Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes

Autoři: Jan Benedikt Groener aff001;  Aikaterini Valkanou aff001;  Zoltan Kender aff001;  Jan Pfeiffenberger aff004;  Lars Kihm aff001;  Thomas Fleming aff001;  Peter Paul Nawroth aff001;  Stefan Kopf aff001
Působiště autorů: Department of Medicine I: Endocrinology and Clinical Chemistry, University Hospital Heidelberg, Heidelberg, Germany aff001;  Deutsches Zentrum für Diabetesforschung (DZD) e.V., Munich-Neuherberg, Germany aff002;  Medicover München Neuroendokrinologie, Munich, Germany aff003;  Department of Medicine IV: Gastroenterology and Hepatology, University Hospital Heidelberg, Heidelberg, Germany aff004;  Joint-IDC, Institute for Diabetes and Cancer at Helmholtz Zentrum Munich and University of Heidelberg, Munich-Neuherberg and Heidelberg, Germany aff005
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222771


Asprosin is a counter-regulatory hormone to insulin which plays a role in fasting. It may therefore also play a role in hypoglycaemia unawareness, which has been subsequently examined in this pilot study. Intravenous glucose tolerance test was used to induce controlled hyperglycemia whereas a hyperinsulinemic clamp test was used to induce a controlled hypoglycaemia in 15 patients with diabetes type 1, with and without hypoglycaemia unawareness. Changes in asprosin plasma levels did not differ between patients with and without hypoglycaemia unawareness. However, nine patients with insulin resistance as well as higher liver stiffness values and low-density lipoprotein but lower high-density lipoprotein levels did not show the expected increase in asprosin plasma levels during hypoglycemia. Therefore, insulin resistance and alterations in liver structure, most likely early stages of non-alcoholic fatty liver disease, seem to be relevant in type 1 diabetes and do not only lead to elevated plasma levels of asprosin, but also to a blunted asprosin response in hypoglycemia.

Klíčová slova:

Medicine and health sciences – Endocrinology – Endocrine disorders – Diabetic endocrinology – Insulin – Endocrine physiology – Metabolic disorders – Hypoglycemia – Blood sugar – Pharmacology – Drugs – Hypoglycemics – Biology and life sciences – Biochemistry – Hormones – Anatomy – Body fluids – Blood – Blood plasma – Physiology – Physical sciences – Chemistry – Chemical compounds – Organic compounds – Carbohydrates – Monosaccharides – Glucose – Organic chemistry


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