Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice


Autoři: T. Kramskaya aff001;  G. Leontieva aff001;  Yu. Desheva aff002;  K. Grabovskaya aff001;  T. Gupalova aff001;  L. Rudenko aff002;  A. Suvorov aff001
Působiště autorů: Department of Molecular Microbiology, Institute of Experimental Medicine, Saint Petersburg, Russian Federation aff001;  Department of Virology, Institute of Experimental Medicine, Saint Petersburg, Russian Federation aff002;  Department of Fundamental Medicine and Medical Technologies, Faculty of Dentistry and Medical Technologies, Saint Petersburg State University, Saint Petersburg, Russian Federation aff003
Vyšlo v časopise: PLoS ONE 14(9)
Kategorie: Research Article
doi: 10.1371/journal.pone.0222148

Souhrn

Influenza and its bacterial complications are a leading cause of morbidity and mortality worldwide. The effect of combined immunization with live influenza vaccine and recombinant chimeric pneumococcal protein in dual infection caused by influenza H1N1 and S. pneumoniae (serotype 3) has been studied. The combined vaccine consisted of the strain A/California/2009/38 (H1N1) pdm and chimeric recombinant protein PSPF composed of immunodominant fragments of the surface virulence factors of S. pneumoniae—PsaA, PspA, and Shr1875—associated with modified salmonella flagellin. Vaccinated mice were infected with the influenza virus 24 hours before or 24 hours after the onset of pneumococcal infection. The protective effect of combined vaccination was shown on both models of viral-bacterial infection.

Klíčová slova:

Medicine and health sciences – Infectious diseases – Viral diseases – Influenza – Infectious disease control – Vaccines – Viral vaccines – Recombinant vaccines – Bacterial diseases – Pathology and laboratory medicine – Pathogens – H1N1 – Streptococcus – Pneumococcus – Immunology – Public and occupational health – Preventive medicine – Biology and life sciences – Organisms – Viruses – RNA viruses – Orthomyxoviruses – Influenza viruses – Influenza A virus – Bacteria – Microbiology – Medical microbiology – Microbial pathogens – Viral pathogens – Bacterial pathogens – Virology – Vaccination and immunization


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2019 Číslo 9

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