Post-exercise high-sensitivity troponin T levels in patients with suspected unstable angina

Autoři: Gaetano Antonio Lanza aff001;  Erica Mencarelli aff001;  Veronica Melita aff001;  Antonio Tota aff002;  Maurizio Gabrielli aff002;  Filippo Sarullo aff003;  Chiara Cordischi aff002;  Annalisa Potenza aff002;  Silvia Cardone aff002;  Antonio De Vita aff001;  Antonio Bisignani aff001;  Laura Manfredonia aff001;  Giuseppa Caccamo aff003;  Giuseppe Vitale aff003;  Silvia Baroni aff004;  Mirca Antenucci aff004;  Filippo Crea aff001;  Francesco Franceschi aff002
Působiště autorů: Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Department of Cardiovascular Disease, Roma, Italy aff001;  Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Department of Emergency Medicine, Roma, Italy aff002;  Ospedale Buccheri La Ferla, Cardiac Rehabilitation Unit, Palermo, Italy aff003;  Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica del Sacro Cuore, Department of Clinical Chemistry, Roma, Italy aff004
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222230



Previous studies showed that troponin blood levels may increase after exercise. In this study we assessed whether, among patients admitted with suspected unstable angina, the increase in high-sensitive troponin T (hs-TnT) levels after exercise stress test (EST) might help identify those with obstructive coronary artery disease (CAD) and predict symptom recurrence during short term follow-up.


Maximal treadmill EST was performed in 69 consecutive patients admitted to the emergency room with a suspicion of unstable angina (acute chest pain but confirmed normal serum levels of cardiac troponins) was measured before and 4 hours after EST. Coronary angiography was performed in 22 patients (32.8%).


hs-TnT increased after EST compared to baseline in the whole population (from 0.84±0.65 to 1.17±0.87 ng/dL, p<0.001). The increase was similar in patients with positive (n = 14) and negative (n = 55) EST (p = 0.72), and was also similar in patients with (n = 12) and without (n = 10) obstructive CAD at angiography (p = 0.91). The achievement of a heart rate at peak EST ≥85% of that predicted for age was the variable mainly associated with the post-EST hs-TnT increase at multivariable linear regression analysis (p = 0.005). The change after EST of hs-TnT did not predict the recurrence of symptoms or readmission for chest pain at 6-month follow-up.


Our data show that hs-TnT increased after EST in patients with suspected unstable angina, which seemed largely independent of most clinical and laboratory variables. Thus, hs-TnT assessed after EST does not seem to be helpful to identify patients with obstructive CAD in this kind of patients.

Klíčová slova:

Biology and life sciences – Biochemistry – Proteins – Cytoskeletal proteins – Troponin – Medicine and health sciences – Vascular medicine – Coronary heart disease – Angina – Ischemia – Cardiology – Cardiovascular medicine – Cardiovascular imaging – Angiography – Diagnostic medicine – Diagnostic radiology – Radiology and imaging – Endocrinology – Endocrine disorders – Metabolic disorders – Surgical and invasive medical procedures – Cardiovascular procedures – Angioplasty – Coronary angioplasty – Research and analysis methods – Imaging techniques – Bioassays and physiological analysis – Electrophysiological techniques – Cardiac electrophysiology – Electrocardiography


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