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Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects


Autoři: Jisuk Park aff001;  Jea Ryung Gil aff001;  Youngbin Shin aff001;  Sang Eun Won aff001;  Jimi Huh aff001;  Myung-Won You aff001;  Hyo Jung Park aff001;  Yu Sub Sung aff001;  Kyung Won Kim aff001
Působiště autorů: Department of Radiology, Asan Image Metrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aff001;  Department of Radiology, VHS Medical Center, Seoul, Korea aff002;  Department of Biomedical Engineering, Asan Medical Institute of Convergence Science and Technology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea aff003;  Department of Radiology, Ajou University School of Medicine, Ajou University Medical Center, Suwon, Korea aff004;  Department of Radiology, Kyung Hee University Hospital, Seoul, Korea aff005
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0222042

Souhrn

Background

Quantification of abdominal muscle mass by cross-sectional imaging has been increasingly used to diagnose sarcopenia; however, the technical method for quantification has not been standardized yet. We aimed to determine an optimal method to measure the abdominal muscle area.

Methods

Among 50 consecutive subjects who underwent abdominal CT and MRI for possible liver donation, total abdominal muscle area (TAMA) and total psoas muscle area (TPA) at the L3 inferior endplate level were measured by two blinded readers. Inter-scan agreement between CT and MRI and inter-reader agreement between the two readers were evaluated using intraclass correlation coefficient (ICC) and within-subject coefficient of variation (WSCV). To evaluate the effect of measurement level, one reader measured TAMA and TPA at six levels from the L2 to L4 vertebral bodies.

Results

TAMA was a more reliable biomarker than TPA in terms of inter-scan agreement (ICC: 0.928 vs. 0.788 for reader 1 and 0.853 vs. 0.821 for reader 2, respectively; WSCV: 8.3% vs. 23.4% for reader 1 and 10.4% vs. 22.3% for reader 2, respectively) and inter-reader agreement (ICC: 0.986 vs. 0.886 for CT and 0.865 vs. 0.669 for MRI, respectively; WSCV: 8.2% vs. 16.0% for CT and 11.6% vs. 29.7% for MRI, respectively). In terms of the measurement level, TAMA did not differ from the L2inf to L4inf levels, whereas TPA increased with a decrease in measurement level.

Conclusions

TAMA is a better biomarker than TPA in terms of inter-scan and inter-reader agreement and robustness to the measurement level. CT was a more reliable imaging modality than MRI. Our results support the use of TAMA measured by CT as a standard biomarker for abdominal muscle area measurement.

Klíčová slova:

Medicine and health sciences – Diagnostic medicine – Diagnostic radiology – Magnetic resonance imaging – Tomography – Computed axial tomography – Signs and symptoms – Sarcopenia – Radiology and imaging – Muscles – Abdominal muscles – Pathology and laboratory medicine – Research and analysis methods – Imaging techniques – Morphometry – Bioassays and physiological analysis – Muscle analysis – Biology and life sciences – Anatomy – Musculoskeletal system – Neuroscience – Neuroimaging – Biochemistry – Lipids – Fats – Biomarkers


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