Comorbidity of age-related macular degeneration with Alzheimer’s disease: A histopathologic case-control study

Autoři: Gordon J. Smilnak aff001;  John R. Deans aff001;  P. Murali Doraiswamy aff002;  Sandra Stinnett aff001;  Heather E. Whitson aff003;  Eleonora M. Lad aff001
Působiště autorů: Department of Ophthalmology, Duke University Medical Center, Durham, NC, United States of America aff001;  Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, United States of America aff002;  Department of Internal Medicine, Division of Geriatrics, Duke University Medical Center, Durham, NC, United States of America aff003
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0223199



Previous studies evaluating the association between clinically diagnosed Alzheimer’s disease (AD) and age-related macular degeneration (AMD) have generated conflicting results. This study is the first to assess whether AMD prevalence is higher in AD patients than non-AD controls by using histopathology to definitively diagnose AD.


This was a retrospective case-control study utilizing diagnostic information extracted from autopsy reports of patients age 75 and above, including 115 with a neuropathological diagnosis of AD and 57 age-matched normal controls.


The rate of AMD was not significantly higher in AD cases (53.0%) than in controls (59.6%) (z = 0.820, p = 0.794). AMD severity as determined by Sarks score was similar between AD patients and controls (χ2 = 2.96, p = 0.706). There was also no significant association between Braak stage of AD severity and AMD (χ2 = 4.55, p = 0.602).


No significant effect of AD diagnosis or pathologic severity on AMD comorbidity was found, suggesting that any shared mechanisms between AMD and AD may be nondeterministic.

Klíčová slova:

Alzheimer's disease – Alzheimer's disease diagnosis and management – Autopsy – Cognitive impairment – Eye diseases – Eyes – Glaucoma – Macular degeneration


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