and development of R functions
- Altered expression of Notch1 in Alzheimer's disease
- The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women
- Trunk velocity-dependent Light Touch reduces postural sway during standing
- Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: An investigation in 78 cases using STARD guidelines
- Trade-offs in motivating volunteer effort: Experimental evidence on voluntary contributions to science
- Does caching strategy vary with microclimate in endangered Mt. Graham red squirrels?
- Assessment of energy expenditure during high intensity cycling and running using a heart rate and activity monitor in young active adults
- Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus)
- Implementation of a screening, brief intervention and referral to treatment programme for risky substance use in South African emergency centres: A mixed methods evaluation study
- Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study
- The calcium sensor OsCBL1 modulates nitrate signaling to regulate seedling growth in rice
- Acceptability of and treatment preferences for recurrent bacterial vaginosis—Topical lactic acid gel or oral metronidazole antibiotic: Qualitative findings from the VITA trial
- Mathematical determination of the HIV-1 matrix shell structure and its impact on the biology of HIV-1
- Contingent negative variation during a modified cueing task in simulated driving
- CAMDI interacts with the human memory-associated protein KIBRA and regulates AMPAR cell surface expression and cognition
- Effect of feeding patterns on growth and nutritional status of children aged 0-24 months: A Chinese cohort study
- A fecal sequel: Testing the limits of a genetic assay for bat species identification
- Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study
- Short and long-term clinical effectiveness and cost-effectiveness of a late-phase community-based balance and gait exercise program following hip fracture. The EVA-Hip Randomised Controlled Trial
- Vaccine cold chain in general practices: A prospective study in 75 refrigerators (Keep Cool study)
- Brazilian norms for the Bank of Standardized Stimuli (BOSS)
- Distinct varieties of aesthetic chills in response to multimedia
- Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses’ Health Study
- Correction: Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
- New formulation of the Gompertz equation to describe the kinetics of untreated tumors
- Development of visual perception of others’ actions: Children’s judgment of lifted weight
- Retrospective comparative analysis of intraocular lens calculation formulas after hyperopic refractive surgery
- Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution
- Development and validation of exhaled breath condensate microRNAs to identify and endotype asthma in children
- Arthroscopic release for frozen shoulder: Does the timing of intervention and diabetes affect outcome?
- Risk factors affecting dairy cattle protective grouping behavior, commonly known as bunching, against Stomoxys calcitrans (L.) on California dairies
- Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing
- Characterisation and microbial community analysis of lipid utilising microorganisms for biogas formation
- Sexuality in male partners of women with fibromyalgia syndrome: A qualitative study
- Exploring optimization strategies for improving explicit water models: Rigid n-point model and polarizable model based on Drude oscillator
- Artificial insemination with fresh, liquid stored and frozen thawed semen in dromedary camels
- Moving into an urban drug scene among people who use drugs in Vancouver, Canada: Latent class growth analysis
- Numerical study on the start and unstart phenomena in a scramjet inlet-isolator model
- Effects of dietary supplementation with apple peel powder on the growth, blood and liver parameters, and transcriptome of genetically improved farmed tilapia (GIFT, Oreochromis niloticus)
- Urban growth simulation in different scenarios using the SLEUTH model: A case study of Hefei, East China
- Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases
- Factors associated with medication adherence among people with diabetes mellitus in poor urban areas of Cambodia: A cross-sectional study
- Mammary microbiome of lactating organic dairy cows varies by time, tissue site, and infection status
- Force field generalization and the internal representation of motor learning
- Polyphenism of visual and chemical secondary sexually-selected wing traits in the butterfly Bicyclus anynana: How different is the intermediate phenotype?
- Minimal genetic differentiation of the malaria vector Nyssorhynchus darlingi associated with forest cover level in Amazonian Brazil
- The impact of leisure activities on older adults’ cognitive function, physical function, and mental health
- scafSLICR: A MATLAB-based slicing algorithm to enable 3D-printing of tissue engineering scaffolds with heterogeneous porous microarchitecture
- Association of serum leptin and adiponectin concentrations with echocardiographic parameters and pathophysiological states in patients with cardiovascular disease receiving cardiovascular surgery
- Operation of cognitive memory inhibition in adults with Down syndrome: Effects of maintenance load and material
- Influences on surgical antimicrobial prophylaxis decision making by surgical craft groups, anaesthetists, pharmacists and nurses in public and private hospitals
- Post-treatment Lyme disease symptoms score: Developing a new tool for research
- Expression of Concern: The Role of the RACK1 Ortholog Cpc2p in Modulating Pheromone-Induced Cell Cycle Arrest in Fission Yeast
- Equine bronchial fibroblasts enhance proliferation and differentiation of primary equine bronchial epithelial cells co-cultured under air-liquid interface
- Investigating cooperation with robotic peers
- Synthesis, purification and crystallization of a putative critical bulge of HAR1 RNA
- Prosthetic push-off power in trans-tibial amputee level ground walking: A systematic review
- A case study of the use of verbal reports for talent identification purposes in soccer: A Messi affair!
- Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
- Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation
- Periodontal disease: Repercussions in pregnant woman and newborn health—A cohort study
- Origins of Chinese reindeer (Rangifer tarandus) based on mitochondrial DNA analyses
- Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in Africa: A systematic review and meta-analysis
- How effective are films in inducing positive and negative emotional states? A meta-analysis
- 3D nanostructural characterisation of grain boundaries in atom probe data utilising machine learning methods
- An outbreak of tuberculosis in a middle school in Henan, China: Epidemiology and risk factors
- Initial clinical radiological findings and staging to predict prognosis of primary hepatic angiosarcoma: A retrospective analysis
- A new early Eocene deperetellid tapiroid illuminates the origin of Deperetellidae and the pattern of premolar molarization in Perissodactyla
- Longevity and marginal bone loss of narrow-diameter implants supporting single crowns: A systematic review
- Impact of UVC-sustained recirculating air filtration on airborne bacteria and dust in a pig facility
- Cold-related Florida manatee mortality in relation to air and water temperatures
- Conceptual fluency in inductive reasoning
- Clinical outcomes and treatment patterns among Medicare patients with nonvalvular atrial fibrillation (NVAF) and chronic kidney disease
- Improvements in the learnability of smartphone haptic interfaces for visually impaired users
- Role of the malic enzyme in metabolism of the halotolerant methanotroph Methylotuvimicrobium alcaliphilum 20Z
- Cyclic loading test study on a new cast-in-situ insulated sandwich concrete wall
- Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies
- Analysis of virulence potential of Escherichia coli O145 isolated from cattle feces and hide samples based on whole genome sequencing
- Pre-clinical medical student reflections on implicit bias: Implications for learning and teaching
- Prognostic significance of non-sustained ventricular tachycardia on stored electrograms in pacemaker recipients
- Determinants of preterm birth among mothers who gave birth at public hospitals in the Amhara region, Ethiopia: A case-control study
- Real-world evidence of the effectiveness of ombitasvir-paritaprevir/r ± dasabuvir ± ribavirin in patients monoinfected with chronic hepatitis C or coinfected with human immunodeficiency virus-1 in Spain
- Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
- Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice
- Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth
- Achievement of weight loss in patients with overweight during dietetic treatment in primary health care
- Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation
- The impacts of parity on lung function data (LFD) of healthy females aged 40 years and more issued from an upper middle income country (Algeria): A comparative study
- Reorganization of spatial configurations in visual working memory: A matter of set size?
- Unravelling travellers’ route choice behaviour at full-scale urban network by focusing on representative OD pairs in computer experiments
- Evaluating the higher-order structure of the Profile of Emotional Competence (PEC): Confirmatory factor analysis and Bayesian structural equation modeling
- HIV prevalence and correlated factors among male clients of female sex workers in a border region of China
- Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis
- Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population
- Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians
- Increasing knowledge of HIV status in a country with high HIV testing coverage: Results from the Botswana Combination Prevention Project
- Friends with benefits: The effects of vegetative shading on plant survival in a green roof environment
- Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis
- Identifying candidate diagnostic markers for early stage of non-small cell lung cancer
- Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
- Correction: KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway
- Unique developmental trajectories of risk behaviors in adolescence and associated outcomes in young adulthood
- Enhanced fibrinolysis detection in a natural occurring canine model with intracavitary effusions: Comparison and degree of agreement between thromboelastometry and FDPs, D-dimer and fibrinogen concentrations
- Overexpression of Saussurea involucrata dehydrin gene SiDHN promotes cold and drought tolerance in transgenic tomato plants
- Foxtail millet (Setaria italica (L.) P. Beauv) CIPKs are responsive to ABA and abiotic stresses
- Autonomous drone hunter operating by deep learning and all-onboard computations in GPS-denied environments
- Heterogeneity Diffusion Imaging of gliomas: Initial experience and validation
- Frequency cluster formation and slow oscillations in neural populations with plasticity
- DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy
- Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
- Analytical solution to swing equations in power grids
- Pathways to conspiracy: The social and linguistic precursors of involvement in Reddit’s conspiracy theory forum
- Spatiotemporally random and diverse grid cell spike patterns contribute to the transformation of grid cell to place cell in a neural network model
- Empathic concern and personal distress depend on situational but not dispositional factors
- Who is more susceptible to job stressors and resources? Sensory-processing sensitivity as a personal resource and vulnerability factor
- Cost-effectiveness of integrating postpartum antiretroviral therapy and infant care into maternal & child health services in South Africa
- A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
- One step at a time: Physical activity is linked to positive interpretations of ambiguity
- Calreticulin regulates vascular endothelial growth factor-A mRNA stability in gastric cancer cells
- Evaluation of various methods of selection of B. subtilis strains capable of secreting surface-active compounds
- Association between US Pharmacopeia (USP) monograph standards, generic entry and prescription drug costs
- Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects
- On sorption hysteresis in wood: Separating hysteresis in cell wall water and capillary water in the full moisture range
- Inbreeding, Allee effects and stochasticity might be sufficient to account for Neanderthal extinction
- Reliability and construct validity of the stepping-forward affordance perception test for fall risk assessment in community-dwelling older adults
- Socioeconomic determinants of nutritional status among ‘Baiga’ tribal children In Balaghat district of Madhya Pradesh: A qualitative study
- Study on characteristics of fire plume in building facade window under lateral blow
- ‘When you talk to someone in a bad way or always put her under pressure, it is actually worse than beating her’: Conceptions and experiences of emotional intimate partner violence in Rwanda and South Africa
- Effects of 6-mercaptopurine in pressure overload induced right heart failure
- The association between haemoglobin levels in the first 20 weeks of pregnancy and pregnancy outcomes
- Implementation and evaluation of an antimicrobial stewardship programme in companion animal clinics: A stepped-wedge design intervention study
- Factors associated with persistently high-cost health care utilization for musculoskeletal pain
- Nitrogen and chlorophyll status determination in durum wheat as influenced by fertilization and soil management: Preliminary results
- Effect of repeated in vivo microCT imaging on the properties of the mouse tibia
- Coupling environment and physiology to predict effects of climate change on the taxonomic and functional diversity of fish assemblages in the Murray-Darling Basin, Australia
- Hematology and plasma biochemistries in the Blanding’s turtle (Emydoidea blandingii) in Lake County, Illinois
- CRISPR-Cas influences the acquisition of antibiotic resistance in Klebsiella pneumoniae
- Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors
- Antidepressant prescriptions, discontinuation, depression and perinatal outcomes, including breastfeeding: A population cohort analysis
- Why men with a low-risk prostate cancer select and stay on active surveillance: A qualitative study
- Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis
- Combined treatment (image-guided thrombectomy and endovascular therapy with open femoral access) for acute lower limb ischemia: Clinical efficacy and outcomes
- Low-latency single channel real-time neural spike sorting system based on template matching
- Quantifying the scale effect in geospatial big data using semi-variograms
- Paper-and-pencil versus computerized administration mode: Comparison of data quality and risk behavior prevalence estimates in the European school Survey Project on Alcohol and other Drugs (ESPAD)
- Regression adjusted colocalisation colour mapping (RACC): A novel biological visual analysis method for qualitative colocalisation analysis of 3D fluorescence micrographs
- Ostrich eggshell bead diameter in the Holocene: Regional variation with the spread of herding in eastern and southern Africa
- Spatial and temporal variations in female size at maturity of a Southern Rock Lobster (Jasus edwardsii) population: A likely response to climate change
- Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
- Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies
- Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity
- Magnitude and factors associated with anemia among pregnant women attending antenatal care in Bench Maji, Keffa and Sheka zones of public hospitals, Southwest, Ethiopia, 2018: A cross -sectional study
- Effectiveness of telerehabilitation in the management of adults with stroke: A systematic review
- Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys
- Correction: Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin
- Retraction: Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization
- Evaluation of neutral oral contrast agents for assessment of the small bowel at abdominal staging CT
- Blood type and breed-associated differences in cell marker expression on equine bone marrow-derived mesenchymal stem cells including major histocompatibility complex class II antigen expression
- Induced abortion and future use of IVF treatment; A nationwide register study
- Psychosocial determinants of sustained maternal functional impairment: Longitudinal findings from a pregnancy-birth cohort study in rural Pakistan
- Measurement of finger joint angle using stretchable carbon nanotube strain sensor
- Determinants of mortality among patients with drug-resistant tuberculosis in northern Nigeria
- Drugs modulating stochastic gene expression affect the erythroid differentiation process
- Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study
- Prognostic value of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma treated with transarterial chemotherapy: A systematic review and meta-analysis
- Avermectin induces the oxidative stress, genotoxicity, and immunological responses in the Chinese Mitten Crab, Eriocheir sinensis
- Antibiotic use in mandarin production (Citrus reticulata Blanco) in major mandarin-producing areas in Thailand: A survey assessment
- Application of CPI cutoff value based on parentage testing of duos and trios typed by four autosomal kits
- Correction: Good and Bad in the Hands of Politicians: Spontaneous Gestures during Positive and Negative Speech
- Adolescents with worse levels of oral health literacy have more cavitated carious lesions
- Effective methods for the inactivation of Francisella tularensis
- Detection of early-stage Alzheimer’s pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients
- Correlation between internal pudendal artery stenosis and erectile dysfunction in patients with suspected coronary artery disease
- Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation
- Population productivity of shovelnose rays: Inferring the potential for recovery
- Correction: Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era
- Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis
- Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression
- Changes in weight and body composition across five years at university: A prospective observational study
- Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning
- Effects of insulin signaling on mouse taste cell proliferation
- Patient-level cost of home- and facility-based child pneumonia treatment in Suba Sub County, Kenya
- TAP: A static analysis model for PHP vulnerabilities based on token and deep learning technology
- Cost-effectiveness of QuantiFERON-TB Gold In-Tube versus tuberculin skin test for diagnosis and treatment of Latent Tuberculosis Infection in primary health care workers in Brazil
- Multifaceted intervention for the prevention and management of musculoskeletal pain in nursing staff: Results of a cluster randomized controlled trial
- Changes over time in creatinine clearance and comparison of emergent adverse events for HIV-positive adults receiving standard doses (300 mg/day) of lamivudine-containing antiretroviral therapy with baseline creatinine clearance of 30–49 vs ≥50 mL/min
- Population dynamics of foxes during restricted-area culling in Britain: Advancing understanding through state-space modelling of culling records
- Impacts of experimental advisory exit speed sign on traffic speeds for freeway exit ramp
- In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium
- Monitoring quality indicators for the Xpert MTB/RIF molecular assay in Ethiopia
- Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
- Correction: Using remote sensing to detect whale strandings in remote areas: The case of sei whales mass mortality in Chilean Patagonia
- Comparison of the inoculum size effects of antibiotics on IMP-6 β-lactamase-producing Enterobacteriaceae co-harboring plasmid-mediated quinolone resistance genes
- Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma
- Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720
- Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
- Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels
- Comparison of two experimental ARDS models in pigs using electrical impedance tomography
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- Stroke risks in women with dysmenorrhea by age and stroke subtype
- Changes in patterns of mortality rates and years of life lost due to firearms in the United States, 1999 to 2016: A joinpoint analysis
- In vitro modeling of Batrachochytrium dendrobatidis infection of the amphibian skin
- Development and validation of LC-MS/MS method for imatinib and norimatinib monitoring by finger-prick DBS in gastrointestinal stromal tumor patients
- Correction: Habitat disturbance and the organization of bacterial communities in Neotropical hematophagous arthropods
- Characterisation of early metazoan secretion through associated signal peptidase complex subunits, prohormone convertases and carboxypeptidases of the marine sponge (Amphimedon queenslandica)
- Time trends between 2002 and 2017 in correlates of self-reported sitting time in European adults
- Performance of patient acuity rating by rapid response team nurses for predicting short-term prognosis
- Changes in HbA1c during the first six years after the diagnosis of Type 2 diabetes mellitus predict long-term microvascular outcomes
- Correction: Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
- Correction: Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Establishing an infrastructure for collaboration in primate cognition research
- Correction: The impact of public health insurance on health care utilisation, financial protection and health status in low- and middle-income countries: A systematic review
- Health provider and service-user experiences of sensory modulation rooms in an acute inpatient psychiatry setting
- Comparison of potential drug-drug interactions with metabolic syndrome medications detected by two databases
- The Polish version of the Cultural Intelligence Scale: Assessment of its reliability and validity among healthcare professionals and medical faculty students
- Selection of optimal reference genes for qRT-PCR analysis of shoot development and graviresponse in prostrate and erect chrysanthemums
- Metastasis risk prediction model in osteosarcoma using metabolic imaging phenotypes: A multivariable radiomics model
- Defining hospital community benefit activities using Delphi technique: A comparison between China and the United States
- Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1
- A robust multi-objective optimization framework to capture both cellular and intercellular properties in cardiac cellular model tuning: Analyzing different regions of membrane resistance profile in parameter fitting
- Sea star wasting disease demography and etiology in the brooding sea star Leptasterias spp.
- Diagnostic plasma miRNA-profiles for ovarian cancer in patients with pelvic mass
- Genetic diversity and drug resistance of HIV-1 among infected pregnant women newly diagnosed in Luanda, Angola
- I’ve been robbed! – Can changes in floral traits discourage bee pollination?
- Visualising statistical models using dynamic nomograms
- Assessing the capacity of Malawi’s district and central hospitals to manage traumatic diaphyseal femoral fractures in adults
- Diagnostic performance of basal cortisol level at 0900-1300h in adrenal insufficiency
- The Mastery Rubric for Bioinformatics: A tool to support design and evaluation of career-spanning education and training
- Microdissection and whole chromosome painting confirm karyotype transformation in cryptic species of the Lariophagus distinguendus (Förster, 1841) complex (Hymenoptera: Pteromalidae)
- Quality of Kangaroo Mother Care services in Ethiopia: Implications for policy and practice
- Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid cancer
- iTRAQ-based high-throughput proteomics analysis reveals alterations of plasma proteins in patients infected with human bocavirus
- The detection of a non-anemophilous plant species using airborne eDNA
- Perception and control of low cable operation forces in voluntary closing body-powered upper-limb prostheses
- Neoadjuvant chemotherapy plus surgery versus concurrent chemoradiotherapy in stage IB2-IIB cervical cancer: A systematic review and meta-analysis
- Randomized methods to characterize large-scale vortical flow networks
- Disentangling the coexistence strategies of mud-daubing wasp species through trophic analysis in oases of Baja California peninsula
- Front-of-pack nutritional labels: Understanding by low- and middle-income Mexican consumers
- Distress in patients with end-stage renal disease: Staff perceptions of barriers to the identification of mild-moderate distress and the provision of emotional support
- Pathways to antibiotics in Bangladesh: A qualitative study investigating how and when households access medicine including antibiotics for humans or animals when they are ill
- DOC export is exceeded by C fixation in May Creek: A late-successional watershed of the Copper River Basin, Alaska
- Behavioral observation of prosocial behavior and social initiative is related to preschoolers’ psychopathological symptoms
- Evaluating the impact of citations of articles based on knowledge flow patterns hidden in the citations
- Correction: Economic sanctions and academia: Overlooked impact and long-term consequences
- Correction: A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization
- Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
- Price dispersion of generic medications
- Sex differences in body composition but not neuromuscular function following long-term, doxycycline-induced reduction in circulating levels of myostatin in mice
- The emotion regulation effect of cognitive control is related to depressive state through the mediation of rumination: An ERP study
- Comparison of SMS-EPI and 3D-EPI at 7T in an fMRI localizer study with matched spatiotemporal resolution and homogenized excitation profiles
- Left ventricular mass normalization for body size in children based on an allometrically adjusted ratio is as accurate as normalization based on the centile curves method
- Correction: Combining biophysical parameters, spectral indices and multivariate hyperspectral models for estimating yield and water productivity of spring wheat across different agronomic practices
- Correction: Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- 'Small small quarrels bring about happiness or love in the relationships’: Exploring community perceptions and gendered norms contributing to male perpetrated intimate partner violence in the Central Region of Ghana
- The performance of practitioners conducting facial comparisons on images of children across age
- Increased amounts and stability of telomeric repeat-containing RNA (TERRA) following DNA damage induced by etoposide
- Patients with limitation or withdrawal of life supporting care admitted in a medico-surgical intermediate care unit: Prevalence, description and outcome over a six-month period
- Correction: Diverse radiofrequency sensitivity and radiofrequency effects of mobile or cordless phone near fields exposure in Drosophila melanogaster
- Predicting the performance of TV series through textual and network analysis: The case of Big Bang Theory
- Risk of temperature, humidity and concentrations of air pollutants on the hospitalization of AECOPD
- Mixed methods grant applications in the health sciences: An analysis of reviewer comments
- Renal abnormalities among children with sickle cell conditions in highly resource-limited setting in Ghana
- Size matters: How reaching and vergence movements are influenced by the familiar size of stereoscopically presented objects
- Willingness to receive institutional and community-based eldercare among the rural elderly in China
- An improved deep learning method for predicting DNA-binding proteins based on contextual features in amino acid sequences
- Beyond executive functions, creativity skills benefit academic outcomes: Insights from Montessori education
- A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions
- Nonarteritic anterior ischemic optic neuropathy is associated with cerebral small vessel disease
- Fiber-tract localized diffusion coefficients highlight patterns of white matter disruption induced by proximity to glioma
- The fight against polio through the NO-DO newsreels during the Francoism period in Spain
- Ocean sound levels in the northeast Pacific recorded from an autonomous underwater glider
- Cost-consequence analysis of influenza vaccination among the staff of a large teaching hospital in Rome, Italy: A pilot study
- The relationship among the progression of inflammation in umbilical cord, fetal inflammatory response, early-onset neonatal sepsis, and chorioamnionitis
- How medical professional students view older people with dementia: Implications for education and practice
- An enhanced nonparametric EWMA sign control chart using sequential mechanism
- Land use change, carbon stocks and tree species diversity in green spaces of a secondary city in Myanmar, Pyin Oo Lwin
- Is there a difference in women’s experiences of care with medication vs. manual vacuum aspiration abortions? Determinants of person-centered care for abortion services
- Maternal complications in pregnancy and childbirth for women with epilepsy: Time trends in a nationwide cohort
- Adsorption of oxytetracycline on kaolinite
- Interdisciplinary stratified care for low back pain: A qualitative study on the acceptability, potential facilitators and barriers to implementation
- The role of resource transfer in positive, non-additive litter decomposition
- The impact of language on the interpretation of resuscitation clinical care plans by doctors. A mixed methods study
- Quantum dots reveal heterogeneous membrane diffusivity and dynamic surface density polarization of dopamine transporter
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- The heavy metals lead and cadmium are cytotoxic to human bone osteoblasts via induction of redox stress
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- Correction: A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions
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- Correction: Identifying performance benchmarks and determinants for reproductive performance and calf survival using a longitudinal field study of cow-calf herds in western Canada
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- Correction: Interspecific Phylogenic Relationships within Genus Melilotus Based on Nuclear and Chloroplast DNA
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- Correction: KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services
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- Retraction: Over-Expression of Superoxide Dismutase Ameliorates Cr(VI) Induced Adverse Effects via Modulating Cellular Immune System of Drosophila melanogaster
- Effect of pre-season training phase on anthropometric, hormonal and fitness parameters in young soccer players
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- Outcome of patients with heart failure after transcatheter aortic valve implantation
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- Appropriate empirical antibiotic therapy and mortality: Conflicting data explained by residual confounding
- Treatment of corneal endothelial damage in a rabbit model with a bioengineered graft using human decellularized corneal lamina and cultured human corneal endothelium
- Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis
- Correction: Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
- Correction: Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
- Retraction: Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage
- Correction: Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5
- Correction: The modulation of facial mimicry by attachment tendencies and their underlying affiliation motives in 3-year-olds: An EMG study
- Correction: Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors
- Discovering novel disease comorbidities using electronic medical records
- Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome
- Epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus isolates colonizing pigs with different exposure to antibiotics
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- Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members
- Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial
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- A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE
- Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma
- Seasonal alternation of the ontogenetic development of the moon jellyfish Aurelia coerulea in Maizuru Bay, Japan
- Reliability of measurement of active trunk movement in wheelchair basketball players
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- Quality and utilization patterns of maternity waiting homes at referral facilities in rural Zambia: A mixed-methods multiple case analysis of intervention and standard of care sites
- Determining an optimal pool size for testing beef herds for Johne’s disease in Australia
- Correction: Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
- APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix
- Testing Species Assignments in Extant Terebratulide Brachiopods: A Three-dimensional Geometric Morphometric Analysis of Long-Looped Brachidia
- A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations
- Improved chemotherapy modeling with RAG-based immune deficient mice
- Effect of tracheal antimicrobial peptide on the development of Mannheimia haemolytica pneumonia in cattle
- The internal realities of individuals with type 2 diabetes – a functional framework of self-management practices via Grounded Theory approach
- Role of platelet parameters in early detection and prediction of severity of preeclampsia: A comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia
- eIF4E and 4EBP1 are prognostic markers of head and neck squamous cell carcinoma recurrence after definitive surgery and adjuvant radiotherapy
- Smoking and other determinants of bone turnover
- Oxygen delivery, oxygen consumption and decreased kidney function after cardiopulmonary bypass
- School engagement of children in early grades: Psychometric, and gender comparisons
- Correction: A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
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- Correction: Population-based dementia prediction model using Korean public health examination data: A cohort study
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- Correction: Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies
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- Correction: Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing
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- Maximum parsimony interpretation of chromatin capture experiments
- Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
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- Estimating measures of latent variables from m-alternative forced choice responses
- Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates
- First evidence of hepatitis E virus infection in a small mammal (yellow-necked mouse) from Croatia
- The inhibitory effects of polypyrrole on the biofilm formation of Streptococcus mutans
- Self-reported adverse drug effects and associated factors among H. pylori infected patients on standard triple therapy: Prospective follow up study
- Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to oxaliplatin-induced chronic neuropathic pain
- Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
- Remote heart rate monitoring - Assessment of the Facereader rPPg by Noldus
- Seroprevalence of rubella virus antibodies among pregnant women in the Center and South-West regions of Cameroon
- Effectiveness of steam sterilization of reusable medical devices in primary and secondary care public hospitals in Nepal and factors associated with ineffective sterilization: A nation-wide cross-sectional study
- Relevance of HTLV-1 proviral load in asymptomatic and symptomatic patients living in endemic and non-endemic areas of Argentina
- Ritualized aggressive behavior reveals distinct social structures in native and introduced range tawny crazy ants
- The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury
- Screening and characterization of long noncoding RNAs involved in the albinism of Ananas comosus var. bracteatus leaves
- Visual attention to emotional faces in adolescents with social anxiety disorder receiving cognitive behavioral therapy
- A Q fever outbreak associated to courier transport of pets
- Antibodies against measles and rubella virus among different age groups in Thailand: A population-based serological survey
- Molecular diet analysis of Anguilliformes leptocephalus larvae collected in the western North Pacific
- Correction: The relationship between context, structure, and processes with outcomes of 6 regional diabetes networks in Europe
- Correction: The C-reactive protein/albumin ratio as an independent predictor of mortality in patients with severe sepsis or septic shock treated with early goal-directed therapy
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- Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data
- The implementation of HTA in medicine pricing and reimbursement policies in Indonesia: Insights from multiple stakeholders
- International experiences during United States ophthalmology residency training: Current structure of international experiences and perspectives of faculty mentors at United States training institutions
- Questionable utility of digoxin in left-ventricular assist device recipients: A multicenter, retrospective analysis
- Genotyping and outcomes of presumptive second line ART failure cases switched to third line or maintained on second line ART in Mumbai, India
- A mathematical model of honey bee colony dynamics to predict the effect of pollen on colony failure
- Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner
- An odorant receptor from Anopheles gambiae that demonstrates enantioselectivity to the plant volatile, linalool
- Factors associated with full immunization of children 12–23 months of age in Ethiopia: A multilevel analysis using 2016 Ethiopia Demographic and Health Survey
- Additional evidence that the rat renal interstitium contracts in vivo
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- Removal efficiency of central vacuum system and protective masks to suspended particles from dental treatment
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- Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs
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- Socioeconomic determinants of cancer screening utilisation in Latin America: A systematic review
- Development of an easy-to-use questionnaire assessing critical care nursing competence in Japan: A cross-sectional study
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- Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
- Correction: Phylogenetic analysis of hepatitis C virus among HIV/ HCV co-infected patients in Nigeria
- Correction: Relationship between self-disclosure to first acquaintances and subjective well-being in people with schizophrenia spectrum disorders living in the community
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- Involvement of human and canine MRP1 and MRP4 in benzylpenicillin transport
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- Correction: Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T
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