Serum E-selectin concentration is associated with risk of metabolic syndrome in females


Autoři: Chien-Hsing Lee aff001;  Feng-Chih Kuo aff001;  Wen-Hao Tang aff002;  Chieh-Hua Lu aff001;  Sheng-Chiang Su aff001;  Jhih-Syuan Liu aff001;  Chang-Hsun Hsieh aff001;  Yi-Jen Hung aff002;  Fu-Huang Lin aff003
Působiště autorů: Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC aff001;  Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, Song Shan Branch, Taipei, Taiwan, ROC aff002;  School of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC aff003
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0222815

Souhrn

Objectives

Traits of metabolic syndrome (MetS) and biomarkers of inflammation and endothelial dysfunction were examined. We investigated the differences of various biomarkers among individuals with or without Mets in a gender-specific manner. The gender-specific associations between E-selectin and MetS were further evaluated.

Methods

A total of 205 patients were recruited from the outpatient clinics of Tri-Service General Hospital, Taipei, Taiwan. Inclusion criteria were age between 20–75 years and BMI < 35 kg/m2. Demographic, anthropometric and MetS index data were compared between genders. Markers of inflammation and endothelial dysfunction were compared between individuals with or without MetS by gender.

Results

Age-adjusted E-selectin values showed significant positive correlations with BMI, waist-hip ratio, fasting plasma glucose, systolic and diastolic blood pressure, triglycerides, TNF-α, hsCRP and ICAM-1, and inverse correlation with HDL cholesterol. E-selectin levels were positively correlated with numbers of MetS components in females (P < 0.001) but not in males (P = 0.125).

Conclusions

Increased E-selectin levels are significantly associated with increased MetS risk in females, but not in males.

Klíčová slova:

Biomarkers – Blood plasma – Hypertension – Cholesterol – Inflammation – Metabolic syndrome – Obesity


Zdroje

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