Reconstructing systematic persistent impacts of promotional marketing with empirical nonlinear dynamics
Authors:
Ray Huffaker aff001; Andrew Fearne aff002
Authors place of work:
Department of Agricultural and Biological Engineering, University of Florida, Gainesville, Florida, United States of America
aff001; Norwich Business School, University of East Anglia, Norwich, England, United Kingdom
aff002
Published in the journal:
PLoS ONE 14(9)
Category:
Research Article
doi:
https://doi.org/10.1371/journal.pone.0221167
Summary
An empirical question of long-standing interest is how price promotions affect a brand’s sale shares in the fast-moving consumer-goods market. We investigated this question with concurrent promotions and sales records of specialty beer brands pooled over Tesco stores in the UK. Most brands were continuously promoted, rendering infeasible a conventional approach of establishing impact against an off-promotion sales baseline, and arguing in favor of a dynamics approach. Moreover, promotion/sales records were volatile without easily-discernable regularity. Past work conventionally attributed volatility to the impact of exogenous random shocks on stable markets, and reasoned that promotions have only an ephemeral impact on sales shares in stationary mean-reverting stochastic markets, or a persistent freely-wandering impact in nonstationary markets. We applied new empirical methods from the applied sciences to uncover an overlooked alternative: ‘systematic persistence’ in which promotional impacts evolve systematically in an endogenously-unstable market governed by deterministic-nonlinear dynamics. We reconstructed real-world market dynamics from the Tesco dataset, and detected deterministic-nonlinear market dynamics. We used reconstructed market dynamics to identify a complex network of systematic interactions between promotions and sales shares among competing brands, and quantified/characterized the dynamics of these interactions. For the majority of weeks in the study, we found that: (1) A brand’s promotions drove down own sales shares (a possibility recognized in the literature), but ‘cannibalized’ sales shares of competing brands (perhaps explaining why brands were promoted despite a negative marginal impact on own sales shares); and (2) Competitive interactions between brands owned by the same multinational brewery differed from those with outside brands. In particular, brands owned by the same brewery enjoyed a ‘mutually-beneficial’ relationship in which an incremental increase in the sales share of one marginally increased the sales share of the other. Alternatively, the sales shares of brands owned by different breweries preyed on each other’s market shares.
Keywords:
Biology and life sciences – Organisms – Eukaryota – Physical sciences – Engineering and technology – Animals – Social sciences – Sociology – Communications – Computer and information sciences – Mathematics – Vertebrates – Amniotes – Mammals – statistics – Marketing – Physics – Statistical data – Leporids – Hares – Cats – Signal processing – Systems science – Nonlinear dynamics – Thermodynamics – Entropy – Dynamical systems – Lynx
Introduction
We investigate the dynamic impact of a stream of price promotions on a brand’s market share of sales in the fast-moving consumer-goods market. Price promotions include temporary price reductions, coupons, rebates, promotion packs with extra content, loyalty discounts with repeated purchases, or free goods and services contingent on the purchase of something else (e.g., a ‘two for one special’ or a free bottle of wine with dinner).
At first glance, we might well expect promotions to have a positive impact on a brand’s sales share; otherwise, why would retailers invest in them? Existing customers should increase their short-term purchases of the promoted brand in response to lower prices, and their longer-term purchases due to increased brand loyalty (from receiving benefits beyond their normal purchase) and an ‘inertia’ effect encouraging repeated purchases. New customers might be induced to switch from other brands on a trial basis [1]. However, the literature teaches us that promotions might also have a negative impact by lowering a consumer’s repurchase probability when the brand is no longer promoted [2]. Promotions could cause consumers to downgrade their perceptions of brand quality, focus too heavily on price rather than the brand’s distinguishing qualities, or lower their price expectations to the promotional level. Moreover, these positive and negative forces could operate simultaneously [1, 3]. Consequently, the ambiguous net impact of price promotions on a brand’s sales share must be resolved empirically from available promotions and sales records, with theory confirmed brick-by-brick from detected empirical regularities across diverse cases [4].
We investigate the impact of price promotions with concurrent sales and promotions time-series records of specialty beer brands pooled over all Tesco stores (the largest chain in the UK). Specialty beers are “typically regular beers brewed to a classic style (such as Porter, Stout, or Pale Ale) but with some new flavor added” http://www.dummies.com/food-drink/drinks/beer/types-of-specialty-beers/. This rich data set affords a valuable opportunity to advance empirical understanding of real-world promotional marketing dynamics. The records cover 104 weeks (February 2009 to January 2011). Weekly sales were provided by scanned purchases of Tesco ClubCard holders numbering roughly 17 million households in the UK (40% of all households) (S1 File). ClubCard purchases account for about 80% of total sales. Weekly promotions made by each brand were collected by dunnhumby—a subsidiary of Tesco focused on consumer data analysis (S2 File). As discussed more extensively below, we converted the records to mean-adjusted weekly brand shares of sales and promotions.
The records are plotted in Fig 1 (black curves). We first observe that most brands were continuously promoted (Fig 1A). Past work commonly evaluated the effectiveness of isolated promotions by comparing sales after a promotion against a prior off-promotion baseline [1]. This approach works best if promotions are indeed independent events. However, when brands are continuously promoted, there are reasons to expect in theory and practice that consumer responses will be linked through time. For example, consumers may stockpile product in response to an earlier price discount, and thus be taken out of the market for a current promotion [3]. Analysts miscasting a continuous promotional stream as a sequence of independent events face the daunting—if not impossible—task of establishing an artificial baseline that cuts off the effectiveness of previous promotions without substantially biasing the results. This argues for an empirical approach that respects the dynamics of real-world promotional activity.
Plots of Tesco weekly promotions and sales records with isolated signals.
We improve the performance of NLTS by isolating structured variation (signal) from unstructured variation (noise) in observed records (black curves) with singular spectrum analysis. Isolated signals (red curves) are dominated by slow-moving trends, a triplet of lower-frequency oscillations (13, 8.667, and 6.5 weeks), and another triplet of higher-frequency oscillations (5.2, 4.2, and 2.1 weeks).
We next observe that the promotions and sales records are volatile without easily-discernable patterns or regularity (Fig 1A and 1B). Early work conventionally attributed observed market volatility to exogenous random shocks; and consequently, relied on an array of linear-stochastic models that restricted the range of empirically-detectable promotional marketing dynamics. In particular, these models presumed that markets self-correct as economic agents re-adjust supply to demand in response to shocks, and thus formulated sales as stationary mean-reverting stochastic processes. As a result, promotions were restricted to have only an ephemeral impact because sales would revert to pre-promotional long-term mean performance levels (see review by Dekimpe et al., 2005). Distributed-lag models (such as the ‘Koyck’ model) forcibly dampened long-term promotional impacts. These models were justified empirically on the basis that they provided good fits to the data [5].
Subsequent work worried that empirical evidence supporting ephemeral promotional impacts was more an artifact of the stationarity modeling restriction than an accurate depiction of real-world market behavior; and consequently, formulated more flexible models allowing for nonstationary sales that randomly evolve (‘freely wander’) in response to promotional shocks [6]. In particular, linear stochastic autoregressive specifications empirically distinguished between stationary and nonstationary sales by determining whether the fitted model’s autoregressive lag polynomial had a less than unitary root (stationarity), or a unit root (nonstationarity). A current change in sales was calculated as the weighted sum of promotional-marketing shocks in previous periods, where weights measured the current impact of a unit shock in a given previous period. This remains a conventional approach for detecting persistent market impacts in other applications as well [7].
In limiting market taxonomy to the dichotomy between self-correcting stationary markets and freely-wandering nonstationary markets, past work foreclosed a third possible explanation for real-world volatility: Markets may be endogenously unstable (not self-correcting) as economic agents are prevented from smoothly re-adjusting supply to demand due, for example, to financial or institutional constraints. In a series of articles entitled “Big Economic Ideas” [8], The Economist recommended that “like physicists, [economists] should study instability instead of assuming that economies naturally self-correct” [9]. Similarly, Galtier (2013) identified diagnosing whether markets are inherently unstable as the key to evaluating the effectiveness of various public market interventions to counter threats to food security from food-price volatility [10]. Acknowledging the possibility of endogenously unstable markets opens the door to the possibility of ‘systematic persistence’ in which the economic impacts of strategic (not random) promotions persist and evolve systematically (not freely wander) in accordance with a complex network of nonlinear state-dependent interactions encoding the history of moves and countermoves of competing brands.
Whether volatility in market records is stochastically or deterministically forced makes a profound difference in how to reliably assess the dynamic impact of promotions. In a linear-stochastic world, we look for randomly-drifting interactions among market variables. In a nonlinear-deterministic world, we look for systematic state-dependent interactions that depend mechanistically on the levels of market variables over time. Indeed, systematic interactions are implied by the mechanistic nature of empirical questions posed in a survey paper by Blattberg et al. (1995): Do a brand’s promotions substantially increase its own sales? Do brands use promotions to cannibalize the sales shares of competing brands in the battle for valuable shelf space in retail outlets?
Since neither a linearly-stochastic or nonlinear-deterministic world is compelled by theory, we let the data guide the selection. This reduces the risk that mistaken presumptions one way or the other distort assessment of real-world impacts of a stream of promotions. We take an innovative data-diagnostic approach that seeks to reconstruct real-world market dynamics directly from observed time-series records on sales and promotions. Our approach operates in the initial inductive window of the classic scientific method in which “[scientists] are presented with observations and asked to build theories…to go backward, to solve for [the system] that made them” [11]. The discipline of nonlinear dynamics has solved the backward problem of mathematically reconstructing system dynamics from system output without knowledge of underlying equations [12]. Nonlinear Time Series Analysis (NLTS) adapts these results to empirically reverse-engineer real-world system dynamics from observable output data given that the real-world system is largely unknown [13, 14]. A rich array of NLTS-based methods has recently emerged in other disciplines that leverages empirically-reconstructed dynamics to identify and measure dynamic causal interactions in real-world networks [15, 16].
A reverse-engineering approach to empirical economics contrasts with more conventional model-centric approaches that indirectly simulate market dynamics with models fitted to the data, and presume that good fits imply real-world correspondence [17, 18]. However, relying on goodness-of-fit to empirically validate models commits the logical fallacy of ‘affirming the consequent’: If A, then B; B, therefore A. In the context of model validation: If the model is true, it provides a good fit; this model provides a good fit, therefore it is true [19]. We can reason that a model providing a poor fit is incorrect, but we cannot presume the opposite because other models formulated differently also might be parameterized to fit well [20].
We use an NLTS data-diagnostic approach to measure time-dependent marginal impacts of a brand’s stream of promotions on its own sales share, and those of competitors with the Tesco dataset.
Materials and methods
Data preprocessing of Tesco sales and promotions records
Data access was made possible as a result of a longstanding relationship between Professor Andrew Fearne and the data providers, dunnhumby. Now in its fourtheenth year, this relationship provides Professor Fearne and his team of researchers with access to the retailer's loyalty card data via a web-portal that is managed by dunnhumby, for the purpose of conducting research.
Promotions were reported in the data set (S2 File) as savings to consumers: S = PR−PP, where PR is the regular (pre-promotion) unit price and PP is the promotional counterpart. Savings S were reported directly for simple price cuts. For more sophisticated promotions—such as any two for £3—the ‘equivalent single promotional price’ was reported (PP = £3/2 = £1.50), along with the ‘depth of cut’ (DC) measuring the percentage decrease from the regular price (for example, 3.85%). We computed consumer savings S for these promotions indirectly by solving for the unreported regular price PR from the definition of DC (S3 File):
The bar chart in Fig 2 plots the category sales and promotions shares of the 25 brands competing in the specialty beer category in declining order of category sales share. We computed a brand’s category sales share as the fraction of its sales to the category total, both aggregated over the total record length (104 weeks). We computed promotions shares in the same way. We limit our investigation to brands with the top nine category sales shares since they exhibited the most continuous sales and promotions over the record length. These brands are listed in Fig 2 with the variable names used to identify them. Two of the brands (Leffe and Hoegaarden) are responsible for five of the nine packaging configurations competing in this category. For example, there are two different configurations of the Hoegaarden brand: ‘White Beer Bottle’ and White Lager Bottles’. The Leffe and Hoegaarden brands are owned by the same multinational brewery (ABInbev), and we will examine whether competition between these brands differs from their competition with outside brands in the category (e.g., Innis & Gunn).
Description of Tesco dataset.
The bar chart plots the category sales and promotions shares for each brand calculated over the entire 104 weeks of the dataset in declining order of sales shares. We focus on the brands with the largest nine category sales shares since they exhibited the most continuous sales/promotions records. The Leffe and Hoegaarden brands are both owned by ABInbev.
For each of the nine retained brands, we computed weekly shares of category sales by dividing weekly brand sales by category totals for the week. We computed weekly shares of category promotions in the same way. We removed the mean (computed over the 104-week record length) from each computed sales and promotion series. These are the time-series records that we analyze below, and refer to as ‘sales shares’ and ‘promotion shares’.
Nonlinear time series analysis (NLTS)
We present a sequential framework of methods for implementing NLTS (Fig 3) drawn from an extensive review of sound empirical practices recommended in the literature [14]. We introduce the methods in the order that we apply them, and in the depth facilitating discussion of results. We leave more technical descriptions to cited primary sources. We also identify the R packages that we used to run NLTS procedures.
A framework for reconstructing real-world market dynamics from observed time-series records with NLTS.
We implement Nonlinear Time Series Analysis (NLTS) with a sequential framework based on an extensive review of sound empirical practices recommended in the literature.
Signal processing
The performance of NLTS depends critically on the extent to which real-world dynamics are embedded into available records, which may be noisy, short and nonstationary. The noise in records is often attributed to errors in measuring, recording, or processing data, and to random environmental shocks [21]. Consequently, we first apply the Singular Spectrum Analysis (SSA) signal processing method to isolate structured variation (‘signal’) from unstructured variation (‘noise’) in a record [14, 22, 23]. The signal can be further decomposed into a slow-moving trend component and oscillatory components. We screen for records with ‘strong’ signals—indicating that structure has greater weight in the processing than noise—and subsequently test them for deterministic nonlinear dynamics.
SSA proceeds in three stages: In the ‘decomposition’ stage, we construct a trajectory matrix whose columns are the observed record followed by its forward-delayed copies. We fix the dimension of the trajectory matrix with the ‘window length’ parameter (L), typically set proportionate to the dominant cycle length in the Fourier power spectrum and less than half of the record length [22, 24]. We decompose the trajectory matrix into the sum of new matrices with singular value decomposition. Each new matrix is composed of an ‘eigentriplet’, which is the product of an eigenvalue, and its corresponding right and left eigenvectors. The eigenvalue measures the weight in the decomposition attributed to the particular matrix component. In the ‘grouping’ stage, we turn to diagnostics provided by singular value decomposition to split the decomposed matrices into groups corresponding to various signal and noise components of the time series. The cumulative weights attributed to matrices grouped into the signal component provides the measure of signal strength. Finally, in the ‘reconstruction’ stage, we transform these matrix groups back into time series vectors with ‘diagonal averaging’ [22].
Stationarity
We next test whether a strong signal is stationary; that is, whether it exhibits similar dynamic behavior throughout its duration [25] that we can justifiably attempt to reconstruct as a single dynamic system with NLTS [26]. In particular, we search for ‘change points’—indicating time periods in which abrupt structural changes in dynamic behavior have occurred—with the Singular Spectrum Transformation (SST) approach [27, 28].
SST is implemented by applying SSA in a sliding window through the signal. We first select the ‘change-point window’ that partitions the signal into past and future series of equal length centered around a given reference time. There are no precise rules for setting the width of the non-overlapping windows. Past studies recommend running SST for wide intervals of window widths to ascertain whether results remain stable [27]. We perform SSA on the past and future series, and compute a ‘change-point score’ (CP-score) indicating the extent to which the SSA decomposition substantially changes [27]. We then increment the reference time and re-compute the CP-score. The result is a curve of CP-scores across time periods within the sliding windows.
We test the statistical significance of the CP-scores along this curve by bootstrapping an upper 95% confidence levels using randomized surrogate data vectors [27]. CP-scores falling below confidence levels are not statistically significant, and consequently do not represent structural shifts. Since we use surrogate data testing throughout the paper, we discuss it in the following section, and detail its application to CP-scores at that point.
Surrogate data testing
Surrogate data testing proceeds in three steps [29, 30]. First, we generate an ensemble of surrogate data vectors that destroy temporal structure in the signal, while maintaining shared statistical properties providing stochastic explanations for the behavior of a ‘discriminating statistic’ (such as the CP-score) computed from observed data. The simplest surrogate data vectors—IID (identically and independently distributed) surrogates—are constructed by shuffling the signal multiple times to destroy its serial structure. Statistically speaking, IID surrogates result from random draws without replacement from the same probability distribution as the observed time series. However, in practice, surrogates are generated to construct more complex stochastic processes. The most commonly used—amplitude-adjusted Fourier transform (AAFT) surrogates—are constructed as a linear-stochastic random variable. We generate AAFT surrogates in testing for statistical significance throughout the paper. Next, we compute the selected discriminating statistic for the observed data and each surrogate data vector.
Finally, we apply nonparametric rank order statistics to test whether the discriminating statistic computed from observed data is significantly different from the those computed from the surrogate ensemble [30]. We generate S = (2k/α)−1 surrogates for a two-tailed test and S = (k/α)−1 for a single-tailed test—where α is probability of a ‘false positive’ (i.e., rejecting a true null hypothesis), and k determines the number of surrogates with larger k values providing more sensitive tests. The discriminating statistic computed from the observed data is statistically significant if it falls within the extreme ranges of surrogate measurements ranked in descending order; that is, among the k largest (smallest) for an upper-tailed (lower-tailed) test.
We use the surrogate data method to test whether CP-scores computed from sales/promotions signals are statistically significant; and consequently, that the corresponding signals are nonstationary. We compute CP-score curves for each surrogate data vector, and rank the array of surrogate CP-scores in descending order for each time period within the sliding windows. Running an upper-tailed test, the CP-scores computed from the data are significant if they rest above an upper 95% confidence limit composed of the lowest of the k largest surrogate CP-scores for each time period. A signal is deemed to be nonstationary if its CP-score curve rests above the upper 95% confidence limit. NLTS requires stationary signals, so we screen nonstationary signals from further analysis.
Phase space reconstruction
The cornerstone of NLTS is phase space reconstruction, which is a mathematically rigorous method for reverse-engineering real-world system dynamics from observed data. Phase space is the graphical portrayal of deterministic system dynamics [31]. Phase space coordinates are provided by the system variables, and each multidimensional point records the levels (states) of system variables at a point in time. Phase space trajectories connecting these points depict the co-evolution of system variables from given initial states. If system dynamics are ‘dissipative’, these trajectories are bounded within a low-dimensional subset of phase space, and forever evolve along an ‘attractor’ in this subspace—a geometric structure with noticeable regularity [32]. Dissipative dynamics are ‘dimension reducing’—an especially useful modeling property since long-term system dynamics can be investigated with relatively few degrees of freedom regardless of the complexity or dimensionality of the system generating the data [33].
We illustrate phase-space dynamics with data on snowshoe hare and lynx populations collected by the Hudson Bay Company in Canada from 1845 to 1935 [34]. The time-series plots show that the populations cycle through time (Fig 4A), and the phase-space portrait (obtained by plotting lynx against hares at each point in time) shows that the populations co-evolve along classic predator-prey cycles constituting the attractor for the system (Fig 4B). A large lynx population overconsumes available hares and eventually crashes for want of prey. Hares recover until pressed again by the recovering lynx population, and so on.
Time-delay embedding method of phase space reconstruction.
Phase space was limited as an empirical tool for recovering real-world dynamics from data because early practitioners assumed that they required time series records on all system variables. Obviously, one cannot hope to identify or measure all of the variables interacting in real-world dynamic systems. However, a major breakthrough in empirical dynamics occurred when mathematicians proved that phase space dynamics could be reconstructed from even a single variable by using its delayed copies as surrogates for unobserved variables [35]. An intuitive explanation is that each variable in an interdependent dynamic system encodes the history of its systematic interactions with the other variables. Returning to the Hudson Bay Company data, recall that we constructed the original predator-prey attractor using both the lynx and hare population records (Fig 4B). Now we reconstruct a shadow version of this attractor with only one of the variables and its one-period forward-delayed copy serving as a surrogate for the omitted variable (time-delay embedding). The shadow attractor reconstructed from only the lynx (hare) population is shown in the leftward (rightward) plot in Fig 4C. The green lines emphasize that the shadow attractors correspond one-to-one with the original attractor, and thus correspond one-to-one with each other [15].
Takens (1980) formally proved that time-delay embedding provides a 1–1 mapping of system dynamics from the original phase space (constructed with all system variables) to the reconstructed shadow phase space so long as the latter has sufficient dimensions to contain the original attractor (at least two dimensions in the Hudson Bay Company example). In general application, we construct an embedded data matrix, M, with the observed time series in the first column followed by other columns storing its forward-delayed copies. For example, we embed the first ten observations of the S3 record in Fig 5A. In the first column of M, S3 is unlagged; in the second column, S3 is forward-lagged by two periods; and in the third column, S3 is forward-lagged by four periods. Observations in the gray rectangle are lost to the forward-lagging process. The rows of M are multidimensional points on a reconstructed attractor. For example, the first point on the attractor is P1 = (-0.04, -0.05, -0.07). The geometric representation of the reconstructed attractor is a scatterplot of all rows of M (Fig 5B).
The embedded data matrix and reconstructed phase space.
(a) The time-delay method of phase space reconstructed is implemented by constructing an ‘embedded data matrix’, M, with the observed time series in the first column followed by columns storing its forward-delayed copies. For example, we embed the first ten observations of the S3 record, where observations in the gray rectangle are lost to the forward-lagging process; (b) The scatter plotted rows of M are multidimensional points on a reconstructed attractor.
The embedding process requires selection of three parameters: the ‘embedding delay’ (number of periods separating delayed copies), the ‘Theiler window’ (correction for serial correlation), and the ‘embedding dimension’ (number of columns in the embedded data matrix, M). The search for embedding parameters is aided by statistical rules-of-thumb designed to select values reconstructing attractors with the clearest resolution [13, 36].
The embedding delay is conventionally selected as the lag giving the first minimum of the average mutual information function—a probabilistic measure of how a time series relates to successively delayed copies of itself. This is thought to introduce a delay that is not too short for system dynamics to evolve, but not so long that it skips over important dynamic structure [36]. The Theiler window can be estimated as the lag giving the first minimum in the autocorrelation function [25]. Time series observations within the window are not used in estimating the embedding dimension because they reflect proximity in time rather than the attractor’s geometric structure [37]. Finally, once the embedding delay and Theiler window are estimated, the embedding dimension is conventionally selected with the false nearest neighbors test [36]. An attractor is initially reconstructed in two dimensions, and distances between points on the attractor are computed. This exercise is repeated in three dimensions, and the percentage of points growing farther apart from two to three dimensions (false nearest neighbors) is computed. If the percentage of false nearest neighbors is below a selected tolerance level, then two dimensions is judged to be sufficient to contain the reconstructed attractor; otherwise, the test proceeds to the next higher dimension. An attractor reconstructed in too few dimensions does not have space to fully express itself, while one constructed in too many loses geometric clarity.
In practice, we are not limited to using only one observed variable to reconstruct phase space. Takens’ theorem has been generalized to ensure that original phase space dynamics are also preserved in reconstructions using different combinations of system variables and their delayed copies [38]. This is a very useful result in empirical practice because it allows us to reconstruct a real-world attractor from multiple perspectives depending on data availability and research objective.
Surrogate data testing provides a statistical safeguard against mistaking apparent geometric regularity in a reconstructed attractor for deterministic nonlinear dynamic structure [29, 30]. We reconstruct attractors from the observed record and each surrogate data vector. AAFT surrogates (discussed above)—the most popular surrogates in practice—are generated to test the hypothesis that an empirical attractor is reconstructed from a linear-stochastic random variable.
Conventional discriminating statistics used to compare hallmark characteristics of nonlinear dynamic behavior in the observed and surrogate attractors include an attractor’s ‘fractal dimension’, the ‘maximum Lyapunov exponent’ measuring an attractor’s sensitivity to initial conditions (i.e., whether trajectories on the attractor exponentially diverge over time), an attractor’s short-term nonlinear predictive skill, and an entropy complexity measure, such as ‘permutation entropy’ [39]. We selected permutation entropy as the discriminating statistic because we could calculate it most reliability given the short duration of the time-series records in our case study. Permutation entropy modifies the classic Shannon H measure of the information contained in a time series for application to finite noisy data [40]. When H = 0, the time series is perfectly predictable from past values. H achieves a maximum value when time series observations are independent and identically distributed. Consequently, large values of H indicate more random behavior.
Convergent cross mapping
The next question is whether the attractors reconstructed from the different perspectives of multiple observed signals reconstruct the same real-world dynamic. If so, then the corresponding signals are deemed to causally interact in the same real-world dynamic system. Convergent cross mapping (CCM) was developed to answer this type of question [15]. The logic underlying CCM is that, if variables X and Y interact in the same dynamic system, then attractors reconstructed from delayed copies of X (MX) and delayed copies of Y (MY) map 1–1 to the original attractor (M), and consequently map 1–1 to each other (as depicted in Fig 4B and 4C). CCM tests whether a 1–1 mapping exists between MX and MY by measuring the skill with which one attractor can be used to cross-predict values on the other. For example, the notation XxmapY indicates that MX is used to cross-predict Y. This asks whether Y’s dynamics are embedded into X’s long-term dynamics (MX); in other words, whether Y forces X.
Sugihara et al. (2012) perform cross mapping with a simplex-projection algorithm. We illustrate this with the cross mapping S3xmapS3P in Fig 6A, where S3 is called the ‘library’ variable and S3P the target variable. We first reconstruct the attractors MS3 and MS3P using S3 and S3P and two of their forward-delayed copies as phase-space coordinates, respectively. In this illustration, we fix a single reference point on MS3 at week 26 (P26). More generally, CCM is run over a sampling of points on the attractor. We next identify the m+1 nearest neighboring points to the reference point, where m = 3 is the embedding dimension of MS3. To locate nearest neighbors, we compute Euclidean distances between the multidimensional points on MS3 (i.e., between the reference point and the other rows of the corresponding embedded data matrix). In general, the Euclidean distance between two tridimensional points P(p1,p2,p3) and Q(q1,q2,q3) is:
Convergent cross mapping.
Sugihara et al. (2012) establish this by seeing how well the reference point on MS3P (P26) can be predicted with a locally-weighted average of the nearest neighboring points transferred from MS3:
The cross-mapped predictions for a sampling of reference points on the attractor must pass three tests before being accepted as representing a real-world causal interaction. The first is a convergence test demanding that the simplex-projection prediction algorithm (Eqs 4–6) becomes more skillful as the portion of the record for S3 used to reconstruct MS3 (the library) increases in length; in other words, as the structural information in MS3 increases. This occurs if ρ converges closer to an acceptable level as library size increases. As an example, we show convergence curves derived by using S3 (i.e., MS3) to cross map the other variables testing positive for nonlinear dynamics (Fig 6B). Causal interactions are stronger the further the curves are away from the origin. We see that S3 is driven most strongly by its own weekly promotions share (S3P), providing preliminary evidence that own promotions have a sustained impact. We also see that S3 is driven by the weekly sales and promotions shares of competing brands (S1 and S1P, respectively). If, for example, we set a convergence threshold of ρ = 0.33 for the cross-mapping curves in Fig 6B, we conclude that S3P, S1P, S1, S8, S2, and S9 pass the test; while S5, S4, S9P, S8P, S7P, and S4P fail.
Second, we test each cross mapping for statistical significance. In particular, we test the null hypothesis that a cross mapping S3xmapS3P, for example, cross predicts with more skill than when S3 (the library variable) is replaced with surrogate library vectors. We run the cross mapping for each of S = (k/α)−1 AAFT library surrogates, and in an upper-tailed test, reject the null hypothesis only if S3 cross predicts with a larger ρ than the kth largest surrogate ρ for each library in the convergence plot. In Fig 6C, we observe that S3xmapS3P is statistically significant since the convergence plot (black curve) rests above the upper 95% confidence curve (red curve) for each library.
Finally, we follow methods developed by Ye et al. (2015) to further screen statistically significant cross mappings for false positives in which synchronized behavior is confused for causal interaction. Non-interactive variables may falsely appear to interact when they are synchronized to the same external variable, for example, when two unrelated environment variables are synchronized to identical climatic or seasonal forces. In Fig 6D, we show the results of running the cross mapping S3xmapS3P (using the entire time series for S3 as the library) over a spectrum of negative and positive delayed responses between the driving variable (S3P) and the response variable (S3) to identify the delay for which CCM performs best. Ye et al. (2015) show that CCM performs best for a non-positive delay in the true causal direction. The cross mapping passes this test since CCM performs best at a zero delay, denoting instantaneous interaction between the two variables.
Characterizing the nature of interactions with the S-mapping method
We use the S-Mapping method [16] to measure the strength of, and characterize, interactions identified with CCM: Are detected interactions mutually-beneficial (symbiotic), mutually-detrimental (competitive), cannibalistic (predator-prey); and how do these interactions vary with time?
The S-mapping method computes a matrix of interactions among state variables as a dynamic system evolves along a phase space attractor. Similar to CCM, it operates with a simplex-projection algorithm. In this case, all the points on the attractor are projected forward one period except for the reference point, and the simplex is fitted with a locally-weighted multivariate linear regression scheme. As this is repeated for successive reference points along the attractor, the fitted lines collectively begin to map out the curvature of phase space, and the estimated regression coefficients measure slopes in the direction of each coordinate variable at each point [41]. When the S-mapping procedure is completed, we have a matrix whose rows are interactions measuring the marginal response of a selected response variable to incremental changes in itself and the other variables at each point on the attractor. The columns of this interaction matrix give the time series of each interaction. For example, if we construct an attractor using S1, S3P, and S3 as phase-space coordinates; select S3 as the response variable; define the library as the 50th through 70th points on the attractor; then the format of the interaction matrix is:
The data inputted into the locally-weighted regression scheme that generates Eq 7 are shown in Fig 7A. The dependent variable is the response variable advanced one period, S3(t+1), with the row of data corresponding to the reference point (P52 in this example) deleted. The independent variables are the multidimensional points on the attractor manifold. These data are imported into a weighted linear regression in which observations corresponding to nearer neigboring points are weighted more heavily according to:
The S-mapping method of quantifying causal interactions.
Computational packages
We used R 3.4.1 and the following packages to run NLTS procedures in this paper: Rssa 0.13–1 (singular spectrum analysis) [42]; tseriesChaos 0.1–13 (phase space reconstruction and surrogate data analysis) [43]; fractal 2.0–1 (compute AAFT surrogates) [44]; fields 9.6 (compute distance matrix) [45]; igraph 1.0.1 (plot network diagrams) [46]; rEDM 0.6.9 (convergent cross mapping) [47]. The code used to compute interaction coefficients with S-maps can be downloaded from supplementary materials to [16]. Remaining code is detailed in [14], and can be downloaded from http://www.dista.unibo.it/~bittelli/. We used Origin 2018b graphics software for three-dimensional plotting [48].
Results
Signal processing
We plot signals isolated from the sales and promotions time-series records in Fig 1 (red curves). While the plotted signals visually reproduce much of the structural variation in several of the corresponding records, the objective is not to obtain a perfect match (since observed records contain noise). All of the isolated signals show strong overall strength (exceeding at least 50 percent), except for promotions of Erdinger Weissbier Lager Bottle 500ml (S5P), which we delete from further NLTS analysis (Table 1). Overall, the retained signals are dominated by slow-moving trends, a triplet of lower-frequency oscillations (13, 8.667, and 6.5 weeks), and another triplet of higher-frequency oscillations (5.2, 4.2, and 2.1 weeks).
Signal processing of weekly category sales and promotions shares.
Stationarity testing
In applying SST to test for stationarity in strong sales and promotions signals, we set window width to 50 weeks (i.e., 25 weeks on either side of a reference point), which allowed for stable signal processing. Given that the length of the signals is 104 weeks, this created five windows. We constructed upper point-by-point 95% limits with 99 AAFT surrogate data vectors (k = 5). The change-point score plots (black curves) visually rest well below the upper confidence levels (red curves) for all sales signals except for S2, and all promotions signals except for S1P, S2P, and S3P (Fig 8). Of these exceptions, only the change-point score for S2P was computed to numerically exceed the confidence level. Consequently, we deem S2P to be nonstationary, and do not analyze it for deterministic nonlinear structure.
Results of nonlinear stationarity testing.
Phase space reconstruction
The estimated embedding parameters used to reconstruct phase space attractors from the stationary sales and promotions signals in the Tesco dataset are reported in Table 2. Most of the embedding dimensions range from two to four, with only one (S4P) reaching six. This is our first indication that the dynamics driving these signals might be low-dimensional. In Fig 9, we reconstruct a potential real-world attractor from the perspective of each signal. Several of these perspectives exhibit strong geometric regularity with a combination of low and high frequency oscillations detected in signal processing—another indication of deterministic nonlinear dynamics that we test with surrogate data.
Attractors reconstructed from Tesco dataset.
We successfully reconstructed low-dimensional shadow attractors from the perspectives of stationary (a) sale and (b) promotion signals. Several of the attractors exhibit striking geometric regularity characterized by oscillatory behavior detected in signal processing.
Embedding parameters.
We tested the null hypothesis that visual regularity in each reconstructed attractor in Fig 9 is more likely fortuitously mimicked by linear-stochastic dynamics, with the alternative being that untested dynamic structures (such as nonlinear deterministic dynamics) remain possibilities. We ran a lower-tailed test with 199 AAFT surrogates and an α = 0.05 significance level to reject the null hypothesis only if permutation entropy computed from the signal falls within the lower extreme surrogate values.
We summarize the results of surrogate data testing in Table 3. The first column shows the signals tested, the second column its identification index, the third column the permutation entropy measured from the corresponding reconstructed attractor, and the fourth column the permutation entropy above which the null hypothesis of linear-stochastic dynamics is accepted. The fifth column indicates whether the null hypothesis was accepted. We accept the null hypothesis for the attractors reconstructed from the S4, S6, and S7 sales signals; and the S4P, S6P, S7P, and S9P promotions signals. These attractors were most likely generated by linear-stochastic dynamics, and we screen the corresponding signals from further NLTS diagnostics. Alternatively, we reject the null hypothesis for attractors reconstructed from the S1, S2, S3, S5, S8, and S9 sales signals, and the S1P, S3P, and S8P promotions signals. We cannot rule out the possibility that these signals were generated by real-world deterministic nonlinear dynamics.
Surrogate data testing.
Convergent cross mapping
We can visualize the causal interactions detected with convergent cross mapping (CCM) in a ‘community interaction diagram’ (Fig 10). The nodes represent sales and promotions signals screened for stationarity and nonlinear deterministic dynamic behavior. Arrows between nodes indicate that the signals interact in the same reconstructed real-world market system, and the direction of interaction. The strength of the interaction is given by the fractions near each arrow head, which are the convergent correlation coefficients for each cross mapping (Fig 11, black curves). For example, the convergent correlation coefficient is 0.81 for the cross mapping S3xmapS3P, which indicates that S3P drives S3. We include interactions in the diagram associated with CCM curves exhibiting convergent correlations exceeding 0.33 (the strength of interactions increases as convergent correlations approach 1), and resting at or above 95% confidence levels (Fig 11, red curves). In addition, we include interactions whose cross mappings pass delayed (extended) CCM tests to rule out non-causal synchronous behavior, as demonstrated by delayed CCM curves with peaks at nonpositive delays (Fig 12).
Community interaction diagram.
We summarize causal interactions detected with CCM in a community interaction diagram whose nodes are sales and promotions signals screened for stationarity and nonlinear deterministic dynamic behavior. Arrows between nodes indicate the direction of interaction. The strength of the interaction is given by the fractions near each arrow head, which are the convergent correlation coefficients for each cross mapping. We focus on the area of the diagram (shaded red) containing bilateral interactions between ABInbev brand configurations Leffe Blonde Lager Bottles 4X330 1320ml and Hoegaarden White Lager Bottles 4X330 1320ml; and between these ABInbev configurations and the Innis & Gunn Original Oak Aged Beer 750ml configuration, which is not owned by ABInbev.
Convergent cross mapping (CCM) results.
Delayed (Extended) CCM results.
We screened for interactions whose cross mappings pass delayed (extended) CCM tests to rule out non-causal synchronous behavior, as demonstrated by delayed CCM curves with peaks at nonpositive delays in the figure.
The community interaction diagram (Fig 10) begins to shed valuable light on empirical questions raised in the literature outlined above: Do a brand’s promotions substantially increase sales? Do brands use promotions to cannibalize the sales shares of competing brands? Given the nature of the Tesco dataset, we additionally consider whether this behavior changes between brands owned by different multinational breweries. A prerequisite for responding to these questions is that the underlying interactions are detected in the first place, and the community interaction diagram provides empirical evidence of this. We focus on the area of the diagram (shaded red) containing bilateral interactions between the 1st (Leffe Blonde Lager Bottles 4X330 1320ml) and 3rd (Hoegaarden White Lager Bottles 4X330 1320ml) leading brand configurations in category sales shares. Both brands are owned by ABInbev. The red-shaded area also includes interactions between these ABInbev brands and the 9th largest sales-share brand (Innis & Gunn Original Oak Aged Beer 750ml), which is not owned by ABInbev.
Quantifying causal interactions with S-mapping
To quantify these interactions with S-mapping, we constructed an empirical attractor manifold with the variables S1, S1P, S3, S3P, and S9 serving as phase space coordinates. The computed partial derivatives quantifying each interaction over time are the black curves with areas shaded black between the curves and the zero-axis to highlight weeks when the interaction is positive or negative (Fig 13). Since computed partial derivatives are volatile time series, we applied singular spectrum analysis to isolate signals measuring systematic interactive behavior (shaded red).
Quantified interactions.
We embedded an empirical attractor with phase space coordinates provided by S1, S1P, S3, S3P, and S9, and applied S-mapping to compute partial derivatives quantifying interactions among these variables over time (black curves). The areas between the curves and the zero-axis are shaded black to highlight weeks when interactions are positive or negative. We next isolated the systematic components (signals) of the computed derivatives with singular spectrum analysis (shaded red). Since partial-derivative signals are mostly either positive or negative for the majority of weeks in the POR, we characterize them by: (1) the percentage of weeks that each partial-derivative signal is mostly positive/negative; and (2) the relative magnitude of positive/negative areas to total area between the curve and the zero-axis. These measures are reported in the headings to each plot. For example, '∂S1/∂S1P (Negative: 0.87, 0.97)’ indicates that the partial derivative is negative 87% of the weeks, and that the negative area comprises 97% of the total area. The partial derivative signals indicate that: (a) A brand’s promotions preyed on its own sales shares (an outcome documented in the literature); (b) A brand’s promotions generated the offsetting benefit of cannibalizing sales shares of competing brands; and (c) The sales shares of ABInbev brands (S1 and S3) were mutually-beneficial, but the sales share of S3 was preyed on by the outside brand owned by a different brewery (S9).
The partial-derivative signals are mostly either positive or negative for the majority of weeks in the POR. We characterize this regularity and its importance with two measures: (1) the percentage of weeks that each partial-derivative signal is mostly positive/negative; and (2) the relative magnitude of positive/negative areas to total area between the curve and the zero-axis. We report these measures in the headings to each plot. For example, '∂S1/∂S1P (Negative: 0.87, 0.97)’ reports that this partial derivative is negative 87% of the weeks, and that the negative area comprises 97% of the total area (Fig 13A, leftward plot).
We first investigate the bilateral interaction between a brand’s promotions and its own sales shares (Fig 13A) for the case of the top selling brand configuration in the category (Leffe Blonde Lager Bottles 4X330 1320ml). We observe that ∂S1P/∂S1 was positive 71% of the weeks, indicating that an incremental increase in the configuration’s weekly market share (S1) most often marginally increased its decision to promote (S1P). The paired interaction, ∂S1/∂S1P, was negative 87% of the weeks, indicating that an incremental increase in promotions most often drove down marginal sales shares. Taking an ecological interpretation, the configuration’s promotions (S1P) preyed on its sales shares (S1). Turning to the third top selling brand configuration in the category (Hoegaarden White Lager Bottles 4X330 1320ml), we observe the same predatory behavior of promotions on own sales shares when examining the paired interactions, ∂S3P/∂S3 and ∂S3/∂S3P.
We next examine the impact of a brand’s promotions on the sales shares of competitors (Fig 13B). Considering first the ABInbev brands (Leffe and Hoegaarden), we observe that each brand’s promotions cannibalized the sales shares of the other in most weeks. Hoegaarden’s decision to promote (S3P) had a mostly negative marginal impact on Leffe’s sales shares (S1) since ∂S1/∂S3P was negative 73% of the weeks; while an incremental increase in Leffe’s sales shares marginally increased Hoegaarden’s promotions since ∂S3P/∂S1 was positive in 73% of the weeks. We observe even stronger evidence of similar cannibalistic behavior of Leffe promotions on Hoegaarden sales shares since ∂S3/∂S1P was negative 81% of the weeks and ∂S1P/∂S3 was positive 88% of the weeks. The latter partial derivative, ∂S1P/∂S3, tells us that, in most weeks, Leffe’s marginally increased its promotions (S1P) in response to an incremental increase in Hoegaarden’s sales share (S3). In striking constrast, the marginal response of Leffe’s promotions to an incremental increase in the sales share of non-ABInbev brand Innis & Gunn (the 9th top selling brand in the category), ∂S1P/∂S9, was negative in 88% of the weeks (Fig 13B, rightward plot).
We further found that incremental increases in the sales shares of ABInbev brands Leffe (S1) and Hoegaarden (S3) marginally increased the sales shares of the other in most weeks (Fig 13C, leftward two plots). The marginal impact of Hoegaarden on top seller Leffe was especially strong since ∂S1/∂S3was positive 100% of the weeks. Ecologically speaking, the sales shares of ABInbev brands coevolved in a mutually-beneficial or symbiotic relationship. In another marked contrast, 9th-largest selling non-ABInbev brand Innis & Gunn tended to prey on the sales shares of 3rd-largest selling Hoegaarden (Fig 13C, rightward plots). An incremental increase in Innis & Gunn’s sales shares (S9) marginally decreased the sales share of Hoegaarden (S3) 77% of the weeks; while an incremental increase in Hoegaarden sales shares marginally increased Innis & Gunn’s sales shares about half of the weeks.
Discussion
In making sense of these results, we emphasize that NLTS provides positive analysis of behavior that ‘actually happened’. Comparing this to what ‘should have happened’ had brands behaved ‘rationally’ in the judgement of the researcher may well be inaccurate without direct knowledge of their internal business objectives—like shooting an arrow without seeing the target. Moreover, brands realizing undesireable outcomes might have reasonably anticipated something better, and avoided the behavior in hindsight. We are limited to speculating a few of many possible explanations for why brands engaged in apparently puzzling behavior uncovered by NLTS diagnostics.
The first puzzling question is why brands would promote when, in most weeks, promotions preyed on their own market shares. One possibility is that brands reasonably anticipated the opposite outcome (i.e., that promotions would marginally increase their own market shares), but these expectations were not met possibly because promotions caused consumers to downgrade their perceptions of brand quality or lower their price expectations to the promotional level, and that these responses overwhelmed an increase in brand loyalty or an inertia repurchasing effect in most weeks. Another possibility is that brands invested in promotions to cannibalize the sales shares of close competitors, which turned out to be the case in most weeks even between brands owned by the same multinational brewery. This intra-brewery brand competition offers some empirical evidence that the international beer market was contestable despite being dominated by a few large multinational breweries [49].
But this begs the next puzzling question: Why did this intra-brewery brand competition exist given evidence that intra-brewery sales shares were strongly mutually beneficial? A post hoc rationalization for this perplexing behavior is not obvious. ABInbev might benefit by using this informtion to rethink the promotion strategies of its internal brands in the specialty beer market.
Conclusion
In this paper, we applied a novel empirical approach—Nonlinear Time Series Analysis (NLTS)—to reconstruct real-world market dynamics concealed in volatile observed time-series records, and used this information to respond to key empirical questions raised in the literature regarding how price promotions and sales shares among competing brands systematically interact over time. We first tackled the essential preliminary question of whether these interactions are systematic in our dataset in the first place; in particular, whether the data conceal random interactions exogenously forced by linear-stochastic real-world market dynamics, or deterministic interactions endogenously forced by real-world nonlinear market dynamics. We found that market dynamics reconstructed from the Tesco dataset are largely deterministic, low-dimensional, and nonlinear.
Borrowing new methods from ecosystem dynamics used to investigate interspecies interactions, we next detected real-world interactions among the promotions and sales of brands, and characterized the nature of detected interactions over time by computing partial derivatives measuring the marginal response of one market variable to an incremental change in another. We uncovered evidence that a brand’s promotions preyed on its own sales shares (an outcome documented in the literature), but generated the offsetting benefit of cannibalizing sales shares of competing brands. We also found evidence that interactions between brands owned by the same multinational brewery differed from their interactions with outside brands. In particular, the sales shares of brands owned by the same brewery were mutually beneficial; whereas the sales shares of brands owned by different breweries preyed on each other’s market shares.
In general, NLTS opens a new window on analyzing complex time series records by illuminating otherwise concealed information: Is observed volatility generated by exogenous shocks to a self-correcting system or endogenous unstable dynamic behavior that is not self-correcting? This distinction—recognized increasingly as pivotal in managing and regulating real-world dynamic systems—is imperceptible to the naked eye, and to exploratory empirical approaches presuming stochastic forcing.
There are important caveats to applying NLTS, especially to short and noisy time-series records encountered in practice. First, we cannot reasonably expect to reconstruct the complex folding and fractal patterns of a real-world attractor [50]. We must lower our expectations to reconstruct a sampling or skeleton of the real-world attractor [51]. Second, these methods can fall short of reconstructing even a skeleton attractor for several reasons. Most obviously, a low-dimensional nonlinear real-world attractor may not exist. Or, the data may be insufficiently informative to reconstruct the real-world attractor even if it does exist. For example, the time series might only sample transitory dynamics heading toward the attractor. However, we do not know any of this until we have tested the data for it.
Supporting information
S1 File [xlsx]
Raw sales data.
S2 File [xls]
Raw promotions data.
S3 File [dc]
Promotions put into equivalent monetary value.
Zdroje
1. Gedenik K, Neslin S, Ailawadi K. Sales Promotion. 2nd ed. Krafft M, Mantrala M, editors. New York: Springer; 2010.
2. Dodson J, Tybout A, Sternthal B. Impact of deals and deal retraction on brand switching. Journal of Marketing Research. 1978;15 : 72–81.
3. Del Vecchio D, Henard D, Freling T. The effect of sales promotion on post-promotion brand preference: A meta-analysis. Journal of Retailing. 2006;82(3):203–13.
4. Blattberg R, Briesch R, Fox E. How promotions work. Marketing Science. 1995;14(3):G122–G32.
5. Bass F, Clarke D. Testing distributed lag models of advertising effect. Journal of Marketing Research. 1972;9 : 298–308.
6. Dekimpe M, Hanssens D. The persistence of marketing effects on sales. Marketing Science. 1995;14(1):1–21.
7. Valera H, Lee J. Do rice prices follow a random walk? Evidence from Markov switching unit root tests for Asian markets. Agicultural Economics. 2016;47(6):683–95.
8. Economist The. Big economic ideas. 2016a;July 23.
9. Economist The. If economists reformed themselves. 2016b;May 16.
10. Galtier F. Managing food price instability: Critical assessment of the dominant doctrine. Global Food Security. 2013;2 : 72–81.
11. Ellenberg J. How Not to Be Wrong: The Power of Mathematical Thinking. New York: Penguin Books; 2015.
12. Takens F. Detecting strange attractors in turbulence. In: Rand D, Young L., editor. Dynamical Systems and Turbulence New York: Springer; 1980. p. 366–81.
13. Kantz H, Schreiber T. Nonlinear Time Series Anaysis. Cambridge: Cambridge University Press; 1997.
14. Huffaker R, Bittelli M, Rosa R. Nonlinear Time Series Analysis with R. Oxford, U.K.: Oxford University Press; 2017.
15. Sugihara G, May R, Hao Y, Chih-hao H, Deyle E, Fogarty M, et al. Detecting causality in complex ecosystems. Science. 2012;338 : 496–500. doi: 10.1126/science.1227079 22997134
16. Deyle E, May R, Munch S, Sugihara G. Tracking and forecasting ecosystem interactions in real time. Proc R Soc B. 2018;283 : 201522358.
17. Gabaix X, Laibson D. The Seven Properties of Good Models. In: Caplin A, Schotter A, editors. The Foundations of Positive and Normative Economics: A Handbook. Oxford: Oxford University Press; 2008.
18. Dhrymes P, Howrey E, Hymans S, Kmenta J, Leamer E, Quandt R, et al. Criteria for evaluation of econometric models. Annals of Economic and Social Measurement. 1972;1(3):291–324.
19. Oreskes N, Shrader-Frechette K, Belitz K. Verification, validation, and confirmation of numerical models in the earth sciences. Science. 1994;263 : 641–6. doi: 10.1126/science.263.5147.641 17747657
20. Rykiel E. Testing ecological models: the meaning of validation. Ecological Modeling. 1991;90 : 229–44.
21. Feder G. Pesticides, information, and pest management under uncertainty. American Journal of Agricultural Economics. 1979;61(February):97–103.
22. Golyandina N, Nekrutkin V, Zhigljavsky A. Analysis of Time Series Structure. New York: Chapman & Hall/CRC; 2001.
23. Elsner J, Tsonsis A. Singular Spectrum Analysis. New York: Plenum Press; 2010.
24. Hassani H. Singular spectrum analysis: Methodology and comparison. Journal of Data Science. 2007;5 : 239–57.
25. Kaplan D, Glass L. Understanding Nonlinear Dynamics. New York: Springer; 1995.
26. Schreiber T. Detecting and analyzing nonstationarity in a time series with nonlinear cross predictions. Phys Rev Lett. 1997;78 : 843–6.
27. Itoh N, Marwan N. An extended singular spectrum analysis transformation (SST) for the investigation of Kenyan precipitation data. Nonlinear Processes in Geophysics. 2013;20 : 467–81.
28. Moskvina V, Zhigljavsky A. An algorithm based on singular spectrum analysis for change-point detection. Communications in Statistics. 2003;32 : 319–53.
29. Theiler J, Eubank S, Longtin A, Galdrikian B, Farmer J. Testing for nonlinearity in time series: The method of surrogate data. Physica D. 1992;58 : 77–94.
30. Schreiber T, Schmitz A. Surrogate time series. Physica D. 2000;142 : 346–82.
31. Sprott J. Chaos and Time Series Analysis. Oxford: Oxford University Press; 2003.
32. Brown T. Measuring Chaos Using the Lyapunov Exponent. In: Kiel E, Elliott E, editors. Chaos Theory in the Social Sciences: Foundations and Applications. Michigan: University of Michigan; 1996. p. 53–66.
33. Theiler J. Estimating the fractal dimension of chaotic time series. Lincoln Laboratory Journal. 1990;3 : 63–86.
34. Odum E. Fundamentals of Ecology. Philadelphia: W. B. Saunders; 1953.
35. Breeden J, Hubler A. Reconstructing equations of motion from experimental data with unobserved variables. Physica Review A. 1990;42(10):5817–26.
36. Williams G. Chaos Theory Tamed. Washington D.C.: John Henry Press; 1997.
37. Theiler J. Spurious dimension from correlation algorithms applied to limited time series data. Phys Rev A. 1986;34 : 2427–32.
38. Deyle E, Sugihara G. Generalized Theorems for Nonlinear State Space Reconstruction. PLoS One. 2011;6(3):1–8.
39. Gotoda H, Kobayashi H. Chaotic dynamics of a swirling flame front instability generated by a change in gravitational orientation. Physical Review E. 2017;95 : 022201. doi: 10.1103/PhysRevE.95.022201 28297884
40. Brandt C, Pompe B. Permutation entropy: a natural complexity measure for time series. Phys Rev Lett. 2012;88 : 174102.
41. Anderson C, Sugihara G. Simplex projection (downloaded July 12, 2018, http://deepeco.ucsd/simplex/) 2018.
42. Golyandina N, Korobeynikov A. Basic singular spectrum analysis and forecasting with R. Computational Statistics and Data Analysis. 2014;71 : 934–54.
43. Di Narzo A, Di Narzo F. tseriesChaos: analysis of nonlinear time series. Retrieved from https://cranr-projectorg/package=tseriesChaos. 2013.
44. Constantine W, Percival D. fractal: Fractal time series modeling and analysis. Retrieved from https://cranr-projectorg/package=fractal. 2014.
45. Furrer R, Paige J, Sain S. Tools for spatial data. Retrieved from https://cranr-projectorg/package=fields. 2018.
46. Csardi G, Nepusz T. The igraph software package for complex network research. Retrieved from https://igraphorg. 2006.
47. Ye H, Deyle E, Munch S. Applications of empirical dynamic modeling from time series. Retrieved from https://cranr-projectorg/package=rEDM. 2018.
48. Origin. Version 2019, OriginLab Corporation. Northampton, MA, USA.
49. Gammelgaard J, Dorrenbacher C. Introduction. In: Gammelgaard J, Dorrenbacher C, editors. The Global Brewery Industry. Northampton, Massachusetts: Edward Elgar Publishing; 2013. p. 1–17.
50. Vautard R. Patterns in time: SSA and MSSA in analysis of climate. In: von Storch H, Navarra A, editors. Analysis of Climate Variability: Springer; 1999.
51. Ghil M, Allen M, Dettinger M, Ide K, Kondrashov D, Mann M, et al. Advanced spectral methods for climatic time series. Reviews of Geophysics. 2002;40(1):1–41.
Článek vyšel v časopise
PLOS One
2019 Číslo 9
- Máj pod bílým pláštěm aneb když mezi směnami vykvete láska
- Bezpečnost dlouhodobé terapie osteoporózy – aktuální data
- Masturbační chování žen v ČR − dotazníková studie
- Pomůže v budoucnu s triáží na pohotovostech umělá inteligence?
- Jak a kdy u celiakie začíná reakce na lepek? Možnou odpověď poodkryla čerstvá kanadská studie
-
Všechny články tohoto čísla
- "The dead shall be raised": Multidisciplinary analysis of human skeletons reveals complexity in 19th century immigrant socioeconomic history and identity in New Haven, Connecticut
- Characterization of ecto- and endoparasite communities of wild Mediterranean teleosts by a metabarcoding approach
- Drink driving engagement in women: An exploration of context, hazardous alcohol use, and behaviour
- The effect of birth weight on body composition: Evidence from a birth cohort and a Mendelian randomization study
- Dolutegravir based antiretroviral therapy compared to other combined antiretroviral regimens for the treatment of HIV-infected naive patients: A systematic review and meta-analysis
- Expression profile of genes encoding allatoregulatory neuropeptides in females of the spider Parasteatoda tepidariorum (Araneae, Theridiidae)
- “My life after stroke through a camera lens”- A photovoice study on participation in Sweden
- Bacterial community composition of biofilms in milking machines of two dairy farms assessed by a combination of culture-dependent and –independent methods
- Health differences between multiple and single job holders in precarious employment in the Netherlands: A cross-sectional study among Dutch workers
- Clinical evaluation and budget impact analysis of cervical cancer screening using cobas 4800 HPV screening technology in the public sector of South Africa
- Rare earth elements in paddy fields from eroded granite hilly land in a southern China watershed
- High-throughput sequencing analysis of microbial community diversity in response to indica and japonica bar-transgenic rice paddy soils
- Physiological and molecular responses to drought stress in teak (Tectona grandis L.f.)
- Long-term performance of an atrial lead capable of accelerometer based detection of cardiac contractility in patients receiving cardiac resynchronisation therapy
- Ectomycorrhizal fungal communities of secondary tropical forests dominated by Tristaniopsis in Bangka Island, Indonesia
- Downregulation of hippocampal NR2A/2B subunits related to cognitive impairment in a pristane-induced lupus BALB/c mice
- Demonstrating specificity of bioactive peptide nucleic acids (PNAs) targeting microRNAs for practical laboratory classes of applied biochemistry and pharmacology
- Xenopus fraseri: Mr. Fraser, where did your frog come from?
- Competing priorities and second chances - A qualitative exploration of prisoners’ journeys through the Hepatitis C continuum of care
- Evaluating coral trophic strategies using fatty acid composition and indices
- Amyloid β oligomers inhibit growth of human cancer cells
- Distraction of olfactory bulb-medial prefrontal cortex circuit may induce anxiety-like behavior in allergic rhinitis
- Hormonal, metabolic and inflammatory circulating biomarker profiles in obese and non-obese Brazilian middle-aged women
- 'He usually has what we call normal fevers’: Cultural perspectives on healthy child growth in rural Southeastern Tanzania: An ethnographic enquiry
- Anatomical connections underlying personally-familiar face processing
- Fe limitation decreases transcriptional regulation over the diel cycle in the model diatom Thalassiosira pseudonana
- Fructose-1,6-bisphosphate prevents pulmonary fibrosis by regulating extracellular matrix deposition and inducing phenotype reversal of lung myofibroblasts
- Correction: Development of interval-valued fuzzy GRA with SERVPERF based on subjective and objective weights for evaluation of airline service quality: A case study of Korea low-cost carriers
- Anatomical analysis of antebrachial cutaneous nerve distribution pattern and its clinical implications for sensory reconstruction
- Characterization of doxycycline-dependent inducible Simian Virus 40 large T antigen immortalized human conjunctival epithelial cell line
- Topographic correlation and asymmetry analysis of ganglion cell layer thinning and the retinal nerve fiber layer with localized visual field defects
- Structuring a conceptual model for cost-effectiveness analysis of frailty interventions
- Characteristics of sarcopenia after distal gastrectomy in elderly patients
- Action spectrum for photoperiodic control of thyroid-stimulating hormone in Japanese quail (Coturnix japonica)
- The determinants of lung cancer after detecting a solitary pulmonary nodule are different in men and women, for both chest radiograph and CT
- Taste perception and oral microbiota are associated with obesity in children and adolescents
- Target women: Equity in access to mHealth technology in a non-communicable disease care intervention in Kenya
- Correction: Attitudes to and experiences with body weight control and changes in body weight in relation to all-cause mortality in the general population
- Homogenous HIV-1 subtype B from the Brazilian Amazon with infrequent diverse BF1 recombinants, subtypes F1 and C among blood donors
- Glucocorticoid stimulation increases cardiac contractility by SGK1-dependent SOCE-activation in rat cardiac myocytes
- Loss of control as a violation of expectations: Testing the predictions of a common inconsistency compensation approach in an inclusionary cyberball game
- Living on the edge - circadian habitat usage in pre-weaning European hares (Lepus europaeus) in an intensively used agricultural area
- NMDA receptor activation induces long-term potentiation of glycine synapses
- Antibody response in snakes with boid inclusion body disease
- Can they imagine the future? A qualitative study exploring the skills employers seek in pharmaceutical sciences doctoral graduates
- Affirmative citation bias in scientific myth debunking: A three-in-one case study
- Streaming chunk incremental learning for class-wise data stream classification with fast learning speed and low structural complexity
- Time trends in healthy lifestyle among adults in Germany: Results from three national health interview and examination surveys between 1990 and 2011
- The impact of door-to-electrocardiogram time on door-to-balloon time after achieving the guideline-recommended target rate
- A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss
- Effect of calcium glucoheptonate on proliferation and osteogenesis of osteoblast-like cells in vitro
- CCR2 knockout ameliorates obesity-induced kidney injury through inhibiting oxidative stress and ER stress
- Multi-method assessment of whale shark (Rhincodon typus) residency, distribution, and dispersal behavior at an aggregation site in the Red Sea
- Duration of symptoms in the quantification of upper limb disability and impairment for individuals with mild degenerative cervical myelopathy (DCM)
- Expression of genes in the skeletal muscle of individuals with cachexia/sarcopenia: A systematic review
- Correction: Alopecia areata patients show deficiency of FOXP3+CD39+ T regulatory cells and clonotypic restriction of Treg TCRβ-chain, which highlights the immunopathological aspect of the disease
- Alcohol, tobacco and cannabis use are associated with job loss at follow-up: Findings from the CONSTANCES cohort
- Estimation of the incidence of animal rabies in Punjab, India
- G-protein-coupled receptor 40 agonist GW9508 potentiates glucose-stimulated insulin secretion through activation of protein kinase Cα and ε in INS-1 cells
- Reasons behind stymied public hospital governance reform in China
- Cognitive and social congruence in peer-assisted learning – A scoping review
- The wing of the ToxR winged helix-turn-helix domain is required for DNA binding and activation of toxT and ompU
- Associations between sexual activity and weight status: Findings from the English Longitudinal Study of Ageing
- Knowledge and practices regarding toxoplasmosis in housewives: A cross sectional study in a northern Mexican city
- Citation gaming induced by bibliometric evaluation: A country-level comparative analysis
- Can we predict which species win when new habitat becomes available?
- Wetlands are keystone habitats for jaguars in an intercontinental biodiversity hotspot
- Research applications of primary biodiversity databases in the digital age
- The Edinburgh Postpartum Depression Scale: Stable structure but subscale of limited value to detect anxiety
- EV71 3C protease induces apoptosis by cleavage of hnRNP A1 to promote apaf-1 translation
- Post-exercise high-sensitivity troponin T levels in patients with suspected unstable angina
- Unexpected sawtooth artifact in beat-to-beat pulse transit time measured from patient monitor data
- Development of highly sensitive and low-cost DNA agarose gel electrophoresis detection systems, and evaluation of non-mutagenic and loading dye-type DNA-staining reagents
- Human mesenchymal stromal cells ameliorate complement induced inflammatory cascade and improve renal functions in a rat model of ischemia-reperfusion induced acute kidney injury
- Macrophage phenotype and its relationship with renal function in human diabetic nephropathy
- Phylogeography of the dugong (Dugong dugon) based on historical samples identifies vulnerable Indian Ocean populations
- Vibrational behavior of psyllids (Hemiptera: Psylloidea): Functional morphology and mechanisms
- Evaluation of the effectiveness and equity of the maternity protection reform in Chile from 2000 to 2015
- Baseline human gut microbiota profile in healthy people and standard reporting template
- Are screening methods useful in feature selection? An empirical study
- Free will beliefs are better predicted by dualism than determinism beliefs across different cultures
- How does the content of nutrients in soil affect the health status of trees in city parks?
- Understanding the intricacy of canid social systems: Structure and temporal stability of red fox (Vulpes vulpes) groups
- The anatomy of a crushing bite: The specialised cranial mechanics of a giant extinct kangaroo
- Nurse-led medicines’ monitoring in care homes, implementing the Adverse Drug Reaction (ADRe) Profile improvement initiative for mental health medicines: An observational and interview study
- Projecting burden of hypertension and its management in Turkey, 2015-2030
- Polyamine biosynthesis in Xenopus laevis: the xlAZIN2/xlODC2 gene encodes a lysine/ornithine decarboxylase
- Cytokines in agitated and non-agitated patients admitted to an acute psychiatric department: A cross-sectional study
- Acute pancreatitis risk after kidney transplantation: Propensity score matching analysis of a national cohort
- Understanding the effect of producers’ attitudes, perceived norms, and perceived behavioral control on intentions to use antimicrobials prudently on New York dairy farms
- Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone- and cartilage-specific toxicity
- Theory of mind in remitted bipolar disorder: Interpersonal accuracy in recognition of dynamic nonverbal signals
- Graviola (Annona muricata) attenuates behavioural alterations and testicular oxidative stress induced by streptozotocin in diabetic rats
- Ecological conditions experienced by offspring during pregnancy and early post-natal life determine mandible size in roe deer
- Calculation of the contribution rate of China’s hydraulic science and technology based on a feedforward neural network
- ViraMiner: Deep learning on raw DNA sequences for identifying viral genomes in human samples
- The absence of interleukin 10 affects the morphology, differentiation, granule content and the production of cryptidin-4 in Paneth cells in mice
- Relationship between Helicobacter pylori infection and obesity in Chinese adults: A systematic review with meta-analysis
- Moving model analysis on the transient pressure and slipstream caused by a metro train passing through a tunnel
- The importance of assigning responsibility during evaluation in order to increase student satisfaction from physical education classes: A structural equation model
- Lower dormancy with rapid germination is an important strategy for seeds in an arid zone with unpredictable rainfall
- Gene Cascade Finder: A tool for identification of gene cascades and its application in Caenorhabditis elegans
- Proteomics approach to identify serum biomarkers associated with the progression of diabetes in Korean patients with abdominal obesity
- Malaria vaccine candidates displayed on novel virus-like particles are immunogenic and induce transmission-blocking activity
- Transcriptome analysis of a nematode resistant and susceptible upland cotton line at two critical stages of Meloidogyne incognita infection and development
- Identification of variant HIV envelope proteins with enhanced affinities for precursors to anti-gp41 broadly neutralizing antibodies
- Distinguishing mild cognitive impairment from healthy aging and Alzheimer’s Disease: The contribution of the INECO Frontal Screening (IFS)
- Novel application of amino-acid buffered solution for neuroprotection against ischemia/reperfusion injury
- Are unpopular children more likely to get sick? Longitudinal links between popularity and infectious diseases in early childhood
- Vegetation communities on commercial developments are heterogenous and determined by development and landscaping decisions, not socioeconomics
- Falls among community-dwelling older adults in Ethiopia; A preliminary cross-sectional study
- Retraction: Social success of perfumes
- The effect of ethyl alcohol on the severity of injuries in fatal pedestrian victims of traffic crashes
- Drought stress has transgenerational effects on soybean seed germination and seedling vigor
- Prevalence of benign osseous lesions of the spine and association with spinal pain in the general population in whole body MRI
- Age-related differences of inter-joint coordination in elderly during squat jumping
- Isolation of five Enterobacteriaceae species harbouring blaNDM-1 and mcr-1 plasmids from a single paediatric patient
- Diagnostic performance and image quality of iterative model-based reconstruction of coronary CT angiography using 100 kVp for heavily calcified coronary vessels
- CAC1 knockdown reverses drug resistance through the downregulation of P-gp and MRP-1 expression in colorectal cancer
- Getting your game on: Using virtual reality to improve real table tennis skills
- Microbiological contamination of young children’s hands in rural Bangladesh: Associations with child age and observed hand cleanliness as proxy
- Expansion of the agricultural frontier in the largest South American Dry Forest: Identifying priority conservation areas for snakes before everything is lost
- Utility of lung ultrasound in ANCA-associated vasculitis with lung involvement
- Aerial surveys cause large but ephemeral decreases in bear presence at salmon streams in Kodiak, Alaska
- Exposure to particle debris generated from passenger and truck tires induces different genotoxicity and inflammatory responses in the RAW 264.7 cell line
- Influence of the cultivation medium and pH on the pigmentation of Trichophyton rubrum
- Intra-arterial catheter-directed CT angiography for assessment of endovascular aortic aneurysm repair
- Association of antibiotic exposure with the mortality in metastatic colorectal cancer patients treated with bevacizumab-containing chemotherapy: A hospital-based retrospective cohort study
- The genetic alteration spectrum of the SWI/SNF complex: The oncogenic roles of BRD9 and ACTL6A
- Plasma chemistry in nesting leatherback sea turtles (Dermochelys coriacea) from Florida: Understanding the importance of sample hemolysis effects on blood analytes
- Myotendinous asymmetries derived from the prolonged practice of badminton in professional players
- Computational tools to detect signatures of mutational processes in DNA from tumours: A review and empirical comparison of performance
- Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD-/- mice
- Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it
- Comparative compositional and functional analyses of Bothrops moojeni specimens reveal several individual variations
- Radiation hardness of cadmium telluride solar cells in proton therapy beam mode
- Bourdieu, networks, and movements: Using the concepts of habitus, field and capital to understand a network analysis of gender differences in undergraduate physics
- A 32-channel parallel transmit system add-on for 7T MRI
- Comparison between Aptima Assays (Hologic) and the Allplex STI Essential Assay (Seegene) for the diagnosis of Sexually transmitted infections
- Knowledge gaps of STIs in Africa; Systematic review
- Correction: Bovine herpesvirus 1 can cross the intact zona pellucida of bovine oocytes after artificial infection
- Distribution of corneal spherical aberration in a Tanzanian population
- Correction: Determinants of physical activity: A path model based on an ecological model of active living
- Wild pollinator activity negatively related to honey bee colony densities in urban context
- Subclinical alterations in left ventricular structure and function according to obesity and metabolic health status
- The epidemiological signature of influenza B virus and its B/Victoria and B/Yamagata lineages in the 21st century
- Identification of bovine CpG SNPs as potential targets for epigenetic regulation via DNA methylation
- Nitric oxide regulates the expression of heme carrier protein-1 via hypoxia inducible factor-1α stabilization
- Development of highly efficient protocols for extraction and amplification of cytomegalovirus DNA from dried blood spots for detection and genotyping of polymorphic immunomodulatory genes
- Construction of pseudomolecule sequences of Brassica rapa ssp. pekinensis inbred line CT001 and analysis of spontaneous mutations derived via sexual propagation
- Effects of flavoring compounds used in electronic cigarette refill liquids on endothelial and vascular function
- Rural pipeline and willingness to work in rural areas: Mixed method study on students in midwifery and obstetric nursing in Mali
- Role of phospholipase A2 receptor 1 antibody level at diagnosis for long-term renal outcome in membranous nephropathy
- Prevalence of anemia in diabetic adult outpatients in Northeast Ethiopia
- Characterization of melanin and optimal conditions for pigment production by an endophytic fungus, Spissiomyces endophytica SDBR-CMU319
- Genetic variability and consequence of Mycobacterium tuberculosis lineage 3 in Kampala-Uganda
- Comparison of in vitro and computational experiments on the relation of inter-beat interval and duration of repolarization in a specific type of human induced pluripotent stem cell-derived cardiomyocytes
- Current and potential contributions of community pharmacy teams to self-harm and suicide prevention: A qualitative interview study
- Prediction of risk scores for colorectal cancer patients from the concentration of proteins involved in mitochondrial apoptotic pathway
- With or without U(K): A pre-Brexit network analysis of the EU ETS
- Graph-theoretical analysis for energy landscape reveals the organization of state transitions in the resting-state human cerebral cortex
- Task-uninformative visual stimuli improve auditory spatial discrimination in humans but not the ideal observer
- Residual stenosis after carotid artery stenting: Effect on periprocedural and long-term outcomes
- gapFinisher: A reliable gap filling pipeline for SSPACE-LongRead scaffolder output
- A plant biostimulant made from the marine brown algae Ascophyllum nodosum and chitosan reduce Fusarium head blight and mycotoxin contamination in wheat
- Monte-Carlo value analysis of High-Throughput Satellites: Value levers, tradeoffs, and implications for operators and investors
- Educational and health outcomes associated with bronchopulmonary dysplasia in 15-year-olds born preterm
- Loss of prostatic acid phosphatase and α-synuclein cause motor circuit degeneration without altering cerebellar patterning
- Neuropathy and neural plasticity in the subcutaneous white adipose depot
- Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells
- The enemy’s gaze: Immersive virtual environments enhance peace promoting attitudes and emotions in violent intergroup conflicts
- Protective effect of lactobacillus plantarum on alcoholic liver injury and regulating of keap-Nrf2-ARE signaling pathway in zebrafish larvae
- Koopman Mode Analysis of agent-based models of logistics processes
- Empirical mode decomposition based long short-term memory neural network forecasting model for the short-term metro passenger flow
- Male sexual dysfunction in obesity: The role of sex hormones and small fibre neuropathy
- Multi-agent reinforcement learning with approximate model learning for competitive games
- Identification of olfactory genes and functional analysis of BminCSP and BminOBP21 in Bactrocera minax
- The use of urinary fluoride excretion to facilitate monitoring fluoride intake: A systematic scoping review
- Development of a family caregiver needs-assessment scale for end-of-life care for senility at home (FADE)
- Epidemiology of pneumonia in the pre-pneumococcal conjugate vaccine era in children 2-59 months of age, in Ulaanbaatar, Mongolia, 2015-2016
- H-EM: An algorithm for simultaneous cell diameter and intensity quantification in low-resolution imaging cytometry
- Public expenditure on Non-Communicable Diseases & Injuries in India: A budget-based analysis
- Doxorubicin induces trans-differentiation and MMP1 expression in cardiac fibroblasts via cell death-independent pathways
- uORF-Tools—Workflow for the determination of translation-regulatory upstream open reading frames
- Comparative analysis of postural control and vertical jump performance between three different measurement devices
- Hierarchical multi-view aggregation network for sensor-based human activity recognition
- Clavien–Dindo classification for grading complications after total pharyngolaryngectomy and free jejunum transfer
- Significantly different expression levels of microRNAs associated with vascular invasion in hepatocellular carcinoma and their prognostic significance after surgical resection
- Clinical correlates of workplace injury occurrence and recurrence in adults
- Medicine and the media: Medical experts’ problems and solutions while working with journalists
- Phylogenic classification and virulence genes profiles of uropathogenic E. coli and diarrhegenic E. coli strains isolated from community acquired infections
- Genetic relatedness in carbapenem-resistant isolates from clinical specimens in Ghana using ERIC-PCR technique
- Forest resilience under global environmental change: Do we have the information we need? A systematic review
- Improving the production of podophyllotoxin in hairy roots of Hyptis suaveolens induced from regenerated plantlets
- Controls on planktonic foraminifera apparent calcification depths for the northern equatorial Indian Ocean
- Notch and Delta are required for survival of the germline stem cell lineage in testes of Drosophila melanogaster
- Children with HIV: A scoping review of auditory processing skills
- Correction: Two distinct actin waves correlated with turns-and-runs of crawling microglia
- Expression of Concern: Neurotoxicity Induced by Bupivacaine via T-Type Calcium Channels in SH-SY5Y Cells
- Sex-dependent and -independent transcriptional changes during haploid phase gametogenesis in the sugar kelp Saccharina latissima
- Vehicle modeling for the analysis of the response of detectors based on inductive loops
- New Mycobacteroides abscessus subsp. massiliense strains with recombinant hsp65 gene laterally transferred from Mycobacteroides abscessus subsp. abscessus: Potential for misidentification of M. abscessus strains with the hsp65-based method
- A prognostic Bayesian network that makes personalized predictions of poor prognostic outcome post resection of pancreatic ductal adenocarcinoma
- Impact of care provider network characteristics on patient outcomes: Usage of social network analysis and a multi-scale community detection
- Valid group comparisons can be made with the Patient Health Questionnaire (PHQ-9): A measurement invariance study across groups by demographic characteristics
- Comparison of risk models for mortality and cardiovascular events between machine learning and conventional logistic regression analysis
- Upgraded molecular models of the human KCNQ1 potassium channel
- Mental health and quality of life outcomes in family members of patients with chronic critical illness admitted to the intensive care units of two Brazilian hospitals serving the extremes of the socioeconomic spectrum
- Correction: Secretome profiling of PC3/nKR cells, a novel highly migrating prostate cancer subline derived from PC3 cells
- The extraordinary osteology and functional morphology of the limbs in Palorchestidae, a family of strange extinct marsupial giants
- Primary hyperhidrosis prevalence and characteristics among medical students in Rio de Janeiro
- Implementation of home blood pressure monitoring among French GPs: A long and winding road
- In vitro and molecular chemosensitivity in human cholangiocarcinoma tissues
- Saiga horn user characteristics, motivations, and purchasing behaviour in Singapore
- The health and cost burden of antibiotic resistant and susceptible Escherichia coli bacteraemia in the English hospital setting: A national retrospective cohort study
- Retraction: Comprehensive Comparison of Three Different Immunosuppressive Regimens for Liver Transplant Patients with Hepatocellular Carcinoma: Steroid-Free Immunosuppression, Induction Immunosuppression and Standard Immunosuppression
- Can acute suicidality be predicted by Instagram data? Results from qualitative and quantitative language analyses
- Computational and experimental analysis of the glycophosphatidylinositol-anchored proteome of the human parasitic nematode Brugia malayi
- Antibacterial activity of silver nanoparticles of different particle size against Vibrio Natriegens
- Genetic variations associated with response to dutasteride in the treatment of male subjects with androgenetic alopecia
- To eat or not to eat: Reward delay impulsivity in children with loss of control eating, attention deficit / hyperactivity disorder, a double diagnosis, and healthy children
- Factors associated with newborn care knowledge and practices in the upper Himalayas
- Correction: A more physiological approach to lipid metabolism alterations in cancer: CRC-like organoids assessment
- Correlates of concurrent partnerships and patterns of condom use among men who have sex with men and transgender women in Peru
- Ocular and systemic risk factors associated with recurrent disc hemorrhage in primary open-angle glaucoma
- Development of a denoising convolutional neural network-based algorithm for metal artifact reduction in digital tomosynthesis for arthroplasty: A phantom study
- Low-level sensory processes play a more crucial role than high-level cognitive ones in the size-weight illusion
- The prevalence of asthma and allergic rhinitis in Nigeria: A nationwide survey among children, adolescents and adults
- Retraction: Human Cystathionine-β-Synthase Phosphorylation on Serine227 Modulates Hydrogen Sulfide Production in Human Urothelium
- Which clinical and biochemical predictors should be used to screen for diabetes in patients with serious mental illness receiving antipsychotic medication? A large observational study
- Characteristics of diabetic macular edema patients refractory to anti-VEGF treatments and a dexamethasone implant
- Correction: Effects of dietary n-6: n-3 polyunsaturated fatty acid ratios on meat quality, carcass characteristics, tissue fatty acid profiles, and expression of lipogenic genes in growing goats
- Speckle tracking derived reference values of myocardial deformation and impact of cardiovascular risk factors – Results from the population-based STAAB cohort study
- Impact of pterygium on the ocular surface and meibomian glands
- Lack of association between hypothyroxinemia of prematurity and transient thyroid abnormalities with adverse long term neurodevelopmental outcome in very low birth weight infants
- Transcriptome divergence during leaf development in two contrasting switchgrass (Panicum virgatum L.) cultivars
- Study on Dalfampridine in the treatment of Multiple Sclerosis Mobility Disability: A meta-analysis
- Circulating progenitor cells and the expression of Cxcl12, Cxcr4 and angiopoietin-like 4 during wound healing in the murine ear
- EUSKOR: End-to-end coreference resolution system for Basque
- Inactivating pathogenic bacteria in greywater by biosynthesized Cu/Zn nanoparticles from secondary metabolite of Aspergillus iizukae; optimization, mechanism and techno economic analysis
- Exopolysaccharide producing rhizobacteria and their impact on growth and drought tolerance of wheat grown under rainfed conditions
- Structural equation modeling for hypertension and type 2 diabetes based on multiple SNPs and multiple phenotypes
- Correction: Association between ultraviolet radiation exposure dose and cataract in Han people living in China and Taiwan: A cross-sectional study
- Short-term exercise training improves cardiac function associated to a better antioxidant response and lower type 3 iodothyronine deiodinase activity after myocardial infarction
- Unexpected low genetic variation in the South American hystricognath rodent Lagostomus maximus (Rodentia: Chinchillidae)
- PRC2 activates interferon-stimulated genes indirectly by repressing miRNAs in glioblastoma
- Surgical resection is sufficient for incidentally discovered solitary pulmonary nodule caused by nontuberculous mycobacteria in asymptomatic patients
- “I do all I can but I still fail them”: Health system barriers to providing Option B+ to pregnant and lactating women in Malawi
- Impact of major illnesses and geographic regions on do-not-resuscitate rate and its potential cost savings in Taiwan
- Implementation of intermittent theta burst stimulation compared to conventional repetitive transcranial magnetic stimulation in patients with treatment resistant depression: A cost analysis
- Genome-wide analysis of DNA methylation profile identifies differentially methylated loci associated with human intervertebral disc degeneration
- Correction: Artificial neural networks reveal individual differences in metacognitive monitoring of memory
- Combining fish and environmental PCR for diagnostics of diseased laboratory zebrafish in recirculating systems
- Reading skill modulates the effect of parafoveal distractors on foveal lexical decision in deaf students
- Association between the posterior part of the circle of Willis and the vertebral artery hypoplasia
- Exposure to marital conflict: Gender differences in internalizing and externalizing problems among children
- Ethanol locks for the prevention of catheter-related infection in patients with central venous catheter: A systematic review and meta-analysis of randomized controlled trials
- The effect of age and perturbation time on online control during rapid pointing
- Oilseed rape (Brassica napus) resistance to growth of Leptosphaeria maculans in leaves of young plants contributes to quantitative resistance in stems of adult plants
- Lymphocyte proliferation induced by high-affinity peptides for HLA-B*51:01 in Behçet’s uveitis
- Sensitization of avian pathogenic Escherichia coli to amoxicillin in vitro and in vivo in the presence of surfactin
- Genomic characterization of the complete terpene synthase gene family from Cannabis sativa
- Inhibition of gap junctional intercellular communication by an anti-migraine agent, flunarizine
- Levels of serum eosinophil cationic protein are associated with hookworm infection and intensity in endemic communities in Ghana
- Plant growth promoting rhizobacterium Stenotrophomonas maltophilia BJ01 augments endurance against N2 starvation by modulating physiology and biochemical activities of Arachis hypogea
- Hierarchical integrated and segregated processing in the functional brain default mode network within attention-deficit/hyperactivity disorder
- Rising co-payments coincide with unwanted effects on continuity of healthcare for patients with schizophrenia in the Netherlands
- Analysis of Zobellella denitrificans ZD1 draft genome: Genes and gene clusters responsible for high polyhydroxybutyrate (PHB) production from glycerol under saline conditions and its CRISPR-Cas system
- False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases
- Identification of potassium phosphite responsive miRNAs and their targets in potato
- Quantification of bell-shaped size selectivity in shrimp trawl fisheries using square mesh panels and a sorting cone after a Nordmøre grid
- Deactivation of somatosensory and visual cortices during vestibular stimulation is associated with older age and poorer balance
- Combined immunization with attenuated live influenza vaccine and chimeric pneumococcal recombinant protein improves the outcome of virus-bacterial infection in mice
- Flooding performance evaluation of alkyl aryl sulfonate in various alkaline environments
- An artificial intelligent diagnostic system on mobile Android terminals for cholelithiasis by lightweight convolutional neural network
- Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads
- COI metabarcoding primer choice affects richness and recovery of indicator taxa in freshwater systems
- Retraction: APRIL Induces Tumorigenesis and Metastasis of Colorectal Cancer Cells via Activation of the PI3K/Akt Pathway
- The intake pattern and feed preference of layer hens selected for high or low feed conversion ratio
- Individualized pattern recognition for detecting mind wandering from EEG during live lectures
- Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison
- Post-activation potentiation effect of eccentric overload and traditional weightlifting exercise on jumping and sprinting performance in male athletes
- Effectiveness of different central venous catheter fixation suture techniques: An in vitro crossover study
- Quantitative detection of ALK fusion breakpoints in plasma cell-free DNA from patients with non-small cell lung cancer using PCR-based target sequencing with a tiling primer set and two-step mapping/alignment
- Nuclei deformation reveals pressure distributions in 3D cell clusters
- Strategies for increasing diagnostic yield of community-onset bacteraemia within the emergency department: A retrospective study
- Rapid evolution of Mexican H7N3 highly pathogenic avian influenza viruses in poultry
- Certified service dogs – A cost-effectiveness analysis appraisal
- Endothelial dysfunction and low-grade inflammation in the transition to renal replacement therapy
- Assessing the impact of a research funder’s recommendation to consider core outcome sets
- Validity of six consumer-level activity monitors for measuring steps in patients with chronic heart failure
- Detection of deceptive motions in rugby from visual motion cues
- The impact of antenatal care on neonatal mortality in sub-Saharan Africa: A systematic review and meta-analysis
- Epidemiological investigation and management of bloody diarrhea among children in India
- Irisin promotes C2C12 myoblast proliferation via ERK-dependent CCL7 upregulation
- Bacteria isolated from Bengal cat (Felis catus × Prionailurus bengalensis) anal sac secretions produce volatile compounds potentially associated with animal signaling
- Petri net–based model of the human DNA base excision repair pathway
- Complexation and conformation of lead ion with poly-γ-glutamic acid in soluble state
- The effects of sympathetic activity induced by ice water on blood flow and brachial artery flow-mediated dilatation response in healthy volunteers
- The Youth-Physical Activity Towards Health (Y-PATH) intervention: Results of a 24 month cluster randomised controlled trial
- The COPD multi-dimensional phenotype: A new classification from the STORICO Italian observational study
- Morphological identification of Amphitetranychus species (Acari: Tetranychidae) with crossbreeding, esterase zymograms and DNA barcode data
- Maintaining hope after a disabling stroke: A longitudinal qualitative study of patients’ experiences, views, information needs and approaches towards making treatment decisions
- Cultural differences in the use of acoustic cues for musical emotion experience
- Effects of a rifampicin pre-treatment on linezolid pharmacokinetics
- High prevalence of multidrug resistant Enterobacteriaceae among residents of long term care facilities in Amsterdam, the Netherlands
- Infection/inflammation-associated preterm delivery within 14 days of presentation with symptoms of preterm labour: A multivariate predictive model
- Prognostic value of preoperative hydronephrosis in patients with bladder cancer undergoing radical cystectomy: A meta-analysis
- Correction: Early life predictors of midlife allostatic load: A prospective cohort study
- PCR-free whole exome sequencing: Cost-effective and efficient in detecting rare mutations
- Epstein-Barr virus genome packaging factors accumulate in BMRF1-cores within viral replication compartments
- Symbiotic incompatibility between soybean and Bradyrhizobium arises from one amino acid determinant in soybean Rj2 protein
- Does anticoagulation needed for distally located incidental pulmonary thromboembolism in patients with active cancer?
- Control of human testis-specific gene expression
- Speaking up culture of medical students within an academic teaching hospital: Need of faculty working in patient safety
- Appraisal on the wound healing potential of Melaleuca alternifolia and Rosmarinus officinalis L. essential oil-loaded chitosan topical preparations
- Understanding parental perspectives on outcomes following paediatric encephalitis: A qualitative study
- Results of scoping review do not support mild traumatic brain injury being associated with a high incidence of chronic cognitive impairment: Commentary on McInnes et al. 2017
- Native seed, soil and atmosphere respond to boreal forest topsoil (LFH) storage
- Development of a quantitative polymerase chain reaction assay and environmental DNA sampling methods for Giant Gartersnake (Thamnophis gigas)
- Genetic diversity and population structure of four Chinese rabbit breeds
- Knowledge, attitude and behaviors towards patients with mental illness: Results from a national Lebanese study
- Correction: An impact evaluation of two rounds of mass drug administration on the prevalence of active trachoma: A clustered cross sectional survey
- Comparative prognostic accuracy of sepsis scores for hospital mortality in adults with suspected infection in non-ICU and ICU at an academic public hospital
- Graph convolutional network approach applied to predict hourly bike-sharing demands considering spatial, temporal, and global effects
- Impact of traffic variability on geographic accessibility to 24/7 emergency healthcare for the urban poor: A GIS study in Dhaka, Bangladesh
- Feeling the heat: Elevated temperature affects male display activity of a lekking grassland bird
- Constructing a comprehensive disaster resilience index: The case of Italy
- Intraocular pressure according to different types of tonometry (non-contact and Goldmann applanation) in patients with different degrees of bilateral tearing
- Prevalent vertebral fracture is dominantly associated with spinal microstructural deterioration rather than bone mineral density in patients with type 2 diabetes mellitus
- Silent volumetric multi-contrast 7 Tesla MRI of ocular tumors using Zero Echo Time imaging
- Nonverbal synchrony in virtual reality
- Do speed cameras reduce road traffic collisions?
- A zero-shot learning approach to the development of brain-computer interfaces for image retrieval
- Use of non-HIV medication among people living with HIV and receiving antiretroviral treatment in Côte d’Ivoire, West Africa: A cross-sectional study
- DNA barcoding of southern African crustaceans reveals a mix of invasive species and potential cryptic diversity
- Development of an international external quality assurance program for HIV-1 incidence using the Limiting Antigen Avidity assay
- Correction: The mean cell volume difference (dMCV) reflects serum hypertonicity in diabetic dogs
- Structural characteristics of lipocalin allergens: Crystal structure of the immunogenic dog allergen Can f 6
- Transport oil product consumption and GHG emission reduction potential in China: An electric vehicle-based scenario analysis
- Ontogenetic shift in the energy allocation strategy and physiological condition of larval plaice (Pleuronectes platessa)
- Increased proliferation and altered cell cycle regulation in pancreatic stem cells derived from patients with congenital hyperinsulinism
- Diagnostic accuracy of Xpert MTB/RIF assay and non-molecular methods for the diagnosis of tuberculosis lymphadenitis
- Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania
- Spatial distribution of breast cancer in Sudan 2010-2016
- Human-induced fire regime shifts during 19th century industrialization: A robust fire regime reconstruction using northern Polish lake sediments
- Enhanced effectiveness of oil dispersants in destabilizing water-in-oil emulsions
- Development of UV spectrophotometry methods for concurrent quantification of amlodipine and celecoxib by manipulation of ratio spectra in pure and pharmaceutical formulation
- Iron and manganese co-limit growth of the Southern Ocean diatom Chaetoceros debilis
- Bilateral and unilateral load-velocity profiling in a machine-based, single-joint, lower body exercise
- Veterans Health Administration nurses’ training and beliefs related to care of patients with traumatic brain injury
- Supplementation strategies affect the feed intake and performance of grazing replacement heifers
- Active transcutaneous bone conduction hearing implants: Systematic review and meta-analysis
- Parameterization-induced uncertainties and impacts of crop management harmonization in a global gridded crop model ensemble
- Acidification effects on isolation of extracellular vesicles from bovine milk
- GPR40 full agonism exerts feeding suppression and weight loss through afferent vagal nerve
- Mining version history to predict the class instability
- Humpback whale song occurrence reflects ecosystem variability in feeding and migratory habitat of the northeast Pacific
- A phase 2 study of an oral mTORC1/mTORC2 kinase inhibitor (CC-223) for non-pancreatic neuroendocrine tumors with or without carcinoid symptoms
- Asprosin response in hypoglycemia is not related to hypoglycemia unawareness but rather to insulin resistance in type 1 diabetes
- Muscle oxygenation maintained during repeated-sprints despite inspiratory muscle loading
- Reconstructing systematic persistent impacts of promotional marketing with empirical nonlinear dynamics
- Trans-national conservation and infrastructure development in the Heart of Borneo
- Prediction of cardiovascular disease risk among people with severe mental illness: A cohort study
- Data in question: A survey of European biobank professionals on ethical, legal and societal challenges of biobank research
- Hypertensive APOL1 risk allele carriers demonstrate greater blood pressure reduction with angiotensin receptor blockade compared to low risk carriers
- Reconstructing birth in Australopithecus sediba
- Value of contrast-enhanced ultrasound for preoperative assessment of liver reserve function in patients with liver tumors
- Correction: Identifying obesity/overweight status in children and adolescents; A cross-sectional medical record review of physicians’ weight screening practice in outpatient clinics, Saudi Arabia
- Incidence and risk factors of loss to follow-up among HIV-infected children in an antiretroviral treatment program
- Changes in intracellular folate metabolism during high-dose methotrexate and Leucovorin rescue therapy in children with acute lymphoblastic leukemia
- Functional role and evolutionary contributions of floral gland morphoanatomy in the Paleotropical genus Acridocarpus (Malpighiaceae)
- On the efficiency of HIV transmission: Insights through discrete time HIV models
- Metabolic cost calculations of gait using musculoskeletal energy models, a comparison study
- Comparison of molecular profile in triple-negative inflammatory and non-inflammatory breast cancer not of mesenchymal stem-like subtype
- Evolutionary analysis of six chloroplast genomes from three Persea americana ecological races: Insights into sequence divergences and phylogenetic relationships
- Cultural transmission in a food preparation task: The role of interactivity, innovation and storytelling
- Correction: Effects of affective priming through music on the use of emotion words
- Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial
- Estimation of vaccination coverage from electronic healthcare records; methods performance evaluation – A contribution of the ADVANCE-project
- Dietary phytogenics and galactomannan oligosaccharides in low fish meal and fish oil-based diets for European sea bass (Dicentrarchus labrax) juveniles: Effects on gut health and implications on in vivo gut bacterial translocation
- Suicide by hanging: Results from a national survey in Switzerland and its implications for suicide prevention
- Gene dysregulation in peripheral blood of moyamoya disease and comparison with other vascular disorders
- Genome wide genetic dissection of wheat quality and yield related traits and their relationship with grain shape and size traits in an elite × non-adapted bread wheat cross
- Safety and tolerability of artesunate-amodiaquine, artemether-lumefantrine and quinine plus clindamycin in the treatment of uncomplicated Plasmodium falciparum malaria in Kinshasa, the Democratic Republic of the Congo
- Factors influencing the admission decision for Medical Psychiatry Units: A concept mapping approach
- Comparison of post-traumatic changes in circulating and bone marrow leukocytes between BALB/c and CD-1 mouse strains
- Physiological stress reactivity and recovery related to behavioral traits in dogs (Canis familiaris)
- Associations between birth order with mental wellbeing and psychological distress in midlife: Findings from the 1970 British Cohort Study (BCS70)
- Non-steroidal anti-inflammatory drugs use in older adults decreases risk of Alzheimer’s disease mortality
- The cost-effectiveness of neonatal versus prenatal screening for congenital toxoplasmosis
- Ancient technology and punctuated change: Detecting the emergence of the Edomite Kingdom in the Southern Levant
- Flowers as viral hot spots: Honey bees (Apis mellifera) unevenly deposit viruses across plant species
- Randomized control trial of Tools of the Mind: Marked benefits to kindergarten children and their teachers
- Preserving cultural heritage: Analyzing the antifungal potential of ionic liquids tested in paper restoration
- PNPLA3 rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age
- Correction: Unraveling the genetic complexity underlying sorghum response to water availability
- Impact of tear metrics on the reliability of perimetry in patients with dry eye
- Using DNA barcoding to improve invasive pest identification at U.S. ports-of-entry
- Correction: Effects of Lactobacillus plantarum 15-1 and fructooligosaccharides on the response of broilers to pathogenic Escherichia coli O78 challenge
- Physico-chemical characterization and transcriptome analysis of 5-methyltryptophan resistant lines in rice
- Patient factors affecting successful linkage to treatment in a cervical cancer prevention program in Kenya: A prospective cohort study
- Is this a man’s world? The effect of gender diversity and gender equality on firm innovativeness
- Procalcitonin to stop antibiotics after cardiovascular surgery in a pediatric intensive care unit—The PROSACAB study
- Temporal trends, predictors, and outcomes of acute kidney injury and hemodialysis use in acute myocardial infarction-related cardiogenic shock
- Quantitation of free glycation compounds in saliva
- Resolving an 87-year-old taxonomical curiosity with the description of Psylla frodobagginsi sp. nov. (Hemiptera: Sternorrhyncha: Psyllidae), a second distinct Psylla species on the New Zealand endemic plant kōwhai
- The effect of cathodal tDCS on fear extinction: A cross-measures study
- Physiological responses to affiliation during conversation: Comparing neurotypical males and males with Asperger syndrome
- Human cord blood (hCB)-CD34+ humanized mice fail to reject human acute myeloid leukemia cells
- Investigating the dispersal of antibiotic resistance associated genes from manure application to soil and drainage waters in simulated agricultural farmland systems
- Continuous norming of psychometric tests: A simulation study of parametric and semi-parametric approaches
- Phylogenetic microbiota profiling in fecal samples depends on combination of sequencing depth and choice of NGS analysis method
- Cost-effectiveness of apixaban compared to other anticoagulants in patients with atrial fibrillation in the real-world and trial settings
- Biochemical profile and in vitro biological activities of extracts from seven folk medicinal plants growing wild in southern Tunisia
- Low genetic differentiation yet high phenotypic variation in the invasive populations of Spartina alterniflora in Guangxi, China
- A mathematical model for designing networks of C-Reactive Protein point of care testing
- Prevalence of hypochondriac symptoms among health science students in China: A systematic review and meta-analysis
- Femtosecond laser induced step-like structures inside transparent hydrogel due to laser induced threshold reduction
- From In Situ to satellite observations of pelagic Sargassum distribution and aggregation in the Tropical North Atlantic Ocean
- The polyether ionophore salinomycin targets multiple cellular pathways to block proliferative vitreoretinopathy pathology
- BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis
- HIV prevalence and risk behavior among male and female adults screened for enrolment into a vaccine preparedness study in Maputo, Mozambique
- Sputum microbiota and inflammation at stable state and during exacerbations in a cohort of chronic obstructive pulmonary disease (COPD) patients
- Direct estimation of the parameters of a delayed, intermittent activation feedback model of postural sway during quiet standing
- Occurrence mechanism and coping paths of accidents of highly aggregated tourist crowds based on system dynamics
- Correction: Low Dose Aerosol Fitness at the Innate Phase of Murine Infection Better Predicts Virulence amongst Clinical Strains of Mycobacterium tuberculosis
- Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α, p53, caspase-3 and Bcl-2 in STZ-induced diabetic rats
- Correction: Public reaction to Chikungunya outbreaks in Italy—Insights from an extensive novel data streams-based structural equation modeling analysis
- Correction: Comparison of neurodegenerative types using different brain MRI analysis metrics in older adults with normal cognition, mild cognitive impairment, and Alzheimer’s dementia
- Intra-individual variability of sleep and nocturnal cardiac autonomic activity in elite female soccer players during an international tournament
- Therapeutic efficacy of equine botulism heptavalent antitoxin against all seven botulinum neurotoxins in symptomatic guinea pigs
- Interleukin 10 knock-down in bovine monocyte-derived macrophages has distinct effects during infection with two divergent strains of Mycobacterium bovis
- Clinical outcomes of bortezomib-based therapy in Taiwanese patients with multiple myeloma: A nationwide population-based study and a single-institute analysis
- Scope and efficacy of the broad-spectrum topical antiseptic choline geranate
- Hematological and biochemical parameters for Chinese rhesus macaque
- Veterinary peer study groups as a method of continuous education—A new approach to identify and address factors associated with antimicrobial prescribing
- Correction: The prognosis of heart failure patients: Does sodium level play a significant role?
- Maternal malaria but not schistosomiasis is associated with a higher risk of febrile infection in infant during the first 3 months of life: A mother-child cohort in Benin
- Systematic identification of facility-based stillbirths and neonatal deaths through the piloted use of an adapted RAPID tool in Liberia and Nepal
- Effects of salbutamol and phlorizin on acute pulmonary inflammation and disease severity in experimental sepsis
- Correction: Age, sex and storage time influence hair cortisol levels in a wild mammal population
- Reasons to care: Personal motivation as a key factor in the practice of the professional foster carer in Romania
- Determinants of clinical, functional and personal recovery for people with schizophrenia and other severe mental illnesses: A cross-sectional analysis
- Continuity of care for TB patients at a South African hospital: A qualitative participatory study of the experiences of hospital staff
- EGF receptor stimulation shifts breast cancer cell glucose metabolism toward glycolytic flux through PI3 kinase signaling
- The Better Management of Patients with Osteoarthritis Program: Outcomes after evidence-based education and exercise delivered nationwide in Sweden
- The negative effects of short-term extreme thermal events on the seagrass Posidonia oceanica are exacerbated by ammonium additions
- Pathogen invasion history elucidates contemporary host pathogen dynamics
- Chinese herbal formulae for the treatment of menopausal hot flushes: A systematic review and meta-analysis
- Healthcare resource utilization and costs for multiple sclerosis management in the Campania region of Italy: Comparison between centre-based and local service healthcare delivery
- Deconstruction of central line insertion guidelines based on the positive deviance approach—Reducing gaps between guidelines and implementation: A qualitative ethnographic research
- PBMCs transcriptome profiles identified breed-specific transcriptome signatures for PRRSV vaccination in German Landrace and Pietrain pigs
- The impact of admission serum lactate on children with moderate to severe traumatic brain injury
- Hypervirulent Klebsiella pneumoniae serotype K1 clinical isolates form robust biofilms at the air-liquid interface
- Determination of the bruise degree for cherry using Vis-NIR reflection spectroscopy coupled with multivariate analysis
- Genome-wide identification and expression profile analysis of nuclear factor Y family genes in Sorghum bicolor L. (Moench)
- Trends in maternal prepregnancy body mass index (BMI) and its association with birth and maternal outcomes in California, 2007–2016: A retrospective cohort study
- Distribution of the Duffy genotypes in Malaysian Borneo and its relation to Plasmodium knowlesi malaria susceptibility
- Hippocampal connectivity with sensorimotor cortex during volitional finger movements: Laterality and relationship to motor learning
- A self-adaptive deep learning method for automated eye laterality detection based on color fundus photography
- The effect of child marriage on the utilization of maternal health care in Nepal: A cross-sectional analysis of Demographic and Health Survey 2016
- Identification of QTLs for powdery mildew (Podosphaera aphanis; syn. Sphaerotheca macularis f. sp. fragariae) susceptibility in cultivated strawberry (Fragaria ×ananassa)
- Chemical volatiles present in cotton gin trash: A by-product of cotton processing
- PTP1B negatively regulates nitric oxide-mediated Pseudomonas aeruginosa killing by neutrophils
- Differential metabolomics networks analysis of menopausal status
- Experimental study of the temporal profile of breath alcohol concentration in a Chinese population after a light meal
- Association between regional brain volumes and BMI z-score change over one year in children
- Relationships between Potentially Toxic Elements in intertidal sediments and their bioaccumulation by benthic invertebrates
- Long-term outcomes of dialysis in patients with chronic kidney disease and new-onset atrial fibrillation: A population-based cohort study
- Hospital burden of pulmonary arterial hypertension in France
- Understanding the variability of Australian fire weather between 1973 and 2017
- Photon-counting cine-cardiac CT in the mouse
- Ecophysiological impacts of Esca, a devastating grapevine trunk disease, on Vitis vinifera L.
- Black “Reading the Mind in the Eyes” task: The development of a task assessing mentalizing from black faces
- Osmolytes ameliorate the effects of stress in the absence of the heat shock protein Hsp104 in Saccharomyces cerevisiae
- Reliable and robust method for abdominal muscle mass quantification using CT/MRI: An explorative study in healthy subjects
- Validation of the Rainbow Model of Integrated Care Measurement Tools (RMIC-MTs) in renal care for patient and care providers
- Multiple origins and the population genetic structure of Rubus takesimensis (Rosaceae) on Ulleung Island: Implications for the genetic consequences of anagenetic speciation
- Genetic profiling of fatty acid desaturase polymorphisms identifies patients who may benefit from high-dose omega-3 fatty acids in cardiac remodeling after acute myocardial infarction—Post-hoc analysis from the OMEGA-REMODEL randomized controlled trial
- A randomized controlled trial examining the efficacy of an internet-based cognitive behavioral therapy program for adolescents with anxiety disorders
- Optimising outputs from a validated online instrument to measure health-related quality of life (HRQL) in dogs
- Young adults’ perceptions of using wearables, social media and other technologies to detect worsening mental health: A qualitative study
- Characteristics of prescription in 29 Level 3 Neonatal Wards over a 2-year period (2017-2018). An inventory for future research
- Genetic characterization of fall armyworm (Spodoptera frugiperda) in Ecuador and comparisons with regional populations identify likely migratory relationships
- Correction: Lkb1 Deficiency Alters Goblet and Paneth Cell Differentiation in the Small Intestine
- Cardiac resynchronization therapy-heart failure (CRT-HF) clinic: A novel model of care
- Synteny and phylogenetic analysis of paralogous thyrostimulin beta subunits (GpB5) in vertebrates
- Dual-Subpopulation as reciprocal optional external archives for differential evolution
- NGS analysis in Marfan syndrome spectrum: Combination of rare and common genetic variants to improve genotype-phenotype correlation analysis
- Optimization of cataract surgery follow-up: A standard set of questions can predict unexpected management changes at postoperative week one
- Silymarin in non-cirrhotics with non-alcoholic steatohepatitis: A randomized, double-blind, placebo controlled trial
- Clinical evaluation of General Electric new Swiftscan solution in bone scintigraphy on NaI-camera: A head to head comparison with Siemens Symbia
- Pharmacist-led academic detailing improves statin therapy prescribing for Malaysian patients with type 2 diabetes: Quasi-experimental design
- Proton pump inhibitors attenuate myofibroblast formation associated with thyroid eye disease through the aryl hydrocarbon receptor
- Clinical outcomes with neoadjuvant versus adjuvant chemotherapy for triple negative breast cancer: A report from the National Cancer Database
- Identification and characterization of a novel heparan sulfate-binding domain in Activin A longest variants and implications for function
- Wikipedia network analysis of cancer interactions and world influence
- Using path signatures to predict a diagnosis of Alzheimer’s disease
- Development and verification of prediction models for preventing cardiovascular diseases
- Additive and heterozygous (dis)advantage GWAS models reveal candidate genes involved in the genotypic variation of maize hybrids to Azospirillum brasilense
- Fish tank granuloma: An emerging skin disease in Iran mimicking Cutaneous Leishmaniasis
- Transience effect in capture-recapture studies: The importance of its biological meaning
- Detailed global modelling of soil organic carbon in cropland, grassland and forest soils
- Oral dosing for antenatal corticosteroids in the Rhesus macaque
- Retraction: Modulation of the Pentose Phosphate Pathway Induces Endodermal Differentiation in Embryonic Stem Cells
- An analysis on HBsAg, Anti-HCV, Anti-HIV½ and VDRL test results in blood donors according to gender, age range and years
- Clinical factors associated with bacterial translocation in Japanese patients with type 2 diabetes: A retrospective study
- Meaningful work and resilience among teachers: The mediating role of work engagement and job crafting
- The conditional Fama-French model and endogenous illiquidity: A robust instrumental variables test
- Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes
- Characterization of sequentially-staged cancer cells using electrorotation
- Vancomycin-laden calcium phosphate-calcium sulfate composite allows bone formation in a rat infection model
- Genetic evidence for plural introduction pathways of the invasive weed Paterson’s curse (Echium plantagineum L.) to southern Australia
- Risk of major autoimmune diseases in female breast cancer patients: A nationwide, population-based cohort study
- Real-time three-dimensional MRI for the assessment of dynamic carpal instability
- Interim report on the effective intraperitoneal therapy of insulin-dependent diabetes mellitus in pet dogs using “Neo-Islets,” aggregates of adipose stem and pancreatic islet cells (INAD 012-776)
- The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue: A single centre experience
- Retraction: Analysis of Mycobacterium tuberculosis-Specific CD8 T-Cells in Patients with Active Tuberculosis and in Individuals with Latent Infection
- The association between role model presence and self-regulation in early adolescence: A cross-sectional study
- Correction: A controlled-release oral opioid supports S. aureus survival in injection drug preparation equipment and may increase bacteremia and endocarditis risk
- Methamphetamine regulation of activity and topology of ventral midbrain networks
- Evaluation and treatment of latent tuberculosis infection among healthcare workers in Korea: A multicentre cohort analysis
- Occult periprosthetic femoral fractures occur frequently during a long, trapezoidal, double-tapered cementless femoral stem fixation in primary THA
- TCF4 induces enzalutamide resistance via neuroendocrine differentiation in prostate cancer
- Structural characterization of EGFR exon 19 deletion mutation using molecular dynamics simulation
- Comparing infiltration rates in soils managed with conventional and alternative farming methods: A meta-analysis
- Correction: Permissivity of Primary Human Hepatocytes and Different Hepatoma Cell Lines to Cell Culture Adapted Hepatitis C Virus
- Radiomics features of the primary tumor fail to improve prediction of overall survival in large cohorts of CT- and PET-imaged head and neck cancer patients
- The complete mitochondrial genome of Calyptogena marissinica (Heterodonta: Veneroida: Vesicomyidae): Insight into the deep-sea adaptive evolution of vesicomyids
- Correction: In vitro larval rearing protocol for the stingless bee species Melipona scutellaris for toxicological studies
- Correction: Morphological and molecular identification of the dioecious “African species Volvox rousseletii (Chlorophyceae) in the water column of a Japanese lake based on field-collected and cultured materials
- Upper versus lower airway microbiome and metagenome in children with cystic fibrosis and their correlation with lung inflammation
- “…or else I close my ears” How women with obesity want to be approached and treated regarding gestational weight management: A qualitative interview study
- Does a spinal implant alter dual energy X-ray absorptiometry body composition measurements?
- Economic and livestock health impacts of birds on dairies: Evidence from a survey of Washington dairy operators
- Repair of subtotal tympanic membrane perforations: A temporal bone study of several tympanoplasty materials
- Shifts in temperature influence how Batrachochytrium dendrobatidis infects amphibian larvae
- Sequential two-step chromatographic purification of infectious poliovirus using ceramic fluoroapatite and ceramic hydroxyapatite columns
- Frequency and distribution of corneal astigmatism and keratometry features in adult life: Methodology and findings of the UK Biobank study
- Differences in the impedance of cochlear implant devices within 24 hours of their implantation
- Suppressive impact of metronomic chemotherapy using UFT and/or cyclophosphamide on mediators of breast cancer dissemination and invasion
- Expression of Concern: miRNA 17 Family Regulates Cisplatin-Resistant and Metastasis by Targeting TGFbetaR2 in NSCLC
- Group leaders establish cooperative norms that persist in subsequent interactions
- Addis Ababa population-based pattern of cancer therapy, Ethiopia
- Agreement between the Cochrane risk of bias tool and Physiotherapy Evidence Database (PEDro) scale: A meta-epidemiological study of randomized controlled trials of physical therapy interventions
- Oxidoreductase disulfide bond proteins DsbA and DsbB form an active redox pair in Chlamydia trachomatis, a bacterium with disulfide dependent infection and development
- DNA barcoding of coastal ray-finned fishes in Vietnam
- Comparison of climbing-specific strength and endurance between lead and boulder climbers
- The performance of different case definitions for severe influenza surveillance among HIV-infected and HIV-uninfected children aged <5 years in South Africa, 2011–2015
- Analgesic drug use in elderly persons: A population-based study in Southern Italy
- RCER: Reliable Cluster-based Energy-aware Routing protocol for heterogeneous Wireless Sensor Networks
- Beta-defensins and analogs in Helicobacter pylori infections: mRNA expression levels, DNA methylation, and antibacterial activity
- Changing educational gradient in long-term care-free life expectancy among German men, 1997-2012
- A non-parametric significance test to compare corpora
- Evaluating the impact of policies recommending PrEP to subpopulations of men and transgender women who have sex with men based on demographic and behavioral risk factors
- Different levels of statistical learning - Hidden potentials of sequence learning tasks
- Dry period heat stress induces microstructural changes in the lactating mammary gland
- Organic resolution function and effects of platinum nanoparticles on bacteria and organic matter
- High levels of fasting glucose and glycosylated hemoglobin values are associated with hyperfiltration in a Spanish prediabetes cohort. The PREDAPS Study
- Genetically distinct Group B Streptococcus strains induce varying macrophage cytokine responses
- Dynamic up- and down-regulation of the default (DMN) and extrinsic (EMN) mode networks during alternating task-on and task-off periods
- ERK1/ATF-2 signaling axis contributes to interleukin-1β-induced MMP-3 expression in dermal fibroblasts
- Cytokine profiles of umbilical cord blood mononuclear cells upon in vitro stimulation with lipopolysaccharides of different vaginal gram-negative bacteria
- Everolimus in de novo kidney transplant recipients participating in the Eurotransplant senior program: Results of a prospective randomized multicenter study (SENATOR)
- Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2
- Does effectiveness in performance appraisal improve with rater training?
- National trends in inpatient endometriosis admissions: Patients, procedures and outcomes, 2006−2015
- Affective and enjoyment responses to 12 weeks of high intensity interval training and moderate continuous training in adults with Crohn’s disease
- Thrombophilic risk factors in hemodialysis: Association with early vascular access occlusion and patient survival in long-term follow-up
- Cabbage stem flea beetle’s (Psylliodes chrysocephala L.) susceptibility to pyrethroids and tolerance to thiacloprid in the Czech Republic
- Implicit learning of artificial grammatical structures after inferior frontal cortex lesions
- Potential survival benefits from optimized chemotherapy implementation in advanced ovarian cancer: Projections from a microsimulation model
- Predictors of SLE relapse in pregnancy and post-partum among multi-ethnic patients in Malaysia
- Heat stress responses in a large set of winter wheat cultivars (Triticum aestivum L.) depend on the timing and duration of stress
- Mice deficient in NKLAM have attenuated inflammatory cytokine production in a Sendai virus pneumonia model
- Dysregulation of microRNAs and target genes networks in human abdominal aortic aneurysm tissues
- Quality of life and associated factors among patients with breast cancer under chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia
- Evaluation of suitable reference genes in Brassica juncea and its wild relative Camelina sativa for qRT-PCR analysis under various stress conditions
- Time-related immunomodulation by stressors and corticosterone transdermal application in toads
- Machine learning discovery of longitudinal patterns of depression and suicidal ideation
- Multi-scale patterns of tick occupancy and abundance across an agricultural landscape in southern Africa
- A matter of taste: Spatial and ontogenetic variations on the trophic ecology of the tiger shark at the Galapagos Marine Reserve
- Retraction: Adaptive double threshold energy detection based on Markov model for cognitive radio
- Adrenal gland size in obstructive sleep apnea: Morphological assessment of hypothalamic pituitary adrenal axis activity
- Out-of-pocket health spending among Medicare beneficiaries: Which chronic diseases are most costly?
- A large-scale chromosomal inversion is not associated with life history development in rainbow trout from Southeast Alaska
- Deployment, suicide, and overdose among comorbidity phenotypes following mild traumatic brain injury: A retrospective cohort study from the Chronic Effects of Neurotrauma Consortium
- Association between alcohol intake and measures of incident CKD: An analysis of nationwide health screening data
- Exploration of icariin analog structure space reveals key features driving potent inhibition of human phosphodiesterase-5
- A quantitative approach for the analysis of clinician recognition of acute respiratory distress syndrome using electronic health record data
- Morphological, microbiological and ultrastructural aspects of sepsis by Aeromonas hydrophila in Piaractus mesopotamicus
- Recidivism rates in individuals receiving community sentences: A systematic review
- The association of intensive care with utilization and costs of outpatient healthcare services and quality of life
- How well do cancer survivor self-classifications of anxiety, depression and stress agree with a standardised tool? Results of a cross-sectional study
- Comparative nutritional characteristics of the three major Chinese Dendrobium species with different growth years
- Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
- Geographic differentiation of agritourism activities in Poland vs. cultural and natural attractiveness of destinations at district level
- Social participation reduces isolation among Japanese older people in urban area: A 3-year longitudinal study
- Explaining age-related decline in theory of mind: Evidence for intact competence but compromised executive function
- Role of GDF15 in methylseleninic acid-mediated inhibition of cell proliferation and induction of apoptosis in prostate cancer cells
- Black people are convicted more for being black than for being poor: The role of social norms and cultural prejudice on biased racial judgments
- Bulked segregant analysis RNA-seq (BSR-Seq) validated a stem resistance locus in Aegilops umbellulata, a wild relative of wheat
- Neurobehavioral dysfunction in non-alcoholic steatohepatitis is associated with hyperammonemia, gut dysbiosis, and metabolic and functional brain regional deficits
- Barriers and enablers to the implementation of a complex quality improvement intervention for acute kidney injury: A qualitative evaluation of stakeholder perceptions of the Tackling AKI study
- Soil and vegetation conditions changes following the different sand dune restoration measures on the Zoige Plateau
- Experimental H1N1pdm09 infection in pigs mimics human seasonal influenza infections
- Emission characteristics of diethylhexyl phthalate (DEHP) from building materials determined using a passive flux sampler and micro-chamber
- Multi-focus microscope with HiLo algorithm for fast 3-D fluorescent imaging
- Pontoscolex corethrurus: A homeless invasive tropical earthworm?
- Modeling reciprocal effects in medical research: Critical discussion on the current practices and potential alternative models
- Does palliative chemotherapy really palliate and are we measuring it correctly? A mixed methods longitudinal study of health related quality of life in advanced soft tissue sarcoma
- Developing cookies formulated with goat cream enriched with conjugated linoleic acid
- The effects of combining focus of attention and autonomy support on shot accuracy in the penalty kick
- Association between hot flashes severity and oxidative stress among Mexican postmenopausal women: A cross-sectional study
- A combined strategy of neuropeptide prediction and tandem mass spectrometry identifies evolutionarily conserved ancient neuropeptides in the sea anemone Nematostella vectensis
- Lipidome profiles of postnatal day 2 vaginal swabs reflect fat composition of gilt’s postnatal diet
- Antitumor activity of a novel dual functional podophyllotoxin derivative involved PI3K/AKT/mTOR pathway
- Genome-wide developed microsatellites reveal a weak population differentiation in the hoverfly Eupeodes corollae (Diptera: Syrphidae) across China
- Prognosis of severe acquired brain injury: Short and long-term outcome determinants and their potential clinical relevance after rehabilitation. A comprehensive approach to analyze cohort studies
- An in silico investigation of menthol metabolism
- Variant analysis pipeline for accurate detection of genomic variants from transcriptome sequencing data
- Identification of candidate flowering and sex genes in white Guinea yam (D. rotundata Poir.) by SuperSAGE transcriptome profiling
- Optimizing the intrinsic parallel diffusivity in NODDI: An extensive empirical evaluation
- The quality of guidelines for diabetic foot ulcers: A critical appraisal using the AGREE II instrument
- Mastitis risk effect on the economic consequences of paratuberculosis control in dairy cattle: A stochastic modeling study
- Confounding by indication of the safety of de-escalation in community-acquired pneumonia: A simulation study embedded in a prospective cohort
- Effects from diet-induced gut microbiota dysbiosis and obesity can be ameliorated by fecal microbiota transplantation: A multiomics approach
- Drivers of HIV-1 transmission: The Portuguese case
- Integration of a FT expression cassette into CRISPR/Cas9 construct enables fast generation and easy identification of transgene-free mutants in Arabidopsis
- A biface production older than 600 ka ago at Notarchirico (Southern Italy) contribution to understanding early Acheulean cognition and skills in Europe
- Mass evacuation and increases in long-term care benefits: Lessons from the Fukushima nuclear disaster
- Circulating levels of free 25(OH)D increase at the onset of rheumatoid arthritis
- The expression of equine keratins K42 and K124 is restricted to the hoof epidermal lamellae of Equus caballus
- Soil respiration from fields under three crop rotation treatments and three straw retention treatments
- Inhibition of polymerase chain reaction: Pathogen-specific controls are better than human gene amplification
- Linkage disequilibrium and haplotype block patterns in popcorn populations
- Downscaling satellite soil moisture using geomorphometry and machine learning
- Choosing efficient actions: Deciding where to walk
- The zooarchaeology and isotopic ecology of the Bahamian hutia (Geocapromys ingrahami): Evidence for pre-Columbian anthropogenic management
- Synergy of the flow behaviour and disperse phase of cellulose nanoparticles in enhancing oil recovery at reservoir condition
- Accuracy of Determine TB-LAM Ag to detect TB in HIV infected patients associated with diagnostic methods used in Brazilian public health units
- Human papillomavirus infection among head and neck squamous cell carcinomas in southern China
- Comparison of feature point detectors for multimodal image registration in plant phenotyping
- Quartet-based inference of cell differentiation trees from ChIP-Seq histone modification data
- Detection and prognostic relevance of circulating tumour cells (CTCs) in Asian breast cancers using a label-free microfluidic platform
- Coralline algal calcification: A morphological and process-based understanding
- Comparing record linkage software programs and algorithms using real-world data
- Antimicrobial resistance and molecular genotyping of Salmonella enterica serovar Enteritidis clinical isolates from Guizhou province of Southwestern China
- Measuring sexual relationship power equity among young women and young men South Africa: Implications for gender-transformative programming
- Effectiveness, safety/tolerability of OBV/PTV/r ± DSV in patients with HCV genotype 1 or 4 with/without HIV-1 co-infection, chronic kidney disease (CKD) stage IIIb-V and dialysis in Spanish clinical practice – Vie-KinD study
- The genome of Alcaligenes aquatilis strain BU33N: Insights into hydrocarbon degradation capacity
- A randomized pilot efficacy and safety trial of diazoxide choline controlled-release in patients with Prader-Willi syndrome
- LMX1A inhibits C-Myc expression through ANGPTL4 to exert tumor suppressive role in gastric cancer
- Lung clearance index to detect the efficacy of Aztreonam lysine inhalation in patients with cystic fibrosis and near normal spirometry – A single-centre feasibility study
- Association of vitamin D nutrition with neuro-developmental outcome of infants of slums in Bangladesh
- Effect of PEPFAR funding policy change on HIV service delivery in a large HIV care and treatment network in Nigeria
- Friends, relatives, sanity, and health: The costs of politics
- European public perceptions of homelessness: A knowledge, attitudes and practices survey
- An overview of the quality assurance programme for HIV rapid testing in South Africa: Outcome of a 2-year phased implementation of quality assurance program
- Transcatheter aortic valve implantation versus surgical aortic valve replacement in patients at low and intermediate risk: A risk specific meta-analysis of randomized controlled trials
- Global smoking trends in inflammatory bowel disease: A systematic review of inception cohorts
- Identification of inflammatory markers suitable for non-invasive, repeated measurement studies in biobehavioral research: A feasibility study
- Genomic analyses reveal an absence of contemporary introgressive admixture between fin whales and blue whales, despite known hybrids
- Tipping the balance towards long-term retention in the HIV care cascade: A mixed methods study in southern Mozambique
- Diagnosis and classification of pediatric acute appendicitis by artificial intelligence methods: An investigator-independent approach
- Stylistic variation on the Donald Trump Twitter account: A linguistic analysis of tweets posted between 2009 and 2018
- Kinematic determinants of scoring success in the fencing flick: Logistic and linear multiple regression analysis
- Preferences for formal and traditional sources of childbirth and postnatal care among women in rural Africa: A systematic review
- Spectral characteristics of urine specimens from healthy human volunteers analyzed using Raman chemometric urinalysis (Rametrix)
- Associations between industry involvement and study characteristics at the time of trial registration in biomedical research
- A review of the elusive bicolored iris Snouted Treefrogs (Anura: Hylidae:Scinax uruguayus group)
- Development of peptide biosensor for the detection of dengue fever biomarker, nonstructural 1
- The predictive performance of SAPS 2 and SAPS 3 in an intermediate care unit for internal medicine at a German university transplant center; A retrospective analysis
- Advancing computational biology and bioinformatics research through open innovation competitions
- Dynamic changes in the physicochemical properties of fresh-cut produce wash water as impacted by commodity type and processing conditions
- Mapping online hate: A scientometric analysis on research trends and hotspots in research on online hate
- Orthogonal projection to latent structures and first derivative for manipulation of PLSR and SVR chemometric models' prediction: A case study
- DNA vaccine based on conserved HA-peptides induces strong immune response and rapidly clears influenza virus infection from vaccinated pigs
- Malaria transmission through the mosquito requires the function of the OMD protein
- Small molecule inhibition of lysine-specific demethylase 1 (LSD1) and histone deacetylase (HDAC) alone and in combination in Ewing sarcoma cell lines
- Governing Tripolye: Integrative architecture in Tripolye settlements
- In vitro selective cytotoxicity of the dietary chalcone cardamonin (CD) on melanoma compared to healthy cells is mediated by apoptosis
- Mortality, perception, and scale: Understanding how predation shapes space use in a wild prey population
- DNA analysis of elasmobranch products originating from Bangladesh reveals unregulated elasmobranch fishery and trade on species of global conservation concern
- Genome-wide analysis of methylation in giant pandas with cataract by methylation-dependent restriction-site associated DNA sequencing (MethylRAD)
- A spherical falling film gas-liquid equilibrator for rapid and continuous measurements of CO2 and other trace gases
- The role of vitamin D in increasing circulating T regulatory cell numbers and modulating T regulatory cell phenotypes in patients with inflammatory disease or in healthy volunteers: A systematic review
- Gastroenteritis and respiratory infection outbreaks in French nursing homes from 2007 to 2018: Morbidity and all-cause lethality according to the individual characteristics of residents
- A pull-down and slot blot-based screening system for inhibitor compounds of the podoplanin-CLEC-2 interaction
- De novo transcriptome analysis of Viola ×wittrockiana exposed to high temperature stress
- Robust methods in Mendelian randomization via penalization of heterogeneous causal estimates
- HMGB1 mediates the development of tendinopathy due to mechanical overloading
- Effects of the Best Possible Self intervention: A systematic review and meta-analysis
- Metabolomic profiling of oxalate-degrading probiotic Lactobacillus acidophilus and Lactobacillus gasseri
- Adjusting cotton planting density under the climatic conditions of Henan Province, China
- Multiple biomarkers of sepsis identified by novel time-lapse proteomics of patient serum
- PTSD in prison settings: A systematic review and meta-analysis of comorbid mental disorders and problematic behaviours
- The female presence in different organisational positions and performance in secondary schools: Does a woman leader function as mediator?
- Beta power encodes contextual estimates of temporal event probability in the human brain
- Molecular characterization of measles virus strains circulating in Cameroon during the 2013-2016 epidemics
- Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain
- Comprehensive analysis of the internal structure and firmness in American cranberry (Vaccinium macrocarpon Ait.) fruit
- Predicting spinal profile using 3D non-contact surface scanning: Changes in surface topography as a predictor of internal spinal alignment
- Assessment modelling approaches for stocks with spawning components, seasonal and spatial dynamics, and limited resources for data collection
- Qualitative analysis of ward staff experiences during research of a novel suicide-prevention psychological therapy for psychiatric inpatients: Understanding the barriers and facilitators
- De-climatizing food security: Lessons from climate change micro-simulations in Peru
- Influence of musculotendon geometry variability in muscle forces and hip bone-on-bone forces during walking
- An international survey of perceptions of the 2014 FIFA World Cup: National levels of corruption as a context for perceptions of institutional corruption
- Dissuasive effect, information provision, and consumer reactions to the term ‘Biotechnology’: The case of reproductive interventions in farmed fish
- "If I have a cancer, it is not my fault I am a refugee”: A qualitative study with expert stakeholders on cancer care management for Syrian refugees in Jordan
- The effect of the use of a decision aid with individual risk estimation on the mode of delivery after a caesarean section: A prospective cohort study
- Geographical location influences the composition of the gut microbiota in wild house mice (Mus musculus domesticus) at a fine spatial scale
- High-throughput RNA-sequencing identifies mesenchymal stem cell-induced immunological signature in a rat model of corneal allograft rejection
- Evaluation of the pain intensity differences among hospitalized cancer patients based on a nursing information system
- Effects of chitin synthesis inhibitor treatment on Lepeophtheirus salmonis (Copepoda, Caligidae) larvae
- Protective mechanism of 1-methylhydantoin against lung injury induced by paraquat poisoning
- Use of high-content analysis and machine learning to characterize complex microbial samples via morphological analysis
- Investigation of a spatial coupling relationship between carbon emission performance and regional urbanization in China
- A mutation in mouse Krüppel-like factor 15 alters the gut microbiome and response to obesogenic diet
- Excellent outcome after desensitization in high immunologic risk kidney transplantation
- Characterization of a new composite membrane for point of need paper-based micro-scale microbial fuel cell analytical devices
- Acute kidney injury during an ultra-distance race
- A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats
- The role of C-reactive protein levels on the association of physical activity with lung function in adults
- The CrowdWater game: A playful way to improve the accuracy of crowdsourced water level class data
- Therapeutic efficacy of neuregulin 1-expressing human adipose-derived mesenchymal stem cells for ischemic stroke
- CRISPR/Cas9-based editing of a sensitive transcriptional regulatory element to achieve cell type-specific knockdown of the NEMO scaffold protein
- Exploring the microbiota of upper respiratory tract during the development of pneumonia in a mouse model
- Improved ICU mortality prediction based on SOFA scores and gastrointestinal parameters
- Social information use and collective foraging in a pursuit diving seabird
- Ozone effects on blood biomarkers of systemic inflammation, oxidative stress, endothelial function, and thrombosis: The Multicenter Ozone Study in oldEr Subjects (MOSES)
- Human osteocyte expression of Nerve Growth Factor: The effect of Pentosan Polysulphate Sodium (PPS) and implications for pain associated with knee osteoarthritis
- Prevalence of Epstein-Barr virus, human papillomavirus, cytomegalovirus and herpes simplex virus type 1 in patients with diabetes mellitus type 2 in south-eastern Poland
- Social and structural factors associated with substance use within the support network of adults living in precarious housing in a socially marginalized neighborhood of Vancouver, Canada
- Characterization of Monkeypox virus dissemination in the black-tailed prairie dog (Cynomys ludovicianus) through in vivo bioluminescent imaging
- LPS induces inflammatory chemokines via TLR-4 signalling and enhances the Warburg Effect in THP-1 cells
- How do seabirds modify their search behaviour when encountering fishing boats?
- The diagnostic value of pleural fluid homocysteine in malignant pleural effusion
- Spatio-temporal variations in wheat aphid populations and their natural enemies in four agro-ecological zones of Pakistan
- Factors associated with burnout amongst healthcare workers providing HIV care in Malawi
- A high-density exome capture genotype-by-sequencing panel for forestry breeding in Pinus radiata
- Self-management action and motivation of Pacific adults in New Zealand with end-stage renal disease
- Drought mediated physiological and molecular changes in muskmelon (Cucumis melo L.)
- A prospective randomized trial on abacavir/lamivudine plus darunavir/ritonavir or raltegravir in HIV-positive drug-naïve patients with CD4<200 cells/uL (the PRADAR study)
- Analyzing data from the digital healthcare exchange platform for surveillance of antibiotic prescriptions in primary care in urban Kenya: A mixed-methods study
- Multi-dimensional evaluation of response to salt stress in wheat
- Tuberculosis in the wild boar: Frequentist and Bayesian estimations of diagnostic test parameters when Mycobacterium bovis is present in wild boars but at low prevalence
- Enhanced mechanical and thermal properties of electrically conductive TPNR/GNP nanocomposites assisted with ultrasonication
- Geospatial modeling of microcephaly and zika virus spread patterns in Brazil
- Maternal cardiovascular-related single nucleotide polymorphisms, genes, and pathways associated with early-onset preeclampsia
- A ten-year review of ESBL and non-ESBL Escherichia coli bloodstream infections among children at a tertiary referral hospital in South Africa
- Reference values for the cervical spinal canal and the vertebral bodies by MRI in a general population
- Dynamic mechanical characteristics and failure mode of serpentine under a three-dimensional high static load and frequent dynamic disturbance
- Incorporating statistical strategy into image analysis to estimate effects of steam and allyl isocyanate on weed control
- Regulation of NF-κB- and STAT1-mediated plasmacytoid dendritic cell functions by A20
- The erythrocyte membrane stability is associated with sleep time and social jetlag in shift workers
- New space-time block codes from spectral norm
- Mexican BRCA1 founder mutation: Shortening the gap in genetic assessment for hereditary breast and ovarian cancer patients
- GIVE me your attention: Differentiating goal identification and goal execution components of the anti-saccade effect
- Maternal serum retinol, 25(OH)D and 1,25(OH)2D concentrations during pregnancy and peak bone mass and trabecular bone score in adult offspring at 26-year follow-up
- Self Multi-Head Attention-based Convolutional Neural Networks for fake news detection
- Why are Chinese workers so unhappy? A comparative cross-national analysis of job satisfaction, job expectations, and job attributes
- Fecal indicator bacteria and virus removal in stormwater biofilters: Effects of biochar, media saturation, and field conditioning
- Personalized microstructural evaluation using a Mahalanobis-distance based outlier detection strategy on epilepsy patients’ DTI data – Theory, simulations and example cases
- Radiographic assessment of pectoral flipper bone maturation in bottlenose dolphins (Tursiops truncatus), as a novel technique to accurately estimate chronological age
- Intraoperative measurement of intraventricular pressure in dogs with communicating internal hydrocephalus
- Relative importance of gene effects for nitrogen-use efficiency in popcorn
- Comparative analysis uncovers the limitations of current molecular detection methods for Fusarium oxysporum f. sp. cubense race 4 strains
- The accuracy of the frontal extent in stereoscopic environments: A comparison of direct selection and virtual cursor techniques
- Confronting pastoralists’ knowledge of cattle breeds raised in the extensive production systems of Benin with multivariate analyses of morphological traits
- CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer’s disease
- Decontamination of aerosolised bacteria from a pig farm environment using a pH neutral electrochemically activated solution (Ecas4 anolyte)
- Transcriptomic changes triggered by ouabain in rat cerebellum granule cells: Role of α3- and α1-Na+,K+-ATPase-mediated signaling
- Simultaneous transcriptome analysis of oil palm clones and Phytophthora palmivora reveals oil palm defense strategies
- Antifungal effects of a 1,3,4-thiadiazole derivative determined by cytochemical and vibrational spectroscopic studies
- Risk factors for unsuccessful tuberculosis treatment outcomes in children
- CRISPR-based tools for targeted transcriptional and epigenetic regulation in plants
- Reliability of high-resolution ultrasound and magnetic resonance arthrography of the shoulder in patients with sports-related shoulder injuries
- Spatial-temporal variation characteristics and evolution of the global industrial robot trade: A complex network analysis
- Axial variation of deoxyhemoglobin density as a source of the low-frequency time lag structure in blood oxygenation level-dependent signals
- On the sustainability of a family planning program in Nigeria when funding ends
- The epidemiology of antidepressant use in South Korea: Does short-term antidepressant use affect the relapse and recurrence of depressive episodes?
- Injury severity level and associated factors among road traffic accident victims attending emergency department of Tirunesh Beijing Hospital, Addis Ababa, Ethiopia: A cross sectional hospital-based study
- How chimpanzees (Pan troglodytes) share the spoils with collaborators and bystanders
- Seed treatment using methyl jasmonate induces resistance to rice water weevil but reduces plant growth in rice
- Placebo analgesia induced by verbal suggestion in the context of experimentally induced fear and anxiety
- Reconsidering the associations between self-reported alcohol use disorder and mental health problems in the light of co-occurring addictions in young Swiss men
- Learning to assist smokers through encounters with standardized patients: An innovative training for physicians in an Eastern European country
- Serum E-selectin concentration is associated with risk of metabolic syndrome in females
- Lipid and fatty acid dynamics by maternal Pacific bluefin tuna
- Adherence to evidence-based recommendations for surgical site infection prevention: Results among Italian surgical ward nurses
- Novel synergistic fungicidal mixtures of oxathiapiprolin protect sunflower seeds from downy mildew caused by Plasmopara halstedii
- Adjustment of a numerical model for pore pressure generation during an earthquake
- The risk, perceived and actual, of developing type 2 diabetes mellitus for mothers of preschool children in urban China
- Effects of turning frequency on the nutrients of Camellia oleifera shell co-compost with goat dung and evaluation of co-compost maturity
- Imaging disease activity of rheumatoid arthritis by macrophage targeting using second generation translocator protein positron emission tomography tracers
- Distribution of SET/I2PP2A protein in gastrointestinal tissues
- Spontaneous lymphoblastoid cell lines from patients with Epstein-Barr virus infection show highly variable proliferation characteristics that correlate with the expression levels of viral microRNAs
- Early pre- and postsynaptic decrease in glutamatergic and cholinergic signaling after spinalization is not modified when stimulating proprioceptive input to the ankle extensor α-motoneurons: Anatomical and neurochemical study
- Anatomy of a demand shock: Quantitative analysis of crowding in hospital emergency departments in Victoria, Australia during the 2009 influenza pandemic
- Oregano essential oil vapour prevents Plasmopara viticola infection in grapevine (Vitis Vinifera) and primes plant immunity mechanisms
- Dual inhibitory action of trazodone on dorsal raphe serotonergic neurons through 5-HT1A receptor partial agonism and α1-adrenoceptor antagonism
- Optimising poly(lactic-co-glycolic acid) microparticle fabrication using a Taguchi orthogonal array design-of-experiment approach
- Repetitive finger movement and circle drawing in persons with Parkinson’s disease
- The association between family members’ migration and cognitive function among people left behind in China
- Association between long-term adherence to class-I recommended medications and risk for potentially preventable heart failure hospitalizations among younger adults
- Differential role of r-met-hu G-CSF on male reproductive function and development in prepubertal domestic mammals
- Agreement between the spatiotemporal gait parameters from two different wearable devices and high-speed video analysis
- In-hospital cardiopulmonary resuscitation of patients with cirrhosis: A population-based analysis
- Vitamin D treatment of peripheral blood mononuclear cells modulated immune activation and reduced susceptibility to HIV-1 infection of CD4+ T lymphocytes
- Someone like me: Size-assortative pairing and mating in an Amazonian fish, sailfin tetra Crenuchus spilurus
- Seasonality of antenatal care attendance, maternal dietary intake, and fetal growth in the VHEMBE birth cohort, South Africa
- Are trials of psychological and psychosocial interventions for schizophrenia and psychosis included in the NICE guidelines pragmatic? A systematic review
- Incidence of retinal vein occlusion with long-term exposure to ambient air pollution
- Inclusion of enclosed hydration effects in the binding free energy estimation of dopamine D3 receptor complexes
- Intensity modulated radiation therapy following lumpectomy in early-stage breast cancer: Patterns of use and cost consequences among Medicare beneficiaries
- The ‘Saw but Forgot’ error: A role for short-term memory failures in understanding junction crashes?
- Multiscale Modelling Tool: Mathematical modelling of collective behaviour without the maths
- A comparison of machine learning algorithms for the surveillance of autism spectrum disorder
- Drivers of deforestation in the basin of the Usumacinta River: Inference on process from pattern analysis using generalised additive models
- Structure of Dictyostelium discoideum telomeres. Analysis of possible replication mechanisms
- Multidrug-resistant profile and prevalence of extended spectrum β-lactamase and carbapenemase production in fermentative Gram-negative bacilli recovered from patients and specimens referred to National Reference Laboratory, Addis Ababa, Ethiopia
- Primary myelofibrosis marrow-derived CD14+/CD34- monocytes induce myelofibrosis-like phenotype in immunodeficient mice and give rise to megakaryocytes
- Intersubject MVPD: Empirical comparison of fMRI denoising methods for connectivity analysis
- Why Cohen’s Kappa should be avoided as performance measure in classification
- A novel strategy for interpreting the T-SPOT.TB test results read by an ELISPOT plate imager
- Computational identification of key genes that may regulate gene expression reprogramming in Alzheimer’s patients
- NPHP proteins are binding partners of nucleoporins at the base of the primary cilium
- Intensive measures of luminescence in GaN/InGaN heterostructures
- The effect of a web-based training for improving primary health care providers’ knowledge about diabetes mellitus management in rural China: A pre-post intervention study
- Isolation, identification and characterization of Streptomyces metabolites as a potential bioherbicide
- Quantitative magnetic resonance imaging indicates brain tissue alterations in patients after liver transplantation
- DNA analysis of Castanea sativa (sweet chestnut) in Britain and Ireland: Elucidating European origins and genepool diversity
- Forecasting the impact of population ageing on tuberculosis incidence
- Conformation and mechanical property of rpoS mRNA inhibitory stem studied by optical tweezers and X-ray scattering
- Voxelwise statistical methods to localize practice variation in brain tumor surgery
- Identification and evolutionary characterization of salt-responsive transcription factors in the succulent halophyte Suaeda fruticosa
- Integrating temperature-dependent life table data into Insect Life Cycle Model for predicting the potential distribution of Scapsipedus icipe Hugel & Tanga
- Rollout of ShangRing circumcision with active surveillance for adverse events and monitoring for uptake in Kenya
- Comparative phenotypic profiling of the JAK2 inhibitors ruxolitinib, fedratinib, momelotinib, and pacritinib reveals distinct mechanistic signatures
- Analyzing a networked social algorithm for collective selection of representative committees
- Gene expression profiling of skeletal myogenesis in human embryonic stem cells reveals a potential cascade of transcription factors regulating stages of myogenesis, including quiescent/activated satellite cell-like gene expression
- Ex vivo physiological compression of human osteoarthritis cartilage modulates cellular and matrix components
- EFForTS-LGraf: A landscape generator for creating smallholder-driven land-use mosaics
- Impact of the severity of negative energy balance on gene expression in the subcutaneous adipose tissue of periparturient primiparous Holstein dairy cows: Identification of potential novel metabolic signals for the reproductive system
- Precision and consistency of the passive leg raising maneuver for determining fluid responsiveness with bioreactance non-invasive cardiac output monitoring in critically ill patients and healthy volunteers
- Optimizing bacterial DNA extraction in urine
- Adherences to oral nutritional supplementation among hospital outpatients: An online cross-sectional survey in Japan
- Effects of inorganic nitrogen and litters of Masson Pine on soil organic carbon decomposition
- Antioxidant properties of potato tubers (Solanum tuberosum L.) as a consequence of genetic potential and growing conditions
- Transcatheter aortic valve implantation versus conservative management for severe aortic stenosis in real clinical practice
- “I put it in my head that the supplement would help me”: Open-placebo improves exercise performance in female cyclists
- Automated diagnosis of heart valve degradation using novelty detection algorithms and machine learning
- Spatiotemporal clustering of malaria in southern-central Ethiopia: A community-based cohort study
- Studying the link between physiological performance of Crotalaria ochroleuca and the distribution of Ca, P, K and S in seeds with X-ray fluorescence
- Characterization of bony changes localized to the cervical articular processes in a mixed population of horses
- Heat shock-induced chaperoning by Hsp70 is enabled in-cell
- Disability and its association with sociodemographic factors among elderly persons residing in an urban resettlement colony, New Delhi, India
- Correlates of prenatal and postnatal mother-to-infant bonding quality: A systematic review
- IGFBP2 promotes immunosuppression associated with its mesenchymal induction and FcγRIIB phosphorylation in glioblastoma
- Dietary supplementation with the extract from Eucommia ulmoides leaves changed epithelial restitution and gut microbial community and composition of weanling piglets
- How did that interaction make you feel? The relationship between quality of everyday social experiences and emotion in people with and without schizophrenia
- Effects of Lyse-It on endonuclease fragmentation, function and activity
- Overexpression of rice gene OsATG8b confers tolerance to nitrogen starvation and increases yield and nitrogen use efficiency (NUE) in Arabidopsis
- Gait can reveal sleep quality with machine learning models
- Blast vacuolization in AML patients indicates adverse-risk AML and is associated with impaired survival after intensive induction chemotherapy
- Mitochondrial fragmentation and network architecture in degenerative diseases
- Quadriceps muscle strength is a discriminant predictor of dependence in daily activities in nursing home residents
- Discovery of novel West Nile Virus protease inhibitor based on isobenzonafuranone and triazolic derivatives of eugenol and indan-1,3-dione scaffolds
- Skin-associated lactic acid bacteria from North American bullfrogs as potential control agents of Batrachochytrium dendrobatidis
- Microbiota of MR1 deficient mice confer resistance against Clostridium difficile infection
- The responses of extracellular enzyme activities and microbial community composition under nitrogen addition in an upland soil
- Post-translational S-glutathionylation of cofilin increases actin cycling during cocaine seeking
- Absolute pitch can be learned by some adults
- Anger while driving in Mexico City
- Glomerular hyperfiltration may be a novel risk factor of restrictive spirometry pattern: Analysis of the Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2015
- Survival of infants ≤24 months of age with brain tumors: A population-based study using the SEER database
- Multiple evoked and induced alpha modulations in a visual attention task: Latency, amplitude and topographical profiles
- Heart rate variability reduction is related to a high amount of visceral adiposity in healthy young women
- Serum and urinary metabolomics and outcomes in cirrhosis
- Optimal threshold of adherence to lipid lowering drugs in predicting acute coronary syndrome, stroke, or mortality: A cohort study
- Systemic antibiotic prophylaxis does not affect infectious complications in pediatric burn injury: A meta-analysis
- How Knowledge Stock Exchanges can increase student success in Massive Open Online Courses
- CT-perfusion in peripheral arterial disease – Correlation with angiographic and hemodynamic parameters
- Pattern of health care utilization and traditional and complementary medicine use among Ebola survivors in Sierra Leone
- Respiratory variations in pulse pressure and photoplethysmographic waveform amplitude during positive expiratory pressure and continuous positive airway pressure in a model of progressive hypovolemia
- Dorsal tongue porphyrin autofluorescence and Candida saprophytism: A prospective observational study
- A usability study to improve a clinical decision support system for the prescription of antibiotic drugs
- Occurrence of and risk factors for extended-spectrum cephalosporin-resistant Enterobacteriaceae determined by sampling of all Norwegian broiler flocks during a six month period
- Healthcare facility-based strategies to improve tuberculosis testing and linkage to care in non-U.S.-born population in the United States: A systematic review
- Correction: Reward abundance interferes with error-based learning in a visuomotor adaptation task
- Correction: Potential user interest in new long-acting contraceptives: Results from a mixed methods study in Burkina Faso and Uganda
- Correction: Recombinant rabbit beta nerve growth factor production and its biological effects on sperm and ovulation in rabbits
- Critically ill patients with community-onset intraabdominal infections: Influence of healthcare exposure on resistance rates and mortality
- Validating a popular outpatient antibiotic database to reliably identify high prescribing physicians for patients 65 years of age and older
- Metabolisable energy content in canine and feline foods is best predicted by the NRC2006 equation
- Group conquers efficacy: Preschoolers’ imitation under conflict between minimal group membership and behavior efficacy
- Warmth and competence stereotypes about immigrant groups in Germany
- Social resistance drives persistent transmission of Ebola virus disease in Eastern Democratic Republic of Congo: A mixed-methods study
- ER stress activation in the intestinal mucosa but not in mesenteric adipose tissue is associated with inflammation in Crohn’s disease patients
- Enhancing percutaneous pedicle screw fixation with hydroxyapatite granules: A biomechanical study using an osteoporotic bone model
- Optimum plant density for crowding stress tolerant processing sweet corn
- Sign and goal tracker rats process differently the incentive salience of a conditioned stimulus
- Interocular symmetry, intraobserver repeatability, and interobserver reliability of cone density measurements in the 13-lined ground squirrel
- Plasma metabolite biomarkers for multiple system atrophy and progressive supranuclear palsy
- Knowledge, attitudes and practices of livestock and aquaculture producers regarding antimicrobial use and resistance in Vietnam
- Scientific sinkhole: The pernicious price of formatting
- Resource consumption of multi-substance users in the emergency room: A neglected patient group
- Association between distress and knowledge among parents of autistic children
- Surgical approach for complete cochlear coverage in EAS-patients after residual hearing loss
- The impact of a rapid molecular identification test on positive blood cultures from critically ill with bacteremia: A pre-post intervention study
- Shortening duration of ertapenem in outpatient parenteral antimicrobial therapy for complicated urinary tract infections: A retrospective study
- Measurement and analysis of partial lightning currents in a head phantom
- Within species expressed genetic variability and gene expression response to different temperatures in the rotifer Brachionus calyciflorus sensu stricto
- Repeated transspinal stimulation decreases soleus H-reflex excitability and restores spinal inhibition in human spinal cord injury
- Expression of Concern: Resveratrol Enhances Antitumor Activity of TRAIL in Prostate Cancer Xenografts through Activation of FOXO Transcription Factor
- Correlation of CT texture changes with treatment response during radiation therapy for esophageal cancer: An exploratory study
- Modeling spatial variation in density of golden eagle nest sites in the western United States
- Retraction: Autophagy in Muscle of Glucose-Infusion Hyperglycemia Rats and Streptozotocin-Induced Hyperglycemia Rats via Selective Activation of m-TOR or FoxO3
- Correction: In Porphyromonas gingivalis VimF Is Involved in Gingipain Maturation through the Transfer of Galactose
- Gibberellic acid in Citrus spp. flowering and fruiting: A systematic review
- Discharge care quality in hospitalised elderly patients: Extended validation of the Discharge Care Experiences Survey
- A novel therapeutic strategy for esophageal varices using endoscopic treatment combined with splenic artery embolization according to the Child-Pugh classification
- Correction: Development of a high-throughput assay to measure measles neutralizing antibodies
- Correction: Provider preference for payment method under a national health insurance scheme: A survey of health insurance-credentialed health care providers in Ghana
- Correction: Second-line HIV treatment failure in sub-Saharan Africa: A systematic review and meta-analysis
- Potential impact of efflux pump genes in mediating rifampicin resistance in clinical isolates of Mycobacterium tuberculosis from India
- Feed-forward visual processing suffices for coarse localization but fine-grained localization in an attention-demanding context needs feedback processing
- Level Set method-based two-dimensional numerical model for simulation of nonuniform open-channel flow
- Compared to non-drinkers, individuals who drink alcohol have a more favorable multisystem physiologic risk score as measured by allostatic load
- Effect of poor glycaemic control on plasma levels and activity of protein C, protein S, and antithrombin III in type 2 diabetes mellitus
- Retraction: IL-21 Regulates the Differentiation of a Human γδ T Cell Subset Equipped with B Cell Helper Activity
- Sugar transporters in Fabaceae, featuring SUT MST and SWEET families of the model plant Medicago truncatula and the agricultural crop Pisum sativum
- Prediction of lymphovascular space invasion in endometrial cancer using the 55-gene signature selected by DNA microarray analysis
- Research on multi-agent genetic algorithm based on tabu search for the job shop scheduling problem
- Diagnosing the current state of out-of-field teaching in high school science and mathematics
- Sensitivity of the fasciae to sex hormone levels: Modulation of collagen-I, collagen-III and fibrillin production
- Comorbidity of age-related macular degeneration with Alzheimer’s disease: A histopathologic case-control study
- Acute ex vivo changes in brain white matter diffusion tensor metrics
- Regulatory interaction between the ZPBP2-ORMDL3/Zpbp2-Ormdl3 region and the circadian clock
- The effect of bacteria on planula-larvae settlement and metamorphosis in the octocoral Rhytisma fulvum fulvum
- Sodium alginate potentiates antioxidant defense and PR proteins against early blight disease caused by Alternaria solani in Solanum lycopersicum Linn.
- Ground reaction forces and muscle activity while walking on sand versus stable ground in individuals with pronated feet compared with healthy controls
- Correction: Roadway traffic crash prediction using a state-space model based support vector regression approach
- MET as resistance factor for afatinib therapy and motility driver in gastric cancer cells
- Genetic analysis and fine mapping of a qualitative trait locus wpb1 for albino panicle branches in rice
- Clinical features of pulmonary embolism in patients with lung cancer: A meta-analysis
- Cinobufacini ameliorates experimental colitis via modulating the composition of gut microbiota
- Factors restraining the population growth of Varroa destructor in Ethiopian honey bees (Apis mellifera simensis)
- Coastal proximity of populations in 22 Pacific Island Countries and Territories
- DKK1 promotes hepatocellular carcinoma inflammation, migration and invasion: Implication of TGF-β1
- Genetic characterization of Angiostrongylus larvae and their intermediate host, Achatina fulica, in Thailand
- Targeted in-vitro-stimulation reveals highly proliferative multi-virus-specific human central memory T cells as candidates for prophylactic T cell therapy
- Influence of ocean circulation and the Kuroshio large meander on the 2018 Japanese eel recruitment season
- Growth response of the ichthyotoxic haptophyte, Prymnesium parvum Carter, to changes in sulfate and fluoride concentrations
- Letrozole treatment of pubertal female mice results in activational effects on reproduction, metabolism and the gut microbiome
- Prognostic nomogram predicts overall survival in pulmonary large cell neuroendocrine carcinoma
- Microbiome profiling of the onion thrips, Thrips tabaci Lindeman (Thysanoptera: Thripidae)
- Characteristics of proximal early gastric cancer differentiating distal early gastric cancer
- Retraction: Impacts of rock properties on Danxia landform formation based on lithological experiments at Kongtongshan National Geopark, northwest China
- Correction: SVR12 rates higher than 99% after sofosbuvir/velpatasvir combination in HCV infected patients with F0-F1 fibrosis stage: A real world experience
- Retraction: Plexin-B1 Activates NF-κB and IL-8 to Promote a Pro-Angiogenic Response in Endothelial Cells
- Relationship between cognitive behavioral variables and mental health status among university students: A meta-analysis
- Association between temperature, sunlight hours and alcohol consumption
- Using graph learning to understand adverse pregnancy outcomes and stress pathways
- Correction: The step-to-step transition mode: A potential indicator of first-fall risk in elderly adults?
- Surgical referral systems in low- and middle-income countries: A review of the evidence
- In vivo clearance of nanoparticles by transcytosis across alveolar epithelial cells
- Correction: The Economic Impact of Malignant Catarrhal Fever on Pastoralist Livelihoods
- Correction: Identification of miRNAs involved in fruit ripening by deep sequencing of Olea europaea L. transcriptome
- Correction: Characterization of ecto- and endoparasite communities of wild Mediterranean teleosts by a metabarcoding approach
- Correction: Vascular Endothelial Growth Factor Receptor-2 Couples Cyclo-Oxygenase-2 with Pro-Angiogenic Actions of Leptin on Human Endothelial Cells
- Correction: Plant traits linked to field-scale flammability metrics in prescribed burns in Eucalyptus forest
- Correction: Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation
- Correction: To keep or not to keep? Decision making in adolescent pregnancies in Jamestown, Ghana
- PLOS One
- Archiv čísel
- Aktuální číslo
- Informace o časopisu
Nejčtenější v tomto čísle
- Graviola (Annona muricata) attenuates behavioural alterations and testicular oxidative stress induced by streptozotocin in diabetic rats
- CH(II), a cerebroprotein hydrolysate, exhibits potential neuro-protective effect on Alzheimer’s disease
- Comparison between Aptima Assays (Hologic) and the Allplex STI Essential Assay (Seegene) for the diagnosis of Sexually transmitted infections
- Assessment of glucose-6-phosphate dehydrogenase activity using CareStart G6PD rapid diagnostic test and associated genetic variants in Plasmodium vivax malaria endemic setting in Mauritania
Zvyšte si kvalifikaci online z pohodlí domova
Mazová zátka a její řešení
nový kurzVšechny kurzy