Surgical resection is sufficient for incidentally discovered solitary pulmonary nodule caused by nontuberculous mycobacteria in asymptomatic patients
Autoři:
Hung-Ling Huang aff001; Chia-Jung Liu aff004; Meng-Rui Lee aff004; Meng-Hsuan Cheng aff002; Po-Liang Lu aff002; Jann-Yuan Wang aff005; Inn-Wen Chong aff002
Působiště autorů:
Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
aff001; Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
aff002; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
aff003; Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu Branch, Hsin-Chu, Taiwan
aff004; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan
aff005; National Taiwan University, College of Medicine, Taipei, Taiwan
aff006; Departments of Respiratory Therapy, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
aff007; Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan
aff008
Vyšlo v časopise:
PLoS ONE 14(9)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0222425
Souhrn
Incidentally discovered solitary pulmonary nodules (SPN) caused by nontuberculous mycobacteria (NTM) is uncommon, and its optimal treatment strategy remains uncertain. This cohort study determined the clinical characteristics and outcome of asymptomatic patients with NTM-SPN after surgical resection. Resected SPNs with culture-positive for NTM in six hospitals in Taiwan during January, 2010 to January, 2017 were identified. Asymptomatic patients without a history of NTM-pulmonary disease (PD) or same NTM species isolated from the respiratory samples were selected. All were followed until May 1, 2019. A total of 43 patients with NTM-SPN were enrolled. Mycobacterium avium complex (60%) and M. kansasii (19%) were the most common species. The mean age was 61.7 ± 13.4. Of them, 60% were female and 4% had history of pulmonary tuberculosis. The NTM-SPN was removed by wedge resection in 38 (88%), lobectomy in 3 (7%) and segmentectomy in 2 (5%). Caseating granuloma was the most common histologic feature (58%), while chronic inflammation accounts for 23%. Mean duration of the follow-up was 5.2 ± 2.8 years (median: 4.2 years [2.5–7.0]), there were no mycobacteriology recurrence or NTM-PD development. In conclusion, surgical resection is likely to curative for incidentally discovered NTM-SPN in asymptomatic patients without culture evidence of the same NTM species from respiratory specimens, and routine mycobacterium culture for resected SPN might be necessary for differentiating pulmonary tuberculosis and NTM because further treatment differs.
Klíčová slova:
Biology and life sciences – Organisms – Bacteria – Actinobacteria – Nontuberculous mycobacteria – Mycobacterium avium complex – Mycobacterium tuberculosis – Anatomy – Body fluids – Mucus – Sputum – Physiology – Neuroscience – Neuroimaging – Medicine and health sciences – Surgical and invasive medical procedures – Surgical resection – Lung resection – Respiratory system procedures – Diagnostic medicine – Diagnostic radiology – Tomography – Computed axial tomography – Radiology and imaging – Research and analysis methods – Imaging techniques – Specimen preparation and treatment
Zdroje
1. Diederich S, Wormanns D, Semik M, Thomas M, Lenzen H, Roos N, et al. Screening for early lung cancer with low-dose spiral CT: prevalence in 817 asymptomatic smokers. Radiology. 2002;222(3):773–81. 11867800
2. Furtado CD, Aguirre DA, Sirlin CB, Dang D, Stamato SK, Lee P, et al. Whole-body CT screening: spectrum of findings and recommendations in 1192 patients. Radiology. 2005;237(2):385–94. 16170016
3. MacMahon H, Naidich DP, Goo JM, Lee KS, Leung AN, Mayo JR, et al. Guidelines for management of incidental pulmonary nodules detected on CT images: from the Fleischner Society 2017. Radiology. 2017;284(1):228–43. doi: 10.1148/radiol.2017161659 28240562
4. Swensen SJ, Jett JR, Sloan JA, Midthun DE, Hartman TE, Sykes A-M, et al. Screening for lung cancer with low-dose spiral computed tomography. Am J Respir Crit Care Med. 2002;165(4):508–13. 11850344
5. McWilliams A, Tammemagi MC, Mayo JR, Roberts H, Liu G, Soghrati K, et al. Probability of cancer in pulmonary nodules detected on first screening CT. N Engl J Med. 2013;369(10):910–9. doi: 10.1056/NEJMoa1214726 24004118
6. Ost D. MD, and Steven H. Feinsilver MD. The Solitary Pulmonary Nodule. N Engl J Med. 2003;348:2535–42. 12815140
7. Kim H, Kang SJ, Suh GY, Chung MP, Kwon OJ, Rhee CH, et al. Predictors for benign solitary pulmonary nodule in tuberculosis-endemic area. Korean J Intern Med. 2001;16(4):236. doi: 10.3904/kjim.2001.16.4.236 11855152
8. Hosaka N, Kameko M, Nishimura H, Hosaka S. Prevalence of tuberculosis in small pulmonary nodules obtained by video-assisted thoracoscopic surgery. Respir Med. 2006;100(2):238–43. 15964180
9. Gribetz AR, Damsker B, Bottone EJ, Kirschner PA, Teirstein AS. Solitary pulmonary nodules due to nontuberculous mycobacterial infection. Am J Med. 1981;70(1):39–43. 7457489
10. Erasmus JJ, Connolly JE, McAdams HP, Roggli VL. Solitary pulmonary nodules: Part I. Morphologic evaluation for differentiation of benign and malignant lesions. Radiographics. 2000;20(1):43–58. 10682770
11. Hahm CR, Park HY, Jeon K, Um S-W, Suh GY, Chung MP, et al. Solitary pulmonary nodules caused by Mycobacterium tuberculosis and Mycobacterium avium complex. Lung. 2010;188(1):25–31. doi: 10.1007/s00408-009-9203-1 19956964
12. Lande L, Peterson DD, Gogoi R, Daum G, Stampler K, Kwait R, et al. Association between pulmonary mycobacterium avium complex infection and lung cancer. J Thorac Oncol. 2012;7(9):1345–51. doi: 10.1097/JTO.0b013e31825abd49 22699888
13. Sim YT, Goh YG, Dempsey MF, Han S, Poon FW. PET–CT evaluation of solitary pulmonary nodules: correlation with maximum standardized uptake value and pathology. Lung. 2013;191(6):625–32. doi: 10.1007/s00408-013-9500-6 24013495
14. Yu Y-Y, Pinsky PF, Caporaso NE, Chatterjee N, Baumgarten M, Langenberg P, et al. Lung cancer risk following detection of pulmonary scarring by chest radiography in the prostate, lung, colorectal, and ovarian cancer screening trial. Arch of Intern Med. 2008;168(21):2326–32.
15. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med. 2007;175(4):367–416. 17277290
16. Haworth CS, Banks J, Capstick T, Fisher AJ, Gorsuch T, Laurenson IF, et al. British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD). Thorax. 2017;72(Suppl 2):ii1–ii64.
17. Char A, Hopkinson NS, Hansell DM, Nicholson AG, Shaw EC, Clark SJ, et al. Evidence of mycobacterial disease in COPD patients with lung volume reduction surgery; the importance of histological assessment of specimens: a cohort study. BMC Pulm Med. 2014;14(1):124.
18. Huang H-L, Cheng M-H, Lu P-L, Shu C-C, Wang J-Y, Wang J-T, et al. Epidemiology and predictors of NTM pulmonary infection in taiwan-a retrospective, five-year multicenter study. Sci Rep. 2017;7(1):16300. doi: 10.1038/s41598-017-16559-z 29176633
19. Chen C-Y, Chen C-H, Shen T-C, Cheng W-C, Hsu C-N, Liao C-H, et al. Lung cancer screening with low-dose computed tomography: experiences from a tertiary hospital in Taiwan. J Formos Med Assoc. 2016;115(3):163–70. doi: 10.1016/j.jfma.2015.11.007 26714425
20. Shah RD, D’Amico TA. Modern impact of video assisted thoracic surgery. J Thorac Dis. 2014;6(Suppl 6):S631. doi: 10.3978/j.issn.2072-1439.2014.08.02 25379201
21. Asakura T, Hayakawa N, Hasegawa N, Namkoong H, Takeuchi K, Suzuki S, et al. Long-term Outcome of Pulmonary Resection for Nontuberculous Mycobacterial Pulmonary Disease. Clin Infect Dis. 2017;65(2):244–51. doi: 10.1093/cid/cix274 28369361
22. Hong SJ, Kim TJ, Lee J-H, Park J-S. Nontuberculous mycobacterial pulmonary disease mimicking lung cancer: clinicoradiologic features and diagnostic implications. Medicine. 2016;95(26).
23. Yi CA, Lee KS, Kim EA, Han J, Kim H, Kwon OJ, et al. Solitary pulmonary nodules: dynamic enhanced multi–detector row CT study and comparison with vascular endothelial growth factor and microvessel density. Radiology. 2004;233(1):191–9. 15304661
24. Hosaka N, Kameko M, Nishimura H, Hosaka S. Prevalence of tuberculosis in small pulmonary nodules obtained by video-assisted thoracoscopic surgery. Respir Med. 2006;100(2):238–43. 15964180
25. Yonemori K, Tateishi U, Tsuta K, Yonemori Y, Uno H, Asamura H, et al. Solitary pulmonary granuloma caused by Mycobacterium avium-intracellulare complex. Int J Tuberc Lung Dis. 2007;11(2):215–21. 17263294
26. Ose N, Maeda H, Takeuchi Y, Susaki Y, Kobori Y, Taniguchi S, et al. Solitary pulmonary nodules due to non-tuberculous mycobacteriosis among 28 resected cases. Int J Tuberc Lung Dis. 2016;20(8):1125–9. doi: 10.5588/ijtld.15.0819 27393550
27. Abe M, Kobashi Y, Mouri K, Obase Y, Miyashita N, Nakata M, et al. Solitary pulmonary nodule due to Mycobacterium kansasii. Intern Med J. 2011;50(7):775–8.
28. Xia Z, Qiao K, He J. Recent advances in the management of pulmonary tuberculoma with focus on the use of tubeless video-assisted thoracoscopic surgery. J Thorac Dis. 2017;9(9):3307–12. doi: 10.21037/jtd.2017.08.44 29221316
29. Yee D, Valiquette C, Pelletier M, Parisien I, Rocher I, Menzies D. Incidence of serious side effects from first-line antituberculosis drugs among patients treated for active tuberculosis. Am J Respir Crit Care Med. 2003;167(11):1472–7. 12569078
30. Chung CL, Chen YF, Lin YT, Wang JY, Kuo SW, Chen JS. Outcome of untreated lung nodules with histological but no microbiological evidence of tuberculosis. BMC Infect Dis. 2018;18(1):530. doi: 10.1186/s12879-018-3442-9 30352562
31. Santin M, Dorca J, Alcaide F, Gonzalez L, Casas S, Lopez M, et al. Long-term relapses after 12-month treatment for Mycobacterium kansasii lung disease. The Eur Respir J. 2009;33(1):148–52. doi: 10.1183/09031936.00024008 19118226
32. Philley JV, DeGroote MA, Honda JR, Chan MM, Kasperbauer S, Walter ND, et al. Treatment of Non-Tuberculous Mycobacterial Lung Disease. Curr Treat Options Infect Dis. 2016;8(4):275–96. doi: 10.1007/s40506-016-0086-4 28529461
33. Marchevsky A, Damsker B, Gribetz A, Tepper S, Geller SA. The spectrum of pathology of nontuberculous mycobacterial infections in open-lung biopsy specimens. Am J Clin Pathol. 1982;78(5):695–700. 7137111
34. Huang HL, Cheng MH, Lu PL, Liu CJ, Chong IW, Wang JY. Predictors of developing Mycobacterium kansasii pulmonary disease within 1 year among patients with single isolation in multiple sputum samples: A retrospective, longitudinal, multicentre study. Sci Rep. 2018;8(1):17826. doi: 10.1038/s41598-018-36255-w 30546032
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PLOS One
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