Impact of tear metrics on the reliability of perimetry in patients with dry eye


Autoři: Hideto Sagara aff001;  Tetsuju Sekiryu aff002;  Kimihiro Imaizumi aff002;  Hiroaki Shintake aff002;  Urara Sugiyama aff002;  Hiroki Maehara aff002
Působiště autorů: The Marui Eye Clinic, Minamisoma City, Fukushima, Japan aff001;  Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima City, Fukushima, Japan aff002
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0222467

Souhrn

Background

The application of artificial tears before performing perimetry can improve the reliability and results of perimetry in patients with glaucoma and dry eye (DE). However, the effects of ocular surface and tear film conditions on perimetry measurements and reliability have not been fully characterized.

Methods

This prospective, cross-sectional, multicenter study investigated tear metrics in perimetry and assessed the relationships that existed among ocular surface condition, tear condition, and perimetry reliability. Forty-three eyes (43 patients) with DE disease according to the 2016 Japanese diagnostic criteria of DE and 43 eyes (43 subjects) of age- and visual field mean deviation-matched normal control subjects were studied. Perimetry was performed using the Humphrey Field Analyzer (30–2 SITA-Standard). Schirmer’s test, strip meniscometry value, blink rate, tear film break-up time (TFBUT), fluorescein staining of ocular surface, and Dry Eye-related Quality of Life Score (DEQS) were measured. Blink rate was re-measured during perimetry. TFBUT and fluorescein staining were re-evaluated after perimetry. Perimetry reliability was evaluated with fixation loss, false-positive, and false-negative rates.

Results

Blink rate during perimetry was significantly lower for both patients with DE and normal controls (both P<0.001). TFBUT after perimetry was significantly higher than before perimetry in patients with DE (P<0.001). Fluorescein staining of ocular surface was significantly increased in patients with DE and normal control subjects (P = 0.002 and P<0.001, respectively). Spearman correlation analysis revealed that blink rate during perimetry was negatively correlated with fixation-loss rate (r = -0.393, P = 0.009) in patients with DE.

Conclusions

Performing perimetry was associated with a significant change in tear condition and ocular surface condition in both patients with DE and normal control subjects. The changes in tear condition and ocular surface condition may impact the reliability of perimetry in patients with DE.

Klíčová slova:

Medicine and health sciences – Ophthalmology – Eye diseases – Glaucoma – Eyes – Ocular system – Diagnostic medicine – Health care – Quality of life – Geriatrics – Biology and life sciences – Anatomy – Head – Research and analysis methods – Research assessment – Research validity


Zdroje

1. Kaštelan S, Tomić M, Metež Soldo K, Salopek-Rabatić J. How ocular surface disease impacts the glaucoma treatment outcome. Biomed Res Int. 2013; 2013: 696328. doi: 10.1155/2013/696328 24224176

2. Rieger G. The importance of precorneal tear film for the quality of optical imaging. Br J Ophthalmol. 1992;76: 157–158. doi: 10.1136/bjo.76.3.157 1540559

3. Yenice O, Temel A, Orüm O. The effect of artificial tear administration on visual field testing in patients with glaucoma and dry eye. Eye. 2007;21: 214–217. doi: 10.1038/sj.eye.6702252 16440009

4. Kocabeyoglu S, Mocan MC, Bozkurt B, Irkec M. Effect of artificial tears on automated visual field testing in patients with glaucoma and dry eye. Can J Ophthalmol. 2013;48: 110–114. doi: 10.1016/j.jcjo.2012.11.001 23561604

5. Arai T, Murata H, Matsuura M, Usui T, Asaoka R. The association between ocular surface measurements with visual field reliability indices and gaze tracking results in preperimetric glaucoma. Br J Ophthalmol. 2018;102: 525–530. doi: 10.1136/bjophthalmol-2017-310309 28765147

6. Matsumoto C, Shirato S, Haneda M, Yamashiro H, Saito M. Study of retinal nerve fiber layer thickness within normal hemivisual field in primary open-angle glaucoma and normal-tension glaucoma. Jpn J Ophthalmol. 2003;47: 22–27. 12586174

7. Yamazaki Y, Mizuki K, Hayamizu F, Tanaka C. Correlation of blue chromatic macular sensitivity with optic disc change in early glaucoma patients. Jpn J Ophthalmol. 2002;46: 89–94. 11853721

8. Horikoshi N, Osako M, Tamura Y, Okano T, Usui M. Comparison of detectability of visual field abnormality by frequency doubling technology in primary open-angle glaucoma and normal-tension glaucoma. Jpn J Ophthalmol. 2001;45: 503–509. 11583674

9. Kunimatsu S, Suzuki Y, Shirato S, Araie M. Usefulness of gaze tracking during perimetry in glaucomatous eyes Jpn J Ophthalmol. 2000;44: 190–191.

10. Uchida H, Tomita G, Onda E, Sugiyama K, Kitazawa Y. Relationship of nerve fiber layer defects and parafoveal visual field defects in glaucomatous eyes. Jpn J Ophthalmol. 1996;40: 548–553. 9130061

11. Anderson DR, Patella VM. Clinical static perimetry. In: Anderson DR editor. Automated static perimetry. 2nd ed. St. Louis: Mosby; 1999. pp. 80–102.

12. Johnson CA, Sherman K, Doyle C, Wall M. A comparison of false negative responses for full threshold and SITA standard perimetry in glaucoma patients and normal observers. J Glaucoma. 2014;23: 288–292. doi: 10.1097/IJG.0b013e31829463ab 23632399

13. Tsubota K. Yokoi N, Shimazaki J, Watanabe H, Dogru M, Yamada M, et al. New perspectives on dry eye defnition and diagnosis: a consensus report by the Asia Dry Eye Society. Ocul Surf. 2017;15: 65–76. doi: 10.1016/j.jtos.2016.09.003 27725302

14. Bengtsson B, Heijl A. False-negative responses in glaucoma perimetry: indicators of patient performance or test reliability? Invest Ophthalmol Vis Sci. 2000;41: 2201–2204. 10892863

15. Sakane Y, Yamaguchi M, Yokoi N, Uchino M, Dogru M, Oishi T, et al. Development and validation of the dry eye-related quality-of-life score questionnaire. JAMA Ophthalmol. 2013;131: 1331–1338. doi: 10.1001/jamaophthalmol.2013.4503 23949096

16. Ishikawa S, Takeuchi M, Kato N. The combination of strip meniscometry and dry eye-related quality-of-life score is useful for dry eye screening during health checkup: Cross-sectional study. Medicine (Baltimore). 2018;97: e12969. doi: 10.1097/MD.0000000000012969 30412120

17. Dogru M, Ishida K, Matsumoto Y, Goto E, Ishioka M, Kojima T, et al. Strip meniscometry: a new and simple method of tear meniscus evaluation. Invest Ophthalmol Vis Sci. 2006;47: 1895–1901. doi: 10.1167/iovs.05-0802 16638996

18. Ibrahim OM, Dogru M, Ward SK, Matsumoto Y, Wakamatsu TH, Ishida K et al. The efficacy, sensitivity, and specificity of strip meniscometry in conjunction with tear function tests in the assessment of tear meniscus. Invest Ophthalmol Vis Sci. 2011;52: 2194–2198. doi: 10.1167/iovs.10-5986 21178139

19. Methodologies to diagnose and monitor dry eye disease: report of the Diagnostic Methodology Subcommittee of the International Dry Eye Work Shop (2007). Ocul Surf. 2007;5: 108–152. 17508118

20. Bron AJ, Evans VE, Smith JA. Grading of corneal and conjunctival staining in the context of other dry eye tests. Cornea. 2003;22: 640–650. 14508260

21. Carl Zeiss Meditec. Humphrey Field Analyzer II-i Series, User Manual. Dublin, CA: Carl Zeiss Meditec; 2017.

22. Holland MK, Tarlow G. Blinking and mental load. Psychol Rep. 1972;31: 119–27. doi: 10.2466/pr0.1972.31.1.119 5055889

23. Ohtsuki M, Yokoi N, Mori K, Adachi W, Ishibashi K, et al. Adverse effects of beta-blocker eye drops on the ocular surface. [Article in Japanese.] Nihon Ganka Gakkai Zasshi. 2001;105: 149–154. 11280872

24. Milla E, Stirbu O, Rey A, Duch S, Buchacra O, Robles A, et al. Spanish multicenter tafluprost tolerability study. Br J Ophthalmol. 2012;96: 826–831. doi: 10.1136/bjophthalmol-2011-301015 22399693

25. Schein OD, Hochberg MC, Muñoz B, Tielsch JM, Bandeen-Roche K, Provost T, et al. Dry eye and dry mouth in the elderly: a population-based assessment. Arch Intern Med. 1999;159: 1359–1363. doi: 10.1001/archinte.159.12.1359 10386512

26. Schein OD, Muñoz B, Tielsch JM, Bandeen-Roche K, West S. Prevalence of dry eye among the elderly. Am J Ophthalmol. 1997;124: 723–728. doi: 10.1016/s0002-9394(14)71688-5 9402817

27. Tsubota K, Nakamori K. Effects of ocular surface area and blink rate on tear dynamics. Arch Ophthalmol. 1995;113: 155–158. doi: 10.1001/archopht.1995.01100020037025 7864746

28. Wang Y, Toor SS, Gautam R, Henson DB. Blink frequency and duration during perimetry and their relationship to test-retest threshold variability. Invest Ophthalmol Vis Sci. 2011:28;52:4546–4550. doi: 10.1167/iovs.10-6553 21447676

29. Lal SK, Craig A. Driver fatigue: electroencephalography and psychological assessment. Psychophysiology. 2002;39: 313–321. doi: 10.1017/s0048577201393095 12212650

30. Van Orden KF, Jung TP, Makeig S. Combined eye activity measures accurately estimate changes in sustained visual task performance. Biol Psychol. 2000;52: 221–240. 10725565

31. Schleicher R, Galley N, Briest S, Galley I. Blinks and saccades as indicators of fatigue in sleepiness warnings: looking tired? Ergonomics. 2008;51: 982–1010. doi: 10.1080/00140130701817062 18568959

32. Pavlidis M, Stupp T, Grenzebach U, Busse H, Thanos S. Ultrasonic visualization of the effect of blinking on the lacrimal pump mechanism, Graefes Arch Clin Exp Ophthalmol. 2005;243: 228–234. doi: 10.1007/s00417-004-1033-5 15455241

33. Wang J, Palakuru JR, Aquavella JV. Correlations among upper and lower tear menisci, noninvasive tear break-up time, and the Schirmer test. Am J Ophthalmol. 2008;145: 795–800. doi: 10.1016/j.ajo.2007.12.035 18328997


Článek vyšel v časopise

PLOS One


2019 Číslo 9
Nejčtenější tento týden