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Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin


Autoři: Gino Agbota aff001;  Katja Polman aff003;  Frank T. Wieringa aff005;  Maiza Campos-Ponce aff004;  Manfred Accrombessi aff001;  Emmanuel Yovo aff001;  Clémentine Roucher aff003;  Sem Ezinmègnon aff006;  Javier Yugueros Marcos aff006;  Laurence Vachot aff006;  Pierre Tissières aff007;  Achille Massougbodji aff002;  Nadine Fievet aff001;  Michel Cot aff001;  Valérie Briand aff001
Působiště autorů: MERIT, IRD, Université Paris 5, Sorbonne Paris Cité, Paris, France aff001;  Centre d’Etude et de Recherche sur le Paludisme Associé à la Grossesse et à l’Enfance (CERPAGE), Cotonou, Bénin aff002;  Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium aff003;  Section Infectious Diseases, Department of Health Sciences, VU Amsterdam, Amsterdam, The Netherlands aff004;  Nutripass, UMR204, Institut de Recherche pour le Développement, IRD/UM/SupAgro, Montpellier, France aff005;  Medical Diagnostic Discovery Department (MD3), bioMérieux, Marcy l’Etoile, France aff006;  UMR 9198, Institut de biologie Intégrative de la Cellule, Université Paris Saclay, Paris, France aff007
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0222864

Souhrn

Background

Malaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. Few studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant’s risk of infection.

Methods

In Benin, women were followed from the preconception period until delivery. Subsequently, their children were followed from birth to 3 months of age. Pre-pregnancy malaria, malaria in pregnancy (MiP)—determined monthly using a thick blood smear—and urinary schistosomiasis—determined once before pregnancy and once at delivery using urine filtration—were the main maternal exposures. Infant’s febrile infection (fever with respiratory, gastrointestinal and/or cutaneous clinical signs anytime during follow-up) was the main outcome. In a secondary analysis, we checked the relation of malaria and schistosomiasis with infant’s hemoglobin (Hb) concentration. Both effects were separately assessed using logistic/mixed linear regression models.

Results

The prevalence of MiP was 35.7% with 10.8% occurring during the 1st trimester, and the prevalence of schistosomiasis was 21.8%. From birth to 3 months, 25.3% of infants had at least one episode of febrile infection. In multivariate analysis, MiP, particularly malaria in the 1st trimester, was significantly associated with a higher risk of infant’s febrile infection (aOR = 4.99 [1.1; 22.6], p = 0.03). In secondary results, pre-pregnancy malaria and schistosomiasis were significantly associated with a lower infant’s Hb concentration during the first 3 months.

Conclusion

We evidenced the deleterious effect of maternal parasitic infections on infant’s health. Our results argue in favor of the implementation of preventive strategies as early as in the peri-conception.

Klíčová slova:

Medicine and health sciences – Parasitic diseases – Malaria – Helminth infections – Schistosomiasis – Tropical diseases – Neglected tropical diseases – Pulmonology – Respiratory infections – Women's health – Maternal health – Pregnancy – Birth – Labor and delivery – Obstetrics and gynecology – Pediatrics – Neonatology – Breast feeding – Infectious diseases – Co-infections – People and places – Population groupings – Age groups – Children – Infants – Families


Zdroje

1. Barker DJP. The origins of the developmental origins theory. J Intern Med. 2007;261: 412–417. doi: 10.1111/j.1365-2796.2007.01809.x 17444880

2. Collier CH, Risnes K, Norwitz ER, Bracken MB, Illuzzi JL. Maternal infection in pregnancy and risk of asthma in offspring. Matern Child Health J. 2013;17: 1940–1950. doi: 10.1007/s10995-013-1220-2 23338127

3. Yu Z, Han S, Zhu J, Sun X, Ji C, Guo X. Pre-pregnancy body mass index in relation to infant birth weight and offspring overweight/obesity: a systematic review and meta-analysis. PloS One. 2013;8: e61627. doi: 10.1371/journal.pone.0061627 23613888

4. Huynh B-T, Cottrell G, Cot M, Briand V. Burden of malaria in early pregnancy: a neglected problem? Clin Infect Dis Off Publ Infect Dis Soc Am. 2015;60: 598–604. doi: 10.1093/cid/ciu848 25362205

5. Ramakrishnan U, Grant F, Goldenberg T, Zongrone A, Martorell R. Effect of women’s nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review. Paediatr Perinat Epidemiol. 2012;26 Suppl 1: 285–301. doi: 10.1111/j.1365-3016.2012.01281.x 22742616

6. World Health Organization. Fact Sheets Detail: Malaria. https://www.who.int/news-room/fact-sheets/detail/malaria. Accessed 7 January 2019.

7. Chico RM, Mayaud P, Ariti C, Mabey D, Ronsmans C, Chandramohan D. Prevalence of malaria and sexually transmitted and reproductive tract infections in pregnancy in sub-Saharan Africa: a systematic review. JAMA. 2012;307: 2079–2086. doi: 10.1001/jama.2012.3428 22665107

8. Rachas A, Le Port A, Cottrell G, Guerra J, Choudat I, Bouscaillou J, et al. Placental malaria is associated with increased risk of nonmalaria infection during the first 18 months of life in a Beninese population. Clin Infect Dis Off Publ Infect Dis Soc Am. 2012;55: 672–678. doi: 10.1093/cid/cis490 22610927

9. Accrombessi M, Yovo E, Fievet N, Cottrell G, Agbota G, Gartner A, et al. Effects of Malaria in the First Trimester of Pregnancy on Poor Maternal and Birth Outcomes in Benin. Clin Infect Dis Off Publ Infect Dis Soc Am. 2018; doi: 10.1093/cid/ciy1073 30561538

10. Le Port A, Watier L, Cottrell G, Ouédraogo S, Dechavanne C, Pierrat C, et al. Infections in infants during the first 12 months of life: role of placental malaria and environmental factors. PloS One. 2011;6: e27516. doi: 10.1371/journal.pone.0027516 22096588

11. World Health Organization. Fact Sheets Detail: Schistosomiasis. https://www.who.int/news-room/fact-sheets/detail/schistosomiasis. Accessed 2 August 2019.

12. Friedman JF, Mital P, Kanzaria HK, Olds GR, Kurtis JD. Schistosomiasis and pregnancy. Trends Parasitol. 2007;23: 159–164. doi: 10.1016/j.pt.2007.02.006 17336160

13. Djènontin A, Bio-Bangana S, Moiroux N, Henry M-C, Bousari O, Chabi J, et al. Culicidae diversity, malaria transmission and insecticide resistance alleles in malaria vectors in Ouidah-Kpomasse-Tori district from Benin (West Africa): A pre-intervention study. Parasit Vectors. 2010;3: 83. doi: 10.1186/1756-3305-3-83 20819214

14. Accrombessi M, Yovo E, Cottrell G, Agbota G, Gartner A, Martin-Prevel Y, et al. Cohort profile: effect of malaria in early pregnancy on fetal growth in Benin (RECIPAL preconceptional cohort). BMJ Open. 2018;8: e019014. doi: 10.1136/bmjopen-2017-019014 29317419

15. Mischlinger J, Pitzinger P, Veletzky L, Groger M, Zoleko-Manego R, Adegnika AA, et al. Validity and reliability of methods to microscopically detect and quantify malaria parasitaemia. Trop Med Int Health TM IH. 2018;23: 980–991. doi: 10.1111/tmi.13124 29956431

16. Peters PA, Warren KS, Mahmoud AA. Rapid, accurate quantification of schistosome eggs via nuclepore filters. J Parasitol. 1976;62: 154–155. 1255368

17. Erhardt JG, Estes JE, Pfeiffer CM, Biesalski HK, Craft NE. Combined measurement of ferritin, soluble transferrin receptor, retinol binding protein, and C-reactive protein by an inexpensive, sensitive, and simple sandwich enzyme-linked immunosorbent assay technique. J Nutr. 2004;134: 3127–3132. doi: 10.1093/jn/134.11.3127 15514286

18. World Health Organization. Indicators for assessing infant and young child feeding practices: conclusions of a consensus meeting held 6–8 November 2007 in Washington D.C. Geneva, Switzerland: WHO; 2008. [Accessed 19 September 2018]. http://www.who.int/nutrition/publications/iycf_indicators_for_peer_review.pdf.

19. World Health Organization. Multicentre Growth Reference Study Group. WHO Child Growth Standards: Length/height-for-age, weight-for-age, weight-for-length, weight-for-height and body mass index-for-age: Methods and development, Geneva: World Health Organization, 2006. [Accessed 17 August 2017]. http://www.who.int/childgrowth/standards/technical_report/en/.

20. Gbédandé K, Varani S, Ibitokou S, Houngbegnon P, Borgella S, Nouatin O, et al. Malaria modifies neonatal and early-life toll-like receptor cytokine responses. Infect Immun. 2013;81: 2686–2696. doi: 10.1128/IAI.00237-13 23690399

21. Cot M, Le Hesran JY, Staalsoe T, Fievet N, Hviid L, Deloron P. Maternally transmitted antibodies to pregnancy-associated variant antigens on the surface of erythrocytes infected with Plasmodium falciparum: relation to child susceptibility to malaria. Am J Epidemiol. 2003;157: 203–209. doi: 10.1093/aje/kwf192 12543619

22. Fievet N, Varani S, Ibitokou S, Briand V, Louis S, Perrin RX, et al. Plasmodium falciparum exposure in utero, maternal age and parity influence the innate activation of foetal antigen presenting cells. Malar J. 2009;8: 251. doi: 10.1186/1475-2875-8-251 19889240

23. Dorman EK, Shulman CE, Kingdom J, Bulmer JN, Mwendwa J, Peshu N, et al. Impaired uteroplacental blood flow in pregnancies complicated by falciparum malaria. Ultrasound Obstet Gynecol Off J Int Soc Ultrasound Obstet Gynecol. 2002;19: 165–170. doi: 10.1046/j.0960-7692.2001.00545.x 11876809

24. Onzo-Aboki A, Ibikounlé M, Boko PM, Savassi BS, Doritchamou J, Siko EJ, et al. Human schistosomiasis in Benin: Countrywide evidence of Schistosoma haematobium predominance. Acta Trop. 2019;191: 185–197. 30633895

25. King CL, Malhotra I, Mungai P, Wamachi A, Kioko J, Ouma JH, et al. B cell sensitization to helminthic infection develops in utero in humans. J Immunol Baltim Md 1950. 1998;160: 3578–3584.

26. Olveda RM, Acosta LP, Tallo V, Baltazar PI, Lesiguez JLS, Estanislao GG, et al. Efficacy and safety of praziquantel for the treatment of human schistosomiasis during pregnancy: a phase 2, randomised, double-blind, placebo-controlled trial. Lancet Infect Dis. 2016;16: 199–208. doi: 10.1016/S1473-3099(15)00345-X 26511959

27. Mombo-Ngoma G, Honkpehedji J, Basra A, Mackanga JR, Zoleko RM, Zinsou J, et al. Urogenital schistosomiasis during pregnancy is associated with low birth weight delivery: analysis of a prospective cohort of pregnant women and their offspring in Gabon. Int J Parasitol. 2017;47: 69–74. 28003151

28. Siegrist D, Siegrist-Obimpeh P. Schistosoma haematobium infection in pregnancy. Acta Trop. 1992;50: 317–321. 1356302

29. Ajanga A, Lwambo NJS, Blair L, Nyandindi U, Fenwick A, Brooker S. Schistosoma mansoni in pregnancy and associations with anaemia in northwest Tanzania. Trans R Soc Trop Med Hyg. 2006;100: 59–63. doi: 10.1016/j.trstmh.2005.06.024 16219330

30. Zhang Y, Jin L, Liu J-M, Ye R, Ren A. Maternal Hemoglobin Concentration during Gestation and Risk of Anemia in Infancy: Secondary Analysis of a Randomized Controlled Trial. J Pediatr. 2016;175: 106–110.e2. doi: 10.1016/j.jpeds.2016.05.011 27263403

31. De Pee S, Bloem MW, Sari M, Kiess L, Yip R, Kosen S. The high prevalence of low hemoglobin concentration among Indonesian infants aged 3–5 months is related to maternal anemia. J Nutr. 2002;132: 2215–2221. doi: 10.1093/jn/132.8.2215 12163665

32. Colomer J, Colomer C, Gutierrez D, Jubert A, Nolasco A, Donat J, et al. Anaemia during pregnancy as a risk factor for infant iron deficiency: report from the Valencia Infant Anaemia Cohort (VIAC) study. Paediatr Perinat Epidemiol. 1990;4: 196–204. 2362876

33. Accrombessi M, Ouédraogo S, Agbota GC, Gonzalez R, Massougbodji A, Menéndez C, et al. Malaria in Pregnancy Is a Predictor of Infant Haemoglobin Concentrations during the First Year of Life in Benin, West Africa. PloS One. 2015;10: e0129510. doi: 10.1371/journal.pone.0129510 26052704


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