Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin
Autoři:
Gino Agbota aff001; Katja Polman aff003; Frank T. Wieringa aff005; Maiza Campos-Ponce aff004; Manfred Accrombessi aff001; Emmanuel Yovo aff001; Clémentine Roucher aff003; Sem Ezinmègnon aff006; Javier Yugueros Marcos aff006; Laurence Vachot aff006; Pierre Tissières aff007; Achille Massougbodji aff002; Nadine Fievet aff001; Michel Cot aff001; Valérie Briand aff001
Působiště autorů:
MERIT, IRD, Université Paris 5, Sorbonne Paris Cité, Paris, France
aff001; Centre d’Etude et de Recherche sur le Paludisme Associé à la Grossesse et à l’Enfance (CERPAGE), Cotonou, Bénin
aff002; Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
aff003; Section Infectious Diseases, Department of Health Sciences, VU Amsterdam, Amsterdam, The Netherlands
aff004; Nutripass, UMR204, Institut de Recherche pour le Développement, IRD/UM/SupAgro, Montpellier, France
aff005; Medical Diagnostic Discovery Department (MD3), bioMérieux, Marcy l’Etoile, France
aff006; UMR 9198, Institut de biologie Intégrative de la Cellule, Université Paris Saclay, Paris, France
aff007
Vyšlo v časopise:
PLoS ONE 14(9)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0222864
Souhrn
Background
Malaria and schistosomiasis represent two of the most prevalent and disabling parasitic infections in developing countries. Few studies have evaluated the effect of maternal schistosomiasis and malaria in the peri-conceptional period on infant’s risk of infection.
Methods
In Benin, women were followed from the preconception period until delivery. Subsequently, their children were followed from birth to 3 months of age. Pre-pregnancy malaria, malaria in pregnancy (MiP)—determined monthly using a thick blood smear—and urinary schistosomiasis—determined once before pregnancy and once at delivery using urine filtration—were the main maternal exposures. Infant’s febrile infection (fever with respiratory, gastrointestinal and/or cutaneous clinical signs anytime during follow-up) was the main outcome. In a secondary analysis, we checked the relation of malaria and schistosomiasis with infant’s hemoglobin (Hb) concentration. Both effects were separately assessed using logistic/mixed linear regression models.
Results
The prevalence of MiP was 35.7% with 10.8% occurring during the 1st trimester, and the prevalence of schistosomiasis was 21.8%. From birth to 3 months, 25.3% of infants had at least one episode of febrile infection. In multivariate analysis, MiP, particularly malaria in the 1st trimester, was significantly associated with a higher risk of infant’s febrile infection (aOR = 4.99 [1.1; 22.6], p = 0.03). In secondary results, pre-pregnancy malaria and schistosomiasis were significantly associated with a lower infant’s Hb concentration during the first 3 months.
Conclusion
We evidenced the deleterious effect of maternal parasitic infections on infant’s health. Our results argue in favor of the implementation of preventive strategies as early as in the peri-conception.
Klíčová slova:
Medicine and health sciences – Parasitic diseases – Malaria – Helminth infections – Schistosomiasis – Tropical diseases – Neglected tropical diseases – Pulmonology – Respiratory infections – Women's health – Maternal health – Pregnancy – Birth – Labor and delivery – Obstetrics and gynecology – Pediatrics – Neonatology – Breast feeding – Infectious diseases – Co-infections – People and places – Population groupings – Age groups – Children – Infants – Families
Zdroje
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