The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection


Autoři: Vitor E. Fernandes aff001;  Giuseppe Ercoli aff002;  Alan Bénard aff003;  Carolin Brandl aff004;  Hannah Fahnenstiel aff004;  Jennifer Müller-Winkler aff004;  Georg F. Weber aff003;  Paul Denny aff005;  Lars Nitschke aff004;  Peter W. Andrew aff001
Působiště autorů: Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom aff001;  Department of Genetics, University of Leicester, Leicester, United Kingdom aff002;  Department of Surgery, University Hospital Erlangen, Erlangen, Germany aff003;  Division of Genetics, Department of Biology, University of Erlangen, Erlangen, Germany aff004;  Mammalian Genetics Unit, Medical Research Council, Harwell, United Kingdom aff005
Vyšlo v časopise: The B-cell inhibitory receptor CD22 is a major factor in host resistance to Streptococcus pneumoniae infection. PLoS Pathog 16(4): e32767. doi:10.1371/journal.ppat.1008464
Kategorie: Research Article
doi: 10.1371/journal.ppat.1008464

Souhrn

Streptococcus pneumoniae is a major human pathogen, causing pneumonia and sepsis. Genetic components strongly influence host responses to pneumococcal infections, but the responsible loci are unknown. We have previously identified a locus on mouse chromosome 7 from a susceptible mouse strain, CBA/Ca, to be crucial for pneumococcal infection. Here we identify a responsible gene, Cd22, which carries a point mutation in the CBA/Ca strain, leading to loss of CD22 on B cells. CBA/Ca mice and gene-targeted CD22-deficient mice on a C57BL/6 background are both similarly susceptible to pneumococcal infection, as shown by bacterial replication in the lungs, high bacteremia and early death. After bacterial infections, CD22-deficient mice had strongly reduced B cell populations in the lung, including GM-CSF producing, IgM secreting innate response activator B cells, which are crucial for protection. This study provides striking evidence that CD22 is crucial for protection during invasive pneumococcal disease.

Klíčová slova:

B cells – Blood – Escherichia coli infections – Genetic loci – Pneumococcus – Respiratory infections – Spleen – Streptococcal infections


Zdroje

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