The Important Role of STAT3 in Chronic Lymphocytic Leukaemia Biology
Background: Signal transducer and activator of transcription (STAT) proteins are cytoplasmic transcription factors that transmit the signal of cytokines, hormones and growth factors. STAT proteins control fundamental cellular processes including s...
Laparoscopic sacrocolpopexy using Seratex Slimsling: pilot study
Objective: To describe a new technique of laparoscopic sacrocolpopexy using material Seratex Slimsling.
Design: Pilot study.
Setting: Department of Obstetrics and Gynecology, Vyškov Hospital; Department of Obstetrics and Gynecology, Faculty of M...
Uterine leiomyomas with bizarre nuclei: analysis of 37 cases after laparoscopic or open myomectomy
Objective: The aim of this study was to analyse the clinical outcome of patients with diagnosis of leiomyoma with bizarre nuclei (LBN) undergoing uterus saving surgery due to fertility preservation.
Design: Retrospective clinical study.
Setting:...
Combined endovascular and surgical treatment of symptomatic tandem occlusion of common carotid artery and middle cerebral artery – case repor
Introduction: Cerebrovascular events are among the most common causes of invalidity or death. The aim of treatment in acute cerebral ischemia is to restore the blood flow before irreversible necrosis of brain tissue and persistent neurologic defic...
Prediction of the pre-eclampsia in the first trimester – pilot study
Aim of study: Aim of study was to find out the possibility of prediction of pre-eclampsia in the first trimester among patients with risk factors.
Type of study: Prospective study.
Name and seat of workplace: 1st Department of Gynecology and Obs...
Compliance with ethical rules for scientific publishing in biomedical Open Access journals indexed in Journal Citation Reports
This study examined compliance with the criteria of transparency and best practice in scholarly publishing defined by COPE, DOAJ, OASPA and WAME in Biomedical Open Access journals indexed in Journal Citation Reports (JCR). 259 Open Access journals...
Merkel Cell Carcinoma of the Eyelids (Clinical-Histological Study)
Aim:
To get acquainted with the issues of Merkel cell carcinoma (MCC) when the eyelid is affected and with its surgical solution.
Materials:
MCC of the right upper eyelid was at the Department of Ophthalmology in the Faculty Hospital Královsk...
Clinical Management and Outcome in Extreme Retroperitoneal Growing Teratoma Syndrome of Testicular Origin – Clinical Management and Effect of the Treatment
Background: Growing teratoma syndrome (GTS) is an uncommon clinical finding in patients treated for testicular cancer. It is diagnosed during or after chemotherapy as an expanding tumour mass not responding to the treatment while the serum tumour...
Hepatic Injury Induced by a Single Dose of Nivolumab – a Case Report and Literature Review
Background: The use of nivolumab in the treatment of metastatic melanoma has become well established during past years. Despite its undeniable efficacy, immune-related side effects may occur, including acute liver injury. Liver toxicity caused by...
Leptomeningeal Metastasis in a Breast Cancer Treated with Two Lines of Intrathecal Chemotherapy – a Case Report
Background: Leptomeningeal metastasis (LM) in breast cancer is associated with a poor prognosis. Although no randomised trial has demonstrated that intrathecal chemotherapy actually prolongs survival, this treatment is considered standard of care...