Acute kidney injury during an ultra-distance race


Autoři: Romain Jouffroy aff001;  Xavier Lebreton aff006;  Nicolas Mansencal aff007;  Dany Anglicheau aff006
Působiště autorů: Intensive Care Unit, Anesthesiology, SAMU, Necker Enfants Malades Hospital, Assistance Publique - Hôpitaux de Paris, Paris, France aff001;  Department of Anesthesia, Clinical Epidemiology and Biostatistics, Michael DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada aff002;  Population Health Research Institute; David Braley Cardiac, Vascular and Stroke Research Institute, Perioperative Medicine and Surgical Research Unit, Hamilton, Ontario, Canada aff003;  Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutical Implications - INSERM U1163 - ERL8254 – CEREMAST - Foundation IMAGINE, Paris, France aff004;  IRMES - Institute for Research in Medicine and Epidemiology of Sport, INSEP, Paris, France aff005;  Necker-Enfants Malades Institute, French National Institute of Health and Medical Research U1151, Paris Descartes, Sorbonne Paris Cité University, Department of Nephrology and Kidney Transplantation, Necker Hospital, Assistance Publique-Hôpitaux de Paris, aff006;  Department of Cardiology, Ambroise Paré Hospital, Assistance Publique-Hôpitaux de Paris (AP-HP), Centre de Référence des Cardiomyopathies et des Troubles du Rythme Cardiaque Héréditaires ou Rares, Université de Versailles-Saint Quentin (UVSQ), Boulogne, F aff007;  INSERM U-1018, CESP, Team 5 (EpReC, Renal and Cardiovascular Epidemiology), UVSQ, Villejuif, France aff008
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222544

Souhrn

Purpose

Previous studies have noted consequences of ultra-distance trail running on health, but few studies are available regarding the temporal variations of renal biomarker injury during the running. The aim of this study was to assess the of kidney function parameters temporal variation during and on short-term after an ultra-distance race.

Methods

We performed an observational study with 47 subjects participating in an ultra-distance race (80 km). Urine (47 subjects) and blood (21 subjects) samples were serially collected before (baseline—km 0), during (21 and 53 km), on arrival (80 km), and 9 days after the race (d9).

Results

Mean serum creatinine increased during the race from 90±14 μmol/L (km0) to 136±32 μmol/L (km 80—p<0.0001) corresponding to a 52% increase. Mean creatininuria progressively increased from 4.7±4.5 mmol/L (km 0) to 22.8±12.0 mmol/L (km 80) (p<0.0001). Both urinary biomarkers (Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1) of acute kidney injury (AKI) progressively increased during the race (p<0.05 vs baseline). However, after adjustment to urine dilution by urine creatinine, no significant changes remained (p>0.05). On day 9, no significant difference remains in blood and urine biomarkers compared to their respective baseline levels.

Conclusions

During an ultra-distance race, despite an acute and transient increase in the serum creatinine levels, urinary biomarkers of AKI displayed only limited changes with a complete regression on day 9. These results suggest the absence of the short-term impact of an ultra-distance race kidney function.

Klíčová slova:

Biomarkers – Blood – Creatinine – Chronic kidney disease – Kidneys – Renal system – Urine – Urinary biomarkers


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