Utility of lung ultrasound in ANCA-associated vasculitis with lung involvement
Autoři:
Natalia Buda aff001; Anna Masiak aff001; Zbigniew Zdrojewski aff001
Působiště autorů:
Department of Internal Medicine, Connective Tissue Diseases and Geriatrics, Medical University of Gdansk, Gdansk, Poland
aff001
Vyšlo v časopise:
PLoS ONE 14(9)
Kategorie:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0222189
Souhrn
Introduction
Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are forms of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). AAV most commonly affects the upper and lower respiratory tract as well as the kidneys. The first symptoms are often nonspecific, requiring careful differential diagnosis with infections and malignancies.
Materials and methods
We analyzed the clinical and radiological data of 38 patients (20 females and 18 males) diagnosed with ANCA-associated vasculitis. Lung involvement was observed in 29 cases. Lung ultrasound (LUS) was performed on 21 patients from the study group and compared to chest CT. For 7 patients the examination was conducted repeatedly.
Results
In total, 35 LUS and CT examinations were performed, revealing the following lesions: nodules, infiltrates with and without features of disintegration, caves (n = 17), diffuse alveolar hemorrhage (n = 3), and features of interstitial lung disease (ILD) with pulmonary fibrosis (PF) (n = 11). In 2 cases LUS and CT were negative. In 4 cases LUS was negative, despite a positive CT result.
Conclusions
Both in CT and LUS, images of pulmonary lesions were consistent though highly variable. Therefore, further studies are required for a larger group of patients.
Klíčová slova:
Research and analysis methods – Imaging techniques – Ultrasound imaging – Biology and life sciences – Neuroscience – Neuroimaging – Anatomy – Respiratory system – Medicine and health sciences – Diagnostic medicine – Diagnostic radiology – Tomography – Computed axial tomography – Signs and symptoms – Lesions – Radiology and imaging – Clinical medicine – Clinical immunology – Autoimmune diseases – Wegener granulomatosis – Immunology – Vasculitis – Inflammatory diseases – Rheumatology – Pathology and laboratory medicine – Hemorrhage – Thorax – Pleurae – Lungs – Vascular medicine
Zdroje
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Článek vyšel v časopise
PLOS One
2019 Číslo 9
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