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ReklamaA developmental trajectory supporting the evaluation and achievement of competencies: Articulating the Mastery Rubric for the nurse practitioner (MR-NP) program curriculum
Authors: Rochelle E. Tractenberg aff001; Melody R. Wilkinson aff002; Amy W. Bull aff002; Tiffany P. Pellathy aff002; Joan B. Riley aff003
Authors place of work: Collaborative for Research on Outcomes and –Metrics, and Departments of Neurology, Biostatistics, Bioinformatics & Biomathematics, and Rehabilitation Medicine, Georgetown University, Washington, D.C., United States of America aff001; Department of Advanced Nursing Practice, School of Nursing & Health Studies, Georgetown University, Washington, D.C., United States of America aff002; Department of Nursing and Human Science, School of Nursing & Health Studies, and Center for New Designs in Learning and Scholarship, Georgetown University, Washington, D.C., United States of America aff003
Published in the journal: PLoS ONE 14(11)
Category: Research Article
doi: https://doi.org/10.1371/journal.pone.0224593Summary
Background
Advanced practice registered nursing (APRN) competencies exist, but there is no structure supporting the operationalization of the competencies by APRN educators. The development of a Mastery Rubric (MR) for APRNs provides a developmental trajectory that supports educational institutions, educators, students, and APRNs. A MR describes the explicit knowledge, skills, and abilities as performed by the individual moving from novice (student) through graduation and into the APRN career.
Method
A curriculum development tool, the Mastery Rubric (MR), was created to structure the curriculum and career of the nurse practitioner (NP), the MR-NP. Cognitive task analysis (CTA) yielded the first of the three required elements for any MR: a list of knowledge, skills, and abilities (KSAs) to be established through the curriculum. The European guild structure and Bloom’s taxonomy of cognitive behaviors provided the second element of the MR, the specific developmental stages that are relevant for the curriculum. The Body of Work method of standard setting was used to create the third required element of the MR, performance level descriptors (PLDs) for each KSA at each of these stages. Although the CTA was informed by the competencies, it was still necessary to formally assess the alignment of competencies with the resulting KSAs; this was achieved via Degrees of Freedom Analysis (DoFA). Validity evidence was obtained from this Analysis and from the DoFA of the KSAs’ alignment with principles of andragogy, and with learning outcomes assessment criteria. These analyses are the first time the national competencies for the NP have been evaluated in this manner.
Results
CTA of the 43 NP Competencies led to seven KSAs that support a developmental trajectory for instruction and documenting achievement towards independent performance on the competencies. The Competencies were objectively evaluable for the first time since their publication due to the psychometric validity attributes of the PLD-derived developmental trajectory. Three qualitatively distinct performance levels for the independent practitioner make the previously implicit developmental requirements of the competencies explicit for the first time.
Discussion
The MR-NP provides the first articulated and observable developmental trajectory for the NP competencies, during and beyond the formal curriculum. A focus on psychometric validity was brought to bear on how learners would demonstrate their development, and ultimately their achievement, of the competencies. The MR-NP goes beyond the competencies with trajectories and PLDs that can engage both learner and instructor in this developmental process throughout the career.
Keywords:
Learning – Human learning – Allied health care professionals – Nurses – Health care policy – Careers – Nursing science – Metacognition
Introduction
Academic progression, readiness for clinical practice, consistent assessment criteria, student empowerment of learning with transparent expectations, curriculum design, lifelong learning goals, and career development are all purposes that would be served by an Advanced Practice Registered Nurse (APRN) developmental trajectory of the knowledge, skills and abilities (KSA) of an APRN practice from education preparation to expert clinician. Competency based education is a starting point to achieve this outcome. NP competency-based education has been at the forefront of the NP educators’ agenda since 1980, with the publication of Guidelines for Family Nurse Practitioner Curricular Planning and the subsequent development of the National Organization for Nurse Practitioner Faculty (NONPF). In 2014, NONPF published the Nurse practitioner core competencies content: A delineation of suggested content specific to NP core competencies [1]. This collection of specific competencies are grouped into nine content areas (scientific foundations (4); leadership (7); quality (5); practice inquiry (6); technology and information literacy (7); policy (6); health delivery system (7) ethics (3); and independent practice (13)).
Competencies are articulated for many health and health science programs, including advanced practice nursing [1], medical informatics and bioinformatics [2, 3], and medicine [4]. The National Organization of Nurse Practitioner Faculty (NONPF) and the American Association of Colleges of Nursing (AACN) have led the development of competencies for advanced practice registered nursing (APRN) education.
Competencies may be intermediate milestones [5] or endpoints for graduates of programs, but howsoever they are placed, they encourage “outcomes-based” education [6–10]. They generally capture what programs within a discipline must do, teach, and provide for graduates, bringing meaning and comparability across such programs [11]. Competencies have been articulated for the ‘main’ purpose of programs, for example in physical therapy [12], pharmacy [13], and bioinformatics [3].
As the articulation of competencies is increasing across disciplines, so is the recognition that competencies can be difficult to fully integrate into a curriculum [14]. The challenges have been highlighted by the disciplines of public health [15], medical education [16] and bioinformatics [3]. Graduate nursing education also experiences challenges related to developing competency-based education. The American Association of Colleges of Nursing (AACN) echoes the importance of competency-based APRN education while also reiterating the lack of a formal framework to develop competency-based education [17]. APRN education models have not significantly changed in over four decades. National APRN education leaders currently advocate the development of competency-based models of education; however, there is no current structure for consistent implementation of competency-based education [18–20]. Creating a framework to guide competency-based education is dauntingly complex.
The national discussion about competency-based education extends across clinical programs. In a June 2017 special issue of Medical Teacher, a set of 11 articles provide overviews of the wide variety of challenges faced by medical education as faculty worldwide seek to promote competency-based medical education (CBME). In that special issue, Holmboe et al. [21] specify that the organization of “teaching and learning experiences… to facilitate an explicitly defined progression of ability in stages” (p.575) is a fundamental characteristic of CBME. The same conclusion–that a list of competencies requires a supporting progression—was independently drawn for bioinformatics competencies as well [16]. The challenges associated with implementing competency-based education are not limited to medical [21] and bioinformatics [16] programs. An explicit and publicly shared developmental trajectory for learners should be a fundamental characteristic of any higher education curriculum. Ideally, this progression should be consistent with the principles of adult learning (andragogy), and decisions about who has, and who has not yet achieved a given stage, should be informed by psychometric considerations of validity.
A Mastery Rubric (MR) is a curriculum development and evaluation tool that specifically provides such a trajectory. The first MR was created in 2005 and published in 2010 [22] to describe the clinical research training curriculum, including application and admissions criteria, for a two-year certificate program. Every MR requires three elements: first is a list of knowledge, skills, and abilities (KSAs1) that the curriculum exists to impart, all of which are concretely observable and evaluable even though they can be both taught and demonstrated at the target level of performance in a variety of ways [23, 24]. A MR also requires an explicit developmental trajectory, within which performance levels (stages) are identified with sufficient concreteness that the third MR feature, performance-level descriptions (PLDs) of each KSA at each level or stage, can be articulated–and recognized when met. PLDs represent standards against which any individual student’s work can be evaluated. The creation of a MR integrates the KSAs with the developmental trajectory across stages that are programmatically meaningful, and that promote sustainable learning–i.e., learning that can continue after formal instruction ends and that can be transferred to new contexts [25].
A curriculum based on a MR is intended to support instruction and assessment that generate actionable evidence [26, 27]. Actionable evidence is information that can be used to make evidence-informed decisions. This would be beneficial to the institution for curriculum [28]; the instructor(s) about their course, a class session, or their assessments [29]; and students about their learning strategies [30, 31].
One of the most important features of a MR is that it is shared with all stakeholders, including the learners—so they can be engaged as full partners in their education. A MR-based curriculum can thereby engage the learner in metacognitive development, so that gaps or weaknesses in their performance or understanding, rather than feelings of satisfaction or unease, identify areas for more learning or practice. Instructors and learners can then use the MR to document that these gaps/weaknesses have been addressed [24, 26, 31]. A MR can support both the formal learning within a curriculum and also supporting the learners and other decision makers throughout the career [32]. Whether described for a career [32] or a curriculum [33], using a MR can support active learner engagement and explicit development towards the learning objectives of the curriculum. That is, instructors can use the MR to design/evaluate or revise a curriculum while the learner or graduate can continue to document their achievements of post-graduate levels of performance on all KSAs, as appropriate.
This paper describes a MR created for the curriculum and career of the nurse practitioner (NP). Intended to be shared with learners and all faculty, the MR-NP was designed to facilitate both curriculum design and ongoing assessment by learners and instructors, “to ensure that trainees continue to progress” [34] towards the achievement of the NP competencies, within the curriculum and beyond it, into the career.
Methods
The MR-NP was developed in two phases, following formal methods. The first phase was a cognitive task analysis (CTA) to identify the constituent KSAs that underpin the core competencies articulated by the National Organization of Nurse Practitioner Faculties [1]. The CTA is explicated further in the (S1 Supplemental Materials). The second phase of developing the MR-NP was a facilitated standard-setting exercise with four expert nursing faculty, through which the PLDs were developed and refined. Both of these methods are described in greater detail below.
Once developed, validity evidence supporting the resulting MR-NP was then collected using Degrees of Freedom Analysis (DoFA) [35, 36]. The first DoFA assessed the alignment of the KSAs with the current NONPF competencies. The second DoFA validation explored the alignment of the MR-NP with the principles for learning outcomes articulation [27] for all participants (program, faculty, students). The final DoFA assessed alignment of a curriculum developed following the MR-NP with the principles of andragogy [37], and compared this alignment with that of a curriculum developed according to the original NONPF competencies without developmental considerations.
Methods: Participants
The five co-authors were engaged in the development of the MR-NP from October 2015 to April 2017 as part of a Community of Practice focused on the stewardly scholarship of teaching and learning. The first author is the developer of the Mastery Rubric construct and a cognitive scientist specializing in higher and post graduate education with experience supporting the development of KSAs for Mastery Rubrics. The other four authors are experienced NP educators with post-graduate specialty certifications. In addition to maintaining active clinical practices they have been full-time educators in nursing across multiple institutional settings for at least five years (maximum 34 years). One co-author serves as Senior Scholar at our university’s center for teaching excellence and also serves in a leadership position for education innovation. Two co-authors are Program Directors of specialty tracks of the NP Master’s degree program. Together we served as the subject matter experts (SMEs) for the CTA.
Methods: Cognitive task analysis
As noted, every MR requires a set of KSAs that the curriculum exists to transmit. An established method for understanding KSAs in any task or learning enterprise is a cognitive task analysis (CTA). There are five general steps in CTA: Collect preliminary knowledge/information; identify knowledge representations and organizations; elicit knowledge; analyze and verify data; and format results [38]. In the NP context, the first three steps of the CTA were already completed and published as the NONPF Competencies. These represent a rich dataset from which concepts, processes and principles were extracted (see S1 Supplemental Materials).
These first three CTA steps led to a first draft of KSAs based on the NONPF competencies, which used Bloom’s taxonomy to extract the minimum cognitive activities needed for each competency [40]. Analysis and verification of the KSAs was accomplished through face-to-face and online meetings to discuss the CTA results until consensus was reached. Specifically, we met bi-weekly to evaluate and work with the derived KSAs, using the NONPF competencies and the SMEs’ individual experiences as nurse practitioners and faculty. We also planned that, once the MR-NP was drafted (i.e., results formatted, CTA step 5), we would further verify these results by alignment (DoFA) of the final version of our KSAs with the NONPF competencies to ensure that every KSA was required for multiple competencies, and any KSA that did not support at least two competencies would then be evaluated for its relevance. The CTA was not going to yield KSAs that were directly representative of any competency, so assessing how the CTA results (i.e., the KSAs) aligned with those competencies was an important validation step for the KSAs.
Methods: Standard setting
As described earlier, every MR requires a set of at least two developmental stages to be articulated for evaluable growth in each KSA, as well as performance level descriptors (PLDs) of each KSA at each of these stages. Together, the establishment of stages and the drafting of PLDs were accomplished through the standard setting exercise. The stages for the MR-NP were initially loosely based on decision-making steps in the NP program (admission to the program; admission to clinical preceptored experiences; graduation from the program; and two additional professional performance levels beyond graduation; see [24] for similar career-spanning stages in medical education).
The stages of most MRs [24] are modeled after the European guild structure: Novice, Apprentice, Journeyman [39]. This structure is chosen purposefully for MR staging because it captures a progressive sequence within which students can see themselves changing from less independent to more independent within the curriculum. Moreover, in this structure, the Apprentice is recognized as actively engaged in learning the craft or practice, while the Journeyman is the independent practitioner. These characteristics also signal to all instructors in a curriculum that students must evolve to progress–student evolution must be supported and the purpose of the curriculum is to facilitate these changes in observable and evaluable ways. Finally, recognizing that the end of a curriculum cannot represent the end of learning for the nurse practitioner, we supplemented the decision-making steps in the typical NP program with concrete career stages that represent distinct growth in responsibilities as well as abilities after graduation.
The final feature of a MR is drafting the PLDs. We iteratively articulated PLDs for each KSA across the decision points in the NP curriculum, and into the NP career, using a Body of Work approach [40]. Specifically, the first pass at drafting a PLD was "range finding" for performance of the KSA at a given stage, and the second pass was "pinpointing" [40], as described below. PLD drafting used Bloom’s taxonomy refined by appealing to the elements of psychometric validity in assessment, as outlined by Messick (1994) [41]:
What is/are the knowledge, skills, and abilities (KSAs) that students should possess at the end of the curriculum?
What actions/behaviors by the students will reveal these KSAs?
What tasks will elicit these specific actions or behaviors?
The integration of Bloom’s taxonomy and the Messick criteria in our standard-setting exercise facilitated the inclusion of concrete and observable behaviors in the PLDs that can be developed sequentially–and reinforced iteratively for deeper and sustainable learning over time. In our implementation of Messick questions 2 and 3, we considered what Bloom’s level the minimum specific actions/behaviors demonstrating that the KSA had been learned would need to be demonstrated for the learner to qualify for a given stage (e.g., “Apprentice”); this is the range-finding. The pin-pointing is accomplished by refining PLDs (see S1 Supplemental Materials) so that each KSA can be recognized at each stage for any sample of student work.
This approach ensures that a curriculum that is developed, or revised, to follow this developmental path for each KSA will likely support evaluable learning goals, and their achievement. Competencies, in general, are multi-dimensional and complex behaviors, whereas learning goals should be simple and not compound, among other things. This may be one reason why there has been difficulty in creating competencies-based educational experiences [3, 14–16]. The MR approach to curriculum development also increases the likelihood of actionable evidence [27, 28] for the institution as well as for instructors/course directors and students, because a MR is always intended to be made public and shared [36]. These features also add evaluability to the PLDs themselves, such that a curriculum or continuing education experience that follows the MR-NP (or one that promotes students following it) can be evaluated in terms of its achievement of intended results [6].
Methods: Validation through Degrees of Freedom Analysis
Degrees of Freedom Analysis (DoFA) [35] is a qualitative method for assessing the alignment of data (observations) with predictions from theory or decisions [36, 42]. The recent modifications for using DoFA in educational contexts are specifically intended to summarize evidence surrounding decisions about teaching, learning, and assessment [36]. Validity evidence for the MR-NP was compiled from three DoFA matrices, assembling the evidence that it is:
sufficiently aligned with the NONPF competencies to conclude that a curriculum based on the MR-NP could support the achievement of these competencies;
consistent with principles of learning outcomes articulation and assessment, supporting a conclusion that a curriculum based on the MR-NP could promote actionable and evaluable learning outcomes, and
well-aligned with principles of andragogy, supporting a conclusion that a curriculum based on the MR-NP would also be so aligned.
Andragogic principles and National Institute for Learning Outcomes Assessment (NILOA) [27] characteristics are important, although underutilized, in higher, graduate, and professional education. The KSAs in the MR-NP, and their developmental trajectories, must support achievement of the consensus-based competencies if anyone would choose the MR-NP for curricular support. This validity evidence supports the decision to use the MR-NP in NP curriculum development.
Results
The results of the Cognitive Task Analysis and standard setting exercise (i.e., the MR-NP) appear in Table 1. Table 2 presents the DoFA testing the alignment of the KSAs with the NONPF Competencies. Table 3 presents the DoFA alignment of the MR-NP with the NILOA criteria for actionable learning outcomes [27] while Table 4 outlines the alignment of the MR-NP with principles of andragogy [37] comparing this alignment with that of the competencies on which the MR-NP was based.
Tab. 1. Mastery Rubric for NP: Knowledge, skills, and abilities underpinning the nonpf competencies, and trajectories in their development. Tab. 2. Alignment of MR-NP KSAs with the NONPF competencies whose development a MR-NP based curriculum will support. Tab. 3. Tab. 4. Comparison of how the principles of andragogy are aligned with, or met by, a curriculum based on the NONPF competencies vs on the MR-NP. Results: Cognitive task analysis
The cognitive task analysis (see S1 Supplemental Materials) initially identified five KSAs as underpinning the NONPF competencies: prerequisite knowledge; communication skills; reflection and metacognition; data and evidence skills; and clinical practice. Two additional KSAs were identified and included/retained: One was needed to accommodate NONPF competencies that fell between “data and evidence skills” and “clinical practice”: this became “translation for evidence-based practice”. The other was needed to capture engagement with policy and advocacy:“policy/advocacy.” As the developmental paths through the performance-level descriptors for these KSAs were developed, both of them retained their differentiations from the other KSAs. All seven KSAs are presented in the MR-NP shown in Table 1.
Results: Standard setting
The Body of Work approach [40] to standard setting, i.e., writing the PLDs that capture standards of performance on each KSA at each stage, was used to draft and revise descriptions of how a “minimally competent individual” [43] would carry out the KSAs at each stage to demonstrate that they were capable of performing at that level.
As can be seen in Table 1, the MR-NP represents the stages in the developmental trajectory of the NP from admission to the program (“Novice”) through their qualification for clinical precepted experiences (“Apprentice”), graduation (“Journeyman 1”) and across their career trajectory (“Journeyman 1” through “Journeyman 3”). Development is implicit, but not articulated, in the NONPF Competencies.
The NP curriculum decision points were used in the first drafts of PLDs, and the final PLDs were revised specifically to characterize the individual at these stages: accepted into a formal training program (“Novice”), the individual who can document their preparation for preceptored clinical experiences (“Apprentice”) and the individual who is newly independent (“Journeyman”). Evidence for admission into an NP program in the United States (based on the requirements for Bachelor’s of Science for Nursing or BSN [44]), and preparedness for clinical preceptorship are consistent with novice and apprentice level performance respectively; graduation from the NP program can be considered to represent an individual’s qualification for independent practice. The complex nature of professional development for the NP beyond the end of formal education is recognized by the inclusion of three distinct levels of “Journeyman”; these were dictated in part by the opportunities and requirements that the NONPF competencies themselves suggest.
The first row of the MR-NP provides a general description of overall performance of the minimally-qualified individual at each level [45]. Once the KSAs were extracted and PLDs were drafted for the Novice level, we determined that the PLDs were consistent with our program’s admission process, providing content validity for that set of PLDs. Three distinct Journeyman stages emerged: the recent graduate is described by Journeyman-1, the individual who has NP experience that must accrue after graduation is at the Journeyman-2 level, and Journeyman-3 describes the recognized NP leader with NP practice expertise. All Journeyman-level individuals are qualified for independent practice; the fact that the standard setting led to three differentiable levels of independence is a function of the competencies themselves. As can be seen in Table 1, the PLDs of all KSAs except “prerequisite knowledge” and “clinical practice” are the same for Journeyman 1–2. Journeyman 3 performance level descriptors characterize the practitioner with sufficient experience to be considered a “recognized leader,” qualitatively different from Journeyman 1 and 2. These levels of performance differ as experience changes to expertise–making implicit developmental requirements of the NONPF competencies, beyond the formal curriculum and throughout a career, explicit for the first time.
Results: Validity evidence from DoFA
Validity evidence for the MR-NP was obtained by appeal to extant criteria. First, Table 2 explores alignment of the KSAs with the individual NONPF competencies.
As Table 2 reflects, most of the 49 competencies articulated in the NONPF statement [1] are supported by at least one KSA. However, not all of these competencies are specifically dependent on the KSAs outlined in the MR-NP. We found that six of 49 competencies could not be aligned with any of the KSAs in the MR-NP; the remaining 87% of the NONPF competencies were aligned with at least two KSAs. Failures in alignment between the KSAs and the competencies were identified independently by different co-authors. Two characteristics were determined to have prevented alignment of KSAs with these six competencies. Either the competency was determined not to have been described concretely enough to identify a clear KSA or instructional approach, or else the competency was evaluable, and did not require any of the KSAs in order to be achieved. These are identified as such within Table 2.
Further validation of the MR-NP was sought by appeal to the 2016 recommendations for actionable learning outcomes published by the National Institute for Learning Outcomes Assessment (NILOA, [27]). NILOA was established to encourage educators nationwide to develop evaluable and robust learning outcomes to improve student learning and higher education generally. Their 2016 policy statement [27] includes five important attributes of meaningful learning outcomes. Table 3 presents the alignment of the MR-NP features with the predictions derived from these five NILOA principles for documenting learning outcomes, plus four additional characteristics of robust learning outcomes highlighted in Tractenberg, et al. (2017) [25].
Table 3 shows how the MR-NP can be used to ensure that learning outcomes for courses and the curriculum are as explicit for students as they are for faculty and the program or institution. A curriculum that is created or revised using the MR-NP will exhibit all five of the NILOA learning outcome characteristics, generating actionable evidence for students as well as for the program and faculty engaged in the curriculum. However, a curriculum that is based on just the NONPF competencies will not generate such evidence. This is a function of the implicit nature of any developmental trajectory in the competencies; the MR-NP makes development explicit, and the PLDs were formulated specifically to conform to psychometric validity [34, 41]. The competencies offer only summative opportunities for assessment while the MR-NP supports formative assessment as well.
Finally, a MR is intended to promote curriculum development, evaluation, or revision that is consistent with principles of andragogy [37]. Table 4 is a descriptive analysis that presents how the MR-NP embodies this alignment.
Table 4 shows concrete differences in alignment with andragogical principles that would arise from a curriculum that is developed to feature the NONPF competencies [1] and one that was developed (or revised) using the MR-NP. This is not an empirical analysis, but a conceptual one. While both types of curricula could lead students to achieve the NONPF competencies, the curriculum developed using the MR-NP would also be consistent with the principles of andragogy, thereby engaging learners as partners in their own development and promoting reflection and metacognition to a greater extent [25].
Discussion
A new MR was created using published national competencies for nurse practitioner (NP) education, together with a formal and iterative standard setting exercise. Seven key areas of knowledge, skills, and abilities (KSAs) were derived so that an NP curriculum can go beyond simply aligning with, or including, the competencies. The MR-NP (Table 1) can be used to develop and evaluate courses and curricula, as well as teaching, learning, and practice. It provides a roadmap to addressing many challenges in NP education: supporting the explicit, but flexible, articulation of valid learning outcomes; promoting growth in students along a newly-specified developmental trajectory; and leading to the achievement of the target competencies—in the curriculum and beyond, into the career of the NP. The structure can be used to create consistency across programs, faculty, and students, enabling specificity and measurability in assessment. By making expectations transparent to all stakeholders, the MR-NP empowers self-directed growth.
The MR-NP has face validity that derives partly from its support of/alignment with the national competencies that are at its core (Table 2), with additional validity accruing from the application of cognitive task analysis emphasizing Bloom’s taxonomy [46] with formal and iterative standard-setting. The infusion of psychometric validity in the PLDs yields a usable and evaluable curriculum description (Table 1). The DoFA analysis on the consistency of the MR-NP, with principles of learning outcomes assessment (Table 3), highlights how existing NP curricula can be revised to generate evidence about learning for both the student and the instructor/institution; these revisions are not clear with the competencies but are accessible with the MR-NP. This DoFA replicates the results from two other MRs for Statistical Literacy [26] and for Ethical Reasoning [32], suggesting that a curriculum that employs the MR approach can promote this actionable evidence. Finally, a curriculum that utilizes the MR-NP is aligned with principles of andragogy (Table 4) in ways that a curriculum that utilizes just the competencies would not be, even if the competencies are shared with learners as fully as the MR-NP is intended.
The creation of the MR-NP is the first step in our educational research program, and as such, we have not had the opportunity to empirically study curricula that do and do not utilize it. The methodology and formal incorporation of psychometric validity, learning outcomes assessment, andragogy principles, and cognitive complexity will hopefully encourage NP curriculum developers to adopt the MR-NP and report on their results.
A MR can engage the learners in the structure and achievement of learning objectives throughout their career [32]. While the competencies represent targeted end states, the MR-NP promotes ongoing engagement with its core KSAs past graduation and well into NP professional practice and ultimately, leadership roles. By developing concrete, measurable objectives that are supportive of the NONPF competencies—across an explicit educational trajectory—nurse faculty and students can document individual accomplishment of competencies as they are developed over time. Students who are not achieving competencies as expected can/may identify the need and opportunity for remedial work focused on the area of deficiency rather than repeating an entire course or an additional prescribed number of clinical hours.
Faculty development and advancement, curriculum evaluation, and classroom innovation can each/all be facilitated when curricular structure is used to align and sequence courses and learning objectives. When formal structure explicitly underpins all components of a curriculum like the MR-NP suggests, both teaching and learning can be made more evaluable. This evaluability can strengthen the curriculum generally, while simultaneously augmenting the likelihood of the success of all students. Anecdotally, all of these claims were supported when the practitioner co-authors utilized the MR-NP in their teaching, mentoring, and student assessment. Because these experiences were not formal or systematic, they are offered as preliminary evidence that encourage future formal studies regarding the implementation and usability of the MR-NP.
The MR-NP flexibly represents how the NONPF competencies, including the most cognitively-complex ones, can be achieved within the NP curriculum by integrating a developmental trajectory that increases the cognitive complexity of instruction and work products across the curriculum and NP career. This MR-NP provides a straightforward, useful tool for instructors to use when revising their objectives and syllabi. The usability of the MR-NP increases the potential for buy-in and uptake within APRN programs. Buy-in, commitment of time and resources, and a formal evaluation plan are all required if the integration of competencies is to be done for all courses in the curriculum [47].
The MR-NP provides clear descriptors of when an APRN student is competent to transition into supervised clinical practice and provided a framework for demonstrating that competencies for independent clinical practice have been met. Without a developmental trajectory, the competencies alone might not support the “transition to practice” [48]; however, the trajectory outlined by the MR-NP might. Our future work will focus on examining the uptake and buy-in to this particular MR-NP at our institution beyond our research group, and the generation of actionable evidence that supports the accreditation claim that the target NONPF competencies are not simply aspirational, but descriptive [49]. The support of the MR-NP of transition to practice is another avenue for research.
In conclusion, these results support the use of an explicit developmental trajectory, like the MR-NP, to promote learning and assessment to ensure that competencies are both achieved by students and explicitly supported throughout the curriculum and throughout the transition to practice.
Supporting information
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- Factors influencing bird-building collisions in the downtown area of a major North American city
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- Sex differences in the treatment and outcome of emergency general surgery
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- Barriers to integration of bioinformatics into undergraduate life sciences education: A national study of US life sciences faculty uncover significant barriers to integrating bioinformatics into undergraduate instruction
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- Being there: A scoping review of grief support training in medical education
- Does the psychological profile influence the position of promising young futsal players?
- Effect of self-rated health status on functioning difficulties among older adults in Ghana: Coarsened exact matching method of analysis of the World Health Organization’s study on global AGEing and adult health, Wave 2
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- Psychological and physiological effects of applying self-control to the mobile phone
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- Modulating transcription through development of semi-synthetic yeast core promoters
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- The impact of hepatic steatosis on portal hypertension
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- School-based obesity prevention for busy low-income families—Organisational and personal barriers and facilitators to implementation
- Neighborhood crime, disorder and substance use in the Caribbean context: Jamaica National Drug Use Prevalence Survey 2016
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- Nurses’ and patients’ experiences and preferences of the ankle-brachial pressure index and multi-site photoplethysmography for the diagnosis of peripheral arterial disease: A qualitative study
- Cluster tendency assessment in neuronal spike data
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- Methods for the identification of farm escapees in feral mink (Neovison vison) populations
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- Pan-caspase inhibitor F573 mitigates liver ischemia reperfusion injury in a murine model
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- Association of thoracic spine deformity and cardiovascular disease in a mouse model for Marfan syndrome
- Predicting atrial fibrillation in primary care using machine learning
- M3VR—A multi-stage, multi-resolution, and multi-volumes-of-interest volume registration method applied to 3D endovaginal ultrasound
- A developmental trajectory supporting the evaluation and achievement of competencies: Articulating the Mastery Rubric for the nurse practitioner (MR-NP) program curriculum
- Mobile medication manager application to improve adherence with immunosuppressive therapy in renal transplant recipients: A randomized controlled trial
- Default Mode Network structural alterations in Kocher-Monro trajectory white matter transection: A 3 and 7 tesla simulation modeling approach
- Phylogenetic revision of Gymnotidae (Teleostei: Gymnotiformes), with descriptions of six subgenera
- Population genetic analysis of 36 Y-chromosomal STRs yields comprehensive insights into the forensic features and phylogenetic relationship of Chinese Tai-Kadai-speaking Bouyei
- Prevention of suicidal behaviour: Results of a controlled community-based intervention study in four European countries
- An assessment of khat consumption habit and its linkage to household economies and work culture: The case of Harar city
- Fixation of genetic variation and optimization of gene expression: The speed of evolution in isolated lizard populations undergoing Reverse Island Syndrome
- One simple claudication question as first step in Peripheral Arterial Disease (PAD) screening: A meta-analysis of the association with reduced Ankle Brachial Index (ABI) in 27,945 subjects
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- A qualitative research synthesis of contextual factors contributing to female overweight and obesity over the life course in sub-Saharan Africa
- Insight into the relationship between aryl-hydrocarbon receptor and β-catenin in human colon cancer cells
- Hidden noise in immunologic parameters might explain rapid progression in early-onset periodontitis
- The role of stigma in the acceptance and disclosure of HIV among recently diagnosed men who have sex with men in Australia: A qualitative study
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- Questioning the lasting effect of galvanic vestibular stimulation on postural control
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- The mutational landscape of quinolone resistance in Escherichia coli
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- EPILAT-IRA Study: A contribution to the understanding of the epidemiology of acute kidney injury in Latin America
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- Development of a novel automatable fabrication method based on electrospinning co electrospraying for rotator cuff augmentation patches
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- Respiratory health and inflammatory markers - Exposure to respirable dust and quartz and chemical binders in Swedish iron foundries
- Trends and predictors of mother-to-child transmission of HIV in an era of protocol changes: Findings from two large health facilities in North East Nigeria
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- The household economic costs associated with depression symptoms: A cross-sectional household study conducted in the North West province of South Africa
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- Acute Influenza A virus outbreak in an enzootic infected sow herd: Impact on viral dynamics, genetic and antigenic variability and effect of maternally derived antibodies and vaccination
- Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon
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- CRISPR/Cas9 gene editing in the West Nile Virus vector, Culex quinquefasciatus Say
- Genetic susceptibility to angiotensin-converting enzyme-inhibitor induced angioedema: A systematic review and evaluation of methodological approaches
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- Comparative distribution of extended-spectrum beta-lactamase–producing Escherichia coli from urine infections and environmental waters
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- Intolerance of uncertainty fuels depressive symptoms through rumination: Cross-sectional and longitudinal studies
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- The association between self-efficacy and self-management behaviors among Chinese patients with type 2 diabetes
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- Affective disorders in the elderly in different European countries: Results from the MentDis_ICF65+ study
- Evaluation of forearm vascular resistance during orthostatic stress: Velocity is proportional to flow and size doesn’t matter
- Proton pencil minibeam irradiation of an in-vivo mouse ear model spares healthy tissue dependent on beam size
- Maternal stress in Shank3ex4-9 mice increases pup-directed care and alters brain white matter in male offspring
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- Exploiting open source 3D printer architecture for laboratory robotics to automate high-throughput time-lapse imaging for analytical microbiology
- Long non-coding RNAs and latent HIV – A search for novel targets for latency reversal
- Clinical characteristics of neonatal fulminant necrotizing enterocolitis in a tertiary Children's hospital in the last 10 years
- Effects of neuromuscular electrical stimulation training on muscle size in collegiate track and field athletes
- Adaptive fuzzy flow rate control considering multifractal traffic modeling and 5G communications
- Evaluation of four commercial tests for detecting ceftiofur in waste milk bulk tank samples
- A smart tele-cytology point-of-care platform for oral cancer screening
- Vasopressin SNP pain factors and stress in sickle cell disease
- Carbonate production of Micronesian reefs suppressed by thermal anomalies and Acanthaster as sea-level rises
- Microbial metabolisms in an abyssal ferromanganese crust from the Takuyo-Daigo Seamount as revealed by metagenomics
- Incidence of chronic kidney disease hospitalisations and mortality in Espírito Santo between 1996 to 2017
- The impact of short-term machine perfusion on the risk of cancer recurrence after rat liver transplantation with donors after circulatory death
- Proteomic profiling of the thrombin-activated canine platelet secretome (CAPS)
- Blood metal levels and serum testosterone concentrations in male and female children and adolescents: NHANES 2011–2012
- The effects of prolonged single night session of videogaming on sleep and declarative memory
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- Mapping developmental QTL for plant height in soybean [Glycine max (L.) Merr.] using a four-way recombinant inbred line population
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- Positive selection and precipitation effects on the mitochondrial NADH dehydrogenase subunit 6 gene in brown hares (Lepus europaeus) under a phylogeographic perspective
- Evaluation of Minimum Inhibitory Concentrations for 154 Mycoplasma synoviae isolates from Italy collected during 2012-2017
- Enhancement of antibiotics antimicrobial activity due to the silver nanoparticles impact on the cell membrane
- Correction: Smoking, alcohol use disorder and tuberculosis treatment outcomes: A dual co-morbidity burden that cannot be ignored
- Correction: Effect of corruption on perceived difficulties in healthcare access in sub-Saharan Africa
- Knowledge-based best of breed approach for automated detection of clinical events based on German free text digital hospital discharge letters
- Importance of thorough tissue and cellular level characterization of targeted drugs in the evaluation of pharmacodynamic effects
- Integrated value-chain and risk assessment of Pig-Related Zoonoses in Ghana
- Failed sperm retrieval from severely oligospermic or non-obstructive azoospermic patients on oocyte retrieval day: Emergent oocyte cryopreservation is a feasible strategy
- Cassava yield traits predicted by genomic selection methods
- Verification of hub genes in the expression profile of aortic dissection
- Pig farmers’ willingness to pay for management strategies to reduce aggression between pigs
- Metabolomic response of Euglena gracilis and its bleached mutant strain to light
- Diagnostic value of ASVS for insulinoma localization: A systematic review and meta-analysis
- Newly educated care managers’ experiences of providing care for persons with stress-related mental disorders in the clinical primary care context
- Real-time telemetry monitoring of oxygen in the central complex of freely-walking Gromphadorhina portentosa
- Qualification programmes for immigrant health professionals: A systematic review
- An analytical model to minimize the latency in healthcare internet-of-things in fog computing environment
- Grain filling of early-season rice cultivars grown under mechanical transplanting
- Intercalation of small molecules into DNA in chromatin is primarily controlled by superhelical constraint
- Correlative evidence for co-regulation of phosphorus and carbon exchanges with symbiotic fungus in the arbuscular mycorrhizal Medicago truncatula
- How to design a dose-finding study on combined agents: Choice of design and development of R functions
- Altered expression of Notch1 in Alzheimer's disease
- The ZJU index is a powerful surrogate marker for NAFLD in severely obese North American women
- Trunk velocity-dependent Light Touch reduces postural sway during standing
- Evaluation of cytological diagnostic accuracy for canine splenic neoplasms: An investigation in 78 cases using STARD guidelines
- Trade-offs in motivating volunteer effort: Experimental evidence on voluntary contributions to science
- Does caching strategy vary with microclimate in endangered Mt. Graham red squirrels?
- Assessment of energy expenditure during high intensity cycling and running using a heart rate and activity monitor in young active adults
- Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus)
- Implementation of a screening, brief intervention and referral to treatment programme for risky substance use in South African emergency centres: A mixed methods evaluation study
- Can the CalproQuest predict a positive Calprotectin test? A prospective diagnostic study
- The calcium sensor OsCBL1 modulates nitrate signaling to regulate seedling growth in rice
- Acceptability of and treatment preferences for recurrent bacterial vaginosis—Topical lactic acid gel or oral metronidazole antibiotic: Qualitative findings from the VITA trial
- Mathematical determination of the HIV-1 matrix shell structure and its impact on the biology of HIV-1
- Contingent negative variation during a modified cueing task in simulated driving
- CAMDI interacts with the human memory-associated protein KIBRA and regulates AMPAR cell surface expression and cognition
- Effect of feeding patterns on growth and nutritional status of children aged 0-24 months: A Chinese cohort study
- A fecal sequel: Testing the limits of a genetic assay for bat species identification
- Measuring the impact of chronic conditions and associated multimorbidity on health-related quality of life in the general population in Hong Kong SAR, China: A cross-sectional study
- Short and long-term clinical effectiveness and cost-effectiveness of a late-phase community-based balance and gait exercise program following hip fracture. The EVA-Hip Randomised Controlled Trial
- Vaccine cold chain in general practices: A prospective study in 75 refrigerators (Keep Cool study)
- Brazilian norms for the Bank of Standardized Stimuli (BOSS)
- Distinct varieties of aesthetic chills in response to multimedia
- Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses’ Health Study
- Correction: Resistance profile of the HIV-1 maturation inhibitor GSK3532795 in vitro and in a clinical study
- New formulation of the Gompertz equation to describe the kinetics of untreated tumors
- Development of visual perception of others’ actions: Children’s judgment of lifted weight
- Retrospective comparative analysis of intraocular lens calculation formulas after hyperopic refractive surgery
- Human vitreous concentrations of citicoline following topical application of citicoline 2% ophthalmic solution
- Development and validation of exhaled breath condensate microRNAs to identify and endotype asthma in children
- Arthroscopic release for frozen shoulder: Does the timing of intervention and diabetes affect outcome?
- Risk factors affecting dairy cattle protective grouping behavior, commonly known as bunching, against Stomoxys calcitrans (L.) on California dairies
- Acceleration of chemical shift encoding-based water fat MRI for liver proton density fat fraction and T2* mapping using compressed sensing
- Characterisation and microbial community analysis of lipid utilising microorganisms for biogas formation
- Sexuality in male partners of women with fibromyalgia syndrome: A qualitative study
- Exploring optimization strategies for improving explicit water models: Rigid n-point model and polarizable model based on Drude oscillator
- Artificial insemination with fresh, liquid stored and frozen thawed semen in dromedary camels
- Moving into an urban drug scene among people who use drugs in Vancouver, Canada: Latent class growth analysis
- Numerical study on the start and unstart phenomena in a scramjet inlet-isolator model
- Effects of dietary supplementation with apple peel powder on the growth, blood and liver parameters, and transcriptome of genetically improved farmed tilapia (GIFT, Oreochromis niloticus)
- Urban growth simulation in different scenarios using the SLEUTH model: A case study of Hefei, East China
- Chronic bronchitis without airflow obstruction, asthma and rhinitis are differently associated with cardiovascular risk factors and diseases
- Factors associated with medication adherence among people with diabetes mellitus in poor urban areas of Cambodia: A cross-sectional study
- Mammary microbiome of lactating organic dairy cows varies by time, tissue site, and infection status
- Force field generalization and the internal representation of motor learning
- Polyphenism of visual and chemical secondary sexually-selected wing traits in the butterfly Bicyclus anynana: How different is the intermediate phenotype?
- Minimal genetic differentiation of the malaria vector Nyssorhynchus darlingi associated with forest cover level in Amazonian Brazil
- The impact of leisure activities on older adults’ cognitive function, physical function, and mental health
- scafSLICR: A MATLAB-based slicing algorithm to enable 3D-printing of tissue engineering scaffolds with heterogeneous porous microarchitecture
- Association of serum leptin and adiponectin concentrations with echocardiographic parameters and pathophysiological states in patients with cardiovascular disease receiving cardiovascular surgery
- Operation of cognitive memory inhibition in adults with Down syndrome: Effects of maintenance load and material
- Influences on surgical antimicrobial prophylaxis decision making by surgical craft groups, anaesthetists, pharmacists and nurses in public and private hospitals
- Post-treatment Lyme disease symptoms score: Developing a new tool for research
- Expression of Concern: The Role of the RACK1 Ortholog Cpc2p in Modulating Pheromone-Induced Cell Cycle Arrest in Fission Yeast
- Equine bronchial fibroblasts enhance proliferation and differentiation of primary equine bronchial epithelial cells co-cultured under air-liquid interface
- Investigating cooperation with robotic peers
- Synthesis, purification and crystallization of a putative critical bulge of HAR1 RNA
- Prosthetic push-off power in trans-tibial amputee level ground walking: A systematic review
- A case study of the use of verbal reports for talent identification purposes in soccer: A Messi affair!
- Transgenerational deep sequencing revealed hypermethylation of hippocampal mGluR1 gene with altered mRNA expression of mGluR5 and mGluR3 associated with behavioral changes in Sprague Dawley rats with history of prolonged febrile seizure
- Obesity is associated with an impaired survival in lymphoma patients undergoing autologous stem cell transplantation
- Periodontal disease: Repercussions in pregnant woman and newborn health—A cohort study
- Origins of Chinese reindeer (Rangifer tarandus) based on mitochondrial DNA analyses
- Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in Africa: A systematic review and meta-analysis
- How effective are films in inducing positive and negative emotional states? A meta-analysis
- 3D nanostructural characterisation of grain boundaries in atom probe data utilising machine learning methods
- An outbreak of tuberculosis in a middle school in Henan, China: Epidemiology and risk factors
- Initial clinical radiological findings and staging to predict prognosis of primary hepatic angiosarcoma: A retrospective analysis
- A new early Eocene deperetellid tapiroid illuminates the origin of Deperetellidae and the pattern of premolar molarization in Perissodactyla
- Longevity and marginal bone loss of narrow-diameter implants supporting single crowns: A systematic review
- Impact of UVC-sustained recirculating air filtration on airborne bacteria and dust in a pig facility
- Cold-related Florida manatee mortality in relation to air and water temperatures
- Conceptual fluency in inductive reasoning
- Clinical outcomes and treatment patterns among Medicare patients with nonvalvular atrial fibrillation (NVAF) and chronic kidney disease
- Improvements in the learnability of smartphone haptic interfaces for visually impaired users
- Role of the malic enzyme in metabolism of the halotolerant methanotroph Methylotuvimicrobium alcaliphilum 20Z
- Cyclic loading test study on a new cast-in-situ insulated sandwich concrete wall
- Natural compounds as angiogenic enzyme thymidine phosphorylase inhibitors: In vitro biochemical inhibition, mechanistic, and in silico modeling studies
- Analysis of virulence potential of Escherichia coli O145 isolated from cattle feces and hide samples based on whole genome sequencing
- Pre-clinical medical student reflections on implicit bias: Implications for learning and teaching
- Prognostic significance of non-sustained ventricular tachycardia on stored electrograms in pacemaker recipients
- Determinants of preterm birth among mothers who gave birth at public hospitals in the Amhara region, Ethiopia: A case-control study
- Real-world evidence of the effectiveness of ombitasvir-paritaprevir/r ± dasabuvir ± ribavirin in patients monoinfected with chronic hepatitis C or coinfected with human immunodeficiency virus-1 in Spain
- Unique transcriptomic landscapes identified in idiopathic spontaneous and infection related preterm births compared to normal term births
- Restrained expansion of the recall germinal center response as biomarker of protection for influenza vaccination in mice
- Arabidopsis TRM5 encodes a nuclear-localised bifunctional tRNA guanine and inosine-N1-methyltransferase that is important for growth
- Achievement of weight loss in patients with overweight during dietetic treatment in primary health care
- Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation
- The impacts of parity on lung function data (LFD) of healthy females aged 40 years and more issued from an upper middle income country (Algeria): A comparative study
- Reorganization of spatial configurations in visual working memory: A matter of set size?
- Unravelling travellers’ route choice behaviour at full-scale urban network by focusing on representative OD pairs in computer experiments
- Evaluating the higher-order structure of the Profile of Emotional Competence (PEC): Confirmatory factor analysis and Bayesian structural equation modeling
- HIV prevalence and correlated factors among male clients of female sex workers in a border region of China
- Next generation sequencing and RNA-seq characterization of adipose tissue in the Nile crocodile (Crocodylus niloticus) in South Africa: Possible mechanism(s) of pathogenesis and pathophysiology of pansteatitis
- Association between advanced maternal age and maternal and neonatal morbidity: A cross-sectional study on a Spanish population
- Ethnic differences in the prevalence, socioeconomic and health related risk factors of knee pain and osteoarthritis symptoms in older Malaysians
- Increasing knowledge of HIV status in a country with high HIV testing coverage: Results from the Botswana Combination Prevention Project
- Friends with benefits: The effects of vegetative shading on plant survival in a green roof environment
- Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis
- Identifying candidate diagnostic markers for early stage of non-small cell lung cancer
- Complex alternative splicing of human Endonuclease V mRNA, but evidence for only a single protein isoform
- Correction: KML001 Induces Apoptosis and Autophagic Cell Death in Prostate Cancer Cells via Oxidative Stress Pathway
- Unique developmental trajectories of risk behaviors in adolescence and associated outcomes in young adulthood
- Enhanced fibrinolysis detection in a natural occurring canine model with intracavitary effusions: Comparison and degree of agreement between thromboelastometry and FDPs, D-dimer and fibrinogen concentrations
- Overexpression of Saussurea involucrata dehydrin gene SiDHN promotes cold and drought tolerance in transgenic tomato plants
- Foxtail millet (Setaria italica (L.) P. Beauv) CIPKs are responsive to ABA and abiotic stresses
- Autonomous drone hunter operating by deep learning and all-onboard computations in GPS-denied environments
- Heterogeneity Diffusion Imaging of gliomas: Initial experience and validation
- Frequency cluster formation and slow oscillations in neural populations with plasticity
- DHP23002 as a next generation oral paclitaxel formulation for pancreatic cancer therapy
- Diagnostic accuracy of SOX11 immunohistochemistry in mantle cell lymphoma: A meta-analysis
- Analytical solution to swing equations in power grids
- Pathways to conspiracy: The social and linguistic precursors of involvement in Reddit’s conspiracy theory forum
- Spatiotemporally random and diverse grid cell spike patterns contribute to the transformation of grid cell to place cell in a neural network model
- Empathic concern and personal distress depend on situational but not dispositional factors
- Who is more susceptible to job stressors and resources? Sensory-processing sensitivity as a personal resource and vulnerability factor
- Cost-effectiveness of integrating postpartum antiretroviral therapy and infant care into maternal & child health services in South Africa
- A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
- One step at a time: Physical activity is linked to positive interpretations of ambiguity
- Calreticulin regulates vascular endothelial growth factor-A mRNA stability in gastric cancer cells
- Evaluation of various methods of selection of B. subtilis strains capable of secreting surface-active compounds
- Association between US Pharmacopeia (USP) monograph standards, generic entry and prescription drug costs
- Molecular characterisation of the synovial fluid microbiome in rheumatoid arthritis patients and healthy control subjects
- On sorption hysteresis in wood: Separating hysteresis in cell wall water and capillary water in the full moisture range
- Inbreeding, Allee effects and stochasticity might be sufficient to account for Neanderthal extinction
- Reliability and construct validity of the stepping-forward affordance perception test for fall risk assessment in community-dwelling older adults
- Socioeconomic determinants of nutritional status among ‘Baiga’ tribal children In Balaghat district of Madhya Pradesh: A qualitative study
- Study on characteristics of fire plume in building facade window under lateral blow
- ‘When you talk to someone in a bad way or always put her under pressure, it is actually worse than beating her’: Conceptions and experiences of emotional intimate partner violence in Rwanda and South Africa
- Effects of 6-mercaptopurine in pressure overload induced right heart failure
- The association between haemoglobin levels in the first 20 weeks of pregnancy and pregnancy outcomes
- Implementation and evaluation of an antimicrobial stewardship programme in companion animal clinics: A stepped-wedge design intervention study
- Factors associated with persistently high-cost health care utilization for musculoskeletal pain
- Nitrogen and chlorophyll status determination in durum wheat as influenced by fertilization and soil management: Preliminary results
- Effect of repeated in vivo microCT imaging on the properties of the mouse tibia
- Coupling environment and physiology to predict effects of climate change on the taxonomic and functional diversity of fish assemblages in the Murray-Darling Basin, Australia
- Hematology and plasma biochemistries in the Blanding’s turtle (Emydoidea blandingii) in Lake County, Illinois
- CRISPR-Cas influences the acquisition of antibiotic resistance in Klebsiella pneumoniae
- Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors
- Antidepressant prescriptions, discontinuation, depression and perinatal outcomes, including breastfeeding: A population cohort analysis
- Why men with a low-risk prostate cancer select and stay on active surveillance: A qualitative study
- Imported severe malaria and risk factors for intensive care: A single-centre retrospective analysis
- Combined treatment (image-guided thrombectomy and endovascular therapy with open femoral access) for acute lower limb ischemia: Clinical efficacy and outcomes
- Low-latency single channel real-time neural spike sorting system based on template matching
- Quantifying the scale effect in geospatial big data using semi-variograms
- Paper-and-pencil versus computerized administration mode: Comparison of data quality and risk behavior prevalence estimates in the European school Survey Project on Alcohol and other Drugs (ESPAD)
- Regression adjusted colocalisation colour mapping (RACC): A novel biological visual analysis method for qualitative colocalisation analysis of 3D fluorescence micrographs
- Ostrich eggshell bead diameter in the Holocene: Regional variation with the spread of herding in eastern and southern Africa
- Spatial and temporal variations in female size at maturity of a Southern Rock Lobster (Jasus edwardsii) population: A likely response to climate change
- Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells
- Training rhesus macaques to take daily oral antiretroviral therapy for preclinical evaluation of HIV prevention and treatment strategies
- Left ventricular structural and functional changes in Friedreich ataxia – Relationship with body size, sex, age and genetic severity
- Magnitude and factors associated with anemia among pregnant women attending antenatal care in Bench Maji, Keffa and Sheka zones of public hospitals, Southwest, Ethiopia, 2018: A cross -sectional study
- Effectiveness of telerehabilitation in the management of adults with stroke: A systematic review
- Hydrogen sulphide-induced hypometabolism in human-sized porcine kidneys
- Correction: Comparison of the molecular properties of retinitis pigmentosa P23H and N15S amino acid replacements in rhodopsin
- Retraction: Regulation of gastric smooth muscle contraction via Ca2+-dependent and Ca2+-independent actin polymerization
- Evaluation of neutral oral contrast agents for assessment of the small bowel at abdominal staging CT
- Blood type and breed-associated differences in cell marker expression on equine bone marrow-derived mesenchymal stem cells including major histocompatibility complex class II antigen expression
- Induced abortion and future use of IVF treatment; A nationwide register study
- Psychosocial determinants of sustained maternal functional impairment: Longitudinal findings from a pregnancy-birth cohort study in rural Pakistan
- Measurement of finger joint angle using stretchable carbon nanotube strain sensor
- Determinants of mortality among patients with drug-resistant tuberculosis in northern Nigeria
- Drugs modulating stochastic gene expression affect the erythroid differentiation process
- Efficacy of UB0316, a multi-strain probiotic formulation in patients with type 2 diabetes mellitus: A double blind, randomized, placebo controlled study
- Prognostic value of des-γ-carboxy prothrombin in patients with hepatocellular carcinoma treated with transarterial chemotherapy: A systematic review and meta-analysis
- Avermectin induces the oxidative stress, genotoxicity, and immunological responses in the Chinese Mitten Crab, Eriocheir sinensis
- Antibiotic use in mandarin production (Citrus reticulata Blanco) in major mandarin-producing areas in Thailand: A survey assessment
- Application of CPI cutoff value based on parentage testing of duos and trios typed by four autosomal kits
- Correction: Good and Bad in the Hands of Politicians: Spontaneous Gestures during Positive and Negative Speech
- Adolescents with worse levels of oral health literacy have more cavitated carious lesions
- Effective methods for the inactivation of Francisella tularensis
- Detection of early-stage Alzheimer’s pathology using blood-based autoantibody biomarkers in elderly hip fracture repair patients
- Correlation between internal pudendal artery stenosis and erectile dysfunction in patients with suspected coronary artery disease
- Analysis of HER2 genomic binding in breast cancer cells identifies a global role in direct gene regulation
- Population productivity of shovelnose rays: Inferring the potential for recovery
- Correction: Long-term clinical outcomes in a cohort of patients with solitary plasmacytoma treated in the modern era
- Effects of tetracycline on myocardial infarct size in obese rats with chemically-induced colitis
- Mineral absorption is an enriched pathway in a brain region of restless legs syndrome patients with reduced MEIS1 expression
- Changes in weight and body composition across five years at university: A prospective observational study
- Adeno-associated virus-mediated expression of human butyrylcholinesterase to treat organophosphate poisoning
- Effects of insulin signaling on mouse taste cell proliferation
- Patient-level cost of home- and facility-based child pneumonia treatment in Suba Sub County, Kenya
- TAP: A static analysis model for PHP vulnerabilities based on token and deep learning technology
- Cost-effectiveness of QuantiFERON-TB Gold In-Tube versus tuberculin skin test for diagnosis and treatment of Latent Tuberculosis Infection in primary health care workers in Brazil
- Multifaceted intervention for the prevention and management of musculoskeletal pain in nursing staff: Results of a cluster randomized controlled trial
- Changes over time in creatinine clearance and comparison of emergent adverse events for HIV-positive adults receiving standard doses (300 mg/day) of lamivudine-containing antiretroviral therapy with baseline creatinine clearance of 30–49 vs ≥50 mL/min
- Population dynamics of foxes during restricted-area culling in Britain: Advancing understanding through state-space modelling of culling records
- Impacts of experimental advisory exit speed sign on traffic speeds for freeway exit ramp
- In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium
- Monitoring quality indicators for the Xpert MTB/RIF molecular assay in Ethiopia
- Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids
- Correction: Using remote sensing to detect whale strandings in remote areas: The case of sei whales mass mortality in Chilean Patagonia
- Comparison of the inoculum size effects of antibiotics on IMP-6 β-lactamase-producing Enterobacteriaceae co-harboring plasmid-mediated quinolone resistance genes
- Contrast-enhanced computed tomography findings of canine primary renal tumors including renal cell carcinoma, lymphoma, and hemangiosarcoma
- Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720
- Overexpression of pink1 or parkin in indirect flight muscles promotes mitochondrial proteostasis and extends lifespan in Drosophila melanogaster
- Fiber stiffness, pore size and adhesion control migratory phenotype of MDA-MB-231 cells in collagen gels
- Comparison of two experimental ARDS models in pigs using electrical impedance tomography
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- Stroke risks in women with dysmenorrhea by age and stroke subtype
- Changes in patterns of mortality rates and years of life lost due to firearms in the United States, 1999 to 2016: A joinpoint analysis
- In vitro modeling of Batrachochytrium dendrobatidis infection of the amphibian skin
- Development and validation of LC-MS/MS method for imatinib and norimatinib monitoring by finger-prick DBS in gastrointestinal stromal tumor patients
- Correction: Habitat disturbance and the organization of bacterial communities in Neotropical hematophagous arthropods
- Characterisation of early metazoan secretion through associated signal peptidase complex subunits, prohormone convertases and carboxypeptidases of the marine sponge (Amphimedon queenslandica)
- Time trends between 2002 and 2017 in correlates of self-reported sitting time in European adults
- Performance of patient acuity rating by rapid response team nurses for predicting short-term prognosis
- Changes in HbA1c during the first six years after the diagnosis of Type 2 diabetes mellitus predict long-term microvascular outcomes
- Correction: Antimicrobial resistance genotypes and phenotypes of Campylobacter jejuni isolated in Italy from humans, birds from wild and urban habitats, and poultry
- Correction: Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Establishing an infrastructure for collaboration in primate cognition research
- Correction: The impact of public health insurance on health care utilisation, financial protection and health status in low- and middle-income countries: A systematic review
- Health provider and service-user experiences of sensory modulation rooms in an acute inpatient psychiatry setting
- Comparison of potential drug-drug interactions with metabolic syndrome medications detected by two databases
- The Polish version of the Cultural Intelligence Scale: Assessment of its reliability and validity among healthcare professionals and medical faculty students
- Selection of optimal reference genes for qRT-PCR analysis of shoot development and graviresponse in prostrate and erect chrysanthemums
- Metastasis risk prediction model in osteosarcoma using metabolic imaging phenotypes: A multivariable radiomics model
- Defining hospital community benefit activities using Delphi technique: A comparison between China and the United States
- Establishment of the experimental procedure for prediction of conjugation capacity in mutant UGT1A1
- A robust multi-objective optimization framework to capture both cellular and intercellular properties in cardiac cellular model tuning: Analyzing different regions of membrane resistance profile in parameter fitting
- Sea star wasting disease demography and etiology in the brooding sea star Leptasterias spp.
- Diagnostic plasma miRNA-profiles for ovarian cancer in patients with pelvic mass
- Genetic diversity and drug resistance of HIV-1 among infected pregnant women newly diagnosed in Luanda, Angola
- I’ve been robbed! – Can changes in floral traits discourage bee pollination?
- Visualising statistical models using dynamic nomograms
- Assessing the capacity of Malawi’s district and central hospitals to manage traumatic diaphyseal femoral fractures in adults
- Diagnostic performance of basal cortisol level at 0900-1300h in adrenal insufficiency
- The Mastery Rubric for Bioinformatics: A tool to support design and evaluation of career-spanning education and training
- Microdissection and whole chromosome painting confirm karyotype transformation in cryptic species of the Lariophagus distinguendus (Förster, 1841) complex (Hymenoptera: Pteromalidae)
- Quality of Kangaroo Mother Care services in Ethiopia: Implications for policy and practice
- Gemcitabine potentiates the anti-tumour effect of radiation on medullary thyroid cancer
- iTRAQ-based high-throughput proteomics analysis reveals alterations of plasma proteins in patients infected with human bocavirus
- The detection of a non-anemophilous plant species using airborne eDNA
- Perception and control of low cable operation forces in voluntary closing body-powered upper-limb prostheses
- Neoadjuvant chemotherapy plus surgery versus concurrent chemoradiotherapy in stage IB2-IIB cervical cancer: A systematic review and meta-analysis
- Randomized methods to characterize large-scale vortical flow networks
- Disentangling the coexistence strategies of mud-daubing wasp species through trophic analysis in oases of Baja California peninsula
- Front-of-pack nutritional labels: Understanding by low- and middle-income Mexican consumers
- Distress in patients with end-stage renal disease: Staff perceptions of barriers to the identification of mild-moderate distress and the provision of emotional support
- Pathways to antibiotics in Bangladesh: A qualitative study investigating how and when households access medicine including antibiotics for humans or animals when they are ill
- DOC export is exceeded by C fixation in May Creek: A late-successional watershed of the Copper River Basin, Alaska
- Behavioral observation of prosocial behavior and social initiative is related to preschoolers’ psychopathological symptoms
- Evaluating the impact of citations of articles based on knowledge flow patterns hidden in the citations
- Correction: Economic sanctions and academia: Overlooked impact and long-term consequences
- Correction: A novel association between relaxin receptor polymorphism and hematopoietic stem cell yield after mobilization
- Expression of Concern: Cooperativity of Oncogenic K-Ras and Downregulated p16/INK4A in Human Pancreatic Tumorigenesis
- Price dispersion of generic medications
- Sex differences in body composition but not neuromuscular function following long-term, doxycycline-induced reduction in circulating levels of myostatin in mice
- The emotion regulation effect of cognitive control is related to depressive state through the mediation of rumination: An ERP study
- Comparison of SMS-EPI and 3D-EPI at 7T in an fMRI localizer study with matched spatiotemporal resolution and homogenized excitation profiles
- Left ventricular mass normalization for body size in children based on an allometrically adjusted ratio is as accurate as normalization based on the centile curves method
- Correction: Combining biophysical parameters, spectral indices and multivariate hyperspectral models for estimating yield and water productivity of spring wheat across different agronomic practices
- Correction: Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- 'Small small quarrels bring about happiness or love in the relationships’: Exploring community perceptions and gendered norms contributing to male perpetrated intimate partner violence in the Central Region of Ghana
- The performance of practitioners conducting facial comparisons on images of children across age
- Increased amounts and stability of telomeric repeat-containing RNA (TERRA) following DNA damage induced by etoposide
- Patients with limitation or withdrawal of life supporting care admitted in a medico-surgical intermediate care unit: Prevalence, description and outcome over a six-month period
- Correction: Diverse radiofrequency sensitivity and radiofrequency effects of mobile or cordless phone near fields exposure in Drosophila melanogaster
- Predicting the performance of TV series through textual and network analysis: The case of Big Bang Theory
- Risk of temperature, humidity and concentrations of air pollutants on the hospitalization of AECOPD
- Mixed methods grant applications in the health sciences: An analysis of reviewer comments
- Renal abnormalities among children with sickle cell conditions in highly resource-limited setting in Ghana
- Size matters: How reaching and vergence movements are influenced by the familiar size of stereoscopically presented objects
- Willingness to receive institutional and community-based eldercare among the rural elderly in China
- An improved deep learning method for predicting DNA-binding proteins based on contextual features in amino acid sequences
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- A LAMP assay for the rapid and robust assessment of Wolbachia infection in Aedes aegypti under field and laboratory conditions
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- Correction: A 1D computer model of the arterial circulation in horses: An important resource for studying global interactions between heart and vessels under normal and pathological conditions
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- Correction: Identifying performance benchmarks and determinants for reproductive performance and calf survival using a longitudinal field study of cow-calf herds in western Canada
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- Association between trunk and gluteus muscle size and long jump performance
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- Correction: Interspecific Phylogenic Relationships within Genus Melilotus Based on Nuclear and Chloroplast DNA
- Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions
- Wolf diet and prey selection in the South-Eastern Carpathian Mountains, Romania
- In vitro activity of aryl-thiazole derivatives against Schistosoma mansoni schistosomula and adult worms
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- Correction: KETOS: Clinical decision support and machine learning as a service – A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services
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- Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile
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- SSR marker development in Clerodendrum trichotomum using transcriptome sequencing
- Risk factors for the carriage of Streptococcus infantarius subspecies infantarius isolated from African fermented dairy products
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- In vitro endothelial cell migration from limbal edge-modified Quarter-DMEK grafts
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- Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS
- Complete Chloroplast Genomes of Vachellia nilotica and Senegalia senegal: Comparative Genomics and Phylogenomic Placement in a New Generic System
- Retraction: Over-Expression of Superoxide Dismutase Ameliorates Cr(VI) Induced Adverse Effects via Modulating Cellular Immune System of Drosophila melanogaster
- Effect of pre-season training phase on anthropometric, hormonal and fitness parameters in young soccer players
- Exosomes from conditioned media of bone marrow-derived mesenchymal stem cells promote bone regeneration by enhancing angiogenesis
- Outcome of patients with heart failure after transcatheter aortic valve implantation
- Fatty acid profile of Romanian’s common bean (Phaseolus vulgaris L.) lipid fractions and their complexation ability by β-cyclodextrin
- Appropriate empirical antibiotic therapy and mortality: Conflicting data explained by residual confounding
- Treatment of corneal endothelial damage in a rabbit model with a bioengineered graft using human decellularized corneal lamina and cultured human corneal endothelium
- Telbivudine on IgG-associated hypergammaglobulinemia and TGF-β1 hyperactivity in hepatitis B virus-related liver cirrhosis
- Correction: Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
- Correction: Mobile health-based physical activity intervention for individuals with spinal cord injury in the community: A pilot study
- Retraction: Placental expression of CD100, CD72 and CD45 is dysregulated in human miscarriage
- Correction: Use of IoT sensing and occupant surveys for determining the resilience of buildings to forest fire generated PM2.5
- Correction: The modulation of facial mimicry by attachment tendencies and their underlying affiliation motives in 3-year-olds: An EMG study
- Correction: Cognitive impairment in multiple sclerosis: An exploratory analysis of environmental and lifestyle risk factors
- Discovering novel disease comorbidities using electronic medical records
- Glutathione contributes to efficient post-Golgi trafficking of incoming HPV16 genome
- Epidemiology and antimicrobial resistance of methicillin-resistant Staphylococcus aureus isolates colonizing pigs with different exposure to antibiotics
- Social information use in adolescents: The impact of adults, peers and household composition
- Public practices on antibiotic use: A cross-sectional study among Qatar University students and their family members
- Effects of Topper Training on psychosocial problems, self-esteem, and peer victimisation in Dutch children: A randomised trial
- Comparative studies of two generations of NanoString nCounter System
- General practitioners’ perceptions of delayed antibiotic prescription for respiratory tract infections: A phenomenographic study
- Can altered magnetic field affect the foraging behaviour of ants?
- Parasitic infections and medical expenses according to Health Insurance Review Assessment claims data in South Korea, 2011–2018
- A prospective observational study of on-treatment plasma homocysteine levels as a biomarker of toxicity, depression and vitamin supplementation lead-in time pre pemetrexed, in patients with non-small cell lung cancer and malignant mesothelioma
- A strategy to identify protein-N-myristoylation-dependent phosphorylation reactions of cellular proteins by using Phos-tag SDS-PAGE
- Expression profile of sonic hedgehog signaling-related molecules in basal cell carcinoma
- Seasonal alternation of the ontogenetic development of the moon jellyfish Aurelia coerulea in Maizuru Bay, Japan
- Reliability of measurement of active trunk movement in wheelchair basketball players
- Chinese SLE Treatment and Research group (CSTAR) registry: Clinical significance of thrombocytopenia in Chinese patients with systemic lupus erythematosus
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- Male-pattern baldness and incident coronary heart disease and risk factors in the Heinz Nixdorf Recall Study
- Quality and utilization patterns of maternity waiting homes at referral facilities in rural Zambia: A mixed-methods multiple case analysis of intervention and standard of care sites
- Determining an optimal pool size for testing beef herds for Johne’s disease in Australia
- Correction: Change in larval fish assemblage in a USA east coast estuary estimated from twenty-six years of fixed weekly sampling
- APOE-knockout in rabbits causes loss of cells in nucleus pulposus and enhances the levels of inflammatory catabolic cytokines damaging the intervertebral disc matrix
- Testing Species Assignments in Extant Terebratulide Brachiopods: A Three-dimensional Geometric Morphometric Analysis of Long-Looped Brachidia
- A daily diary study on maladaptive daydreaming, mind wandering, and sleep disturbances: Examining within-person and between-persons relations
- Improved chemotherapy modeling with RAG-based immune deficient mice
- Effect of tracheal antimicrobial peptide on the development of Mannheimia haemolytica pneumonia in cattle
- The internal realities of individuals with type 2 diabetes – a functional framework of self-management practices via Grounded Theory approach
- Role of platelet parameters in early detection and prediction of severity of preeclampsia: A comparative cross-sectional study at Ayder comprehensive specialized and Mekelle general hospitals, Mekelle, Tigray, Ethiopia
- eIF4E and 4EBP1 are prognostic markers of head and neck squamous cell carcinoma recurrence after definitive surgery and adjuvant radiotherapy
- Smoking and other determinants of bone turnover
- Oxygen delivery, oxygen consumption and decreased kidney function after cardiopulmonary bypass
- School engagement of children in early grades: Psychometric, and gender comparisons
- Correction: A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
- Perceived attractiveness of Czech faces across 10 cultures: Associations with sexual shape dimorphism, averageness, fluctuating asymmetry, and eye color
- Discovery of stable and prognostic CT-based radiomic features independent of contrast administration and dimensionality in oesophageal cancer
- Correction: Population-based dementia prediction model using Korean public health examination data: A cohort study
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- Correction: ISED: Constructing a high-resolution elevation road dataset from massive, low-quality in-situ observations derived from geosocial fitness tracking data
- Correction: Use of validated objective methods of locomotion characteristics and weight distribution for evaluating the efficacy of ketoprofen for alleviating pain in cows with limb pathologies
- Monitoring fine root growth to identify optimal fertilization timing in a forest plantation: A case study in Northeast Vietnam
- Metabolic costs of spontaneous swimming in Sprattus sprattus L., at different water temperatures
- Enterovirus 71 vaccine acceptance among parents of children < 5 years old and their knowledge of hand, foot and mouth disease, Chongqing, China, 2017
- Correction: Transcriptome profiling of mouse brain and lung under Dip2a regulation using RNA-sequencing
- Genetic diversity and antiretroviral resistance-associated mutation profile of treated and naive HIV-1 infected patients from the Northwest and Southwest regions of Cameroon
- Maximum parsimony interpretation of chromatin capture experiments
- Multiple innate antibacterial immune defense elements are correlated in diverse ungulate species
- Incidence and characteristics of ventricular tachycardia in patients after percutaneous coronary revascularization of chronic total occlusions
- Estimating measures of latent variables from m-alternative forced choice responses
- Clade F AAVHSCs cross the blood brain barrier and transduce the central nervous system in addition to peripheral tissues following intravenous administration in nonhuman primates
- First evidence of hepatitis E virus infection in a small mammal (yellow-necked mouse) from Croatia
- The inhibitory effects of polypyrrole on the biofilm formation of Streptococcus mutans
- Self-reported adverse drug effects and associated factors among H. pylori infected patients on standard triple therapy: Prospective follow up study
- Upregulation of ERK phosphorylation in rat dorsal root ganglion neurons contributes to oxaliplatin-induced chronic neuropathic pain
- Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
- Remote heart rate monitoring - Assessment of the Facereader rPPg by Noldus
- Seroprevalence of rubella virus antibodies among pregnant women in the Center and South-West regions of Cameroon
- Effectiveness of steam sterilization of reusable medical devices in primary and secondary care public hospitals in Nepal and factors associated with ineffective sterilization: A nation-wide cross-sectional study
- Relevance of HTLV-1 proviral load in asymptomatic and symptomatic patients living in endemic and non-endemic areas of Argentina
- Ritualized aggressive behavior reveals distinct social structures in native and introduced range tawny crazy ants
- The value of kinetic glomerular filtration rate estimation on medication dosing in acute kidney injury
- Screening and characterization of long noncoding RNAs involved in the albinism of Ananas comosus var. bracteatus leaves
- Visual attention to emotional faces in adolescents with social anxiety disorder receiving cognitive behavioral therapy
- A Q fever outbreak associated to courier transport of pets
- Antibodies against measles and rubella virus among different age groups in Thailand: A population-based serological survey
- Molecular diet analysis of Anguilliformes leptocephalus larvae collected in the western North Pacific
- Correction: The relationship between context, structure, and processes with outcomes of 6 regional diabetes networks in Europe
- Correction: The C-reactive protein/albumin ratio as an independent predictor of mortality in patients with severe sepsis or septic shock treated with early goal-directed therapy
- Interleukin 21 (IL-21) regulates chronic allograft vasculopathy (CAV) in murine heart allograft rejection
- Semantic computational analysis of anticoagulation use in atrial fibrillation from real world data
- The implementation of HTA in medicine pricing and reimbursement policies in Indonesia: Insights from multiple stakeholders
- International experiences during United States ophthalmology residency training: Current structure of international experiences and perspectives of faculty mentors at United States training institutions
- Questionable utility of digoxin in left-ventricular assist device recipients: A multicenter, retrospective analysis
- Genotyping and outcomes of presumptive second line ART failure cases switched to third line or maintained on second line ART in Mumbai, India
- A mathematical model of honey bee colony dynamics to predict the effect of pollen on colony failure
- Airway microbiome composition correlates with lung function and arterial stiffness in an age-dependent manner
- An odorant receptor from Anopheles gambiae that demonstrates enantioselectivity to the plant volatile, linalool
- Factors associated with full immunization of children 12–23 months of age in Ethiopia: A multilevel analysis using 2016 Ethiopia Demographic and Health Survey
- Additional evidence that the rat renal interstitium contracts in vivo
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- Removal efficiency of central vacuum system and protective masks to suspended particles from dental treatment
- Psychological well-being and distress in patients with generalized anxiety disorder: The roles of positive and negative functioning
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- An evaluation of genetic causes and environmental risks for bilateral optic atrophy
- Comparative vector competence of the Afrotropical soft tick Ornithodoros moubata and Palearctic species, O. erraticus and O. verrucosus, for African swine fever virus strains circulating in Eurasia
- Effects of the solubility of yeast cell wall preparations on their potential prebiotic properties in dogs
- Carbogen gas-challenge BOLD fMRI in assessment of liver hypoxia after portal microcapsules implantation
- Socioeconomic determinants of cancer screening utilisation in Latin America: A systematic review
- Development of an easy-to-use questionnaire assessing critical care nursing competence in Japan: A cross-sectional study
- Towards successful business process improvement – An extension of change acceleration process model
- Correction: Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model
- Correction: Phylogenetic analysis of hepatitis C virus among HIV/ HCV co-infected patients in Nigeria
- Correction: Relationship between self-disclosure to first acquaintances and subjective well-being in people with schizophrenia spectrum disorders living in the community
- Impact of ATM rs1801516 on late skin reactions of radiotherapy for breast cancer: Evidences from a cohort study and a trial sequential meta-analysis
- Involvement of human and canine MRP1 and MRP4 in benzylpenicillin transport
- Soil organic matter rather than ectomycorrhizal diversity is related to urban tree health
- Clinical risk assessment in early pregnancy for preeclampsia in nulliparous women: A population based cohort study
- The relation between circulating levels of vitamin D and parathyroid hormone in children and adolescents with overweight or obesity: Quest for a threshold
- Behavioural evidence for segments as subordinate units in Chinese spoken word production: The form-preparation paradigm revisited
- Correction: Measuring the impact of an interdisciplinary learning project on nursing, architecture and landscape design students’ empathy
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- The characteristics and treatment patterns of patients with Parkinson’s disease in the United States and United Kingdom: A retrospective cohort study
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- Unconventional SCCmec types and low prevalence of the Panton-Valentine Leukocidin exotoxin in South African blood culture Staphylococcus aureus surveillance isolates, 2013-2016
- Prosocial perceptions of taxation predict support for taxes
- Correction: Clonality analysis of pulmonary tumors by genome-wide copy number profiling
- Improved oxygenation following methylprednisolone therapy and survival in paediatric acute respiratory distress syndrome
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- Correction: Intensive longitudinal modelling predicts diurnal activity of salivary alpha-amylase
- Correction: SNV discovery and functional candidate gene identification for milk composition based on whole genome resequencing of Holstein bulls with extremely high and low breeding values
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- Diurnal variations of amplitude of accommodation in different age groups
- HHIP overexpression inhibits the proliferation, migration and invasion of non-small cell lung cancer
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- Correlation analysis of cold-related gene expression with physiological and biochemical indicators under cold stress in oil palm
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- Influence of season and social context on male giant panda (Ailuropoda melanoleuca) vocal behaviour
- Development of an intravaginal ring for the topical delivery of Aurora kinase A inhibitor, MLN8237
- Differential phosphorylation determines the repressor and activator potencies of GLI1 proteins and their efficiency in modulating the HPV life cycle
- Polymorphisms of FDPS, LRP5, SOST and VKORC1 genes and their relation with osteoporosis in postmenopausal Romanian women
- Depression increases the risk of rotator cuff tear and rotator cuff repair surgery: A nationwide population-based study
- Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes
- Correction: Fast, quantitative, murine cardiac 19F MRI/MRS of PFCE-labeled progenitor stem cells and macrophages at 9.4T
- Persistent post-discharge opioid prescribing after traumatic brain injury requiring intensive care unit admission: A cross-sectional study with longitudinal outcome
- Genome-wide histone modification profiling of inner cell mass and trophectoderm of bovine blastocysts by RAT-ChIP
- Aerobic exercise increases post-exercise exogenous protein oxidation in healthy young males
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- Research ethics in inter- and multi-disciplinary teams: Differences in disciplinary interpretations
- Correction: Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study
- Correction: People making deontological judgments in the Trapdoor dilemma are perceived to be more prosocial in economic games than they actually are
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- Correction: An international randomised placebo-controlled trial of a four-component combination pill (“polypill”) in people with raised cardiovascular risk
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- Retraction: Pathological Roles of Interleukin-22 in the Development of Recurrent Hepatitis C after Liver Transplantation
- Correction: Elevational Distribution and Ecology of Small Mammals on Tanzania's Second Highest Mountain
- Correction: Decreased breast cancer-specific mortality risk in patients with a history of thyroid cancer
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