Distraction of olfactory bulb-medial prefrontal cortex circuit may induce anxiety-like behavior in allergic rhinitis

English version

Autoři: Morteza Salimi ^aff001; Sepideh Ghazvineh ^aff001; Meysam Zare ^aff001; Tannaz Parsazadegan ^aff001; Kolsum Dehdar ^aff001; Milad Nazari ^aff002; Javad Mirnajafi-Zadeh ^aff001; Hamidreza Jamaati ^aff004; Mohammad Reza Raoufy ^aff001
Působiště autorů: Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran ^aff001; Faculty of Electrical Engineering, Sharif University of Technology, Tehran, Iran ^aff002; Institute for Brain Sciences and Cognition, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran ^aff003; Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran ^aff004
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: https://doi.org/10.1371/journal.pone.0221978

Souhrn

Allergic rhinitis is a chronic inflammatory disease of the upper respiratory tract, which is associated with high incidence of anxiety symptom. There is evidence that medial prefrontal cortex modulates anxiety-related behaviors and receives projections from olfactory bulb. Since olfactory dysfunction has been reported in allergic rhinitis, we aimed to evaluate anxiety-like behavior and oscillations of olfactory bulb-medial prefrontal cortex circuit in an animal model of allergic rhinitis. The number of open arm entries in elevated zero maze was significantly reduced in sensitized rats exposed to intranasal ovalbumin compared to the control group, which was indicating the enhancement of anxiety-like behavior in allergic rhinitis animals. Analysis of local field potentials in olfactory bulb and medial prefrontal cortex during immobility and exploration state showed that anxiety-like behavior induced by allergic rhinitis was in association with increased activity of medial prefrontal cortex and enhancement of olfactory bulb-medial prefrontal cortex coupling in delta and theta bands. Moreover, in allergic rhinitis animals, theta strongly coordinates local gamma activity in olfactory bulb and medial prefrontal cortex, which means to have a strong local theta/gamma coupling. We suggested that disruption of olfactory bulb-medial prefrontal cortex circuit due to allergic reactions might have a governing role for inducing anxiety-like behavior in the allergic rhinitis experimental model.

Klíčová slova:

Biology and life sciences – Anatomy – Brain – Prefrontal cortex – Olfactory bulb – Psychology – Emotions – Anxiety – Behavior – Animal behavior – Allergies – Allergic diseases – Allergic rhinitis – Zoology – Organisms – Eukaryota – Animals – Vertebrates – Amniotes – Mammals – Rodents – Rats – Medicine and health sciences – Clinical medicine – Clinical immunology – Immunology – Otorhinolaryngology – Rhinology – Nasal diseases – Rhinitis – Social sciences – Research and analysis methods – Animal studies – Experimental organism systems – Model organisms – Animal models

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Distraction of olfactory bulb-medial prefrontal cortex circuit may induce anxiety-like behavior in allergic rhinitis

Souhrn

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