The determinants of lung cancer after detecting a solitary pulmonary nodule are different in men and women, for both chest radiograph and CT
Autoři:
Elisa Chilet-Rosell aff001; Lucy A. Parker aff001; Ildefonso Hernández-Aguado aff001; María Pastor-Valero aff001; José Vilar aff003; Isabel González-Álvarez aff004; José María Salinas-Serrano aff005; Fermina Lorente-Fernández aff004; M. Luisa Domingo aff003; Blanca Lumbreras aff001
Působiště autorů:
Public Health, History of Science and Gynaecology Department, Miguel Hernández University, Alicante, Spain
aff001; CIBER en Epidemiologia y Salud Pública, Madrid, Spain
aff002; Radiodiagnostic Department, Peset Hospital, Valencia, Spain
aff003; Radiodiagnostic Department, San Juan Hospital, San Juan de Alicante, Spain
aff004; Computer Department, San Juan Hospital, San Juan de Alicante, Spain
aff005
Vyšlo v časopise:
PLoS ONE 14(9)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0221134
Souhrn
Objectives
To determine the factors associated with lung cancer diagnosis and mortality after detecting a solitary pulmonary nodule (SPN) in routine clinical practice, in men and in women for both chest radiograph and CT.
Materials and methods
A 5-year follow-up of a retrospective cohort of of 25,422 (12,594 men, 12,827 women) patients aged ≥35 years referred for chest radiograph or CT in two hospitals in Spain (2010–2011). SPN were detected in 893 (546 men, 347 women) patients. We estimated the cumulative incidence of lung cancer at 5-years, the association of patient and nodule characteristics with SPN malignancy using Poisson logistic regression, stratifying by sex and type of imaging test. We calculated lung cancer specific mortality rate by sex and SPN detection and hazard rates by cox regression.
Results
133 (14.9%) out of 893 patients with an SPN and 505 (2.06%) of the 24,529 patients without SPN were diagnosed with lung cancer. Median diameter of SPN in women who developed cancer was larger than in men. Men who had a chest radiograph were more likely to develop a lung cancer if the nodule was in the upper-lobes, which was not the case for women. In patients with an SPN, smoking increased the risk of lung cancer among men (chest radiograph: RR = 11.3, 95%CI 1.5–83.3; CT: RR = 7.5, 95%CI 2.2, 26.0) but smoking was not significantly associated with lung cancer diagnosis or mortality among women with an SPN. The relative risk of lung cancer diagnosis in women with SPN versus those without was much higher compared to men (13.7; 95%CI 9.2, 20.4 versus 6.2; 95%CI 4.9,7.9).
Conclusion
The factors associated with SPN malignancy and 5-year lung cancer mortality were different among men and women, especially regarding smoking history and SPN characteristics, where we observed a relatively high rate of lung cancer diagnosis among female non-smokers.
Klíčová slova:
Medicine and health sciences – Oncology – Cancers and neoplasms – Lung and intrathoracic tumors – Diagnostic medicine – Cancer detection and diagnosis – Diagnostic radiology – Tomography – Computed axial tomography – Pulmonary imaging – Radiology and imaging – Pulmonology – Chronic obstructive pulmonary disease – Health care – Patients – Outpatients – Biology and life sciences – Population biology – Population metrics – Death rates – Neuroscience – Neuroimaging – Psychology – Behavior – Habits – Smoking habits – Research and analysis methods – Imaging techniques – Social sciences
Zdroje
1. Chung K, Mets OM, Gerke PK, Jacobs C, den Harder AM, Scholten ET, et al. Brock malignancy risk calculator for pulmonary nodules: validation outside a lung cancer screening population. Thorax. 2018;73(9):857–63. Epub 2018/05/20. doi: 10.1136/thoraxjnl-2017-211372 29777062
2. Gould MK, Donington J, Lynch WR, Mazzone PJ, Midthun DE, Naidich DP, et al. Evaluation of individuals with pulmonary nodules: when is it lung cancer? Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e93S–e120S. doi: 10.1378/chest.12-2351 23649456
3. MacMahon H, Naidich DP, Goo JM, Lee KS, Leung ANC, Mayo JR, et al. Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017. Radiology. 2017;284(1):228–43. Epub 2017/02/28. doi: 10.1148/radiol.2017161659 28240562
4. IARC Working group on the evaluation of Carcinogenic Risks to Humans. Tobacco smoke and involuntary smoking. IARC Monogr Eval Carcinog Risks Hum. 2004;83:1–1438. Epub 2004/08/03. 15285078
5. Kiyohara C, Ohno Y. Sex differences in lung cancer susceptibility: a review. Gend Med. 2010;7(5):381–401. Epub 2010/11/09. doi: 10.1016/j.genm.2010.10.002 21056866
6. McCartney G, Mahmood L, Leyland AH, Batty GD, Hunt K. Contribution of smoking-related and alcohol-related deaths to the gender gap in mortality: evidence from 30 European countries. Tob Control. 2011;20(2):166–8. Epub 2011/01/14. doi: 10.1136/tc.2010.037929 21228431
7. Vineis P, Alavanja M, Buffler P, Fontham E, Franceschi S, Gao YT, et al. Tobacco and cancer: recent epidemiological evidence. J Natl Cancer Inst. 2004;96(2):99–106. Epub 2004/01/22. doi: 10.1093/jnci/djh014 14734699
8. Wakelee HA, Chang ET, Gomez SL, Keegan TH, Feskanich D, Clarke CA, et al. Lung cancer incidence in never smokers. J Clin Oncol. 2007;25(5):472–8. Epub 2007/02/10. doi: 10.1200/JCO.2006.07.2983 17290054
9. Payne S. 'Smoke like a man, die like a man'?: a review of the relationship between gender, sex and lung cancer. Soc Sci Med. 2001;53(8):1067–80. Epub 2001/09/15. 11556776
10. De Matteis S, Consonni D, Pesatori AC, Bergen AW, Bertazzi PA, Caporaso NE, et al. Are women who smoke at higher risk for lung cancer than men who smoke? Am J Epidemiol. 2013;177(7):601–12. Epub 2013/02/22. doi: 10.1093/aje/kws445 23425629
11. Dias M, Linhas R, Campainha S, Conde S, Barroso A. Lung cancer in never-smokers—what are the differences? Acta Oncol. 2017;56(7):931–5. Epub 2017/05/19. doi: 10.1080/0284186X.2017.1287944 28514931
12. Alberg AJ, Wallace K, Silvestri GA, Brock MV. Invited commentary: the etiology of lung cancer in men compared with women. Am J Epidemiol. 2013;177(7):613–6. Epub 2013/02/22. doi: 10.1093/aje/kws444 23425628
13. Eberle A, Jansen L, Castro F, Krilaviciute A, Luttmann S, Emrich K, et al. Lung cancer survival in Germany: A population-based analysis of 132,612 lung cancer patients. Lung Cancer. 2015;90(3):528–33. Epub 2015/10/21. doi: 10.1016/j.lungcan.2015.10.007 26480866
14. Naidich DP, Bankier AA, MacMahon H, Schaefer-Prokop CM, Pistolesi M, Goo JM, et al. Recommendations for the management of subsolid pulmonary nodules detected at CT: a statement from the Fleischner Society. Radiology. 2013;266(1):304–17. Epub 2012/10/17. doi: 10.1148/radiol.12120628 23070270
15. Mets OM, de Jong PA, Chung K, Lammers JJ, van Ginneken B, Schaefer-Prokop CM. Fleischner recommendations for the management of subsolid pulmonary nodules: high awareness but limited conformance—a survey study. Eur Radiol. 2016;26(11):3840–9. Epub 2016/03/08. doi: 10.1007/s00330-016-4249-y 26945759
16. Nair A, Devaraj A, Callister MEJ, Baldwin DR. The Fleischner Society 2017 and British Thoracic Society 2015 guidelines for managing pulmonary nodules: keep calm and carry on. Thorax. 2018;73(9):806–12. doi: 10.1136/thoraxjnl-2018-211764
17. Gomez-Saez N, Gonzalez-Alvarez I, Vilar J, Hernandez-Aguado I, Domingo ML, Lorente MF, et al. Prevalence and variables associated with solitary pulmonary nodules in a routine clinic-based population: a cross-sectional study. Eur Radiol. 2014;24(9):2174–82. Epub 2014/06/26. doi: 10.1007/s00330-014-3249-z 24962823
18. Gomez-Saez N, Hernandez-Aguado I, Vilar J, Gonzalez-Alvarez I, Lorente MF, Domingo ML, et al. Lung cancer risk and cancer-specific mortality in subjects undergoing routine imaging test when stratified with and without identified lung nodule on imaging study. Eur Radiol. 2015;25(12):3518–27. Epub 2015/05/09. doi: 10.1007/s00330-015-3775-3 25953000
19. Alberg AJ, Brock MV, Ford JG, Samet JM, Spivack SD. Epidemiology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e1S–e29S. Epub 2013/05/10. doi: 10.1378/chest.12-2345 23649439
20. Fritz A PC, Jack et al. International Classification of Diseases for Oncology. 2013.
21. Reid M, Choi HK, Han X, Wang X, Mukhopadhyay S, Kou L, et al. Development of a Risk Prediction Model to Estimate the Probability of Malignancy in Pulmonary Nodules Being Considered for Biopsy. Chest. 2019. Epub 2019/04/04. doi: 10.1016/j.chest.2019.01.038
22. Seki T, Nishino Y, Tanji F, Maemondo M, Takahashi S, Sato I, et al. Cigarette smoking and lung cancer risk according to histologic type in Japanese men and women. Cancer Sci. 2013;104(11):1515–22. Epub 2013/09/03. doi: 10.1111/cas.12273 23992614
23. Chlebowski RT, Anderson GL, Manson JE, Schwartz AG, Wakelee H, Gass M, et al. Lung cancer among postmenopausal women treated with estrogen alone in the women's health initiative randomized trial. J Natl Cancer Inst. 2010;102(18):1413–21. Epub 2010/08/17. doi: 10.1093/jnci/djq285 20709992
24. Usman Ali M, Miller J, Peirson L, Fitzpatrick-Lewis D, Kenny M, Sherifali D, et al. Screening for lung cancer: A systematic review and meta-analysis. Prev Med. 2016;89:301–14. Epub 2016/05/01. doi: 10.1016/j.ypmed.2016.04.015 27130532
Článek vyšel v časopise
PLOS One
2019 Číslo 9
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