Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin


Autoři: Jiaxu Liu aff001;  Xu Wang aff001;  Weiqi Shi aff001;  Zhuoyu Qian aff002;  Yongqiang Wang aff001
Působiště autorů: Haid Central Research Institute, Animal Husbandry and Fisheries Research Center of Guangdong Haid Group Co., Ltd, Guangzhou, China aff001;  Guangzhou Foreign Languages School, Guangzhou, China aff002
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0222413

Souhrn

The purpose of this study is to assess the antibiotics adjuvant effect of surfactin for boosting the treatment effect of amoxicillin. Surfactin is used as a surfactant to mediate flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. In this study, we demonstrated that surfactin can increase the activity of amoxicillin against avian pathogenic Escherichia coli (APEC) in vitro with antimicrobial assays such as minimum inhibitory concentrations (MIC) and fractional inhibitory concentration (FIC). Additionally in the model of chick infection, surfactin exerted adjuvant effects with amoxicillin against APEC by lowering the numerical value of mortality and liver bacterial loads, and regulating the expression of inflammatory cytokines et al. We concluded that surfactin can act as a novel antimicrobial adjuvant with amoxicillin against AEPC infection in chicken.

Klíčová slova:

Medicine and health sciences – Diagnostic medicine – Prognosis – Signs and symptoms – Immune physiology – Immunology – Immune system – Innate immune system – Cytokines – Immune response – Inflammation – Pathology and laboratory medicine – Pathogens – Anatomical pathology – Histopathology – Euthanasia – Pharmacology – Drugs – Biology and life sciences – Physiology – Developmental biology – Molecular development – Microbiology – Medical microbiology – Microbial pathogens – Bacterial pathogens – Microbial control – Antimicrobials – Physical sciences – Materials science – Materials – Surfactants


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