Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits


Autoři: Suzanne Vogelezang aff001;  Jonathan P. Bradfield aff004;  Tarunveer S. Ahluwalia aff006;  John A. Curtin aff009;  Timo A. Lakka aff010;  Niels Grarup aff008;  Markus Scholz aff013;  Peter J. van der Most aff015;  Claire Monnereau aff001;  Evie Stergiakouli aff016;  Anni Heiskala aff019;  Momoko Horikoshi aff020;  Iryna O. Fedko aff023;  Natalia Vilor-Tejedor aff024;  Diana L. Cousminer aff028;  Marie Standl aff030;  Carol A. Wang aff031;  Jorma Viikari aff032;  Frank Geller aff034;  Carmen Iñiguez aff027;  Niina Pitkänen aff037;  Alessandra Chesi aff028;  Jonas Bacelis aff039;  Loic Yengo aff041;  Maties Torrent aff043;  Ioanna Ntalla aff045;  Øyvind Helgeland aff046;  Saskia Selzam aff048;  Judith M. Vonk aff049;  Mohammed H. Zafarmand aff050;  Barbara Heude aff053;  Ismaa Sadaf Farooqi aff054;  Akram Alyass aff055;  Robin N. Beaumont aff056;  Christian T. Have aff008;  Peter Rzehak aff057;  Jose Ramon Bilbao aff058;  Theresia M. Schnurr aff008;  Inês Barroso aff061;  Klaus Bønnelykke aff006;  Lawrence J. Beilin aff063;  Lisbeth Carstensen aff034;  Marie-Aline Charles aff053;  Bo Chawes aff006;  Karine Clément aff064;  Ricardo Closa-Monasterolo aff065;  Adnan Custovic aff066;  Johan G. Eriksson aff067;  Joaquin Escribano aff065;  Maria Groen-Blokhuis aff023;  Veit Grote aff057;  Dariusz Gruszfeld aff069;  Hakon Hakonarson aff005;  Torben Hansen aff008;  Andrew T. Hattersley aff056;  Mette Hollensted aff008;  Jouke-Jan Hottenga aff023;  Elina Hyppönen aff073;  Stefan Johansson aff046;  Raimo Joro aff010;  Mika Kähönen aff077;  Ville Karhunen aff079;  Wieland Kiess aff081;  Bridget A. Knight aff071;  Berthold Koletzko aff057;  Andreas Kühnapfel aff013;  Kathrin Landgraf aff081;  Jean-Paul Langhendries aff083;  Terho Lehtimäki aff084;  Jaakko T. Leinonen aff086;  Aihuali Li aff055;  Virpi Lindi aff087;  Estelle Lowry aff019;  Mariona Bustamante aff024;  Carolina Medina-Gomez aff001;  Mads Melbye aff034;  Kim F. Michaelsen aff092;  Camilla S. Morgen aff093;  Trevor A. Mori aff063;  Tenna R. H. Nielsen aff095;  Harri Niinikoski aff097;  Albertine J. Oldehinkel aff099;  Katja Pahkala aff037;  Kalliope Panoutsopoulou aff101;  Oluf Pedersen aff008;  Craig E. Pennell aff031;  Christine Power aff102;  Sijmen A. Reijneveld aff103;  Fernando Rivadeneira aff003;  Angela Simpson aff009;  Peter D. Sly aff104;  Jakob Stokholm aff006;  Kook K. Teo aff106;  Elisabeth Thiering aff030;  Nicholas J. Timpson aff016;  André G. Uitterlinden aff003;  Catharina E. M. van Beijsterveldt aff023;  Barbera D. C. van Schaik aff108;  Marc Vaudel aff046;  Elvira Verduci aff109;  Rebecca K. Vinding aff006;  Mandy Vogel aff081;  Eleftheria Zeggini aff101;  Sylvain Sebert aff019;  Mads V. Lind aff092;  Christopher D. Brown aff113;  Loreto Santa-Marina aff114;  Eva Reischl aff117;  Christine Frithioff-Bøjsøe aff008;  David Meyre aff055;  Eleanor Wheeler aff061;  Ken Ong aff119;  Ellen A. Nohr aff120;  Tanja G. M. Vrijkotte aff050;  Gerard H. Koppelman aff121;  Robert Plomin aff048;  Pål R. Njølstad aff046;  George D. Dedoussis aff124;  Philippe Froguel aff041;  Thorkild I. A. Sørensen aff008;  Bo Jacobsson aff039;  Rachel M. Freathy aff056;  Babette S. Zemel aff070;  Olli Raitakari aff037;  Martine Vrijheid aff024;  Bjarke Feenstra aff034;  Leo-Pekka Lyytikainen aff084;  Harold Snieder aff015;  Holger Kirsten aff013;  Patrick G. Holt aff129;  Joachim Heinrich aff030;  Elisabeth Widén aff086;  Jordi Sunyer aff024;  Dorret I. Boomsma aff023;  Marjo-Riitta Jarvelin aff019;  Antje Körner aff081;  George Davey Smith aff016;  Jens-Christian Holm aff008;  Mustafa Atalay aff010;  Clare Murray aff009;  Hans Bisgaard aff006;  Mark I. McCarthy aff020;  ;  Vincent W. V. Jaddoe aff001;  Struan F. A. Grant aff005;  Janine F. Felix aff001;  John A. Curtin aff010;  Timo A. Lakka aff011;  Markus Scholz aff014;  Peter J. van der Most aff016;  Evie Stergiakouli aff017;  Anni Heiskala aff020;  Momoko Horikoshi aff021;  Iryna O. Fedko aff024;  Natalia Vilor-Tejedor aff025;  Diana L. Cousminer aff029;  Marie Standl aff031;  Carol A. Wang aff032;  Jorma Viikari aff033;  Frank Geller aff035;  Carmen Iñiguez aff028;  Niina Pitkänen aff038;  Alessandra Chesi aff029;  Jonas Bacelis aff040;  Loic Yengo aff042;  Maties Torrent aff044;  Ioanna Ntalla aff046;  Øyvind Helgeland aff047;  Saskia Selzam aff049;  Judith M. Vonk aff050;  Mohammed H. Zafarmand aff051;  Barbara Heude aff054;  Ismaa Sadaf Farooqi aff055;  Akram Alyass aff056;  Robin N. Beaumont aff057;  Peter Rzehak aff058;  Jose Ramon Bilbao aff059;  Inês Barroso aff062;  Lawrence J. Beilin aff064;  Lisbeth Carstensen aff035;  Marie-Aline Charles aff054;  Karine Clément aff065;  Ricardo Closa-Monasterolo aff066;  Adnan Custovic aff067;  Johan G. Eriksson aff068;  Joaquin Escribano aff066;  Maria Groen-Blokhuis aff024;  Veit Grote aff058;  Dariusz Gruszfeld aff070;  Andrew T. Hattersley aff057;  Jouke-Jan Hottenga aff024;  Elina Hyppönen aff074;  Stefan Johansson aff047;  Raimo Joro aff011;  Mika Kähönen aff078;  Ville Karhunen aff080;  Wieland Kiess aff082;  Bridget A. Knight aff072;  Berthold Koletzko aff058;  Andreas Kühnapfel aff014;  Kathrin Landgraf aff082;  Jean-Paul Langhendries aff084;  Terho Lehtimäki aff085;  Jaakko T. Leinonen aff087;  Aihuali Li aff056;  Virpi Lindi aff088;  Estelle Lowry aff020;  Mariona Bustamante aff025;  Mads Melbye aff035;  Kim F. Michaelsen aff093;  Camilla S. Morgen aff094;  Trevor A. Mori aff064;  Tenna R. H. Nielsen aff096;  Harri Niinikoski aff098;  Albertine J. Oldehinkel aff100;  Katja Pahkala aff038;  Kalliope Panoutsopoulou aff102;  Craig E. Pennell aff032;  Christine Power aff103;  Sijmen A. Reijneveld aff104;  Angela Simpson aff010;  Peter D. Sly aff105;  Kook K. Teo aff107;  Elisabeth Thiering aff031;  Nicholas J. Timpson aff017;  Catharina E. M. van Beijsterveldt aff024;  Barbera D. C. van Schaik aff109;  Marc Vaudel aff047;  Elvira Verduci aff110;  Mandy Vogel aff082;  Eleftheria Zeggini aff102;  Sylvain Sebert aff020;  Mads V. Lind aff093;  Christopher D. Brown aff114;  Loreto Santa-Marina aff115;  Eva Reischl aff118;  David Meyre aff056;  Eleanor Wheeler aff062;  Ken Ong aff120;  Ellen A. Nohr aff121;  Tanja G. M. Vrijkotte aff051;  Gerard H. Koppelman aff122;  Robert Plomin aff049;  Pål R. Njølstad aff047;  George D. Dedoussis aff125;  Philippe Froguel aff042;  Bo Jacobsson aff040;  Rachel M. Freathy aff057;  Babette S. Zemel aff071;  Olli Raitakari aff038;  Martine Vrijheid aff025;  Bjarke Feenstra aff035;  Leo-Pekka Lyytikainen aff085;  Harold Snieder aff016;  Holger Kirsten aff014;  Patrick G. Holt aff130;  Joachim Heinrich aff031;  Elisabeth Widén aff087;  Jordi Sunyer aff025;  Dorret I. Boomsma aff024;  Marjo-Riitta Jarvelin aff020;  Antje Körner aff082;  George Davey Smith aff017;  Mustafa Atalay aff011;  Clare Murray aff010;  Mark I. McCarthy aff021
Působiště autorů: The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands aff001;  Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, the Netherlands aff002;  Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands aff003;  Quantinuum Research LLC, San Diego, California, United States of America aff004;  Center for Applied Genomics, Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America aff005;  Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark aff006;  Steno Diabetes Center Copenhagen, Gentofte, Denmark aff007;  Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark aff008;  Division of Infection Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, United Kingdom aff009;  The Bioinformatics Center, Department of Biology, University of Copenhagen, Copenhagen, Denmark aff009;  Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland aff010;  Division of Infection Immunity and Respiratory Medicine, School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust, Manchester, United Kingdom aff010;  Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland aff011;  Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland aff011;  Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland aff012;  Foundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio, Finland aff012;  Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany aff013;  Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland aff013;  LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany aff014;  Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany aff014;  Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands aff015;  LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany aff015;  MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom aff016;  Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands aff016;  Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom aff017;  MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom aff017;  School of Oral and Dental Sciences, University of Bristol, Bristol, United Kingdom aff018;  Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom aff018;  Center for Life Course Health Research, University of Oulu, Oulu, Finland aff019;  School of Oral and Dental Sciences, University of Bristol, Bristol, United Kingdom aff019;  Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom aff020;  Center for Life Course Health Research, University of Oulu, Oulu, Finland aff020;  Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom aff021;  Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom aff021;  RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan aff022;  Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom aff022;  Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands aff023;  RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan aff023;  ISGlobal, Barcelona, Spain aff024;  Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands aff024;  Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain aff025;  ISGlobal, Barcelona, Spain aff025;  BarcelonaBeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain aff026;  Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain aff026;  CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain aff027;  BarcelonaBeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain aff027;  Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America aff028;  CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain aff028;  Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America aff029;  Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America aff029;  Institute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany aff030;  Department of Genetics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America aff030;  School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, Australia aff031;  Institute of Epidemiology, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany aff031;  Department of Medicine, University of Turku, Turku, Finland aff032;  School of Medicine and Public Health, Faculty of Medicine and Health, The University of Newcastle, Newcastle, Australia aff032;  Division of Medicine, Turku University Hospital, Turku, Finland aff033;  Department of Medicine, University of Turku, Turku, Finland aff033;  Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark aff034;  Division of Medicine, Turku University Hospital, Turku, Finland aff034;  Department of Statistics and Computational Research–Universitat de València, València, Spain aff035;  Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark aff035;  Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, València, Spain aff036;  Department of Statistics and Computational Research–Universitat de València, València, Spain aff036;  Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland aff037;  Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, València, Spain aff037;  Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland aff038;  Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland aff038;  Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg Sweden aff039;  Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland aff039;  Region Västra Götaland, Sahlgrenska University Hospital, Department of Obstetrics and Gynecology, Gothenburg Sweden aff040;  Department of Obstetrics and Gynecology, Institute of Clinical Science, Sahlgrenska Academy, University of Gothenburg, Gothenburg Sweden aff040;  University Lille, Centre National de la Recherche Scientifique, Institut Pasteur de Lille, UMR 8199—European Genomic Institute for Diabetes, Lille, France aff041;  Region Västra Götaland, Sahlgrenska University Hospital, Department of Obstetrics and Gynecology, Gothenburg Sweden aff041;  Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia aff042;  University Lille, Centre National de la Recherche Scientifique, Institut Pasteur de Lille, UMR 8199—European Genomic Institute for Diabetes, Lille, France aff042;  Area de Salut de Menorca ib-salut, Menorca, Spain aff043;  Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia aff043;  Institut d'Investigacio Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain aff044;  Area de Salut de Menorca ib-salut, Menorca, Spain aff044;  William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom aff045;  Institut d'Investigacio Sanitaria Illes Balears (IdISBa), Palma de Mallorca, Spain aff045;  KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway aff046;  William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom aff046;  Department of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway aff047;  KG Jebsen Center for Diabetes Research, Department of Clinical Science, University of Bergen, Bergen, Norway aff047;  Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom aff048;  Department of Genetics and Bioinformatics, Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway aff048;  Department of Epidemiology, GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands aff049;  Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom aff049;  Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands aff050;  Department of Epidemiology, GRIAC (Groningen Research Institute for Asthma and COPD), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands aff050;  Department of Obstetrics & Gynecology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands aff051;  Department of Public Health, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands aff051;  Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands aff052;  Department of Obstetrics & Gynecology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands aff052;  Université de Paris, CRESS, INSERM, INRA, Paris, France aff053;  Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands aff053;  University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom aff054;  Université de Paris, CRESS, INSERM, INRA, Paris, France aff054;  Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada aff055;  University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, United Kingdom aff055;  Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, United Kingdom aff056;  Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada aff056;  Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig-Maximilians Universität München (LMU), Munich, Germany aff057;  Institute of Biomedical and Clinical Science, College of Medicine and Health, University of Exeter, Exeter, United Kingdom aff057;  University of the Basque Country (UPV/EHU), Leioa, Spain aff058;  Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig-Maximilians Universität München (LMU), Munich, Germany aff058;  Biocrues-Bizkaia Health Research Institute, Barakaldo, Spain aff059;  University of the Basque Country (UPV/EHU), Leioa, Spain aff059;  CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM), Spain aff060;  Biocrues-Bizkaia Health Research Institute, Barakaldo, Spain aff060;  Wellcome Sanger Institute, Cambridge, United Kingdom aff061;  CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM), Spain aff061;  MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom aff062;  Wellcome Sanger Institute, Cambridge, United Kingdom aff062;  Medical School, The University of Western Australia, Perth, Western Australia, Australia aff063;  MRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom aff063;  Nutrition and Obesities; systemic approaches research unit, Sorbonne University, INSERM, Pitie- Salpêtrière Hospital, Assistance Publique hôpital de Paris, Paris, France aff064;  Medical School, The University of Western Australia, Perth, Western Australia, Australia aff064;  Pediatrics, Nutrition and Development Research Unit, Universitat Rovira i Virgili, IISPV, Reus, Spain aff065;  Nutrition and Obesities; systemic approaches research unit, Sorbonne University, INSERM, Pitie- Salpêtrière Hospital, Assistance Publique hôpital de Paris, Paris, France aff065;  National Heart and Lung Institute, Imperial College London, London, United Kingdom aff066;  Pediatrics, Nutrition and Development Research Unit, Universitat Rovira i Virgili, IISPV, Reus, Spain aff066;  Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland aff067;  National Heart and Lung Institute, Imperial College London, London, United Kingdom aff067;  Department of Obstetrics & Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore aff068;  Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland aff068;  Neonatal Department, Children's Memorial Health Institute, Warsaw, Poland aff069;  Department of Obstetrics & Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore aff069;  Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America aff070;  Neonatal Department, Children's Memorial Health Institute, Warsaw, Poland aff070;  NIHR Exeter Clinical Research Facility, College of Medicine and Health, University of Exeter, and Royal Devon and Exeter NHS Foundation Trust, Exeter, United Kingdom aff071;  Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, United States of America aff071;  The Danish Diabetes Academy, Odense, Denmark aff072;  NIHR Exeter Clinical Research Facility, College of Medicine and Health, University of Exeter, and Royal Devon and Exeter NHS Foundation Trust, Exeter, United Kingdom aff072;  Australian Centre for Precision Health, University of South Australia Cancer Research Institute, Adelaide, Australia aff073;  The Danish Diabetes Academy, Odense, Denmark aff073;  Population, Policy and Practice, UCL Institute of Child Health, University College London, London, United Kingdom aff074;  Australian Centre for Precision Health, University of South Australia Cancer Research Institute, Adelaide, Australia aff074;  South Australian Health and Medical Research Institute, Adelaide, Australia aff075;  Population, Policy and Practice, UCL Institute of Child Health, University College London, London, United Kingdom aff075;  Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway aff076;  South Australian Health and Medical Research Institute, Adelaide, Australia aff076;  Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland aff077;  Department of Medical Genetics, Haukeland University Hospital, Bergen, Norway aff077;  Department of Clinical Physiology, Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland aff078;  Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland aff078;  Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom aff079;  Department of Clinical Physiology, Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland aff079;  MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, United Kingdom aff080;  Department of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, United Kingdom aff080;  Center for Pediatric Research, University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany aff081;  MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College, London, United Kingdom aff081;  Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany aff082;  Center for Pediatric Research, University Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany aff082;  CHC–Health Group, Liège, Belgium aff083;  Integrated Research and Treatment Center (IFB) Adiposity Diseases, University of Leipzig, Leipzig, Germany aff083;  Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland aff084;  CHC–Health Group, Liège, Belgium aff084;  Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland aff085;  Department of Clinical Chemistry, Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland aff085;  Department of Clinical Chemistry, Finnish Cardiovascular Research Center—Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland aff086;  Institute For Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland aff086;  Institute For Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland aff087;  University of Eastern Finland Library Kuopio, Kuopio, Finland aff087;  University of Eastern Finland Library Kuopio, Kuopio, Finland aff088;  Biocenter Oulu, Oulu University Hospital, Oulu, Finland aff088;  Biocenter Oulu, Oulu University Hospital, Oulu, Finland aff089;  Universitat Pompeu Fabra (UPF), Barcelona, Spain aff089;  Universitat Pompeu Fabra (UPF), Barcelona, Spain aff090;  Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands aff090;  Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, the Netherlands aff091;  Department of Medicine, Stanford School of Medicine, Stanford, California, United States of America aff091;  Department of Medicine, Stanford School of Medicine, Stanford, California, United States of America aff092;  Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark aff092;  Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark aff093;  Department of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark aff093;  Department of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark aff094;  National Insitute of Public Health, University of Southern Denmark, Copenhagen, Denmark aff094;  National Insitute of Public Health, University of Southern Denmark, Copenhagen, Denmark aff095;  Department of Pediatrics, Hvidovre Hospital, Hvidovre, Denmark aff095;  Department of Pediatrics, Hvidovre Hospital, Hvidovre, Denmark aff096;  The Children’s Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark aff096;  The Children’s Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark aff097;  Department of Physiology, University of Turku, Turku, Finland aff097;  Department of Physiology, University of Turku, Turku, Finland aff098;  Department of Pediatrics, University of Turku, Turku, Finland aff098;  Department of Pediatrics, University of Turku, Turku, Finland aff099;  Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center, Groningen, the Netherlands aff099;  Interdisciplinary Center Psychopathology and Emotion Regulation, University of Groningen, University Medical Center, Groningen, the Netherlands aff100;  Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland aff100;  Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland aff101;  Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom aff101;  Wellcome Trust Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, United Kingdom aff102;  Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom aff102;  Population, Policy and Practice, UCL Great Ormond Street Institute of Child Health, University College London, London, United Kingdom aff103;  Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands aff103;  Department of Health Sciences, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands aff104;  Child Health Research Centre, University of Queensland, Brisbane, Australia aff104;  Child Health Research Centre, University of Queensland, Brisbane, Australia aff105;  World Health Organization, WHO Collaborating Centre for Children’s Health and Environment, Brisbane, Queensland, Australia aff105;  World Health Organization, WHO Collaborating Centre for Children’s Health and Environment, Brisbane, Queensland, Australia aff106;  Department of Medicine, McMaster University, Hamilton, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada aff106;  Department of Medicine, McMaster University, Hamilton, Canada; Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Canada aff107;  Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging NCHA), Leiden, the Netherlands aff107;  Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging NCHA), Leiden, the Netherlands aff108;  Bioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands aff108;  Bioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands aff109;  Department of Pediatrics, San Paolo Hospital, University of Milan, Milan, Italy aff109;  Department of Pediatrics, San Paolo Hospital, University of Milan, Milan, Italy aff110;  Institute of Translational Genomics, 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Vyšlo v časopise: Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits. PLoS Genet 16(10): e32767. doi:10.1371/journal.pgen.1008718
Kategorie: Research Article
doi: 10.1371/journal.pgen.1008718

Souhrn

The genetic background of childhood body mass index (BMI), and the extent to which the well-known associations of childhood BMI with adult diseases are explained by shared genetic factors, are largely unknown. We performed a genome-wide association study meta-analysis of BMI in 61,111 children aged between 2 and 10 years. Twenty-five independent loci reached genome-wide significance in the combined discovery and replication analyses. Two of these, located near NEDD4L and SLC45A3, have not previously been reported in relation to either childhood or adult BMI. Positive genetic correlations of childhood BMI with birth weight and adult BMI, waist-to-hip ratio, diastolic blood pressure and type 2 diabetes were detected (Rg ranging from 0.11 to 0.76, P-values <0.002). A negative genetic correlation of childhood BMI with age at menarche was observed. Our results suggest that the biological processes underlying childhood BMI largely, but not completely, overlap with those underlying adult BMI. The well-known observational associations of BMI in childhood with cardio-metabolic diseases in adulthood may reflect partial genetic overlap, but in light of previous evidence, it is also likely that they are explained through phenotypic continuity of BMI from childhood into adulthood.

Klíčová slova:

Adipose tissue – Body mass index – Genetic loci – Genetics of disease – Genome-wide association studies – Human genetics – Metaanalysis – Single nucleotide polymorphisms


Zdroje

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Imunitní trombocytopenie (ITP) u dospělých pacientů
Autoři: prof. MUDr. Tomáš Kozák, Ph.D., MBA

Pěnová skleroterapie
Autoři: MUDr. Marek Šlais

White paper - jak vidíme optimální péči o zubní náhrady
Autoři: MUDr. Jindřich Charvát, CSc.

Hemofilie - série kurzů

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